-
1
-
-
8144226856
-
The gut microbiota as an environmental factor that regulates fat storage
-
F. Bäckhed, H. Ding, T. Wang, L.V. Hooper, G.Y. Koh, A. Nagy, C.F. Semenkovich, and J.I. Gordon The gut microbiota as an environmental factor that regulates fat storage Proc. Natl. Acad. Sci. USA 101 2004 15718 15723
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15718-15723
-
-
Bäckhed, F.1
Ding, H.2
Wang, T.3
Hooper, L.V.4
Koh, G.Y.5
Nagy, A.6
Semenkovich, C.F.7
Gordon, J.I.8
-
2
-
-
0025177196
-
Elevation of C-reactive protein in "active" coronary artery disease
-
B.C. Berk, W.S. Weintraub, and R.W. Alexander Elevation of C-reactive protein in "active" coronary artery disease Am. J. Cardiol. 65 1990 168 172
-
(1990)
Am. J. Cardiol.
, vol.65
, pp. 168-172
-
-
Berk, B.C.1
Weintraub, W.S.2
Alexander, R.W.3
-
3
-
-
33646134126
-
Effects of etanercept in patients with the metabolic syndrome
-
L.E. Bernstein, J. Berry, S. Kim, B. Canavan, and S.K. Grinspoon Effects of etanercept in patients with the metabolic syndrome Arch. Intern. Med. 166 2006 902 908
-
(2006)
Arch. Intern. Med.
, vol.166
, pp. 902-908
-
-
Bernstein, L.E.1
Berry, J.2
Kim, S.3
Canavan, B.4
Grinspoon, S.K.5
-
4
-
-
84865461206
-
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
-
A. Bertola, T. Ciucci, D. Rousseau, V. Bourlier, C. Duffaut, S. Bonnafous, C. Blin-Wakkach, R. Anty, A. Iannelli, and J. Gugenheim Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients Diabetes 61 2012 2238 2247
-
(2012)
Diabetes
, vol.61
, pp. 2238-2247
-
-
Bertola, A.1
Ciucci, T.2
Rousseau, D.3
Bourlier, V.4
Duffaut, C.5
Bonnafous, S.6
Blin-Wakkach, C.7
Anty, R.8
Iannelli, A.9
Gugenheim, J.10
-
5
-
-
84875332275
-
Identification of a SIRT1 mutation in a family with type 1 diabetes
-
A. Biason-Lauber, M. Böni-Schnetzler, B.P. Hubbard, K. Bouzakri, A. Brunner, C. Cavelti-Weder, C. Keller, M. Meyer-Böni, D.T. Meier, and C. Brorsson Identification of a SIRT1 mutation in a family with type 1 diabetes Cell Metab. 17 2013 448 455
-
(2013)
Cell Metab.
, vol.17
, pp. 448-455
-
-
Biason-Lauber, A.1
Böni-Schnetzler, M.2
Hubbard, B.P.3
Bouzakri, K.4
Brunner, A.5
Cavelti-Weder, C.6
Keller, C.7
Meyer-Böni, M.8
Meier, D.T.9
Brorsson, C.10
-
6
-
-
70349859675
-
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
-
A. Bierhaus, and P.P. Nawroth Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications Diabetologia 52 2009 2251 2263
-
(2009)
Diabetologia
, vol.52
, pp. 2251-2263
-
-
Bierhaus, A.1
Nawroth, P.P.2
-
7
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
G. Boden Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 46 1997 3 10
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
8
-
-
53749100698
-
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
-
M. Böni-Schnetzler, J. Thorne, G. Parnaud, L. Marselli, J.A. Ehses, J. Kerr-Conte, F. Pattou, P.A. Halban, G.C. Weir, and M.Y. Donath Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation J. Clin. Endocrinol. Metab. 93 2008 4065 4074
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 4065-4074
-
-
Böni-Schnetzler, M.1
Thorne, J.2
Parnaud, G.3
Marselli, L.4
Ehses, J.A.5
Kerr-Conte, J.6
Pattou, F.7
Halban, P.A.8
Weir, G.C.9
Donath, M.Y.10
-
9
-
-
71949118923
-
Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor i
-
M. Böni-Schnetzler, S. Boller, S. Debray, K. Bouzakri, D.T. Meier, R. Prazak, J. Kerr-Conte, F. Pattou, J.A. Ehses, F.C. Schuit, and M.Y. Donath Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I Endocrinology 150 2009 5218 5229
-
(2009)
Endocrinology
, vol.150
, pp. 5218-5229
-
-
Böni-Schnetzler, M.1
Boller, S.2
Debray, S.3
Bouzakri, K.4
Meier, D.T.5
Prazak, R.6
Kerr-Conte, J.7
Pattou, F.8
Ehses, J.A.9
Schuit, F.C.10
Donath, M.Y.11
-
10
-
-
80755176918
-
Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls
-
T-Cell Workshop Committee, Immunology of Diabetes Society
-
B. Brooks-Worrell, T. Tree, S.I. Mannering, I. Durinovic-Bello, E. James, P. Gottlieb, S. Wong, Z. Zhou, L. Yang, C.M. Cilio T-Cell Workshop Committee, Immunology of Diabetes Society Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls Diabetes Metab. Res. Rev. 27 2011 737 745
-
(2011)
Diabetes Metab. Res. Rev.
, vol.27
, pp. 737-745
-
-
Brooks-Worrell, B.1
Tree, T.2
Mannering, S.I.3
Durinovic-Bello, I.4
James, E.5
Gottlieb, P.6
Wong, S.7
Zhou, Z.8
Yang, L.9
Cilio, C.M.10
-
11
-
-
84868687011
-
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
-
R. Caesar, C.S. Reigstad, H.K. Bäckhed, C. Reinhardt, M. Ketonen, G.O. Lundén, P.D. Cani, and F. Bäckhed Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice Gut 61 2012 1701 1707
-
(2012)
Gut
, vol.61
, pp. 1701-1707
-
-
Caesar, R.1
Reigstad, C.S.2
Bäckhed, H.K.3
Reinhardt, C.4
Ketonen, M.5
Lundén, G.O.6
Cani, P.D.7
Bäckhed, F.8
-
12
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
P.D. Cani, J. Amar, M.A. Iglesias, M. Poggi, C. Knauf, D. Bastelica, A.M. Neyrinck, F. Fava, K.M. Tuohy, and C. Chabo Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 2007 1761 1772
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
-
13
-
-
48249125862
-
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
-
P.D. Cani, R. Bibiloni, C. Knauf, A. Waget, A.M. Neyrinck, N.M. Delzenne, and R. Burcelin Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 57 2008 1470 1481
-
(2008)
Diabetes
, vol.57
, pp. 1470-1481
-
-
Cani, P.D.1
Bibiloni, R.2
Knauf, C.3
Waget, A.4
Neyrinck, A.M.5
Delzenne, N.M.6
Burcelin, R.7
-
14
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
A.L. Carey, G.R. Steinberg, S.L. Macaulay, W.G. Thomas, A.G. Holmes, G. Ramm, O. Prelovsek, C. Hohnen-Behrens, M.J. Watt, and D.E. James Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase Diabetes 55 2006 2688 2697
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
Steinberg, G.R.2
MacAulay, S.L.3
Thomas, W.G.4
Holmes, A.G.5
Ramm, G.6
Prelovsek, O.7
Hohnen-Behrens, C.8
Watt, M.J.9
James, D.E.10
-
15
-
-
84864386088
-
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes
-
C. Cavelti-Weder, A. Babians-Brunner, C. Keller, M.A. Stahel, M. Kurz-Levin, H. Zayed, A.M. Solinger, T. Mandrup-Poulsen, C.A. Dinarello, and M.Y. Donath Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes Diabetes Care 35 2012 1654 1662
-
(2012)
Diabetes Care
, vol.35
, pp. 1654-1662
-
-
Cavelti-Weder, C.1
Babians-Brunner, A.2
Keller, C.3
Stahel, M.A.4
Kurz-Levin, M.5
Zayed, H.6
Solinger, A.M.7
Mandrup-Poulsen, T.8
Dinarello, C.A.9
Donath, M.Y.10
-
16
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
S. Cinti, G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A.S. Greenberg, and M.S. Obin Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans J. Lipid Res. 46 2005 2347 2355
-
(2005)
J. Lipid Res.
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
Mitchell, G.2
Barbatelli, G.3
Murano, I.4
Ceresi, E.5
Faloia, E.6
Wang, S.7
Fortier, M.8
Greenberg, A.S.9
Obin, M.S.10
-
17
-
-
84878810790
-
Pathways in microbe-induced obesity
-
this issue
-
L.M. Cox, and M.J. Blaser Pathways in microbe-induced obesity Cell Metab. 17 2013 882 894 this issue
-
(2013)
Cell Metab.
