Contribution of organically grown crops to human health

International Journal of Environmental Research and Public Health

Volumn 11, Issue 4, 2014, Pages 3870-3893

  Johansson, Eva ^a   Hussain, Abrar ^b   Kuktaite, Ramune ^a   Andersson, Staffan C ^a   Olsson, Marie E ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b Sahiwal Campus   (Pakistan)

Author keywords

Animal studies; Bioactive compounds; In vitro; Micronutrients; Organic farming; Pesticide residues

Indexed keywords

ALPHA TOCOPHEROL; CAROTENOID; HEAVY METAL; IRON; RETINOL; TRACE ELEMENT; ZINC;

BIOMARKER; CROP PRODUCTION; FOOD CONSUMPTION; HEALTH IMPACT; HEALTH RISK; ORGANIC FARMING; PESTICIDE RESIDUE; PUBLIC HEALTH; TRACE ELEMENT;

ANTIOXIDANT ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; CROP PRODUCTION; DNA MODIFICATION; FARMING SYSTEM; FOOD INTAKE; GENETIC VARIABILITY; GENOTYPE; HUMAN; NUTRIENT CONTENT; NUTRITIONAL DEFICIENCY; NUTRITIONAL REQUIREMENT; ORGANIC FARMING; PUBLIC HEALTH; REVIEW;

ANIMALS; FOOD CONTAMINATION; FOOD, ORGANIC; HUMANS; METALS, HEAVY; ORGANIC AGRICULTURE; PESTICIDE RESIDUES; PUBLIC HEALTH;

EID: 84898430302     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph110403870     Document Type: Review

References (167)

1. Lotter, D. Organic agriculture. J. Sustainable Agr. 2003, 21, 59-128.
2. Food and Agriculture Organization. Organic Agriculture. Available online: http://www.fao.org/ unfao/bodies/COAG/COAG15/X0075E.htm#P99_8218 (accessed on 7 December 2013).
3. International Federation of Organic Agriculture Movements (IFOAM). IFOAM International Federation of Organic Agriculture Annual Report 2007; International Federation of Organic Agriculture Movements: Bonn, Germany, 2007.
4. United States Department of Agriculture (USDA). Report and Recommendations on Organic Farming; United States Department of Agriculture: Washington, DC, USA, 1980.
5. United States Department of Agriculture (USDA). Organic Agriculture. Organic Policy. Available online: http://www.ers.usda.gov/topics/natural-resources-environment/organic-agriculture/ organic-policy.aspx (accessed on 20 December 2013).
6. European Comission. European Action Plan for Organic Farming. Available online: http://ec.europa.eu/agriculture/organic/eu-policy/action-plan_en (accessed on 20 December 2013).
7. Willer, H.; Kilcher, L. The World of Organic Agriculture-Statistics and Emerging Trends 2012; Research Institute of Organic Agriculture (FiBL), International Federation of Organic Agriculture Movements (IFOAM): Bonn, Germany, 2012.
8. Hussain, A.; Larsson, H.; Kuktaite, R.; Johansson, E. Mineral composition of organically grown wheat genotypes: Contribution to daily minerals intake. Int. J. Environ. Res. Public Health 2010, 7, 3442-3456.
9. Hussain, A.; Larsson, H.; Olsson, M.E.; Kuktaite, R.; Grausgruber, H.; Johansson, E. Is organically produced wheat a source of tocopherols and tocotrienols for health food? Food Chem. 2012, 132, 1789-1795.
10. Hussain, A.; Larsson, H.; Kuktaite, R.; Johansson, E. Healthy food from organic wheat: Choice of genotypes for production and breeding. J. Sci. Food Agr. 2012, 92, 2826-2832.
11. Benbrook, C.; Zhao, X.; Yáñez, J.; Davies, N.; Andrews, P. New Evidence Confirms the Nutritional Superiority of Plant-based Organic Foods. Available online: http://www.organic-center.org (assessed on 20 December 2013).
12. World Health Organization. Diet, Nutrition and the Prevention of Chronic Diseases; WHO: Geneva, Switzerland, 2003.
13. Welch, R.M. The impact of mineral nutrients in food crops on global human health. Plant Soil 2002, 247, 83-90.
14. Grusak, M.A.; DellaPenna, D. Improving the nutrient composition of plants to enhance human nutrition and health. Annu. Rev. Plant. Physiol. Plant Mol. Biol. 1999, 50, 133-161.
15. Welch, R.M.; Graham, R.D. Breeding for micronutrients in staple food crops from a human nutrition perspective. J. Exp. Bot. 2004, 55, 353-364.
16. Bazzano, L.A.; He, J.; Ogden, L.G.; Loria, C.M.; Vupputuri, S.; Myers, L.; Whelton, P.K. Fruit and vegetable intake and risk of cardiovascular disease in US adults: The first national health and nutrition examination survey epidemiologic follow-up study. Amer. J. Clin. Nutr. 2002, 76, 93-99.
17. Slavin, J. Whole grains and human health. Nutr. Res. Rev. 2004, 17, 99-110.
18. Tharanathan, R.N.; Mahadevamma, S. Grain legumes-A boon to human nutrition. Trends Food Sci. Technol. 2003, 14, 507-518.
19. Traber, M.G.; Sies, H. Vitamin E in humans: Demand and delivery. Ann. Rev. Nutr. 1996, 16, 321-347.
20. Mattoo, A.K.; Shukla, V.; Fatima, T.; Handa, A.K.; Yachha, S.K. Genetic engineering to enhance crop-based phytonutrients (nutraceuticals) to alleviate diet-related diseases. Adv. Exp. Med. Biol. 2010, 698, 122-143.
