-
1
-
-
30944443590
-
Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis
-
Abrami L, Leppla SH, van der Goot FG. Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol 172: 309-320, 2006.
-
(2006)
J Cell Biol
, vol.172
, pp. 309-320
-
-
Abrami, L.1
Leppla, S.H.2
van der Goot, F.G.3
-
2
-
-
63349109171
-
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic β-cells via activation of mTORC1
-
Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic β-cells via activation of mTORC1. PLos One 4: e4954, 2009.
-
(2009)
PLos One
, vol.4
-
-
Bachar, E.1
Ariav, Y.2
Ketzinel-Gilad, M.3
Cerasi, E.4
Kaiser, N.5
Leibowitz, G.6
-
3
-
-
0029145798
-
Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins
-
Berthiaume L, Resh MD. Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins. J Biol Chem 270: 22399-22405, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 22399-22405
-
-
Berthiaume, L.1
Resh, M.D.2
-
4
-
-
0037213362
-
The on-off story of protein palmitoylation
-
Bijlmakers MJ, Marsh M. The on-off story of protein palmitoylation. Trends Cell Biol 13: 32-42, 2003.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 32-42
-
-
Bijlmakers, M.J.1
Marsh, M.2
-
5
-
-
0035830701
-
Structural determinants influencing the reaction of cysteine-containing peptides with palmitoyl-coenzyme A and other thioesters
-
Bizzozero OA, Bixler HA, Pastuszyn A. Structural determinants influencing the reaction of cysteine-containing peptides with palmitoyl-coenzyme A and other thioesters. Biochim Biophys Acta 1545: 278-288, 2001.
-
(2001)
Biochim Biophys Acta
, vol.1545
, pp. 278-288
-
-
Bizzozero, O.A.1
Bixler, H.A.2
Pastuszyn, A.3
-
6
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93: 2438-2446, 1994.
-
(1994)
J Clin Invest
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
7
-
-
4344597286
-
Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17
-
Bonapace G, Waheed A, Shah GN, Sly WS. Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Proc Natl Acad Sci USA 101: 12300-12305, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12300-12305
-
-
Bonapace, G.1
Waheed, A.2
Shah, G.N.3
Sly, W.S.4
-
8
-
-
71949118923
-
Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I
-
Boni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 150: 5218-5229, 2009.
-
(2009)
Endocrinology
, vol.150
, pp. 5218-5229
-
-
Boni-Schnetzler, M.1
Boller, S.2
Debray, S.3
Bouzakri, K.4
Meier, D.T.5
Prazak, R.6
Kerr-Conte, J.7
Pattou, F.8
Ehses, J.A.9
Schuit, F.C.10
Donath, M.Y.11
-
9
-
-
0021990499
-
Toxicity determined in vitro by morphological alterations and neutral red absorption
-
Borenfreund E, Puerner JA. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 24: 119-124, 1985.
-
(1985)
Toxicol Lett
, vol.24
, pp. 119-124
-
-
Borenfreund, E.1
Puerner, J.A.2
-
10
-
-
0035145780
-
Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
-
Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V. Lipotoxicity of the pancreatic β-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Diabetes 50: 315-321, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 315-321
-
-
Briaud, I.1
Harmon, J.S.2
Kelpe, C.L.3
Segu, V.B.4
Poitout, V.5
-
11
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
12
-
-
25844454854
-
Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis
-
Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ. Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis. Diabetes 54: 2917-2924, 2005.
-
(2005)
Diabetes
, vol.54
, pp. 2917-2924
-
-
Busch, A.K.1
Gurisik, E.2
Cordery, D.V.3
Sudlow, M.4
Denyer, G.S.5
Laybutt, D.R.6
Hughes, W.E.7
Biden, T.J.8
-
14
-
-
0015379202
-
Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters
-
Chase JF, Tubbs PK. Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters. Biochem J 129: 55-65, 1972.
-
(1972)
Biochem J
, vol.129
, pp. 55-65
-
-
Chase, J.F.1
Tubbs, P.K.2
-
15
-
-
0026532884
-
2-Bromopalmitoyl-CoA and 2-bromopalmitate: Promiscuous inhibitors of membrane-bound enzymes
-
Coleman RA, Rao P, Fogelsong RJ, Bardes ES. 2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. Biochim Biophys Acta 1125: 203-209, 1992.
