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Volumn 62, Issue 8, 2013, Pages 2917-2922

β-Cell lipotoxicity in response to free fatty acid elevation in prepubertal youth

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FATTY ACID; GLUCOSE; INSULIN; INTRALIPID; SODIUM CHLORIDE; LIPID EMULSION; PHOSPHOLIPID; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION; EMULSION;

EID: 84891713797     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1664     Document Type: Article
Times cited : (23)

References (30)
  • 1
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002;51:7-18
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 2
    • 0035032780 scopus 로고    scopus 로고
    • Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator - activated receptor-g gene
    • Stefan N, Fritsche A, Häring H, Stumvoll M. Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator - activated receptor-g gene. Diabetes 2001;50:1143-1148
    • (2001) Diabetes , vol.50 , pp. 1143-1148
    • Stefan, N.1    Fritsche, A.2    Häring, H.3    Stumvoll, M.4
  • 3
    • 0034905492 scopus 로고    scopus 로고
    • Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans
    • Stefan N, Wahl HG, Fritsche A, Haring H, Stumvoll M. Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans. Horm Metab Res 2001;33:432-438
    • (2001) Horm Metab Res , vol.33 , pp. 432-438
    • Stefan, N.1    Wahl, H.G.2    Fritsche, A.3    Haring, H.4    Stumvoll, M.5
  • 4
    • 0024995157 scopus 로고
    • A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill VE. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 1990;127: 1580-1589
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.E.2
  • 5
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995;44:863-870
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 6
    • 0028849148 scopus 로고
    • Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects
    • Paolisso G, Gambardella A, Amato L, et al. Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 1995;38:1295-1299
    • (1995) Diabetologia , vol.38 , pp. 1295-1299
    • Paolisso, G.1    Gambardella, A.2    Amato, L.3
  • 8
    • 0031032274 scopus 로고    scopus 로고
    • Effects of free fatty acids and glucose on splanchnic insulin dynamics
    • Hennes MM, Dua A, Kissebah AH. Effects of free fatty acids and glucose on splanchnic insulin dynamics. Diabetes 1997;46:57-62
    • (1997) Diabetes , vol.46 , pp. 57-62
    • Hennes, M.M.1    Dua, A.2    Kissebah, A.H.3
  • 9
    • 0028268936 scopus 로고
    • Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994;93:870-876
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.P.1    Grill, V.E.2
  • 10
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP, Grill V. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 1995;80:1584-1590
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 11
    • 0034005968 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
    • Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes 2000;49:399-408
    • (2000) Diabetes , vol.49 , pp. 399-408
    • Carpentier, A.1    Mittelman, S.D.2    Bergman, R.N.3    Giacca, A.4    Lewis, G.F.5
  • 12
    • 0141755328 scopus 로고    scopus 로고
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    • Kashyap S, Belfort R, Gastaldelli A, et al. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 2003;52:2461-2474
    • (2003) Diabetes , vol.52 , pp. 2461-2474
    • Kashyap, S.1    Belfort, R.2    Gastaldelli, A.3
  • 13
    • 0036787386 scopus 로고    scopus 로고
    • Hyperinsulinemia in African-American children: Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity
    • Arslanian SA, Saad R, Lewy V, Danadian K, Janosky J. Hyperinsulinemia in African-American children: Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes 2002; 51:3014-3019
    • (2002) Diabetes , vol.51 , pp. 3014-3019
    • Arslanian, S.A.1    Saad, R.2    Lewy, V.3    Danadian, K.4    Janosky, J.5
  • 14
    • 11844295968 scopus 로고    scopus 로고
    • Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth
    • Arslanian SA, Bacha F, Saad R, Gungor N. Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth. Diabetes Care 2005;28:115-119
    • (2005) Diabetes Care , vol.28 , pp. 115-119
    • Arslanian, S.A.1    Bacha, F.2    Saad, R.3    Gungor, N.4
  • 15
    • 79955403369 scopus 로고    scopus 로고
    • Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth
    • Lee S, Kuk JL, Kim Y, Arslanian SA. Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth. Pediatr Diabetes 2011;12:250-257
    • (2011) Pediatr Diabetes , vol.12 , pp. 250-257
    • Lee, S.1    Kuk, J.L.2    Kim, Y.3    Arslanian, S.A.4
  • 16
    • 61849141249 scopus 로고    scopus 로고
    • Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents
    • Burns SF, Kelsey SF, Arslanian SA. Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents. Diabetes Care 2009;32:355-360
    • (2009) Diabetes Care , vol.32 , pp. 355-360
    • Burns, S.F.1    Kelsey, S.F.2    Arslanian, S.A.3
  • 17
    • 43249108322 scopus 로고    scopus 로고
    • Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents
    • Cali' AM, Bonadonna RC, Trombetta M, Weiss R, Caprio S. Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents. J Clin Endocrinol Metab 2008;93:1767-1773
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1767-1773
    • Cali, A.M.1    Bonadonna, R.C.2    Trombetta, M.3    Weiss, R.4    Caprio, S.5
  • 18
    • 84857868331 scopus 로고    scopus 로고
