The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

Peptides

Volumn 39, Issue 1, 2013, Pages 71-79

  Miao, Xin Yu ^a   Gu, Zhao Yan ^a   Liu, Ping ^a   Hu, Yuan ^a   Li, Lin ^a   Gong, Yan Ping ^a   Shu, Hua ^a   Liu, Yu ^a   Li, Chun Lin ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

AMPK; Apoptosis; Glucagon like peptide 1; mTOR; Pancreatic beta cell; Proliferation

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; LIRAGLUTIDE; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; S6 KINASE;

APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLOW CYTOMETRY; GLUCOLIPOTOXICITY; HUMAN; HUMAN CELL; LIPOTOXICITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; AMINOIMIDAZOLE CARBOXAMIDE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBONUCLEOTIDES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 84871407673     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.10.006     Document Type: Article

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