, vol.17
, pp. 882-894
-
-
Cox, L.M.1
Blaser, M.J.2
-
18
-
-
78650773537
-
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
-
M.R. Dasu, and I. Jialal Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors Am. J. Physiol. Endocrinol. Metab. 300 2011 E145 E154
-
(2011)
Am. J. Physiol. Endocrinol. Metab.
, vol.300
-
-
Dasu, M.R.1
Jialal, I.2
-
19
-
-
77951955627
-
Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3
-
R. Deopurkar, H. Ghanim, J. Friedman, S. Abuaysheh, C.L. Sia, P. Mohanty, P. Viswanathan, A. Chaudhuri, and P. Dandona Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3 Diabetes Care 33 2010 991 997
-
(2010)
Diabetes Care
, vol.33
, pp. 991-997
-
-
Deopurkar, R.1
Ghanim, H.2
Friedman, J.3
Abuaysheh, S.4
Sia, C.L.5
Mohanty, P.6
Viswanathan, P.7
Chaudhuri, A.8
Dandona, P.9
-
20
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
C.A. Dinarello Immunological and inflammatory functions of the interleukin-1 family Annu. Rev. Immunol. 27 2009 519 550
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
21
-
-
27344441019
-
Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes
-
H. Dominguez, H. Storgaard, C. Rask-Madsen, T. Steffen Hermann, N. Ihlemann, D. Baunbjerg Nielsen, C. Spohr, L. Kober, A. Vaag, and C. Torp-Pedersen Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes J. Vasc. Res. 42 2005 517 525
-
(2005)
J. Vasc. Res.
, vol.42
, pp. 517-525
-
-
Dominguez, H.1
Storgaard, H.2
Rask-Madsen, C.3
Steffen Hermann, T.4
Ihlemann, N.5
Baunbjerg Nielsen, D.6
Spohr, C.7
Kober, L.8
Vaag, A.9
Torp-Pedersen, C.10
-
22
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat. Rev. Immunol. 11 2011 98 107
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
23
-
-
0033034807
-
Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
-
M.Y. Donath, D.J. Gross, E. Cerasi, and N. Kaiser Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes Diabetes 48 1999 738 744
-
(1999)
Diabetes
, vol.48
, pp. 738-744
-
-
Donath, M.Y.1
Gross, D.J.2
Cerasi, E.3
Kaiser, N.4
-
24
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
P. Duewell, H. Kono, K.J. Rayner, C.M. Sirois, G. Vladimer, F.G. Bauernfeind, G.S. Abela, L. Franchi, G. Nuñez, and M. Schnurr NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature 464 2010 1357 1361
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
Bauernfeind, F.G.6
Abela, G.S.7
Franchi, L.8
Nuñez, G.9
Schnurr, M.10
-
25
-
-
65649117802
-
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
-
C. Duffaut, J. Galitzky, M. Lafontan, and A. Bouloumié Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity Biochem. Biophys. Res. Commun. 384 2009 482 485
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.384
, pp. 482-485
-
-
Duffaut, C.1
Galitzky, J.2
Lafontan, M.3
Bouloumié, A.4
-
26
-
-
84859449180
-
Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation
-
K. Eguchi, I. Manabe, Y. Oishi-Tanaka, M. Ohsugi, N. Kono, F. Ogata, N. Yagi, U. Ohto, M. Kimoto, and K. Miyake Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation Cell Metab. 15 2012 518 533
-
(2012)
Cell Metab.
, vol.15
, pp. 518-533
-
-
Eguchi, K.1
Manabe, I.2
Oishi-Tanaka, Y.3
Ohsugi, M.4
Kono, N.5
Ogata, F.6
Yagi, N.7
Ohto, U.8
Kimoto, M.9
Miyake, K.10
-
27
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
J.A. Ehses, A. Perren, E. Eppler, P. Ribaux, J.A. Pospisilik, R. Maor-Cahn, X. Gueripel, H. Ellingsgaard, M.K. Schneider, and G. Biollaz Increased number of islet-associated macrophages in type 2 diabetes Diabetes 56 2007 2356 2370
-
(2007)
Diabetes
, vol.56
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
Ribaux, P.4
Pospisilik, J.A.5
Maor-Cahn, R.6
Gueripel, X.7
Ellingsgaard, H.8
Schneider, M.K.9
Biollaz, G.10
-
28
-
-
70449394029
-
Pancreatic islet inflammation in type 2 diabetes: From alpha and beta cell compensation to dysfunction
-
J.A. Ehses, H. Ellingsgaard, M. Böni-Schnetzler, and M.Y. Donath Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction Arch. Physiol. Biochem. 115 2009 240 247
-
(2009)
Arch. Physiol. Biochem.
, vol.115
, pp. 240-247
-
-
Ehses, J.A.1
Ellingsgaard, H.2
Böni-Schnetzler, M.3
Donath, M.Y.4
-
29
-
-
69549098032
-
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
-
J.A. Ehses, G. Lacraz, M.H. Giroix, F. Schmidlin, J. Coulaud, N. Kassis, J.C. Irminger, M. Kergoat, B. Portha, F. Homo-Delarche, and M.Y. Donath IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat Proc. Natl. Acad. Sci. USA 106 2009 13998 14003
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13998-14003
-
-
Ehses, J.A.1
Lacraz, G.2
Giroix, M.H.3
Schmidlin, F.4
Coulaud, J.5
Kassis, N.6
Irminger, J.C.7
Kergoat, M.8
Portha, B.9
Homo-Delarche, F.10
Donath, M.Y.11
-
30
-
-
0032570269
-
Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice
-
R. Elhage, A. Maret, M.T. Pieraggi, J.C. Thiers, J.F. Arnal, and F. Bayard Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice Circulation 97 1998 242 244
-
(1998)
Circulation
, vol.97
, pp. 242-244
-
-
Elhage, R.1
Maret, A.2
Pieraggi, M.T.3
Thiers, J.C.4
Arnal, J.F.5
Bayard, F.6
-
31
-
-
51349133256
-
Interleukin-6 regulates pancreatic alpha-cell mass expansion
-
H. Ellingsgaard, J.A. Ehses, E.B. Hammar, L. Van Lommel, R. Quintens, G. Martens, J. Kerr-Conte, F. Pattou, T. Berney, and D. Pipeleers Interleukin-6 regulates pancreatic alpha-cell mass expansion Proc. Natl. Acad. Sci. USA 105 2008 13163 13168
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13163-13168
-
-
Ellingsgaard, H.1
Ehses, J.A.2
Hammar, E.B.3
Van Lommel, L.4
Quintens, R.5
Martens, G.6
Kerr-Conte, J.7
Pattou, F.8
Berney, T.9
Pipeleers, D.10
-
32
-
-
81255157471
-
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
-
H. Ellingsgaard, I. Hauselmann, B. Schuler, A.M. Habib, L.L. Baggio, D.T. Meier, E. Eppler, K. Bouzakri, S. Wueest, and Y.D. Muller Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells Nat. Med. 17 2011 1481 1489
-
(2011)
Nat. Med.
, vol.17
, pp. 1481-1489
-
-
Ellingsgaard, H.1
Hauselmann, I.2
Schuler, B.3
Habib, A.M.4
Baggio, L.L.5
Meier, D.T.6
Eppler, E.7
Bouzakri, K.8
Wueest, S.9
Muller, Y.D.10
-
33
-
-
0642307072
-
Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus
-
K. Esposito, F. Nappo, F. Giugliano, C. Di Palo, M. Ciotola, M. Barbieri, G. Paolisso, and D. Giugliano Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus Am. J. Clin. Nutr. 78 2003 1135 1140
-
(2003)
Am. J. Clin. Nutr.
