Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: Severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass

Diabetologia

Volumn 52, Issue 6, 2009, Pages 1122-1132

  Delghingaro Augusto, V ^a   Nolan, C J ^b   Gupta, D ^c   Jetton, T L ^c   Latour, M G ^a   Peshavaria, M ^c   Madiraju, S R Murthy ^a   Joly, E ^a   Peyot, M L ^a   Prentki, M ^a   Leahy, J ^c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

Beta cell mass; Fatty acid metabolism; Glucolipotoxicity; Glycerolipid fatty acid cycling; Insulin biosynthesis; Insulin resistance; Insulin secretion; Pancreatectomy; Pancreatic islet; Zucker fatty rat

Indexed keywords

ACYL COENZYME A DESATURASE; DIACYLGLYCEROL; GLUCOSE; GLYCEROLIPID; INSULIN; LIPID; MESSENGER RNA; MONOACYLGLYCEROL; PROINSULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCOSE METABOLISM; HORMONE SYNTHESIS; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; HYPOINSULINEMIA; INSULIN RELEASE; LIPID METABOLISM; LIPOLYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STEATOSIS; ZUCKER RAT;

ANIMALS; BODY WEIGHT; CELL PROLIFERATION; CELLS, CULTURED; FATTY ACIDS, NONESTERIFIED; HYPERLIPIDEMIAS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIPID METABOLISM; MALE; OBESITY; PANCREATECTOMY; PROINSULIN; RATS; RATS, ZUCKER;

EID: 67349130784     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1317-8     Document Type: Article

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