Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

BMC Cell Biology

Volumn 14, Issue 1, 2013, Pages

  Somesh, Baggavalli P ^a   Verma, Mahesh Kumar ^a   Sadasivuni, Manoj Kumar ^a   Mammen Oommen, Anup ^a   Biswas, Sanghamitra ^a   Shilpa, Pavagada C ^a   Reddy, Ashok Kumar ^a   Yateesh, Aggunda N ^a   Pallavi, Puttrevana M ^a   Nethra, Siddaraju ^a   Smitha, Rachapalli ^a   Neelima, Korrapati ^a   Narayanan, Usha ^a   Jagannath, Madanahalli R ^a  

^a Connexios Life Sciences Pvt Ltd ^*  (India)

Author keywords

Glucolipotoxicity; Glucose metabolism; Insulin content; Insulin secretion; Rat islets; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; FATTY ACID; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; INOSITOL TRISPHOSPHATE; INSULIN; MESSENGER RNA; PYRUVATE CARBOXYLASE; TRIACYLGLYCEROL; CALCIUM; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL FUNCTION; CELL GRANULE; CELL LEVEL; CELL MEMBRANE; CELL STIMULATION; CITRIC ACID CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOLIPOTOXICITY; GLUCOSE METABOLISM; IN VITRO STUDY; INSULIN GENE; INSULIN RELEASE; LIPID METABOLISM; LIPOTOXICITY; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; ANIMAL; ANIMAL MODEL; CELL CULTURE; DRUG EFFECTS; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; FATTY ACIDS; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; IN VITRO TECHNIQUES; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOCHONDRIA; MODELS, ANIMAL; PALMITATES; PYRUVATE CARBOXYLASE; RATS; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 84879495791     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-14-31     Document Type: Article

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