, vol.78
, pp. 1135-1140
-
-
Esposito, K.1
Nappo, F.2
Giugliano, F.3
Di Palo, C.4
Ciotola, M.5
Barbieri, M.6
Paolisso, G.7
Giugliano, D.8
-
34
-
-
84884902312
-
Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes
-
10.1007/s00592-011-0329-2 Published online September 22, 2011
-
E. Faqhihimani, A. Aminorroaya, H. Rezvanian, P. Adibi, F. Ismail-Beigi, and M. Amini Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes Acta Diabetol. 2011 10.1007/s00592-011-0329-2 Published online September 22, 2011
-
(2011)
Acta Diabetol.
-
-
Faqhihimani, E.1
Aminorroaya, A.2
Rezvanian, H.3
Adibi, P.4
Ismail-Beigi, F.5
Amini, M.6
-
35
-
-
0036720342
-
Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles
-
M.A. Febbraio, and B.K. Pedersen Muscle-derived interleukin-6: mechanisms for activation and possible biological roles FASEB J. 16 2002 1335 1347
-
(2002)
FASEB J.
, vol.16
, pp. 1335-1347
-
-
Febbraio, M.A.1
Pedersen, B.K.2
-
36
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
M. Feuerer, L. Herrero, D. Cipolletta, A. Naaz, J. Wong, A. Nayer, J. Lee, A.B. Goldfine, C. Benoist, S. Shoelson, and D. Mathis Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nat. Med. 15 2009 930 939
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
Nayer, A.6
Lee, J.7
Goldfine, A.B.8
Benoist, C.9
Shoelson, S.10
Mathis, D.11
-
37
-
-
38949119419
-
Salsalate improves glycemia and inflammatory parameters in obese young adults
-
A. Fleischman, S.E. Shoelson, R. Bernier, and A.B. Goldfine Salsalate improves glycemia and inflammatory parameters in obese young adults Diabetes Care 31 2008 289 294
-
(2008)
Diabetes Care
, vol.31
, pp. 289-294
-
-
Fleischman, A.1
Shoelson, S.E.2
Bernier, R.3
Goldfine, A.B.4
-
38
-
-
4844231461
-
Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation
-
EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators
-
D. Fliser, K. Buchholz, H. Haller EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation Circulation 110 2004 1103 1107
-
(2004)
Circulation
, vol.110
, pp. 1103-1107
-
-
Fliser, D.1
Buchholz, K.2
Haller, H.3
-
39
-
-
79959732295
-
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
-
S. Freigang, F. Ampenberger, G. Spohn, S. Heer, A.T. Shamshiev, J. Kisielow, M. Hersberger, M. Yamamoto, M.F. Bachmann, and M. Kopf Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis Eur. J. Immunol. 41 2011 2040 2051
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 2040-2051
-
-
Freigang, S.1
Ampenberger, F.2
Spohn, G.3
Heer, S.4
Shamshiev, A.T.5
Kisielow, J.6
Hersberger, M.7
Yamamoto, M.8
Bachmann, M.F.9
Kopf, M.10
-
40
-
-
79955438066
-
Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice
-
S. Fujisaka, I. Usui, Y. Kanatani, M. Ikutani, I. Takasaki, K. Tsuneyama, Y. Tabuchi, A. Bukhari, Y. Yamazaki, and H. Suzuki Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice Endocrinology 152 2011 1789 1799
-
(2011)
Endocrinology
, vol.152
, pp. 1789-1799
-
-
Fujisaka, S.1
Usui, I.2
Kanatani, Y.3
Ikutani, M.4
Takasaki, I.5
Tsuneyama, K.6
Tabuchi, Y.7
Bukhari, A.8
Yamazaki, Y.9
Suzuki, H.10
-
41
-
-
0029793624
-
Interleukin-1 beta in coronary arteries of patients with ischemic heart disease
-
J. Galea, J. Armstrong, P. Gadsdon, H. Holden, S.E. Francis, and C.M. Holt Interleukin-1 beta in coronary arteries of patients with ischemic heart disease Arterioscler. Thromb. Vasc. Biol. 16 1996 1000 1006
-
(1996)
Arterioscler. Thromb. Vasc. Biol.
, vol.16
, pp. 1000-1006
-
-
Galea, J.1
Armstrong, J.2
Gadsdon, P.3
Holden, H.4
Francis, S.E.5
Holt, C.M.6
-
43
-
-
77950849253
-
ANG II receptor antagonists as modulators of macrophages polarization
-
G.E. Garcia ANG II receptor antagonists as modulators of macrophages polarization Am. J. Physiol. Renal Physiol. 298 2010 F868 F869
-
(2010)
Am. J. Physiol. Renal Physiol.
, vol.298
-
-
Garcia, G.E.1
-
44
-
-
0029115152
-
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme
-
Y.J. Geng, and P. Libby Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme Am. J. Pathol. 147 1995 251 266
-
(1995)
Am. J. Pathol.
, vol.147
, pp. 251-266
-
-
Geng, Y.J.1
Libby, P.2
-
45
-
-
64149121817
-
Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes
-
A.B. Goldfine, R. Silver, W. Aldhahi, D. Cai, E. Tatro, J. Lee, and S.E. Shoelson Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes Clin. Transl. Sci. 1 2008 36 43
-
(2008)
Clin. Transl. Sci.
, vol.1
, pp. 36-43
-
-
Goldfine, A.B.1
Silver, R.2
Aldhahi, W.3
Cai, D.4
Tatro, E.5
Lee, J.6
Shoelson, S.E.7
-
46
-
-
77950885686
-
The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial
-
TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team
-
A.B. Goldfine, V. Fonseca, K.A. Jablonski, L. Pyle, M.A. Staten, S.E. Shoelson TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial Ann. Intern. Med. 152 2010 346 357
-
(2010)
Ann. Intern. Med.
, vol.152
, pp. 346-357
-
-
Goldfine, A.B.1
Fonseca, V.2
Jablonski, K.A.3
Pyle, L.4
Staten, M.A.5
Shoelson, S.E.6
-
47
-
-
84876485218
-
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
-
A.B. Goldfine, P.R. Conlin, F. Halperin, J. Koska, P. Permana, D. Schwenke, S.E. Shoelson, and P.D. Reaven A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance Diabetologia 56 2013 714 723
-
(2013)
Diabetologia
, vol.56
, pp. 714-723
-
-
Goldfine, A.B.1
Conlin, P.R.2
Halperin, F.3
Koska, J.4
Permana, P.5
Schwenke, D.6
Shoelson, S.E.7
Reaven, P.D.8
-
48
-
-
79960359853
-
Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation
-
G.H. Goossens, A. Bizzarri, N. Venteclef, Y. Essers, J.P. Cleutjens, E. Konings, J.W. Jocken, M. Cajlakovic, V. Ribitsch, K. Clément, and E.E. Blaak Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation Circulation 124 2011 67 76
-
(2011)
Circulation
, vol.124
, pp. 67-76
-
-
Goossens, G.H.1
Bizzarri, A.2
Venteclef, N.3
Essers, Y.4
Cleutjens, J.P.5
Konings, E.6
Jocken, J.W.7
Cajlakovic, M.8
Ribitsch, V.9
Clément, K.10
Blaak, E.E.11
-
49
-
-
73949095907
-
The discovery of cellular immunity in the atherosclerotic plaque
-
G.K. Hansson, and L. Jonasson The discovery of cellular immunity in the atherosclerotic plaque Arterioscler. Thromb. Vasc. Biol. 29 2009 1714 1717
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 1714-1717
-
-
Hansson, G.K.1
Jonasson, L.2
-
50
-
-
0036895383
-
Endoplasmic reticulum stress and the development of diabetes: A review
-
H.P. Harding, and D. Ron Endoplasmic reticulum stress and the development of diabetes: a review Diabetes 51 Suppl 3 2002 S455 S461
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 3
-
-
Harding, H.P.1
Ron, D.2
-
51
-
-
80053554640
-
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation
-
R.G. Holzer, E.J. Park, N. Li, H. Tran, M. Chen, C. Choi, G. Solinas, and M. Karin Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation Cell 147 2011 173 184
-
(2011)
Cell
, vol.147
, pp. 173-184
-
-
Holzer, R.G.1
Park, E.J.2
Li, N.3
Tran, H.4
Chen, M.5
Choi, C.6
Solinas, G.7
Karin, M.8
-
52
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
V. Hornung, F. Bauernfeind, A. Halle, E.O. Samstad, H. Kono, K.L. Rock, K.A. Fitzgerald, and E. Latz Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat. Immunol. 9 2008 847 856
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
53
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
54
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
55
-
-
79251589063
-
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes
-
M. Jagannathan-Bogdan, M.E. McDonnell, H. Shin, Q. Rehman, H. Hasturk, C.M. Apovian, and B.S. Nikolajczyk Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes J. Immunol. 186 2011 1162 1172
-
(2011)