21. Pinheiro, M.M.; Ciconelli, R.M.; Chaves, G.V.; Aquino, L.; Juzwiak, C.R.; Genaro, P.D.; Ferraz, M.B. Antioxidant Intake among Brazilian adults-The Brazilian osteoporosis study (BRAZOS): A cross-sectional study. Nutr. J. 2011, 10, doi:10.1186/1475-2091-10-39.
22. Recommended Daily Intake of Vitamins and Minerals. Available online: http://www.lenntech.com/ recommended-daily-intake.htm (assessed on 27 January 2014).
23. German Nutrition Society. Referenzwerte. fur die Nährstoffzufuhr, 1. Auflage, 1st ed.; Umschau/Braus: Frankfurt, Germany, 2001.
24. Chun, O.K.; Kim, D.-O.; Smith, N.; Schroeder, D.; Han, J.H. Daily consumption of phenolics and total antioxidant capacity from fruit and vegetables in the American diet. J. Sci. Food Agr. 2005, 85, 1715-1724.
25. Bjelakovic, G.; Nikolova, D.; Gluud, C. Antioxidant supplements and mortality. Curr. Opin. Clin. Nutr. Met. Care 2014, 17, 40-44.
26. Omenn, G.S.; Goodman, G.E.; Thornquist, M.D.; Balmes, J.; Cullen, M.R.; Glass, A.; Keogh, J.P.; Meyskens, F.L.; Valanis, B.; Williams, J.H.; Barnhart, S.; Hammar, S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 1996, 334, 1150-1155.
27. Jiang, S.L.; Wu, J.G.; Thang, N.B.; Feng, Y.; Yang, W.E.; Shi, C.H. Genotypic variation of mineral elements contents in rice (Oryza. sativa L.). Eur. Food Res. Technol. 2008, 228, 115-122.
28. Menkir, A. Genetic variation for grain mineral content in tropical-adapted maize inbred lines. Food Chem. 2008, 110, 454-464.
29. Özcan, M.M.; Harmankaya, M.; Gezgin, S. Mineral and heavy metal contents of the outer and inner tissues of commonly used fruits. Environ. Monit. Assess. 2012, 184, 313-320.
30. Davey, M.W.; van den Bergh, I., Markham, R.; Swennen, R.; Keulemans, J. Genetic variability in Musa fruit provitamin A carotenoids, lutein and mineral micronutrient contents. Food Chem. 2009, 115, 806-813.
31. Nour, V.; Trandafir, I.; Ionica, M.E. Ascorbic acid, anthocyanins, organic acids and mineral content of some black and red currant cultivars. Fruits 2011, 66, 353-362.
32. Wasim, M.; Khalid, N.; Asif, A.; Arif, M.; Zaidi, J.H. Elemental characterization of strawberry grown in Islamabad by k0-instrumental neutron activation analysis and atomic absorption spectrophotometry and its dietary assessment. J. Radioanal. Nucl. Chem. 2012, 292, 1153-1159.
33. Ercisli, S.; Orhan, E.; Ozdemir, O.; Sengul, M. The genotypic effects on the chemical composition and antioxidant activity of sea buckthorn (Hippophae rhamnoides L.) berries grown in Turkey. Sci. Hort. 2007, 115, 27-33.
34. Kazaz, S.; Baydar, H.; Erbas, S. Variations in chemical compositions of Rosa damascene Mill. and Rosa canina L. fruits. Czech. J. Food Sci. 2009, 27, 178-184.
35. Smolen, S.; Wlodzimierz, S.; Rozek, S.; Ledwozyw-Smolen, I.; Strzetelski, P. Preliminary evaluation of the influence of iodine and nitrogen fertilization on the effectiveness of iodine biofortification and mineral composition of carrot storage roots. J. Elem. 2011, 16, 275-285.
36. Wang, N.; Hatcher, D.W.; Gawalko, E.J. Effect of variety and processing on nutrients and certain anti-nutrients in field peas (Pisum. sativum). Food Chem. 2008, 111, 132-138.
37. Andersson, S.C.; Rumpunen, K.; Johansson, E.; Olsson, M.E. Tocopherols and tocotrienols in Sea Buchthorn (Hoppophae. rhamnoides) berries during ripening. J. Agric. Food Chem. 2008, 56, 6701-6706.
38. Andersson, S.C.; Olsson, M.E.; Gustavsson, K.-E.; Johansson, E.; Rumpunen, K. Tocopherols in rose hips (Rosa spp.) during ripening. J. Sci. Food Agric. 2012, 92, 2116-2121.
39. Heinemann, R.J.B.; Xu, Z.M.; Godber, J.S.; Lanfer-Marquez, U.M. Tocopherols, tocotrienols and gamma-oryzanol contents in Japonica and Indica subspecies of rice (Oryza sativa L.) cultivated in Brazil. Cereal Chem. 2008, 85, 243-247.
40. Chun, J.; Lee, J.; Ye, L.; Exler, J.; Eitenmiller, R.R. Tocopherol and tocotrienol contents of raw and processed fruits and vegetables in the United States diet. J. Food Compos. Anal. 2006, 19, 196-204.
41. Englberger, L.; Lyons, G.; Foley, W.; Daniells, J.; Aalbergsberg, B.; Dolodolotawake, U.; Watoto, C.; Iramu, E.; Taki, B.; Wehi, F.; Warito, P.; Taylor, M. Carotenoid and riboflavin content of banana cultivars from Makira Solomon Island. J. Food Compos. Anal. 2010, 23, 624-632.
42. Aluru, M.; Xu, Y.; Guo, R.; Wang, Z.; Li, S.; White, W.; Wang, K.; Rodermel, S. Generation of transgenic maize with enhanced provitamin A content. J. Exp. Bot. 2008, 59, 3551-3562.