-
(1992)
Biochim Biophys Acta
, vol.1125
, pp. 203-209
-
-
Coleman, R.A.1
Rao, P.2
Fogelsong, R.J.3
Bardes, E.S.4
-
16
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
-
Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M. Initiation and execution of lipotoxic ER stress in pancreatic β-cells. J Cell Sci 121: 2308-2318, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham, M.C.6
Moore, F.7
Rasschaert, J.8
Cardozo, A.K.9
Bellomo, E.10
Overbergh, L.11
Mathieu, C.12
Lupi, R.13
Hai, T.14
Herchuelz, A.15
Marchetti, P.16
Rutter, G.A.17
Eizirik, D.L.18
Cnop, M.19
-
17
-
-
0036907626
-
Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and intracellular translocation of myelin proteolipid protein
-
DeJesus G, Bizzozero OA. Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and intracellular translocation of myelin proteolipid protein. Neurochem Res 27: 1669-1675, 2002.
-
(2002)
Neurochem Res
, vol.27
, pp. 1669-1675
-
-
DeJesus, G.1
Bizzozero, O.A.2
-
18
-
-
53849086177
-
Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell
-
Diakogiannaki E, Morgan NG. Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell. Biochem Soc Trans 36: 959-962, 2008.
-
(2008)
Biochem Soc Trans
, vol.36
, pp. 959-962
-
-
Diakogiannaki, E.1
Morgan, N.G.2
-
19
-
-
44949214679
-
Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids
-
Diakogiannaki E, Welters HJ, Morgan NG. Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol 197: 553-563, 2008.
-
(2008)
J Endocrinol
, vol.197
, pp. 553-563
-
-
Diakogiannaki, E.1
Welters, H.J.2
Morgan, N.G.3
-
20
-
-
10044268365
-
On the mechanism of protein palmitoylation
-
Dietrich LE, Ungermann C. On the mechanism of protein palmitoylation. EMBO Rep 5: 1053-1057, 2004.
-
(2004)
EMBO Rep
, vol.5
, pp. 1053-1057
-
-
Dietrich, L.E.1
Ungermann, C.2
-
21
-
-
0029814190
-
Autoacylation of G protein α-subunits
-
Duncan JA, Gilman AG. Autoacylation of G protein α-subunits. J Biol Chem 271: 23594-23600, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 23594-23600
-
-
Duncan, J.A.1
Gilman, A.G.2
-
22
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death
-
El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M. Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death. Endocrinology 144: 4154-4163, 2003.
-
(2003)
Endocrinology
, vol.144
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
Peyot, M.L.3
Nolan, C.4
Roduit, R.5
Hardy, S.6
Joly, E.7
Dbaibo, G.8
Rosenberg, L.9
Prentki, M.10
-
23
-
-
77954595108
-
Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells
-
El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E, Prentki M. Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells. Endocrinology 151: 3061-3073, 2010.
-
(2010)
Endocrinology
, vol.151
, pp. 3061-3073
-
-
El-Assaad, W.1
Joly, E.2
Barbeau, A.3
Sladek, R.4
Buteau, J.5
Maestre, I.6
Pepin, E.7
Zhao, S.8
Iglesias, J.9
Roche, E.10
Prentki, M.11
-
24
-
-
70449321364
-
Metabolism of serum-free fatty acids
-
Gordon RS Jr. Metabolism of serum-free fatty acids. Fed Proc 19 Suppl 5: 120-121, 1960.
-
(1960)
Fed Proc
, vol.19
, Issue.SUPPL. 5
, pp. 120-121
-
-
Gordon Jr., R.S.1
-
25
-
-
33846620628
-
Palmitoylation-dependent protein sorting
-
Greaves J, Chamberlain LH. Palmitoylation-dependent protein sorting. J Cell Biol 176: 249-254, 2007.
-
(2007)
J Cell Biol
, vol.176
, pp. 249-254
-
-
Greaves, J.1
Chamberlain, L.H.2
-
26
-
-
61449217928
-
The fat controller: Roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains
-
Greaves J, Prescott GR, Gorleku OA, Chamberlain LH. The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains. Mol Membr Biol 26: 67-79, 2009.
-
(2009)
Mol Membr Biol
, vol.26
, pp. 67-79
-
-
Greaves, J.1
Prescott, G.R.2
Gorleku, O.A.3
Chamberlain, L.H.4
-
27
-
-
36249024099
-
Peroxisome proliferator-activated receptor α-retinoid X receptor agonists induce β-cell protection against palmitate toxicity
-
Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P, Pipeleers D. Peroxisome proliferator-activated receptor α-retinoid X receptor agonists induce β-cell protection against palmitate toxicity. FEBS J 274: 6094-6105, 2007.
