Pancreatic steatosis and its relationship to β-cell dysfunction in humans: Racial and ethnic variations

Diabetes Care

Volumn 35, Issue 11, 2012, Pages 2377-2383

  Szczepaniak, Lidia S ^a   Victor, Ronald G ^a   Mathur, Ruchi ^a   Nelson, Michael D ^a   Szczepaniak, Edward W ^a   Tyer, Nicole ^a   Chen, Ida ^a   Unger, Roger H ^b   Bergman, Richard N ^a   Lingvay, Ildiko ^b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TRIACYLGLYCEROL;

ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; HISPANIC; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS DISEASE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; RACE DIFFERENCE; STEATOSIS;

ADOLESCENT; ADULT; AFRICAN AMERICANS; AGED; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE TOLERANCE TEST; HISPANIC AMERICANS; HUMANS; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OBESITY; PANCREAS; PANCREATIC DISEASES; TRIGLYCERIDES; YOUNG ADULT;

EID: 84868110769     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0701     Document Type: Article

References (33)

1. Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 2010;21:345-352
2. Field AE, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 2001;161:1581-1586 (Pubitemid 32681139)
3. Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-5165 (Pubitemid 37476041)
4. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A 1994;91:10878-10882
5. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998;95:2498-2502 (Pubitemid 28145970)
6. Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology 2012;142:711-725, e6
7. Szczepaniak LS, Babcock EE, Schick F, et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 1999;276:E977-E989 (Pubitemid 29249618)
8. Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005;288:E462-E468 (Pubitemid 40110657)
9. Szczepaniak LS, Dobbins RL, Metzger GJ, et al. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 2003;49:417-423 (Pubitemid 36262808)
10. Szczepaniak LS, Victor RG, Orci L, Unger RH. Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ Res 2007;101:759-767 (Pubitemid 350287190)
11. McGarry JD. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 1992;258:766-770
12. Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387-1395 (Pubitemid 39657013)
13. 1H-magnetic resonance spectroscopy study. Circulation 2007;116:1170-1175
14. Lingvay I, Esser V, Legendre JL, et al. Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab 2009;94:4070-4076
15. National Diabetes Statistics, 2011 [Internet], c2011, last updated 6 December 2011. Bethesda, MD: National Diabetes Information Clearinghouse. Available from http://diabetes.niddk.nih.gov/dm/pubs/statistics/index.aspx. Accessed 13 June 2012.
16. Victor RG, Haley RW, Willett DL, et al.; Dallas Heart Study Investigators. The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol 2004;93:1473-1480 (Pubitemid 38749202)
17. Genuth S, Alberti KG, Bennett P, et al.; Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160-3167
18. Bergman RN. Orchestration of glucose homeostasis: from a small acorn to the California oak. Diabetes 2007;56:1489-1501 (Pubitemid 46842592)
19. Abate N, Garg A, Coleman R, Grundy SM, Peshock RM. Prediction of total subcutaneous abdominal, intraperitoneal, and retroperitoneal adipose tissue masses in men by a single axial magnetic resonance imaging slice. Am J Clin Nutr 1997;65:403-408 (Pubitemid 27130746)
20. Kaplan LA. Methods in Clinical Chemistry. St. Louis, The CV Mosby Company, 1987
21. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502
22. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007;30:2916-2921 (Pubitemid 350083144)
23. van der Zijl NJ, Goossens GH, Moors CC, et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 2011;96:459-467
24. van Raalte DH, van der Zijl NJ, Diamant M. Pancreatic steatosis in humans: cause or marker of lipotoxicity? Curr Opin Clin Nutr Metab Care 2010;13:478-485
25. Lê KA, Ventura EE, Fisher JQ, et al. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 2011;34:485-490
26. Boden G. Free fatty acids-the link between obesity and insulin resistance. Endocr Pract 2001;7:44-51 (Pubitemid 32834246)
27. Koyama K, Chen G, Lee Y, Unger RH. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 1997;273:E708-E713
28. McGarry JD. Banting Lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002;51:7-18
29. Taylor R. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 2008;51:1781-1789
30. Yki-Järvinen H. Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. Dig Dis 2010;28:203-209
31. Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461-1465
32. Lee Y, Lingvay I, Szczepaniak LS, Ravazzola M, Orci L, Unger RH. Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents. Int J Obes (Lond) 2010;34:396-400
33. Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011;54:2506-2514