43. Paine, J.A.; Shipton, C.A.; Chaggar, S.; Howells, R.M.; Kennedy, M.J.; Vernon, G.; Wright, S.Y.; Hinchliffe, E.; Adams, J.L.; Silverstone, A.L.; Drake, R. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotech. 2005, 23, 482-487.
44. Tabart, J.; Kevers, C.; Evers, D.; Dommes, J. Ascorbic acid, phenolic acid, flavonoid, and carotenoid profiles of selected extracts from Ribes. nigrum. J. Agric. Food Chem. 2011, 59, 4763-4770.
45. Andersson, S.C.; Olsson, M.E.; Johansson, E.; Rumpunen, K. Carotenoids in sea buckthorn (Hippophae. rhamnoides L.) berries during ripening and use of pheophytin a as a maturity marker. J. Agric. Food Chem. 2009, 57, 250-258.
46. Andersson, S.C.; Rumpunen, K.; Johansson, E.; Olsson, M.E. Carotenoid content and composition in rose hips (Rosa spp.) during ripening, determination of suitable maturity marker and implications for health promoting food products. Food Chem. 2011, 128, 689-696.
47. Reif, C.; Arrigoni, E.; Schärer, H.; Nyström, L.; Hurrell, R.F. Carotenoid database of commonly eaten Swiss vegetables and their estimated contribution to carotenoid intake. J. Food Compos. Anal. 2013, 29, 64-72.
48. Shao, Y.F.; Xu, F.F.; Sun, X.; Bao, J.S.; Beta, T. Phenolic acids, anthocyanins, and antioxidant capacity in rice (Oryza sativa L.) grains at four stages of development after flowering. Food Chem. 2014, 143, 90-96.
49. Volz, R.K.; McGhie, T.K. Genetic variability in apple fruit polyphenol composition in Malus × domestica and Malus sieversii germplasm grown in New Zealand. J. Agric. Food Chem. 2011, 59, 11509-11521.
50. Patthamakanokporn, O.; Puwastien, P.; Nitithamyong, A.; Sirichakwal, P.P. Changes of antioxidant activity and total phenolics compounds during storage of selected fruits. J. Food Compos. Anal. 2008, 21, 241-248.
51. Vagiri, M.; Ekholm, A.; Oberg, E.; Johansson, E.; Andersson, S.C.; Rumpunen, K. Phenols and ascorbic acid in black currants (Ribes nigrum L.): Variation due to genotype, location, and year. J. Agr. Food Chem. 2013, 61, 9298-9306.
52. Ciolek, A.; Makarska, E.; Wesolowski, M.; Cierpiala, R. Content of selected nutrients in wheat, barley and oat grain from organic and conventional farming. J. Elementol. 2012. 17, 181-189.
53. Ordonez-Santos, L.E.; Vazquez-Oderiz, M.L.; Romero-Rodriguez, M.A. Micronutrient contents in organic and conventional tomatoes (Solanum. lycopersicum L.). Int. J. Food Sci. Technol. 2011, 46, 1561-1568.
54. Citak, S.; Sonmez, S. Mineral contents of organically and conventionally grown spinach (Spinacea oleracea L.) during two successive seasons. J. Agr. Food Chem. 2009, 57, 7892-7898.
55. Gunes, A.; Inal, A.; Adak, M.S.; Alpaslan, M.; Bagci, E.G.; Erol, T.; Pilbeam, D.J. Mineral nutrition of wheat, chickpea and lentil as affected by mixed cropping and soil moisture. Nutr. Cycl. Agroecosyst. 2007, 78, 83-96.
56. Cardoso, P.C.; Tomazini, A.P.B.; Stringheta, P.C.; Ribeiro, S.M.R.; Pinheiro-Sant'Ana, H.M. Vitamin C and carotenoids in organic and conventional fruits grown in Brazil. Food Chem. 2011, 126, 411-416.
57. Konopka, I.; Tanska, M.; Faron, A.; Stepien, A.; Wojtkowiak, K. Comparison of the phenolic compounds, carotenoids and tocochromanols content in wheat grain under organic and mineral fertilization regimes. Molecules 2012, 17, 12341-12356.
58. Maiani, G.; Caston, M.J.P.; Catasta, G.; Toti, E.; Cambrodon, I.G.; Bysted, A.; Granado-Lorencio, F.; Olmedilla-Alonso, B.; Knuthsen, P.; Valoti, M. Carotenoids: Actual knowledge on food sources, intake, stability and bioavailability and their protective role in humans. Mol. Nutr. Food Res. 2009, 53, 194-218.
59. O'Neill, M.E.; Carroll, Y.; Corridan, B.; Olmedilla, B.; Granado, F.; Blanco, I.; van den Berg, H.; Hininger, I.; Rousell, A.M.; Chopra, M. A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. Brit. J. Nutr. 2001, 85, 499-507.
60. Gao, X.; Ohlander, M.; Jeppsson, N.; Björk, L.; Trajkovski, V. Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea Buckthorn (Hippophae. rhamnoides L.) during maturation. J. Agr. Food Chem. 2000, 48, 1485-1490.
61. Gao, X.; Björk, L.; Trajkovski, V.; Uggla, M.; Evaluation of antioxidant activities of rosehip ethanol extracts in different test systems. J. Sci. Food Agr. 2000, 80, 2021-2027.
62. Johansson, E.; Prieto-Linde, M.-L.; Gissén, C. Influences of weather, cultivar and fertilizer rate on grain protein accumulation in field-grown wheat, and relations to grain water content and falling number. J. Sci. Food Agr. 2008, 88, 2011-2018.
