Free Fatty Acid Induces Endoplasmic Reticulum Stress and Apoptosis of β-cells by Ca2+/Calpain-2 Pathways

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Cui, Wei ^a   Ma, Jie ^b   Wang, Xingqin ^b   Yang, Wenjuan ^a   Zhang, Jing ^c   Ji, Qiuhe ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c No 371 Central Hospital of People's Liberation Army   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; CALPAIN 2; CASPASE 12; CASPASE 3; FATTY ACID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN IRE1; STROMAL INTERACTION MOLECULE 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALPAIN; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; FATTY ACIDS, NONESTERIFIED; GENE SILENCING; HEAT-SHOCK PROTEINS; IMMUNOPRECIPITATION; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84875151418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059921     Document Type: Article

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