J. Immunol.
, vol.186
, pp. 1162-1172
-
-
Jagannathan-Bogdan, M.1
McDonnell, M.E.2
Shin, H.3
Rehman, Q.4
Hasturk, H.5
Apovian, C.M.6
Nikolajczyk, B.S.7
-
56
-
-
18844449196
-
Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes
-
K.A. Jandeleit-Dahm, C. Tikellis, C.M. Reid, C.I. Johnston, and M.E. Cooper Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes J. Hypertens. 23 2005 463 473
-
(2005)
J. Hypertens.
, vol.23
, pp. 463-473
-
-
Jandeleit-Dahm, K.A.1
Tikellis, C.2
Reid, C.M.3
Johnston, C.I.4
Cooper, M.E.5
-
57
-
-
33846867939
-
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
-
author reply 825
-
J.O. Jansson, and V. Wallenius Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis J. Appl. Physiol. 102 2007 821 author reply 825
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 821
-
-
Jansson, J.O.1
Wallenius, V.2
-
58
-
-
17644393196
-
Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis
-
D.N. Kiortsis, A.K. Mavridis, S. Vasakos, S.N. Nikas, and A.A. Drosos Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis Ann. Rheum. Dis. 64 2005 765 766
-
(2005)
Ann. Rheum. Dis.
, vol.64
, pp. 765-766
-
-
Kiortsis, D.N.1
Mavridis, A.K.2
Vasakos, S.3
Nikas, S.N.4
Drosos, A.A.5
-
59
-
-
0037388984
-
Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice
-
H. Kirii, T. Niwa, Y. Yamada, H. Wada, K. Saito, Y. Iwakura, M. Asano, H. Moriwaki, and M. Seishima Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice Arterioscler. Thromb. Vasc. Biol. 23 2003 656 660
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
, pp. 656-660
-
-
Kirii, H.1
Niwa, T.2
Yamada, Y.3
Wada, H.4
Saito, K.5
Iwakura, Y.6
Asano, M.7
Moriwaki, H.8
Seishima, M.9
-
60
-
-
59449090513
-
The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: Results of a randomised double-blind placebo-controlled study
-
J. Koska, E. Ortega, J.C. Bunt, A. Gasser, J. Impson, R.L. Hanson, J. Forbes, B. de Courten, and J. Krakoff The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study Diabetologia 52 2009 385 393
-
(2009)
Diabetologia
, vol.52
, pp. 385-393
-
-
Koska, J.1
Ortega, E.2
Bunt, J.C.3
Gasser, A.4
Impson, J.5
Hanson, R.L.6
Forbes, J.7
De Courten, B.8
Krakoff, J.9
-
61
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
C.M. Larsen, M. Faulenbach, A. Vaag, A. Vølund, J.A. Ehses, B. Seifert, T. Mandrup-Poulsen, and M.Y. Donath Interleukin-1-receptor antagonist in type 2 diabetes mellitus N. Engl. J. Med. 356 2007 1517 1526
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Vølund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
62
-
-
69549105888
-
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
-
C.M. Larsen, M. Faulenbach, A. Vaag, J.A. Ehses, M.Y. Donath, and T. Mandrup-Poulsen Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes Diabetes Care 32 2009 1663 1668
-
(2009)
Diabetes Care
, vol.32
, pp. 1663-1668
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Ehses, J.A.4
Donath, M.Y.5
Mandrup-Poulsen, T.6
-
63
-
-
12344266697
-
How obesity causes diabetes: Not a tall tale
-
M.A. Lazar How obesity causes diabetes: not a tall tale Science 307 2005 373 375
-
(2005)
Science
, vol.307
, pp. 373-375
-
-
Lazar, M.A.1
-
64
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
-
J.Y. Lee, K.H. Sohn, S.H. Rhee, and D. Hwang Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 J. Biol. Chem. 276 2001 16683 16689
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
65
-
-
2342435824
-
Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
-
J.Y. Lee, L. Zhao, H.S. Youn, A.R. Weatherill, R. Tapping, L. Feng, W.H. Lee, K.A. Fitzgerald, and D.H. Hwang Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 J. Biol. Chem. 279 2004 16971 16979
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16971-16979
-
-
Lee, J.Y.1
Zhao, L.2
Youn, H.S.3
Weatherill, A.R.4
Tapping, R.5
Feng, L.6
Lee, W.H.7
Fitzgerald, K.A.8
Hwang, D.H.9
-
66
-
-
23344442120
-
Obesity alters gut microbial ecology
-
R.E. Ley, F. Bäckhed, P. Turnbaugh, C.A. Lozupone, R.D. Knight, and J.I. Gordon Obesity alters gut microbial ecology Proc. Natl. Acad. Sci. USA 102 2005 11070 11075
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 11070-11075
-
-
Ley, R.E.1
Bäckhed, F.2
Turnbaugh, P.3
Lozupone, C.A.4
Knight, R.D.5
Gordon, J.I.6
-
67
-
-
33845901507
-
Microbial ecology: Human gut microbes associated with obesity
-
R.E. Ley, P.J. Turnbaugh, S. Klein, and J.I. Gordon Microbial ecology: human gut microbes associated with obesity Nature 444 2006 1022 1023
-
(2006)
Nature
, vol.444
, pp. 1022-1023
-
-
Ley, R.E.1
Turnbaugh, P.J.2
Klein, S.3
Gordon, J.I.4
-
69
-
-
34547099307
-
Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
-
J. Lo, L.E. Bernstein, B. Canavan, M. Torriani, M.B. Jackson, R.S. Ahima, and S.K. Grinspoon Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome Am. J. Physiol. Endocrinol. Metab. 293 2007 E102 E109
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Lo, J.1
Bernstein, L.E.2
Canavan, B.3
Torriani, M.4
Jackson, M.B.5
Ahima, R.S.6
Grinspoon, S.K.7
-
70
-
-
0035432491
-
Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets
-
K. Maedler, G.A. Spinas, R. Lehmann, P. Sergeev, M. Weber, A. Fontana, N. Kaiser, and M.Y. Donath Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets Diabetes 50 2001 1683 1690
-
(2001)
Diabetes
, vol.50
, pp. 1683-1690
-
-
Maedler, K.1
Spinas, G.A.2
Lehmann, R.3
Sergeev, P.4
Weber, M.5
Fontana, A.6
Kaiser, N.7
Donath, M.Y.8
-
71
-
-
0037062429
-
FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
-
K. Maedler, A. Fontana, F. Ris, P. Sergeev, C. Toso, J. Oberholzer, R. Lehmann, F. Bachmann, A. Tasinato, and G.A. Spinas FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication Proc. Natl. Acad. Sci. USA 99 2002 8236 8241
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8236-8241
-
-
Maedler, K.1
Fontana, A.2
Ris, F.3
Sergeev, P.4
Toso, C.5
Oberholzer, J.6
Lehmann, R.7
Bachmann, F.8
Tasinato, A.9
Spinas, G.A.10
-
72
-
-
0036738398
-
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
K. Maedler, P. Sergeev, F. Ris, J. Oberholzer, H.I. Joller-Jemelka, G.A. Spinas, N. Kaiser, P.A. Halban, and M.Y. Donath Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets J. Clin. Invest. 110 2002 851 860
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
Oberholzer, J.4
Joller-Jemelka, H.I.5
Spinas, G.A.6
Kaiser, N.7
Halban, P.A.8
Donath, M.Y.9
-
73
-
-
33750846939
-
Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets
-
K. Maedler, D.M. Schumann, N. Sauter, H. Ellingsgaard, D. Bosco, R. Baertschiger, Y. Iwakura, J. Oberholzer, C.B. Wollheim, B.R. Gauthier, and M.Y. Donath Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets Diabetes 55 2006 2713 2722
-
(2006)
Diabetes
, vol.55
, pp. 2713-2722
-
-
Maedler, K.1
Schumann, D.M.2
Sauter, N.3
Ellingsgaard, H.4
Bosco, D.5
Baertschiger, R.6
Iwakura, Y.7
Oberholzer, J.8
Wollheim, C.B.9
Gauthier, B.R.10
Donath, M.Y.11
-
74
-
-
84871426151
-
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
-
T. Mahdi, S. Hänzelmann, A. Salehi, S.J. Muhammed, T.M. Reinbothe, Y. Tang, A.S. Axelsson, Y. Zhou, X. Jing, and P. Almgren Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes Cell Metab. 16 2012 625 633
-
(2012)
Cell Metab.