63. Malik, A.H.; Prieto-Linde, M.L.; Kuktaite, R.; Andersson, A.; Johansson, E. Individual and interactive effects of cultivar maturation time, nitrogen regime and temperature level on accumulation of wheat grain proteins. J. Sci. Food Agr. 2011, 91, 2192-2200.
64. Francisco, M.; Cartea, M.E.; Soengas, P.; Velasco, P. Effect of genotype and environmental conditions on health-promoting compounds in Vrassica rapa. J. Agr. Food Chem. 2011, 59, 2421-2431.
65. Labuschagne, M.T.; Mkhatywa, N.; Wentzel, B.; Johansson, E.; van Biljon, A. Tocochromanol concentration, protein composition and baking quality of white flour of South African wheat cultivars. J. Food Compos. Anal. 2014, 33, 127-131.
66. Mpofu, A.; Sapirstein, H.D.; Beta, T. Genotype and environmental variation in phenolic content, phenolic acid composition, and antioxidant activity of hard spring wheat. J. Agr. Food Chem. 2006, 1265-1270.
67. Anttonen, M.J.; Karjalainen, R.O. Environmental and genetic variation of phenolic compounds in red raspberry. J. Food Compos. Anal. 2005, 18, 759-769.
68. Receptfavoriter. Available online: http://receptfavoriter.se/matartiklar/matt-och-vikt-pa-olika-livsmedel.html (assessed on 11 January 2014).
69. Lester, G.E.; Saftner, R.A. Organically vs. conventionally grown produce: common production inputs, nutritional quality, and nitrogen delivery between the two systems. J. Agr. Food Chem. 2011, 59, 10401-10406.
70. Harker, F.R. Organic food claims cannot be substantiated through testing of samples intercepted in the marketplace: A horticulturalist's opinion. Food Qual. Pref. 2004, 15, 91-95.
71. Huber, M.; Rembialkowska, E.; Srednicka, D.; Bugel, S.; van de Vijver L.P.L. Organic food and impact on human health: Assessing the status quo and prospects of research. J. Life Sci. 2011, 58, 103-109.
72. Dangour, D.A.; Dodhia, S.K.; Hayter, A.; Allen, E.; Lock, K.; Uauy, R. Nutritional quality of organic foods: A systematic review. Amer. J. Clin. Nutr. 2009, 90, 680-685.
73. Woese, K.; Lange, D.; Boess, C.; Bogl, K.W. A comparison of organically and conventionally grown foods-Results of a review of the relevant literature. J. Sci. Food Agric. 1997, 74, 281-293.
74. Smith-Spangler, C.; Brandeau, M.L.; Hunter, G.; Clay Bavinger, J.; Pearson, M.; Echbach, P.J.; Sundaram, V.; Liu, H.; Schirmer, P.; Stave, C.; Olkin, I.; Bravata, D.M. Are organic foods safer or healthier than conventional alternatives? A systematic review. Annal. Int. Med. 2012, 157, 348-366.
75. Watson, C.A.; Walker, R.L.; Stockdale, E.A. Research in organic production systems-Past, present and future. J. Agric. Sci. 2008, 146, 1-19.
76. Murphy, K.M.; Campbell, K.G.; Lyon, S.R.; Jones, S.S. Evidence of varietal adaptation to organic farming systems. Field Crop. Res. 2007, 102, 172-177.
77. Van Bueren, E.T.L.; Struik, P.C.; Tiemens-Hulscher, M.; Jacobsen, E. Concepts of intrinsic value and integrity of plants in organic plant breeding and propagation. Crop. Sci. 2003, 43, 1922-1929.
78. Vrcek, I.V.; Cepo, D.V.; Rasic, D.; Peraica, M.; Zuntar, I.; Bojic, M.; Mendas, G.; Medic-Saric, M. A comparison of the nutritional value and food safety of organically and conventionally produced wheat flours. Food Chem. 2014, 143, 522-529.
79. Kristl, J.; Krajnc, A.U.; Kramberger, B.; Mlakar, S.G. Strawberries from integrated and organic production: Mineral contents and antioxidant activity. Acta Chim. Slov. 2013, 60, 19-25.
80. Martinez-Ballesta, M.C.; Dominguez-Perles, R.; Moreno, D.A.; Muries, B.; Alcaraz-Lopez, C.; Bastias, E.; Garcia-Viguera, C.; Carvajal, M. Minerals in plant food: Effect of agricultural practices and role in human health: A review. Agron. Sustain. Dev. 2010, 30, 295-309.
81. He, Z.Q.; Shankle, M.; Zhang, H.; Way, T.R.; Tewolde, H.; Uchimiya, M. Mineral composition of cottonseed is affected by fertilization management practices. Agron. J. 2013, 105, 341-350.
82. Akbaba, U.; Sahin, Y.; Turkez, H. Comparison of element contents in haricot beans grown under organic and conventional farming regimes for human nutrition and health. Acta Scientiarum Polonorum-Hortorum Cultus 2012, 11, 117-125.
83. Lo Scalzo, R.; Picchi, V.; Migliori, C.A.; Campanelli, G. Variations in the phytochemical contents and antioxidant capacity of organically and conventionally grown Italian cauliflower (Brassica oleracea L. subsp botrytis): Results from a three-year field study. J. Agr. Food Chem. 2013, 61, 10335-10344.
84. Borguini, R.G.; Bastos, D.H.M.; Moita-Neto, J.M.; Capasso, F.S.; Torres, E.A.F.D. Antioxidant potential of tomatoes cultivated in organic and conventional systems. Braz. Arch. Biol. Technol. 2013, 56, 521-529.