-
(2007)
FEBS J
, vol.274
, pp. 6094-6105
-
-
Hellemans, K.1
Kerckhofs, K.2
Hannaert, J.C.3
Martens, G.4
van Veldhoven, P.5
Pipeleers, D.6
-
28
-
-
77957580825
-
Homogeneous insulin and C-peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets
-
Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T. Homogeneous insulin and C-peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. Diabetes 59: 2360-2365, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 2360-2365
-
-
Heyduk, E.1
Moxley, M.M.2
Salvatori, A.3
Corbett, J.A.4
Heyduk, T.5
-
29
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917, 2010.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
30
-
-
67649882018
-
Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism
-
Hou H, John Peter AT, Meiringer C, Subramanian K, Ungermann C. Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Traffic 10: 1061-1073, 2009.
-
(2009)
Traffic
, vol.10
, pp. 1061-1073
-
-
Hou, H.1
John Peter, A.T.2
Meiringer, C.3
Subramanian, K.4
Ungermann, C.5
-
31
-
-
25844522857
-
Modulation of neuronal protein trafficking and function by palmitoylation
-
Huang K, El-Husseini A. Modulation of neuronal protein trafficking and function by palmitoylation. Curr Opin Neurobiol 15: 527-535, 2005.
-
(2005)
Curr Opin Neurobiol
, vol.15
, pp. 527-535
-
-
Huang, K.1
El-Husseini, A.2
-
32
-
-
77955658618
-
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes
-
Igoillo-Esteve M, Marselli L, Cunha DA, Ladriere L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia 53: 1395-1405, 2010.
-
(2010)
Diabetologia
, vol.53
, pp. 1395-1405
-
-
Igoillo-Esteve, M.1
Marselli, L.2
Cunha, D.A.3
Ladriere, L.4
Ortis, F.5
Grieco, F.A.6
Dotta, F.7
Weir, G.C.8
Marchetti, P.9
Eizirik, D.L.10
Cnop, M.11
-
33
-
-
34547781132
-
Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A
-
Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell 18: 2960-2969, 2007.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 2960-2969
-
-
Jiang, X.1
Benovic, J.L.2
Wedegaertner, P.B.3
-
34
-
-
0028827388
-
Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes
-
Jochen AL, Hays J, Mick G. Inhibitory effects of cerulenin on protein palmitoylation and insulin internalization in rat adipocytes. Biochim Biophys Acta 1259: 65-72, 1995.
-
(1995)
Biochim Biophys Acta
, vol.1259
, pp. 65-72
-
-
Jochen, A.L.1
Hays, J.2
Mick, G.3
-
35
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis. Endocrinology 147: 3398-3407, 2006.
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
36
-
-
0025231709
-
Purification of protein fatty acyltransferase and determination of its distribution and topology
-
Kasinathan C, Grzelinska E, Okazaki K, Slomiany BL, Slomiany A. Purification of protein fatty acyltransferase and determination of its distribution and topology. J Biol Chem 265: 5139-5144, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 5139-5144
-
-
Kasinathan, C.1
Grzelinska, E.2
Okazaki, K.3
Slomiany, B.L.4
Slomiany, A.5
-
37
-
-
0033562966
-
Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
-
Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 1211-1233
-
-
Kaufman, R.J.1
-
38
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-B and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL. Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-B and endoplasmic reticulum stress. Endocrinology 145: 5087-5096, 2004.
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
39
-
-
0033518174
-
Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors
-
Lawrence DS, Zilfou JT, Smith CD. Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors. J Med Chem 42: 4932-4941, 1999.
-
(1999)
J Med Chem
, vol.42
, pp. 4932-4941
-
-
Lawrence, D.S.1
Zilfou, J.T.2
Smith, C.D.3
-
40
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50: 752-763, 2007.
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
Biankin, A.V.6
Biden, T.J.7
-
41
-
-
12344266697
-
How obesity causes diabetes: Not a tall tale
-
Lazar MA. How obesity causes diabetes: not a tall tale. Science 307: 373-375, 2005.
