Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26569-26582

  Boslem, Ebru ^a   Weir, Jacquelyn M ^b   MacIntosh, Gemma ^b   Sue, Nancy ^a   Cantley, James ^a   Meikle, Peter J ^b   Biden, Trevor J ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; LIPID RAFT; PROTEIN TRAFFICKING; SPHINGOMYELIN; TYPE-2 DIABETES;

CELL DEATH; PHOSPHOLIPIDS; PROTEINS; SATURATED FATTY ACIDS;

CELL MEMBRANES;

CERAMIDE GLUCOSYLTRANSFERASE; CHOLESTEROL; GREEN FLUORESCENT PROTEIN; PALMITIC ACID; PHOSPHOLIPID; SPHINGOLIPID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL MIGRATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; LIPID RAFT; LIPIDOMICS; LIPOTOXICITY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS;

CERAMIDE; ENDOPLASMIC RETICULUM STRESS; ER LIPID RAFT; LIPIDOMICS; LIPOTOXICITY; PALMITATE; PANCREATIC ISLETS; SPHINGOMYELIN; TRAFFICKING; TYPE 2 DIABETES;

ANIMALS; APOPTOSIS; CELL LINE; CERAMIDES; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; FATTY ACIDS; INSULIN-SECRETING CELLS; LIPIDS; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; PALMITIC ACID; PROTEIN TRANSPORT; SPHINGOMYELINS; SUBCELLULAR FRACTIONS;

EID: 84884182501     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489310     Document Type: Article

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