85. Hallmann, E.; Rembialkowska, E. Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems. J. Sci. Food Agric. 2012, 92, 2409-2415.
86. Chebrolu, K.K.; Jayaprakasha, G.K.; Jifon, J.; Patil, B.S. Production system and storage temperature influence grapefruit vitamin C, limonoids, and carotenoids. J. Agric. Food Chem. 2012, 60, 7096-7103.
87. Bunea, C.I.; Pop, N.; Babes, A.C.; Matea, C.; Dulf, F.V.; Bunea, A. Carotenoids, total polyphenols and antioxidant activity of grapes (Vitis vinifera) cultivated in organic and conventional systems. Chem. Central J. 2012, 6, 66.
88. Yuri, J.A.; Maldonado, F.J.; Razmilic, I.; Neira, A.; Quilodran, A.; Palomo, I. Concentrations of total phenols and antioxidant activity in apple do not differ between conventional and organic orchard management. J. Food Agr. Environ. 2012, 10, 207-216.
89. Picchi, V.; Migliori, C.; Lo Scalzo, R.; Campanelli, G.; Ferrari, V.; Di Cesare, L.F. Phytochemical content in organic and conventionally grown Italian cauliflower. Food Chem. 2012, 130, 501-509.
90. Soltoft, M.; Bysted, A.; Madsen, K.H.; Mark, A.B.; Bugel, S.G.; Nielsen, J.; Knuthsen, P. Effects of organic and conventional growth systems on the content of carotenoids in carrot roots, and on intake and plasma status of carotenoids in humans. J. Sci. Food Agr. 2011, 91, 767-775.
91. Stracke, B.A.; Ruefer, C.E.; Watzl, B. Polyphenol and carotenoid content of organically and conventionally produced apples (Malus domestica Bork., Elstar variety) and carrots (Daucus carota L., Narbonne and Nerac varieties). Ernahrungs Umschau 2010, 57, 526-531.
92. Stracke, B.A.; Eitel, J.; Watzl, B.; Mader, P.; Rufer, C.E. Influence of the production method on phytochemical concentrations in whole wheat (Triticum aestivum L.): A comparative study. J. Agr. Food Chem. 2009, 57, 10116-10121.
93. Roose, M.; Kahl, J.; Ploeger, A. Influence of the farming system on the xanthophyll content of soft and hard wheat. J. Agr. Food Chem. 2009, 57, 182-188.
94. Caris-Veyrat, C.; Amiot, M.J.; Tyssandier, V.; Grasselly, D.; Buret, M.; Mikolajczak, M.; Guilland, J.C.; Bouteloup-Demange, C.; Borel, P. Influence of organic vs. conventional agricultural practice on the antioxidant microconstituent content of tomatoes and derived purees: Consequences on antioxidant plasma status in humans. J. Agr. Food Chem. 2004, 52, 6503-6509.
95. Ranalli, F.; Ranalli, A.; Contento, S.; Casanovas, M.; Antonucci, M.; Di Simone, G. Bioactives and nutraceutical phytochemicals naturally occurring in virgin olive oil: The case study of the Nocellara del Belice Italian olive cultivar. Natural Prod. Res. 2013, 27, 1686-1690.
96. Tsochatzis, E.D.; Bladenopoulos, K.; Papageorgiou, M. Determination of tocopherol and tocotrienol content of Greek barley varieties under conventional and organic cultivation techniques using validated reverse phase high-performance liquid chromatography method. J. Sci. Food Agr. 2012, 92, 1732-1739.
97. Cho, J.Y.; Lee, H.J.; Kim, G.A.; Kim, G.D.; Lee, Y.S.; Shin, S.C.; Park, K.H.; Moon, J.H. Quantitative analyses of individual gamma-Oryzanol (Steryl ferulates) in conventional and organic brown rice (Oryza sativa L.). J. Cereal Sci. 2012, 55, 337-343.
98. Dolgun, O.; Ozkan, G.; Erbay, B. Comparison of olive oils derived from certified organic and conventional agricultural methods. Asian J. Chem. 2010, 22, 2339-2348.
99. Perretti, G.; Finotti, E.; Adamuccio, S.; Della Sera, R.; Montanari, L. Composition of organic and conventionally produced sunflower seed oil. J. Amer. Oil Chem. Soc. 2004, 81, 1119-1123.
100. Lombardi-Boccia, G.; Lucarini, M.; Lanzi, S.; Aguzzi, A.; Cappelloni, M. Nutrients and antioxidant molecules in yellow plums (Prunus domestica L.) from conventional and organic productions: A comparative study. J. Agr. Food Chem. 2004, 52, 90-94.
101. Carbonaro, M.; Mattera, M.; Nicoli, S.; Bergamo, P.; Cappelloni, M. Modulation of antioxidant compounds in organic vs. conventional fruits (peach, Prunus persica L., and pear, Pyrus communis L.). J. Agr. Food Chem. 2002, 50, 5458-5462.
102. Jensen, M.M.; Jorgensen, H.C. Can agricultural cultivation methods influence the healthfulness of crops for foods? J. Agr. Food Chem. 2012, 60, 6383-6390.
103. Brazinskiene, V.; Asakaviciute, R.; Miezeliene, A.; Alencikiene, G.; Ivanauskas, L.; Jakstas, V.; Viskelis, P.; Razukas, A. Effect of farming systems on yield, quality parameters and sensory properties of conventionally and organically grown potato (Solanum tuberosum L.) tubers. Food Chem. 2014, 145, 903-909.
104. Gyore-Kis, G.; Deak, K.; Lugasi, A.; Csur-Varga, A.; Helyes, L. Comparison of conventional and organic tomato yield from a three-year-term experiment. Acta Alimen. 2013, 41, 486-493.