-
(2005)
Science
, vol.307
, pp. 373-375
-
-
Lazar, M.A.1
-
42
-
-
33845794047
-
Palmitoylation: Policing protein stability and traffic
-
Linder ME, Deschenes RJ. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 8: 74-84, 2007.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 74-84
-
-
Linder, M.E.1
Deschenes, R.J.2
-
43
-
-
0035805629
-
Palmitate-induced apoptosis can occur through a ceramide-independent pathway
-
Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem 276: 14890-14895, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 14890-14895
-
-
Listenberger, L.L.1
Ory, D.S.2
Schaffer, J.E.3
-
44
-
-
0029789954
-
Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide
-
Liu L, Dudler T, Gelb MH. Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide. J Biol Chem 271: 23269-23276, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 23269-23276
-
-
Liu, L.1
Dudler, T.2
Gelb, M.H.3
-
45
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
di Mario, U.13
del Prato, S.14
Marchetti, P.15
-
46
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
-
Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 52: 726-733, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
47
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1
-
Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1. Endocrinology 144: 335-345, 2003.
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
Reig, J.A.4
Cena, V.5
Soria, B.6
Prentki, M.7
Roche, E.8
-
48
-
-
0015218728
-
Effect of bromo-palmitate on the oxidation of palmitic acid by rat liver cells
-
Mahadevan S, Sauer F. Effect of bromo-palmitate on the oxidation of palmitic acid by rat liver cells. J Biol Chem 246: 5862-5867, 1971.
-
(1971)
J Biol Chem
, vol.246
, pp. 5862-5867
-
-
Mahadevan, S.1
Sauer, F.2
-
49
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
-
Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 9: 2277-2293, 2007.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
50
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50: 2486-2494, 2007.
-
(2007)
Diabetologia
, vol.50
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliani, M.2
Lupi, R.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Filipponi, F.7
Weir, G.C.8
Eizirik, D.L.9
Cnop, M.10
-
51
-
-
42449126643
-
Inhibition of Foxo1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
-
Martinez SC, Tanabe K, Cras-Meneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA. Inhibition of Foxo1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 57: 846-859, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 846-859
-
-
Martinez, S.C.1
Tanabe, K.2
Cras-Meneur, C.3
Abumrad, N.A.4
Bernal-Mizrachi, E.5
Permutt, M.A.6
-
52
-
-
0020973549
-
A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans
-
McDaniel ML, Colca JR, Kotagal N, Lacy PE. A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol 98: 182-200, 1983.
-
(1983)
Methods Enzymol
, vol.98
, pp. 182-200
-
-
McDaniel, M.L.1
Colca, J.R.2
Kotagal, N.3
Lacy, P.E.4
-
53
-
-
0037223174
-
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
-
Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289: 76-79, 2003.
-
(2003)
JAMA
, vol.289
, pp. 76-79
-
-
Mokdad, A.H.1
Ford, E.S.2
Bowman, B.A.3
Dietz, W.H.4
Vinicor, F.5
Bales, V.S.6
Marks, J.S.7
-
54
-
-
4644287377
-
Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
-
Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 53: 2610-2616, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 2610-2616
-
-
Moore, P.C.1
Ugas, M.A.2
Hagman, D.K.3
Parazzoli, S.D.4
Poitout, V.5
-
55
-
-
34848907786
-
Protein lipidation
-
Nadolski MJ, Linder ME. Protein lipidation. FEBS J 274: 5202-5210, 2007.
-
(2007)
FEBS J
, vol.274
, pp. 5202-5210
-
-
Nadolski, M.J.1
Linder, M.E.2
-
56
-
-
34547830983
-
Diabetes associated cell stress and dysfunction: Role of mitochondrial and nonmitochondrial ROS production and activity
-
Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R. Diabetes associated cell stress and dysfunction: role of mitochondrial and nonmitochondrial ROS production and activity. J Physiol 583: 9-24, 2007.
-
(2007)
J Physiol
, vol.583
, pp. 9-24
-
-
Newsholme, P.1
Haber, E.P.2
Hirabara, S.M.3
Rebelato, E.L.4
Procopio, J.5
Morgan, D.6
Oliveira-Emilio, H.C.7
Carpinelli, A.R.8
Curi, R.9
-
57
-
-
33846267745
-
Life and death decisions of the pancreatic β-cell: The role of fatty acids
-
Newsholme P, Keane D, Welters HJ, Morgan NG. Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clin Sci (Lond) 112: 27-42, 2007.
-
(2007)
Clin Sci (Lond)
, vol.112
, pp. 27-42
-
-
Newsholme, P.1
Keane, D.2
Welters, H.J.3
Morgan, N.G.4
-
58
-
-
36649027086
-
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo
-
Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A. Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes 56: 2927-2937, 2007.