, vol.16
, pp. 625-633
-
-
Mahdi, T.1
Hänzelmann, S.2
Salehi, A.3
Muhammed, S.J.4
Reinbothe, T.M.5
Tang, Y.6
Axelsson, A.S.7
Zhou, Y.8
Jing, X.9
Almgren, P.10
-
75
-
-
33644671224
-
Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension
-
S. Manabe, T. Okura, S. Watanabe, T. Fukuoka, and J. Higaki Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension J. Cardiovasc. Pharmacol. 46 2005 735 739
-
(2005)
J. Cardiovasc. Pharmacol.
, vol.46
, pp. 735-739
-
-
Manabe, S.1
Okura, T.2
Watanabe, S.3
Fukuoka, T.4
Higaki, J.5
-
76
-
-
84878793136
-
The relationship between metabolism and autophagy machinery during the innate immune response
-
this issue
-
J. Martinez, K. Verbist, R. Wang, and D.R. Green The relationship between metabolism and autophagy machinery during the innate immune response Cell Metab. 17 2013 895 900 this issue
-
(2013)
Cell Metab.
, vol.17
, pp. 895-900
-
-
Martinez, J.1
Verbist, K.2
Wang, R.3
Green, D.R.4
-
77
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
F. Martinon, V. Pétrilli, A. Mayor, A. Tardivel, and J. Tschopp Gout-associated uric acid crystals activate the NALP3 inflammasome Nature 440 2006 237 241
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Pétrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
78
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
-
S.L. Masters, A. Dunne, S.L. Subramanian, R.L. Hull, G.M. Tannahill, F.A. Sharp, C. Becker, L. Franchi, E. Yoshihara, and Z. Chen Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes Nat. Immunol. 11 2010 897 904
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
Dunne, A.2
Subramanian, S.L.3
Hull, R.L.4
Tannahill, G.M.5
Sharp, F.A.6
Becker, C.7
Franchi, L.8
Yoshihara, E.9
Chen, Z.10
-
79
-
-
84876567161
-
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
-
T. Misawa, M. Takahama, T. Kozaki, H. Lee, J. Zou, T. Saitoh, and S. Akira Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome Nat. Immunol. 14 2013 454 460
-
(2013)
Nat. Immunol.
, vol.14
, pp. 454-460
-
-
Misawa, T.1
Takahama, M.2
Kozaki, T.3
Lee, H.4
Zou, J.5
Saitoh, T.6
Akira, S.7
-
80
-
-
33947518747
-
Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
-
discussion 818-819
-
R.A. Mooney Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis J. Appl. Physiol. 102 2007 816 818 discussion 818-819
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 816-818
-
-
Mooney, R.A.1
-
82
-
-
36849005372
-
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
-
M.T. Nguyen, S. Favelyukis, A.K. Nguyen, D. Reichart, P.A. Scott, A. Jenn, R. Liu-Bryan, C.K. Glass, J.G. Neels, and J.M. Olefsky A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways J. Biol. Chem. 282 2007 35279 35292
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35279-35292
-
-
Nguyen, M.T.1
Favelyukis, S.2
Nguyen, A.K.3
Reichart, D.4
Scott, P.A.5
Jenn, A.6
Liu-Bryan, R.7
Glass, C.K.8
Neels, J.G.9
Olefsky, J.M.10
-
83
-
-
84861782461
-
Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes
-
Y. Nie, R.C. Ma, J.C. Chan, H. Xu, and G. Xu Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes FASEB J. 26 2012 2383 2393
-
(2012)
FASEB J.
, vol.26
, pp. 2383-2393
-
-
Nie, Y.1
Ma, R.C.2
Chan, J.C.3
Xu, H.4
Xu, G.5
-
84
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
S. Nishimura, I. Manabe, M. Nagasaki, K. Eto, H. Yamashita, M. Ohsugi, M. Otsu, K. Hara, K. Ueki, and S. Sugiura CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nat. Med. 15 2009 914 920
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
Ohsugi, M.6
Otsu, M.7
Hara, K.8
Ueki, K.9
Sugiura, S.10
-
85
-
-
0029906375
-
Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
-
F. Ofei, S. Hurel, J. Newkirk, M. Sopwith, and R. Taylor Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM Diabetes 45 1996 881 885
-
(1996)
Diabetes
, vol.45
, pp. 881-885
-
-
Ofei, F.1
Hurel, S.2
Newkirk, J.3
Sopwith, M.4
Taylor, R.5
-
86
-
-
84864693470
-
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome
-
C.M. Oslowski, T. Hara, B. O'Sullivan-Murphy, K. Kanekura, S. Lu, M. Hara, S. Ishigaki, L.J. Zhu, E. Hayashi, and S.T. Hui Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome Cell Metab. 16 2012 265 273
-
(2012)
Cell Metab.
, vol.16
, pp. 265-273
-
-
Oslowski, C.M.1
Hara, T.2
O'Sullivan-Murphy, B.3
Kanekura, K.4
Lu, S.5
Hara, M.6
Ishigaki, S.7
Zhu, L.J.8
Hayashi, E.9
Hui, S.T.10
-
87
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
10.1038/nm.2851 Published online July 29, 2012
-
D. Pal, S. Dasgupta, R. Kundu, S. Maitra, G. Das, S. Mukhopadhyay, S. Ray, S.S. Majumdar, and S. Bhattacharya Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance Nat. Med. 2012 10.1038/nm.2851 Published online July 29, 2012
-
(2012)
Nat. Med.
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
Mukhopadhyay, S.6
Ray, S.7
Majumdar, S.S.8
Bhattacharya, S.9
-
88
-
-
0034454915
-
No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients
-
N. Paquot, M.J. Castillo, P.J. Lefèbvre, and A.J. Scheen No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients J. Clin. Endocrinol. Metab. 85 2000 1316 1319
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 1316-1319
-
-
Paquot, N.1
Castillo, M.J.2
Lefèbvre, P.J.3
Scheen, A.J.4
-
89
-
-
1542380035
-
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
-
J.S. Park, D. Svetkauskaite, Q. He, J.Y. Kim, D. Strassheim, A. Ishizaka, and E. Abraham Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein J. Biol. Chem. 279 2004 7370 7377
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7370-7377
-
-
Park, J.S.1
Svetkauskaite, D.2
He, Q.3
Kim, J.Y.4
Strassheim, D.5
Ishizaka, A.6
Abraham, E.7
-
90
-
-
79955581558
-
Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation
-
M.G. Pavlatou, G. Mastorakos, A. Margeli, E. Kouskouni, N. Tentolouris, N. Katsilambros, G.P. Chrousos, and I. Papassotiriou Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation Eur. J. Clin. Invest. 41 2011 652 658
-
(2011)
Eur. J. Clin. Invest.