105. Zuchowski, J.; Jonczyk, K.; Pecio, L.; Oleszek, W. Phenolic acid concentrations in organically and conventionally cultivated spring and winter wheat. J. Sci. Food Agr. 2011, 91, 1089-1095.
106. Zuchowski, J.; Kapusta, I.; Szajwaj, B.; Jonczyk, K.; Oleszek, W. Phenolic acid content of organic and conventionally grown winter wheat. Cereal Res. Commun. 2009, 37, 189-197.
107. Asami, D.K.; Hong, Y.J.; Barrett, D.M.; Mitchell, A.E. Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practices. J. Agr. Food Chem. 2003, 51, 1237-1241.
108. Dimberg, L.H.; Gissen, C.; Nilsson, J. Phenolic compounds in oat grains (Avena sativa L.) grown in conventional and organic systems. Ambio 2005, 34, 331-337.
109. Crecente-Campo, J; Nunes-Damaceno, M.; Romero-Rodriguez, M.A.; Vazquez-Oderiz, M.L. Color, anthocyanin pigment, ascorbic acid and total phenolic compound determination in organic vs. conventional strawberries (Fragaria × ananassa Duch, cv Selva). J. Food Comp. Anal. 2012, 28, 23-30.
110. You, Q.; Wang, B.W.; Chen, F.; Huang, Z.L; Wang, X.; Luo, P.G. Comparison of anthocyanins and phenolics in organically and conventionally grown blueberries in selected cultivars. Food Chem. 2011, 125, 201-208.
111. Mikulic-Petkovsek, M.; Slatnar, A.; Stampar, F.; Veberic, R. The influence of organic/integrated production on the content of phenolic compounds in apple leaves and fruits in four different varieties over a 2-year period. J. Sci. Food Agr. 2010, 90, 2366-2378.
112. Zhao, X.; Nichols, J.R.; Williams, K.A.; Wang, W.Q.; Carey, E.E. Comparison of phenolic acids in organically and conventionally grown pac choi (Brassica rapa L. chinensis). J. Sci. Food Agr. 2009, 89, 940-946.
113. Wang, S.Y.; Chen, C.T.; Sciarappa, W.; Wang, C.Y.; Camp, M.J. Fruit quality, antioxidant capacity, and flavonoid content of organically and conventionally grown blueberries. J. Agr. Food Chem. 2008, 56, 5788-5794.
114. Amodio, M.L.; Colelli, G.; Hasey, J.K.; Kader, A.A. A comparative study of composition and postharvest performance of organically and conventionally grown kiwifruits. J. Sci. Food Agr. 2007, 87, 1228-1236.
115. Chassy, A.W.; Bui, L.; Renaud, E.N.C.; van Horn, M.; Mitchell, A.E. Three-year comparison of the content of antioxidant microconstituents and several quality characteristics in organic and conventionally managed tomatoes and bell peppers. J. Agr. Food Chem. 2006, 54, 8244-8252.
116. Woydylo, A.; Oszmianski, J.; Milczarek, M.; Wietrzyk, J. Phenolic profile, antioxidant and antiproliferative activity of black and red currants (Ribes spp.) from organic and conventional cultivation. Int. J. Food Sci. Technol. 2013, 48, 715-726.
117. Kazimierczak, R.; Hallmann, E.; Brodzka, A.; Rembialkowska, E. A comparison of the polyphenol and vitamin C content in jams of several varieties of black currants Ribes. nigrum L. from the organic and conventional cultivations. J. Res. Appl. Agr. Eng. 2009, 54, 123-129.
118. Arbos, K.A.; de Freitas, R.J.S.; Stertz, S.C.; Dornas, M.F. Antioxidant activity and phenolic content in organic and conventional vegetables. Cienc. Tecnol. Aliment. 2010, 30, 501-506.
119. Young, J.E.; Zhao, X.; Carey, E.E.; Welti, R.; Yang, S.S.; Wang, W.Q. Phytochemical phenolics in organically grown vegetables. Mol. Nutr. Food Res. 2005, 49, 1136-1142.
120. Reganold, J.P.; Andrews, P.K.; Reeve, J.R.; Carpenter-Boggs, L.; Schadt, C.W.; Alldredge, J.R.; Ross, C.F.; Davies, N.M.; Zhou, J. Fruit and soil quality of organic and conventional strawberry agroecosystems. PLoS One 2010, 5, doi:10.1371/journal.pone.0012346.
121. Brandt, K.; Leifert, C.; Sanderson, R.; Seal, C.J. Agroecosystem management and nutritional quality of plant foods: The case of organic fruits and vegetables. Crit. Rev. Plant. Sci. 2011, 30, 177-197.
122. Nationale berichterstattung Pflanzenschutzmittel rückstände in Lebensmitteln. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit. Available online: http://www.bvl.bund.de (accessed on 23 January 2014).
123. Howard V.; Newby, J. Environmental influences in cancer aetiology. J. Nutr. Env. Med. 2006, 1-59.
124. Landau-Ossondo, M.; Rabia, N.; Jos-Pelage, J.; Marquet, L.M.; Isidore, Y.; Saint-Aimé, C.; Martin, M.; Irigaray, P.; Belpomme, D. Why pesticides could be a common cause of prostate and breast cancers in the French Carribbean Island, Martinique. An overview on key mechanisms of pesticide-Induced cancer. Biomed. Pharmacother. 2009, 63, 383-395
125. Ryan, S.D.; Dolatabadi, N.; Chan, S.F.; Zhang, X.F.; Akhtar, M.W.; Parker, J.; Soldner, F.; Sunico, C.R.; Nagar, S.; Talantova, M.; Lee, B.; Lopez, K.; Nutter, A.; Shan, B.; Molokanova, E.; Zhang, Y.Y.; Han, X.M.; Nakamura, T.; Masliah, E.; Yates, J.R.; Nakaniski, N.; Andreyev, A.Y.; Okamoto, S.; Jaenisch, R.; Ambasudhan, R.; Lipton, S.A. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1 alpha transcription. Cell 2013, 155, 1652-1653.
