GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats

Molecular and Cellular Endocrinology

Volumn 381, Issue 1-2, 2013, Pages 150-159

  Meidute Abaraviciene, Sandra ^a,b   Muhammed, Sarheed J ^a   Amisten, Stefan ^a   Lundquist, Ingmar ^a   Salehi, Albert ^a  

^a LUND UNIVERSITY   (Sweden)

^b State Research Institute Centre for Innovative Medicine   (Lithuania)

Author keywords

Free fatty acid; G protein coupled receptor 40; Hormone secretion; Obesity; Receptor

Indexed keywords

FATTY ACID; G PROTEIN COUPLED RECEPTOR 40; GLUCAGON; GLUCOSE; INSULIN; PALMITIC ACID; ROSIGLITAZONE; SOMATOSTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; GLUCAGON RELEASE; GOTO KAKIZAKI RAT; HORMONE RELEASE; HORMONE RESPONSE; HYPERGLYCEMIA; HYPERLIPIDEMIA; INSULIN RELEASE; LIPOTOXICITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SOMATOSTATIN RELEASE; WESTERN BLOTTING; ZUCKER DIABETIC FATTY RAT;

FREE FATTY ACID; G-PROTEIN COUPLED RECEPTOR 40; HORMONE SECRETION; OBESITY; RECEPTOR;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; MALE; PALMITIC ACIDS; RATS; RATS, WISTAR; RATS, ZUCKER; RECEPTORS, G-PROTEIN-COUPLED; THIAZOLIDINEDIONES; TISSUE CULTURE TECHNIQUES;

EID: 84882761792     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.07.025     Document Type: Article

References (34)