-
(2007)
Diabetes
, vol.56
, pp. 2927-2937
-
-
Oprescu, A.I.1
Bikopoulos, G.2
Naassan, A.3
Allister, E.M.4
Tang, C.5
Park, E.6
Uchino, H.7
Lewis, G.F.8
Fantus, I.G.9
Rozakis-Adcock, M.10
Wheeler, M.B.11
Giacca, A.12
-
59
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532, 2002.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
60
-
-
0242367268
-
Palmitate potentiation of glucose-induced insulin release: A study using 2-bromopalmitate
-
Parker SM, Moore PC, Johnson LM, Poitout V. Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. Metab Clin Exp 52: 1367-1371, 2003.
-
(2003)
Metab Clin Exp
, vol.52
, pp. 1367-1371
-
-
Parker, S.M.1
Moore, P.C.2
Johnson, L.M.3
Poitout, V.4
-
61
-
-
0031013369
-
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
-
Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272: 3324-3329, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 3324-3329
-
-
Paumen, M.B.1
Ishida, Y.2
Muramatsu, M.3
Yamamoto, M.4
Honjo, T.5
-
62
-
-
0036797785
-
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress
-
Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metab Clin Exp 51: 1340-1347, 2002.
-
(2002)
Metab Clin Exp
, vol.51
, pp. 1340-1347
-
-
Piro, S.1
Anello, M.2
di Pietro, C.3
Lizzio, M.N.4
Patane, G.5
Rabuazzo, A.M.6
Vigneri, R.7
Purrello, M.8
Purrello, F.9
-
63
-
-
76049113712
-
Glucolipotoxicity of the pancreatic beta cell
-
Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontes G. Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta 1801: 289-298, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 289-298
-
-
Poitout, V.1
Amyot, J.2
Semache, M.3
Zarrouki, B.4
Hagman, D.5
Fontes, G.6
-
64
-
-
43549108142
-
Glucolipotoxicity: Fuel excess and β-cell dysfunction
-
Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev 29: 351-366, 2008.
-
(2008)
Endocr Rev
, vol.29
, pp. 351-366
-
-
Poitout, V.1
Robertson, R.P.2
-
65
-
-
70349871409
-
Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload
-
Preston AM, Gurisik E, Bartley C, Laybutt DR, Biden TJ. Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload. Diabetologia 52: 2369-2373, 2009.
-
(2009)
Diabetologia
, vol.52
, pp. 2369-2373
-
-
Preston, A.M.1
Gurisik, E.2
Bartley, C.3
Laybutt, D.R.4
Biden, T.J.5
-
66
-
-
50249171227
-
Neutral red uptake assay for the estimation of cell viability/cytotoxicity
-
Repetto G, del Peso A, Zurita JL. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc 3: 1125-1131, 2008.
-
(2008)
Nat Protoc
, vol.3
, pp. 1125-1131
-
-
Repetto, G.1
del Peso, A.2
Zurita, J.L.3
-
67
-
-
34247590130
-
Palmitoylation of ligands, receptors, and intracellular signaling molecules
-
Resh MD. Palmitoylation of ligands, receptors, and intracellular signaling molecules. Science STKE 2006: re14, 2006.
-
(2006)
Science STKE 2006
-
-
Resh, M.D.1
-
68
-
-
77951913833
-
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins
-
Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI. The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell 141: 458-471, 2010.
-
(2010)
Cell
, vol.141
, pp. 458-471
-
-
Rocks, O.1
Gerauer, M.2
Vartak, N.3
Koch, S.4
Huang, Z.P.5
Pechlivanis, M.6
Kuhlmann, J.7
Brunsveld, L.8
Chandra, A.9
Ellinger, B.10
Waldmann, H.11
Bastiaens, P.I.12
-
69
-
-
33645765312
-
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
-
Rolo AP, Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212: 167-178, 2006.
-
(2006)
Toxicol Appl Pharmacol
, vol.212
, pp. 167-178
-
-
Rolo, A.P.1
Palmeira, C.M.2
-
70
-
-
33847628837
-
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid
-
Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP. Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid. J Cell Physiol 211: 244-252, 2007.
-
(2007)
J Cell Physiol
, vol.211
, pp. 244-252
-
-
Sabin, M.A.1
Stewart, C.E.2
Crowne, E.C.3
Turner, S.J.4
Hunt, L.P.5
Welsh, G.I.6
Grohmann, M.J.7
Holly, J.M.8
Shield, J.P.9
-
71
-
-
0038509036
-
Lipotoxicity: When tissues overeat
-
Schaffer JE. Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14: 281-287, 2003.
