NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents

Diabetologia

Volumn 56, Issue 5, 2013, Pages 1078-1087

  Koulajian, K ^a   Desai, T ^a   Liu, G C ^b   Ivovic, A ^a   Patterson, J N ^c   Tang, C ^a   El Benna, J ^d,e   Joseph, J W ^c   Scholey, J W ^b   Giacca, A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF WATERLOO   (Canada)

^d CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Beta cell dysfunction; In vivo; Lipotoxicity; NADPH oxidase; Oleate; Oxidative stress

Indexed keywords

APOCYNIN; FATTY ACID; OLEIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HYPERGLYCEMIA; IN VIVO STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RAT; RODENT; WILD TYPE;

ACETOPHENONES; ANIMALS; CYTOSOL; ENZYME INHIBITORS; FATTY ACIDS, NONESTERIFIED; FEMALE; INFUSIONS, INTRAVENOUS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; NADPH OXIDASE; OLEIC ACID; OXIDATIVE STRESS; PROTEIN SUBUNITS; RANDOM ALLOCATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 84876478424     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2858-4     Document Type: Article

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