1. Abaraviciene S.M., Lundquist I., Salehi A. Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities. Cell Mol. Life Sci. 2008, 65:2256-2265.
2. Alquier T., Peyot M.L., Latour M.G., Kebede M., Sorensen C.M., Gesta S., Ronald Kahn C., Smith R.D., Jetton T.L., Metz T.O., Prentki M., Poitout V. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes 2009, 58:2607-2615.
3. Amisten S. A rapid and efficient platelet purification protocol for platelet gene expression studies. Methods Mol. Biol. 2012, 788:155-172.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
5. Briaud I., Kelpe C.L., Johnson L.M., Tran P.O., Poitout V. Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats. Diabetes 2002, 51:662-668.
6. Briscoe C.P., Tadayyon M., Andrews J.L., Benson W.G., Chambers J.K., Eilert M.M., Ellis C., Elshourbagy N.A., Goetz A.S., Minnick D.T., Murdock P.R., Sauls H.R., Shabon U., Spinage L.D., Strum J.C., Szekeres P.G., Tan K.B., Way J.M., Ignar D.M., Wilson S., Muir A.I. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 2003, 278:11303-11311.
7. Brownlie R., Mayers R.M., Pierce J.A., Marley A.E., Smith D.M. The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice. Biochem. Soc. Trans. 2008, 36:950-954.
8. Del Guerra S., Bugliani M., D'Aleo V., Del Prato S., Boggi U., Mosca F., Filipponi F., Lupi R. G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids. Nutr. Metab. Cardiovasc. Dis. 2010, 20:22-25.
9. Finegood D.T., McArthur M.D., Kojwang D., Thomas M.J., Topp B.G., Leonard T., Buckingham R.E. Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death. Diabetes 2001, 50:1021-1029.
10. Flodgren E., Olde B., Meidute-Abaraviciene S., Winzell M.S., Ahren B., Salehi A. GPR40 is expressed in glucagon producing cells and affects glucagon secretion. Biochem. Biophys. Res. Commun. 2007, 354:240-245.
11. Gotoh M., Maki T., Kiyoizumi T., Satomi S., Monaco A.P. An improved method for isolation of mouse pancreatic islets. Transplantation 1985, 40:437-438.
12. Itoh Y., Kawamata Y., Harada M., Kobayashi M., Fujii R., Fukusumi S., Ogi K., Hosoya M., Tanaka Y., Uejima H., Tanaka H., Maruyama M., Satoh R., Okubo S., Kizawa H., Komatsu H., Matsumura F., Noguchi Y., Shinohara T., Hinuma S., Fujisawa Y., Fujino M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003, 422:173-176.
13. Jimenez-Feltstrom J., Salehi A., Meidute Abaraviciene S., Henningsson R., Lundquist I. Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes. Regul. Pept. 2011, 170:43-51.
14. Kebede M.A., Alquier T., Latour M.G., Poitout V. Lipid receptors and islet function: therapeutic implications?. Diabetes Obes. Metab. 2009, 11(Suppl. 4):10-20.
15. Kotarsky K., Nilsson N.E., Flodgren E., Owman C., Olde B. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem. Biophys. Res. Commun. 2003, 301:406-410.
16. Latour M.G., Alquier T., Oseid E., Tremblay C., Jetton T.L., Luo J., Lin D.C., Poitout V. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes 2007, 56:1087-1094.
17. Lee Y., Hirose H., Ohneda M., Johnson J.H., McGarry J.D., Unger R.H. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc. Natl. Acad. Sci. USA 1994, 91:10878-10882.
18. Meidute Abaraviciene S., Lundquist I., Galvanovskis J., Flodgren E., Olde B., Salehi A. Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms. PLoS ONE 2008, 3:e2182.
19. Morgan N.G., Dhayal S. G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem. Pharmacol. 2009, 78:1419-1427.
20. Mosen H., Ostenson C.G., Lundquist I., Alm P., Henningsson R., Jimenez-Feltstrom J., Guenifi A., Efendic S., Salehi A. Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production. Regul. Pept. 2008, 151:139-146.
21. Nagasumi K., Esaki R., Iwachidow K., Yasuhara Y., Ogi K., Tanaka H., Nakata M., Yano T., Shimakawa K., Taketomi S., Takeuchi K., Odaka H., Kaisho Y. Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes 2009, 58:1067-1076.
22. Nolan C.J., Madiraju M.S., Delghingaro-Augusto V., Peyot M.L., Prentki M. Fatty acid signaling in the beta-cell and insulin secretion. Diabetes 2006, 55(Suppl. 2):S16-S23.
23. Ostenson C.G., Khan A., Abdel-Halim S.M., Guenifi A., Suzuki K., Goto Y., Efendic S. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993, 36:3-8.
24. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
25. Rayasam G.V., Tulasi V.K., Davis J.A., Bansal V.S. Fatty acid receptors as new therapeutic targets for diabetes. Expert Opin. Ther. Targets 2007, 11:661-671.
26. Salehi A., Henningsson R., Mosen H., Ostenson C.G., Efendic S., Lundquist I. Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat. Endocrinology 1999, 140:3045-3053.
27. Salehi A., Ekelund M., Henningsson R., Lundquist I. Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets. Endocrine 2001, 16:97-104.
28. Salehi A., Flodgren E., Nilsson N.E., Jimenez-Feltstrom J., Miyazaki J., Owman C., Olde B. Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. Cell Tissue Res. 2005, 322:207-215.
29. Salehi A., Meidute Abaraviciene S., Jimenez-Feltstrom J., Ostenson C.G., Efendic S., Lundquist I. Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1. PLoS ONE 2008, 3:e2165.
30. Shimabukuro M., Ohneda M., Lee Y., Unger R.H. Role of nitric oxide in obesity-induced beta cell disease. J. Clin. Invest. 1997, 100:290-295.
31. Steneberg P., Rubins N., Bartoov-Shifman R., Walker M.D., Edlund H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab. 2005, 1:245-258.
32. Tan C.P., Feng Y., Zhou Y.P., Eiermann G.J., Petrov A., Zhou C., Lin S., Salituro G., Meinke P., Mosley R., Akiyama T.E., Einstein M., Kumar S., Berger J.P., Mills S.G., Thornberry N.A., Yang L., Howard A.D. Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes 2008, 57:2211-2219.
33. Tsujihata Y., Ito R., Suzuki M., Harada A., Negoro N., Yasuma T., Momose Y., Takeuchi K. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. J. Pharmacol. Exp. Ther. 2011, 339:228-237.
34. Zhou Y.P., Ostenson C.G., Ling Z.C., Grill V. Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats. Endocrinology 1995, 136:3546-3551.