, vol.41
, pp. 652-658
-
-
Pavlatou, M.G.1
Mastorakos, G.2
Margeli, A.3
Kouskouni, E.4
Tentolouris, N.5
Katsilambros, N.6
Chrousos, G.P.7
Papassotiriou, I.8
-
91
-
-
33846883060
-
Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
-
B.K. Pedersen, and M.A. Febbraio Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis J. Appl. Physiol. 102 2007 814 816
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 814-816
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
92
-
-
33947720482
-
Beneficial health effects of exercise - The role of IL-6 as a myokine
-
B.K. Pedersen, and C.P. Fischer Beneficial health effects of exercise - the role of IL-6 as a myokine Trends Pharmacol. Sci. 28 2007 152 156
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 152-156
-
-
Pedersen, B.K.1
Fischer, C.P.2
-
93
-
-
0031720795
-
Is type II diabetes mellitus a disease of the innate immune system?
-
J.C. Pickup, and M.A. Crook Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41 1998 1241 1248
-
(1998)
Diabetologia
, vol.41
, pp. 1241-1248
-
-
Pickup, J.C.1
Crook, M.A.2
-
94
-
-
0030731621
-
NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X
-
J.C. Pickup, M.B. Mattock, G.D. Chusney, and D. Burt NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X Diabetologia 40 1997 1286 1292
-
(1997)
Diabetologia
, vol.40
, pp. 1286-1292
-
-
Pickup, J.C.1
Mattock, M.B.2
Chusney, G.D.3
Burt, D.4
-
95
-
-
0035908632
-
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
-
A.D. Pradhan, J.E. Manson, N. Rifai, J.E. Buring, and P.M. Ridker C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus JAMA 286 2001 327 334
-
(2001)
JAMA
, vol.286
, pp. 327-334
-
-
Pradhan, A.D.1
Manson, J.E.2
Rifai, N.3
Buring, J.E.4
Ridker, P.M.5
-
96
-
-
79952437112
-
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice
-
X. Prieur, C.Y. Mok, V.R. Velagapudi, V. Núñez, L. Fuentes, D. Montaner, K. Ishikawa, A. Camacho, N. Barbarroja, and S. O'Rahilly Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice Diabetes 60 2011 797 809
-
(2011)
Diabetes
, vol.60
, pp. 797-809
-
-
Prieur, X.1
Mok, C.Y.2
Velagapudi, V.R.3
Núñez, V.4
Fuentes, L.5
Montaner, D.6
Ishikawa, K.7
Camacho, A.8
Barbarroja, N.9
O'Rahilly, S.10
-
97
-
-
77955356552
-
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
-
K. Rajamäki, J. Lappalainen, K. Oörni, E. Välimäki, S. Matikainen, P.T. Kovanen, and K.K. Eklund Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation PLoS ONE 5 2010 e11765
-
(2010)
PLoS ONE
, vol.5
, pp. 11765
-
-
Rajamäki, K.1
Lappalainen, J.2
Oörni, K.3
Välimäki, E.4
Matikainen, S.5
Kovanen, P.T.6
Eklund, K.K.7
-
98
-
-
80054701972
-
Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: A randomized clinical trial
-
M.G. Ramos-Zavala, M. González-Ortiz, E. Martínez-Abundis, J.A. Robles-Cervantes, R. González-López, and N.J. Santiago-Hernández Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial Diabetes Care 34 2011 1591 1594
-
(2011)
Diabetes Care
, vol.34
, pp. 1591-1594
-
-
Ramos-Zavala, M.G.1
González-Ortiz, M.2
Martínez-Abundis, E.3
Robles-Cervantes, J.A.4
González-López, R.5
Santiago-Hernández, N.J.6
-
99
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice
-
S.M. Reilly, S.H. Chiang, S.J. Decker, L. Chang, M. Uhm, M.J. Larsen, J.R. Rubin, J. Mowers, N.M. White, and I. Hochberg An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice Nat. Med. 19 2013 313 321
-
(2013)
Nat. Med.
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
Chiang, S.H.2
Decker, S.J.3
Chang, L.4
Uhm, M.5
Larsen, M.J.6
Rubin, J.R.7
Mowers, J.8
White, N.M.9
Hochberg, I.10
-
100
-
-
67650685521
-
Islet-associated macrophages in type 2 diabetes
-
S.J. Richardson, A. Willcox, A.J. Bone, A.K. Foulis, and N.G. Morgan Islet-associated macrophages in type 2 diabetes Diabetologia 52 2009 1686 1688
-
(2009)
Diabetologia
, vol.52
, pp. 1686-1688
-
-
Richardson, S.J.1
Willcox, A.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
101
-
-
0030956673
-
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
-
P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, and C.H. Hennekens Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men N. Engl. J. Med. 336 1997 973 979
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 973-979
-
-
Ridker, P.M.1
Cushman, M.2
Stampfer, M.J.3
Tracy, R.P.4
Hennekens, C.H.5
-
102
-
-
56749106312
-
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
-
JUPITER Study Group
-
P.M. Ridker, E. Danielson, F.A. Fonseca, J. Genest, A.M. Gotto Jr., J.J. Kastelein, W. Koenig, P. Libby, A.J. Lorenzatti, J.G. MacFadyen JUPITER Study Group Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N. Engl. J. Med. 359 2008 2195 2207
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2195-2207
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.3
Genest, J.4
Gotto Jr., A.M.5
Kastelein, J.J.6
Koenig, W.7
Libby, P.8
Lorenzatti, A.J.9
MacFadyen, J.G.10
-
103
-
-
84870619337
-
Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: A phase IIb randomized, placebo-controlled trial
-
CANTOS Pilot Investigative Group
-
P.M. Ridker, C.P. Howard, V. Walter, B. Everett, P. Libby, J. Hensen, T. Thuren CANTOS Pilot Investigative Group Effects of interleukin-1β inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial Circulation 126 2012 2739 2748
-
(2012)
Circulation
, vol.126
, pp. 2739-2748
-
-
Ridker, P.M.1
Howard, C.P.2
Walter, V.3
Everett, B.4
Libby, P.5
Hensen, J.6
Thuren, T.7
-
104
-
-
84873271227
-
Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: Results of a randomized, placebo-controlled trial
-
for the Global Investigators 10.1111/j.1463-1326.2012.01637.x Published online June 21, 2012
-
A. Rissanen, C.P. Howard, J. Botha, T. Thuren for the Global Investigators Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial Diabetes Obes. Metab. 2012 10.1111/j.1463-1326.2012.01637.x Published online June 21, 2012
-
(2012)
Diabetes Obes. Metab.
-
-
Rissanen, A.1
Howard, C.P.2
Botha, J.3
Thuren, T.4
-
105
-
-
54049086276
-
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
-
V.Z. Rocha, E.J. Folco, G. Sukhova, K. Shimizu, I. Gotsman, A.H. Vernon, and P. Libby Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity Circ. Res. 103 2008 467 476
-
(2008)
Circ. Res.
, vol.103
, pp. 467-476
-
-
Rocha, V.Z.1
Folco, E.J.2
Sukhova, G.3
Shimizu, K.4
Gotsman, I.5
Vernon, A.H.6
Libby, P.7
-
106
-
-
84869797922
-
IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6
-
S. Rose-John IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6 Int. J. Biol. Sci. 8 2012 1237 1247
-
(2012)
Int. J. Biol. Sci.
, vol.8
, pp. 1237-1247
-
-
Rose-John, S.1
-
107
-
-
34247640820
-
Insulin resistance in patients with rheumatoid arthritis: Effect of anti-TNFalpha therapy
-
A. Rosenvinge, R. Krogh-Madsen, B. Baslund, and B.K. Pedersen Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy Scand. J. Rheumatol. 36 2007 91 96
-
(2007)
Scand. J. Rheumatol.