-
(2003)
Curr Opin Lipidol
, vol.14
, pp. 281-287
-
-
Schaffer, J.E.1
-
72
-
-
73749083481
-
Global estimates of the prevalence of diabetes for 2010 and 2030
-
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87: 4-14, 2010.
-
(2010)
Diabetes Res Clin Pract
, vol.87
, pp. 4-14
-
-
Shaw, J.E.1
Sicree, R.A.2
Zimmet, P.Z.3
-
73
-
-
0032484132
-
Lipoapoptosis in β-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
-
Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in β-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 273: 32487-32490, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 32487-32490
-
-
Shimabukuro, M.1
Higa, M.2
Zhou, Y.T.3
Wang, M.Y.4
Newgard, C.B.5
Unger, R.H.6
-
74
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95: 2498-2502, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
75
-
-
3543099503
-
Palmitoylation of intracellular signaling proteins: Regulation and function
-
Smotrys JE, Linder ME. Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73: 559-587, 2004.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 559-587
-
-
Smotrys, J.E.1
Linder, M.E.2
-
76
-
-
33644843857
-
Interleukin-1 stimulates β-cell necrosis and release of the immunological adjuvant HMGB1
-
Steer SA, Scarim AL, Chambers KT, Corbett JA. Interleukin-1 stimulates β-cell necrosis and release of the immunological adjuvant HMGB1. PLoS Med 3: e17, 2006.
-
(2006)
PLoS Med
, vol.3
-
-
Steer, S.A.1
Scarim, A.L.2
Chambers, K.T.3
Corbett, J.A.4
-
77
-
-
0032863183
-
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
-
Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci USA 96: 10857-10862, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10857-10862
-
-
Tanaka, Y.1
Gleason, C.E.2
Tran, P.O.3
Harmon, J.S.4
Robertson, R.P.5
-
78
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
-
Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44: 863-870, 1995.
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
79
-
-
0031680028
-
Palmitoylation of rhodopsin with S-protein acyltransferase: Enzyme catalyzed reaction versus autocatalytic acylation
-
Veit M, Sachs K, Heckelmann M, Maretzki D, Hofmann KP, Schmidt MF. Palmitoylation of rhodopsin with S-protein acyltransferase: enzyme catalyzed reaction versus autocatalytic acylation. Biochim Biophys Acta 1394: 90-98, 1998.
-
(1998)
Biochim Biophys Acta
, vol.1394
, pp. 90-98
-
-
Veit, M.1
Sachs, K.2
Heckelmann, M.3
Maretzki, D.4
Hofmann, K.P.5
Schmidt, M.F.6
-
80
-
-
26244456414
-
ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity
-
Wang H, Kouri G, Wollheim CB. ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity. J Cell Sci 118: 3905-3915, 2005.
-
(2005)
J Cell Sci
, vol.118
, pp. 3905-3915
-
-
Wang, H.1
Kouri, G.2
Wollheim, C.B.3
-
81
-
-
9144242433
-
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6
-
Wang X, Li H, De Leo D, Guo W, Koshkin V, Fantus IG, Giacca A, Chan CB, Der S, Wheeler MB. Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6. Diabetes 53: 129-140, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 129-140
-
-
Wang, X.1
Li, H.2
de Leo, D.3
Guo, W.4
Koshkin, V.5
Fantus, I.G.6
Giacca, A.7
Chan, C.B.8
Der, S.9
Wheeler, M.B.10
-
82
-
-
1342286820
-
Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
-
Welters HJ, Tadayyon M, Scarpello JH, Smith SA, Morgan NG. Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett 560: 103-108, 2004.
-
(2004)
FEBS Lett
, vol.560
, pp. 103-108
-
-
Welters, H.J.1
Tadayyon, M.2
Scarpello, J.H.3
Smith, S.A.4
Morgan, N.G.5
-
83
-
-
33745627659
-
Palmitoylation of Huntington by HIP14 is essential for its trafficking and function
-
Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Palmitoylation of Huntington by HIP14 is essential for its trafficking and function. Nat Neurosci 9: 824-831, 2006.
-
(2006)
Nat Neurosci
, vol.9
, pp. 824-831
-
-
Yanai, A.1
Huang, K.2
Kang, R.3
Singaraja, R.R.4
Arstikaitis, P.5
Gan, L.6
Orban, P.C.7
Mullard, A.8
Cowan, C.M.9
Raymond, L.A.10
Drisdel, R.C.11
Green, W.N.12
Ravikumar, B.13
Rubinsztein, D.C.14
El-Husseini, A.15
Hayden, M.R.16
|