    • Very-low-calorie diet: A quick therapeutic tool to improve b cell function in morbidly obese patients with type 2 diabetes
    • Malandrucco I, Pasqualetti P, Giordani I, et al. Very-low-calorie diet: A quick therapeutic tool to improve b cell function in morbidly obese patients with type 2 diabetes. Am J Clin Nutr 2012;95:609-613
    • (2012) Am J Clin Nutr , vol.95 , pp. 609-613
    • Malandrucco, I.1    Pasqualetti, P.2    Giordani, I.3
  • 19
    • 0037312840 scopus 로고    scopus 로고
    • Altered homeostatic adaptation of first- and second-phase b-cell secretion in the offspring of patients with type 2 diabetes: Studies with a minimal model to assess b-cell function
    • Bonadonna RC, Stumvoll M, Fritsche A, et al. Altered homeostatic adaptation of first- and second-phase b-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess b-cell function. Diabetes 2003;52:470-480
    • (2003) Diabetes , vol.52 , pp. 470-480
    • Bonadonna, R.C.1    Stumvoll, M.2    Fritsche, A.3
  • 20
    • 0036311151 scopus 로고    scopus 로고
    • Assessing insulin secretion by modeling in multiple-meal tests: Role of potentiation
    • Mari A, Tura A, Gastaldelli A, Ferrannini E. Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation. Diabetes 2002;51 (Suppl. 1):S221-S226
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Mari, A.1    Tura, A.2    Gastaldelli, A.3    Ferrannini, E.4
  • 21
    • 0347624612 scopus 로고    scopus 로고
    • Modeling beta-cell insulin secretion - Implications for closed-loop glucose homeostasis
    • Steil GM, Rebrin K, Janowski R, Darwin C, Saad MF. Modeling beta-cell insulin secretion - implications for closed-loop glucose homeostasis. Diabetes Technol Ther 2003;5:953-964
    • (2003) Diabetes Technol Ther , vol.5 , pp. 953-964
    • Steil, G.M.1    Rebrin, K.2    Janowski, R.3    Darwin, C.4    Saad, M.F.5
  • 23
    • 84877707734 scopus 로고    scopus 로고
    • Measuring b-cell function relative to insulin sensitivity in youth: Does the hyperglycemic clamp suffice?
    • Sjaarda L, Lee S, Tfayli H, Bacha F, Bertolet M, Arslanian S. Measuring b-cell function relative to insulin sensitivity in youth: Does the hyperglycemic clamp suffice? Diabetes Care 2013;36:1607-1612
    • (2013) Diabetes Care , vol.36 , pp. 1607-1612
    • Sjaarda, L.1    Lee, S.2    Tfayli, H.3    Bacha, F.4    Bertolet, M.5    Arslanian, S.6
  • 24
    • 84868031897 scopus 로고    scopus 로고
    • Whole-body MRI and ethnic differences in adipose tissue and skeletal muscle distribution in overweight black and white adolescent boys
    • Lee S, Kim Y, Kuk JL, Boada FE, Arslanian S. Whole-body MRI and ethnic differences in adipose tissue and skeletal muscle distribution in overweight black and white adolescent boys. J Obes 2011;2011:159373
    • (2011) J Obes , vol.2011 , pp. 159373
    • Lee, S.1    Kim, Y.2    Kuk, J.L.3    Boada, F.E.4    Arslanian, S.5
  • 25
    • 49649092208 scopus 로고    scopus 로고
    • Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity: A reflection of upregulated b-cell function?
    • Hannon TS, Bacha F, Lin Y, Arslanian SA. Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity: A reflection of upregulated b-cell function? Diabetes Care 2008;31:1445-1447
    • (2008) Diabetes Care , vol.31 , pp. 1445-1447
    • Hannon, T.S.1    Bacha, F.2    Lin, Y.3    Arslanian, S.A.4
  • 26
    • 0034112066 scopus 로고    scopus 로고
    • Lack of effect of a physiological elevation of plasma non-esterified fatty acid levels on insulin secretion
    • Frias JP, Basabe L, Macaraeg G, Kruszynska YT. Lack of effect of a physiological elevation of plasma non-esterified fatty acid levels on insulin secretion. Diabetes Metab 2000;26:133-139
    • (2000) Diabetes Metab , vol.26 , pp. 133-139
    • Frias, J.P.1    Basabe, L.2    Macaraeg, G.3    Kruszynska, Y.T.4
  • 27
    • 0031716376 scopus 로고    scopus 로고
    • Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects
    • Boden G, Chen X, Iqbal N. Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects. Diabetes 1998; 47:1609-1612
    • (1998) Diabetes , vol.47 , pp. 1609-1612
    • Boden, G.1    Chen, X.2    Iqbal, N.3
  • 28
    • 0031683543 scopus 로고    scopus 로고
    • Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans
    • Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT. Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Diabetes 1998;47:1613-1618
    • (1998) Diabetes , vol.47 , pp. 1613-1618
    • Dobbins, R.L.1    Chester, M.W.2    Daniels, M.B.3    McGarry, J.D.4    Stein, D.T.5
  • 29
    • 0031025156 scopus 로고    scopus 로고
    • Race and ethnicity determine serum insulin and C-peptide concentrations and hepatic insulin extraction and insulin clearance: Comparative studies of three populations of West African ancestry and white Americans
    • Osei K, Schuster DP, Owusu SK, Amoah AG. Race and ethnicity determine serum insulin and C-peptide concentrations and hepatic insulin extraction and insulin clearance: comparative studies of three populations of West African ancestry and white Americans. Metabolism 1997;46:53-58
    • (1997) Metabolism , vol.46 , pp. 53-58
    • Osei, K.1    Schuster, D.P.2    Owusu, S.K.3    Amoah, A.G.4
  • 30
    • 0030459185 scopus 로고    scopus 로고
    • Regulation of beta-cell function in vivo: From health to disease
    • Kahn SE. Regulation of beta-cell function in vivo: From health to disease. Diabetes Rev 1996;4:372-389
    • (1996) Diabetes Rev , vol.4 , pp. 372-389
    • Kahn, S.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.