, vol.36
, pp. 91-96
-
-
Rosenvinge, A.1
Krogh-Madsen, R.2
Baslund, B.3
Pedersen, B.K.4
-
108
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
G. Sabio, M. Das, A. Mora, Z. Zhang, J.Y. Jun, H.J. Ko, T. Barrett, J.K. Kim, and R.J. Davis A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 322 2008 1539 1543
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
109
-
-
58149310977
-
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
-
A. Schaeffler, P. Gross, R. Buettner, C. Bollheimer, C. Buechler, M. Neumeier, A. Kopp, J. Schoelmerich, and W. Falk Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity Immunology 126 2009 233 245
-
(2009)
Immunology
, vol.126
, pp. 233-245
-
-
Schaeffler, A.1
Gross, P.2
Buettner, R.3
Bollheimer, C.4
Buechler, C.5
Neumeier, M.6
Kopp, A.7
Schoelmerich, J.8
Falk, W.9
-
110
-
-
33847250987
-
The Fas pathway is involved in pancreatic beta cell secretory function
-
D.M. Schumann, K. Maedler, I. Franklin, D. Konrad, J. Størling, M. Böni-Schnetzler, A. Gjinovci, M.O. Kurrer, B.R. Gauthier, and D. Bosco The Fas pathway is involved in pancreatic beta cell secretory function Proc. Natl. Acad. Sci. USA 104 2007 2861 2866
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 2861-2866
-
-
Schumann, D.M.1
Maedler, K.2
Franklin, I.3
Konrad, D.4
Størling, J.5
Böni-Schnetzler, M.6
Gjinovci, A.7
Kurrer, M.O.8
Gauthier, B.R.9
Bosco, D.10
-
111
-
-
77958532945
-
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
-
T.A. Seimon, M.J. Nadolski, X. Liao, J. Magallon, M. Nguyen, N.T. Feric, M.L. Koschinsky, R. Harkewicz, J.L. Witztum, and S. Tsimikas Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress Cell Metab. 12 2010 467 482
-
(2010)
Cell Metab.
, vol.12
, pp. 467-482
-
-
Seimon, T.A.1
Nadolski, M.J.2
Liao, X.3
Magallon, J.4
Nguyen, M.5
Feric, N.T.6
Koschinsky, M.L.7
Harkewicz, R.8
Witztum, J.L.9
Tsimikas, S.10
-
112
-
-
33748755008
-
Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
-
J.J. Senn Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes J. Biol. Chem. 281 2006 26865 26875
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26865-26875
-
-
Senn, J.J.1
-
113
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
H. Shi, M.V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J.S. Flier TLR4 links innate immunity and fatty acid-induced insulin resistance J. Clin. Invest. 116 2006 3015 3025
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
115
-
-
84878774925
-
Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients with Type 2 Diabetes
-
J. Sloan-Lancaster, E. Abu-Raddad, J. Polzer, J.W. Miller, J.C. Scherer, A. De Gaetano, J.K. Berg, and W.H. Landschulz Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes Diabetes Care 2013
-
(2013)
Diabetes Care
-
-
Sloan-Lancaster, J.1
Abu-Raddad, E.2
Polzer, J.3
Miller, J.W.4
Scherer, J.C.5
De Gaetano, A.6
Berg, J.K.7
Landschulz, W.H.8
-
116
-
-
33745187112
-
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
-
M.J. Song, K.H. Kim, J.M. Yoon, and J.B. Kim Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes Biochem. Biophys. Res. Commun. 346 2006 739 745
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 739-745
-
-
Song, M.J.1
Kim, K.H.2
Yoon, J.M.3
Kim, J.B.4
-
117
-
-
0345700727
-
Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
-
J. Spranger, A. Kroke, M. Möhlig, K. Hoffmann, M.M. Bergmann, M. Ristow, H. Boeing, and A.F. Pfeiffer Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study Diabetes 52 2003 812 817
-
(2003)
Diabetes
, vol.52
, pp. 812-817
-
-
Spranger, J.1
Kroke, A.2
Möhlig, M.3
Hoffmann, K.4
Bergmann, M.M.5
Ristow, M.6
Boeing, H.7
Pfeiffer, A.F.8
-
118
-
-
78650917112
-
TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome
-
Published online November 3, 2010
-
T.L. Stanley, M.V. Zanni, S. Johnsen, S. Rasheed, H. Makimura, H. Lee, V.K. Khor, R.S. Ahima, and S.K. Grinspoon TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome J. Clin. Endocrinol. Metab. 96 2011 E146 E150 Published online November 3, 2010
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
-
-
Stanley, T.L.1
Zanni, M.V.2
Johnsen, S.3
Rasheed, S.4
Makimura, H.5
Lee, H.6
Khor, V.K.7
Ahima, R.S.8
Grinspoon, S.K.9
-
119
-
-
84871682971
-
Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: A potential link between β-cell lipotoxicity and islet inflammation
-
C. Tang, A.E. Naassan, A. Chamson-Reig, K. Koulajian, T.T. Goh, F. Yoon, A.I. Oprescu, H. Ghanim, G.F. Lewis, and P. Dandona Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation Endocrinology 154 2013 89 101
-
(2013)
Endocrinology
, vol.154
, pp. 89-101
-
-
Tang, C.1
Naassan, A.E.2
Chamson-Reig, A.3
Koulajian, K.4
Goh, T.T.5
Yoon, F.6
Oprescu, A.I.7
Ghanim, H.8
Lewis, G.F.9
Dandona, P.10
-
120
-
-
84871871605
-
Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
-
K. Timper, J. Grisouard, N.S. Sauter, T. Herzog-Radimerski, K. Dembinski, R. Peterli, D.M. Frey, H. Zulewski, U. Keller, B. Müller, and M. Christ-Crain Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes Am. J. Physiol. Endocrinol. Metab. 304 2013 E1 E13
-
(2013)
Am. J. Physiol. Endocrinol. Metab.
, vol.304
-
-
Timper, K.1
Grisouard, J.2
Sauter, N.S.3
Herzog-Radimerski, T.4
Dembinski, K.5
Peterli, R.6
Frey, D.M.7
Zulewski, H.8
Keller, U.9
Müller, B.10
Christ-Crain, M.11
-
121
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 2006 1027 1031
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
Gordon, J.I.6
-
122
-
-
79960086288
-
Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: A randomized, double-blind, placebo-controlled study
-
E.J. van Asseldonk, R. Stienstra, T.B. Koenen, L.A. Joosten, M.G. Netea, and C.J. Tack Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study J. Clin. Endocrinol. Metab. 96 2011 2119 2126
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, pp. 2119-2126
-
-
Van Asseldonk, E.J.1
Stienstra, R.2
Koenen, T.B.3
Joosten, L.A.4
Netea, M.G.5
Tack, C.J.6
-
123
-
-
84861898665
-
Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms
-
N.J. van der Zijl, C.C. Moors, G.H. Goossens, E.E. Blaak, and M. Diamant Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms Diabetes Obes. Metab. 14 2012 586 595
-
(2012)
Diabetes Obes. Metab.
, vol.14
, pp. 586-595
-
-
Van Der Zijl, N.J.1
Moors, C.C.2
Goossens, G.H.3
Blaak, E.E.4
Diamant, M.5
-
124
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
B. Vandanmagsar, Y.H. Youm, A. Ravussin, J.E. Galgani, K. Stadler, R.L. Mynatt, E. Ravussin, J.M. Stephens, and V.D. Dixit The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance Nat. Med. 17 2011 179 188
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
Galgani, J.E.4
Stadler, K.5
Mynatt, R.L.6
Ravussin, E.7
Stephens, J.M.8
Dixit, V.D.9
-
125
-
-
84866738529
-
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
-
e7
-
A. Vrieze, E. Van Nood, F. Holleman, J. Salojärvi, R.S. Kootte, J.F. Bartelsman, G.M. Dallinga-Thie, M.T. Ackermans, M.J. Serlie, and R. Oozeer Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome Gastroenterology 143 2012 913 916 e7
-
(2012)
Gastroenterology
, vol.143
, pp. 913-916
-
-
Vrieze, A.1
Van Nood, E.2
Holleman, F.3
Salojärvi, J.4
Kootte, R.S.5
Bartelsman, J.F.6
Dallinga-Thie, G.M.7
Ackermans, M.T.8
Serlie, M.J.9
Oozeer, R.10
-
126
-
-
33846873249
-
Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
-
author reply 825
-
C. Weigert, R. Lehmann, and E.D. Schleicher Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis J. Appl. Physiol. 102 2007 820 821 author reply 825
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 820-821
-
-
Weigert, C.1
Lehmann, R.2
Schleicher, E.D.3
-
127
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante Jr., A.W.6
-
129
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
H. Wen, D. Gris, Y. Lei, S. Jha, L. Zhang, M.T. Huang, W.J. Brickey, and J.P. Ting Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling Nat. Immunol. 12 2011 408 415
-
(2011)
Nat. Immunol.
