Diminished Acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion

Journal of Biological Chemistry

Volumn 288, Issue 30, 2013, Pages 21618-21629

  Klett, Eric L ^a   Chen, Shufen ^a   Edin, Matthew L ^b   Li, Lei O ^c   Ilkayeva, Olga ^d   Zeldin, Darryl C ^b   Newgard, Christopher B ^d   Coleman, Rosalind A ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c University of North Carolina at Chapel Hill   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA SYNTHETASE; BETA CELL; EPOXYEICOSATRIENOIC ACIDS; GLUCOSE-STIMULATED INSULIN SECRETIONS; INSULIN SECRETION; ISOFORMS; LIPID METABOLISMS; NOVEL STRATEGIES;

GLUCOSE; INSULIN; METABOLISM;

PHYSIOLOGY;

ACYL COA SYNTHETASE ISOFORM 4; ACYL COENZYME A; ARACHIDONIC ACID; EPOXYICOSATRIENOIC ACID; GLUCOSE; GLYCEROPHOSPHOLIPID; INSULIN; LINOLEIC ACID; LONG CHAIN ACYL COENZYME A; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACSL4 GENE; ACSL5 GENE; ANIMAL CELL; ARTICLE; CELL LEVEL; CELL MEMBRANE; CELL STRAIN; CELL STRAIN INS 13; CELL STRAIN INS 832; CONTROLLED STUDY; ENDOCRINE DISEASE; ENZYME ACTIVITY; ENZYME REGULATION; ESTERIFICATION; FATTY ACID OXIDATION; GENE SILENCING; GLUCOSE STIMULATED INSULIN SECRETION; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; RAT; REGULATORY MECHANISM;

ACYL-COA SYNTHETASE; ARACHIDONIC ACID; BETA-CELL; EICOSANOID; EPOXYEICOSATRIENOIC ACIDS; INSULIN SECRETION; POLYUNSATURATED FATTY ACIDS;

8,11,14-EICOSATRIENOIC ACID; ACYL COENZYME A; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; COENZYME A LIGASES; FATTY ACIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLYCEROPHOSPHOLIPIDS; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; MEMBRANE LIPIDS; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 84881248414     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.481077     Document Type: Article

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