126. McKinlay, R.; Plant, J.A.; Bell, J.N.B.; Voulvoulis, N. Endocrine disrupting pesticides: Implications for risk assessment. Environ. Int. 2008, 34, 168-183.
127. Mnif, W.; Hassine, A.I.H.; Bouaziz, A.; Bertegi, A.; Thomas, O.; Roig, B. Effect of endocrine disruptor pesticides: A review. Int. J. Environ. Res. Public Health. 2011, 8, 2265-2303.
128. Lu, C.; Toepel, K.; Irish, R.; Fenske, R.A.; Barr, D.B.; Bravo, R. Organic diets significantly lower children's dietary exposure to organophosphorous pesticides. Environ. Health Perspect. 2006, 114, 260-263.
129. Lu, C.; Knutson, D.E.; Fisker-Andersen, J.; Fenske, R.A.; Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle Metropolitan area. Environ. Health Perspect. 2001, 109, 299-303.
130. Magkos, F.; Arvaniti, F.; Organic food: Buing more safety or just peace in mind? A critical review of the literature. Crit. Rev. Food Sci. Nutr. 2006, 46, 23-56.
131. Zaccone, C.; Di Caterina, R.; Rotunno, T.; Quinto, M. Soil-farming system-Food-Health: Effect of conventional and organic fertilizers on heavy metal (Cd, Cr, Cu, Ni, Pb, Zn) content in semolina samples. Soil Till. Res. 2010, 107, 97-105.
132. Mansour, S.A.; Belal, M.H.; Abou-Arab, A.A.K.; Gad, M.F. Monitoring of pesticides and heavy metals in cucumber fruits produced from different farming systems. Chemosphere 2009, 75, 601-609.
133. Mansour, S.A.; Belal, M.H.; Abou-Arab, A.A.K.; Ashour, H.M.; Gad, M.F. Evaluation of some pollutant levels in conventionally and organically farmed potato tubers and their risks to human health. Food Chem. Toxicol. 2009, 47, 615-624.
134. Rossi, F.; Bertuzzi, T.; Comizzoli, S.; Turconi, G.; Roggi, C.; Pagani, M.; Cravedi, P.; Pietri, A. Preliminary survey on composition and quality of conventional and organic wheat. Ital. J. Food Sci. 2006, 18, 355-366.
135. Muchova, Z.; Jaska, P. The influence of growing conditions on the cadmium and lead accumulation in food wheat. Rostl. Vyroba 1996, 42, 59-62.
136. Domagala-Swiatkiewicz, I.; Gastol, M. Comparative study on mineral content of organic and conventional carrot, celery and red beet juices. Acta Scientiarum Polonorum-Hortorum Cultus 2012, 11, 173-183.
137. Vrcek, V.; Vrcek, I.V. Metals in organic and conventional wheat flours determined by an optimized and validated ICP-MS method. Int. J. Food Sci. Technol. 2012, 47, 1777-1783.
138. Rossi, F.; Godani, F.; Bertuzzi, T.; Trevisan, M.; Ferrari, F.; Gatti, S. Health-promoting substances and heavy metal content in tomatoes grown with different farming techniques. Eur. J. Nutr. 2008, 47, 266-272.
139. Dos Santos, J.S.; Dos Santos, M.L.P.; Contil, M.M. Comparative study of metal contents in Brazilian coffees cultivated by conventional and organic agriculture applying principal component analysis. J. Braz. Chem. Soc. 2010, 21, 1468-1476.
140. Hussain A.; Larsson H.; Kuktaite, R.; Johansson, E. Concentration of some heavy metals in organically grown primitive, old and modern wheat genotypes: Implications for human health. J. Environ. Sci. Health Part. B 2012, 47, 751-758.
141. Velimirov, A.; Huber, M.; Lauridsen, C.; Rembialkowska, E.; Seidel, K.; Bügel, S. Feeding trials in organic food quality and health research. J. Sci. Food Agr.2010, 90, 175-182.
142. Paci, G.; Lisi, E.; Bagliacca, M.; Maritan, A. Reproductive performance in a local rabbit population reared under organiconventional system (Tuscany). Ann. Facolta Med. Veterinria Pisa 2003, 56. Available online: http://eprints.adm.unipi.it/142/1/115.pdf (accessed on 3 April 2014).
143. Huber, M.; de Vijver, L.P.L.V.; Parmentier, H.; Savelkoul, H.; Coulier, L.; Wopereis, S.; Verheij, E.; van der Greef, J.; Nierop, D.; Hoogenboom, R.A.P. Effects of organically andconventionally produced feed on biomarkers of health in a chicken model. Brit. J. Nutr. 2010, 103, 663-676.
144. Finamore, A.; Britti, M.S.; Roselli, M.; Bellovino, D.; Gaetani, S.; Mengheri, E. Novel approach for food safety evaluation. Results of a pilot experiment to evaluate organic and conventional foods. J. Agr. Food Chem. 2004, 52, 7425-7431.
145. Lauridsen, C.; Young, C.; Halekoh, U.; Bügel, S.H.; Brandt, K.; Christensen, L.P.; Jorgensen, H. Rats show differences in some biomarkers of health when eating diets based on ingredients produced with three different cultivation strategies. J. Sci. Food Agr. 2008, 88, 720-732.