, vol.12
, pp. 408-415
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
Jha, S.4
Zhang, L.5
Huang, M.T.6
Brickey, W.J.7
Ting, J.P.8
-
130
-
-
70349305566
-
Reappraising the stereotypes of diabetes in the modern diabetogenic environment
-
J.M. Wentworth, S. Fourlanos, and L.C. Harrison Reappraising the stereotypes of diabetes in the modern diabetogenic environment Nat Rev Endocrinol 5 2009 483 489
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 483-489
-
-
Wentworth, J.M.1
Fourlanos, S.2
Harrison, L.C.3
-
131
-
-
79954535899
-
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus
-
P. Westermark, A. Andersson, and G.T. Westermark Islet amyloid polypeptide, islet amyloid, and diabetes mellitus Physiol. Rev. 91 2011 795 826
-
(2011)
Physiol. Rev.
, vol.91
, pp. 795-826
-
-
Westermark, P.1
Andersson, A.2
Westermark, G.T.3
-
132
-
-
80052650475
-
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
-
C. Westwell-Roper, D.L. Dai, G. Soukhatcheva, K.J. Potter, N. van Rooijen, J.A. Ehses, and C.B. Verchere IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction J. Immunol. 187 2011 2755 2765
-
(2011)
J. Immunol.
, vol.187
, pp. 2755-2765
-
-
Westwell-Roper, C.1
Dai, D.L.2
Soukhatcheva, G.3
Potter, K.J.4
Van Rooijen, N.5
Ehses, J.A.6
Verchere, C.B.7
-
133
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
D.A. Winer, S. Winer, L. Shen, P.P. Wadia, J. Yantha, G. Paltser, H. Tsui, P. Wu, M.G. Davidson, and M.N. Alonso B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies Nat. Med. 17 2011 610 617
-
(2011)
Nat. Med.
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
Winer, S.2
Shen, L.3
Wadia, P.P.4
Yantha, J.5
Paltser, G.6
Tsui, H.7
Wu, P.8
Davidson, M.G.9
Alonso, M.N.10
-
134
-
-
70350482557
-
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
-
S.W. Wong, M.J. Kwon, A.M. Choi, H.P. Kim, K. Nakahira, and D.H. Hwang Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner J. Biol. Chem. 284 2009 27384 27392
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 27384-27392
-
-
Wong, S.W.1
Kwon, M.J.2
Choi, A.M.3
Kim, H.P.4
Nakahira, K.5
Hwang, D.H.6
-
135
-
-
33847280286
-
T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
-
H. Wu, S. Ghosh, X.D. Perrard, L. Feng, G.E. Garcia, J.L. Perrard, J.F. Sweeney, L.E. Peterson, L. Chan, C.W. Smith, and C.M. Ballantyne T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity Circulation 115 2007 1029 1038
-
(2007)
Circulation
, vol.115
, pp. 1029-1038
-
-
Wu, H.1
Ghosh, S.2
Perrard, X.D.3
Feng, L.4
Garcia, G.E.5
Perrard, J.L.6
Sweeney, J.F.7
Peterson, L.E.8
Chan, L.9
Smith, C.W.10
Ballantyne, C.M.11
-
136
-
-
77956335194
-
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action
-
F.T. Wunderlich, P. Ströhle, A.C. Könner, S. Gruber, S. Tovar, H.S. Brönneke, L. Juntti-Berggren, L.S. Li, N. van Rooijen, and C. Libert Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action Cell Metab. 12 2010 237 249
-
(2010)
Cell Metab.
, vol.12
, pp. 237-249
-
-
Wunderlich, F.T.1
Ströhle, P.2
Könner, A.C.3
Gruber, S.4
Tovar, S.5
Brönneke, H.S.6
Juntti-Berggren, L.7
Li, L.S.8
Van Rooijen, N.9
Libert, C.10
-
137
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, C.J. Chou, J. Sole, A. Nichols, J.S. Ross, L.A. Tartaglia, and H. Chen Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112 2003 1821 1830
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
138
-
-
60549110804
-
Receptor for AGE (RAGE) and its ligands-cast into leading roles in diabetes and the inflammatory response
-
S.F. Yan, R. Ramasamy, and A.M. Schmidt Receptor for AGE (RAGE) and its ligands-cast into leading roles in diabetes and the inflammatory response J. Mol. Med. 87 2009 235 247
-
(2009)
J. Mol. Med.
, vol.87
, pp. 235-247
-
-
Yan, S.F.1
Ramasamy, R.2
Schmidt, A.M.3
-
139
-
-
4944258755
-
Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab
-
B. Yazdani-Biuki, H. Stelzl, H.P. Brezinschek, J. Hermann, T. Mueller, P. Krippl, W. Graninger, and T.C. Wascher Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab Eur. J. Clin. Invest. 34 2004 641 642
-
(2004)
Eur. J. Clin. Invest.
, vol.34
, pp. 641-642
-
-
Yazdani-Biuki, B.1
Stelzl, H.2
Brezinschek, H.P.3
Hermann, J.4
Mueller, T.5
Krippl, P.6
Graninger, W.7
Wascher, T.C.8
-
140
-
-
33746445962
-
Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-alpha antibody infliximab: A case observation
-
B. Yazdani-Biuki, T. Mueller, H.P. Brezinschek, J. Hermann, W. Graninger, and T.C. Wascher Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-alpha antibody infliximab: a case observation Diabetes Care 29 2006 1712 1713
-
(2006)
Diabetes Care
, vol.29
, pp. 1712-1713
-
-
Yazdani-Biuki, B.1
Mueller, T.2
Brezinschek, H.P.3
Hermann, J.4
Graninger, W.5
Wascher, T.C.6
-
141
-
-
58149500277
-
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
-
J. Ye Emerging role of adipose tissue hypoxia in obesity and insulin resistance Int J Obes (Lond) 33 2009 54 66
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 54-66
-
-
Ye, J.1
-
142
-
-
70349440053
-
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
-
J. Zhang, S.M. Lee, S. Shannon, B. Gao, W. Chen, A. Chen, R. Divekar, M.W. McBurney, H. Braley-Mullen, H. Zaghouani, and D. Fang The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice J. Clin. Invest. 119 2009 3048 3058
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3048-3058
-
-
Zhang, J.1
Lee, S.M.2
Shannon, S.3
Gao, B.4
Chen, W.5
Chen, A.6
Divekar, R.7
McBurney8
-
143
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
R. Zhou, A. Tardivel, B. Thorens, I. Choi, and J. Tschopp Thioredoxin-interacting protein links oxidative stress to inflammasome activation Nat. Immunol. 11 2010 136 140
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
144
-
-
78650655167
-
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
-
L.A. Zúñiga, W.J. Shen, B. Joyce-Shaikh, E.A. Pyatnova, A.G. Richards, C. Thom, S.M. Andrade, D.J. Cua, F.B. Kraemer, and E.C. Butcher IL-17 regulates adipogenesis, glucose homeostasis, and obesity J. Immunol. 185 2010 6947 6959
-
(2010)
J. Immunol.
, vol.185
, pp. 6947-6959
-
-
Zúñiga, L.A.1
Shen, W.J.2
Joyce-Shaikh, B.3
Pyatnova, E.A.4
Richards, A.G.5
Thom, C.6
Andrade, S.M.7
Cua, D.J.8
Kraemer, F.B.9
Butcher, E.C.10
|