146. Baranska, A.; Skwarlo-Sonta, K.; Rembialkowska, E.; Brandt, K.; Lueck, L.; Leifert, C. The Effect of Short Term Feeding with Organic and Conventional Diets on Selected Immune Parameters in Rat. In Improving Sustainability in Organic and Low Input Food Production Systems; Niggli, A., Leifert, C., Alfoldi, C., Luck, L., Willer, H., Eds.; University of Hohenheim: Stuttgart, Germany, 2007; pp. 108-111.
147. Roselli, M.; Finamore, A.; Brasili, E.; Capuani, G.; Kristensen, H.L.; Micheloni, C.; Mengheri, E. Impact of organic and conventional carrots on intestinal and peripheral immunity. J. Sci. Food Agric. 2012, 92, 2913-2922.
148. Chhabra, R.; Kolli, S.; Bauer, J.H. Organically grown food provides health benefits to Drosophila melanogaster. PLoS One 2013, 8, doi:10.1371/journal.pone0052988.
149. Plochberger, K. Feeding experiments-A criterion for quality estimation of biologically and conventionally produced foods. Agr. Ecosyst. Environ. 1989, 27, 1-4.
150. Magkos, F.; Arvaniti, F.; Zampelas, A. Organic food: Nutritious food or food for thought? A review of the evidence. Int. J. Food Sci. Nutr. 2003, 54, 357-371.
151. Rembialkowska, E.; Kazimierczak, R.; Srednicka, D.; Bienko, K.; Bielska, M. Different aspects of organic and conventional food consumers' lifestyle. New Med. 2008, 12, 16-19.
152. Kesse-Guyot, E.; Péneau, S.; Méjean, C.; de Edelenyi, F.S.; Galan, P.; Hercberg, S.; Lairon, D. Profiles of organic food consumers in a large sample of French adults: Results from the nutrinet-sante cohort study. PLoS One 2013, 8, doi:10.1371/journal.pone0076998.
153. Akcay, Y.D.; Yildirim, H.K.; Guvenac, U.; Sozmen, E.Y. The effects of consumption of organic and nonorganic red wine on low-density lipoprotein oxidation and antioxidant capacity in humans. Nutr. Res. 2004, 24, 541-554.
154. Briviba, K.; Stracke, B.A.; Rufer, C.E.; Watzl, B.; Weibel, F.P.; Bub, A. Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans. J. Agr. Food Chem. 2007, 55, 7716-7721.
155. Stracke, B.A.; Ruefer, C.E.; Bub, A.; Briviba, K.; Seifert, S.; Kunz, C.; Watzl, B. Bioavailability and nutritional effects of carotenoids from organically and conventionally produced carrots in health men. Brit. J. Nutr. 2009, 101, 1664-1672.
156. Stracke, B.A.; Ruefer, C.E.; Weibel, F.P.; Bub, A.; Watzl, B. Three-year comparison of the polyphenol contents and antioxidant capacities in organically and conventionally produced apples (Malus domestica Bork. Cultivar "Golden Delicious". J. Agr. Chem. 2009, 57, 4598-4605.
157. Grinder-Pedersen, L.; Rasmussen, S.E.; Bugel, S.; Jorgensen, L.V.; Dragsted, L.O.; Gundersen, V.; Sandstrom, B. Effect of diets based on foods from conventional vs. organic production on intake and excretion of flavonoids and markers of antioxidative defense in humans. J. Agr. Food Chem. 2003, 51, 5671-5676.
158. Kummeling, I.; Thijs, C.; Huber, M.; van de Vijver, L.P.L.; Snijders, B.E.P.; Penders, J.; Stelma, F.; van Ree, R.; van den Brandt, P.A.; Dagnelie, P.C. Consumption of organic foods and risk of atopic disease during the first 2 years of life in the Netherlands. Brit. J. Nutr. 2008, 99, 598-605.
159. Alfven, T.; Braun-Fahrlander, C.; Brunekreef, B.; von Mutius, E.; Riedler, J.; Scheynius, A.; van Hage, M.; Wickman, M.; Benz, M.R.; Budde, J. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle-The PARSIFAL study. Allergy 2006, 61, 414-421.
160. Organic, More Healthy? A Search for Biomarkers of Potential Health Effects Induced by Organic Products, Investigated in a Chicken Model, 2nd ed.; Huber, M., Ed.; Louis Bolk Instituut: Driebergen, The Netherlands, 2007.
161. Paynter, N.P.; Everett, B.M.; Cook, N.R. Cardiovascular disease risk prediction in women: Is there a role for novel biomarkers? Clin. Chem. 2014, 60, 88-97.
162. Weigelt, B.; Bissell, M.J. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv. Drug Delivery Rev. 2014, doi:10.1016/j.addr.2014.01.001.
163. Olsson, M.E.; Gustavsson, K.E.; Andersson, S.; Nilsson, A.; Duan, R.D. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J. Agr. Food Chem. 2004, 52, 7264-7271.
164. Stoner, G.D.; Wang, L.S.; Casto, B.C. Laboratory and clinical studies on cancer chemoention by antioxidants in berries. Carcinogenesis 2008, 29, 1655-1674.
165. Olsson, M.E.; Andersson, C.S.; Oredsson, S.; Berglund, R.H.; Gustavsson, K.E. Antioxidant levels and inhibition of cancer cell prolifieration in vitro by extracts from organically and conventionally cultivated strawberries. J. Agr. Food Chem. 2006, 54, 1248-1255.
166. Wang, S.A.; Meckling, K.A.; Marcone, M.F.; Kakuda, Y.; Tsao, R. Can phytochemical antioxidant rich foods act as anti-cancer agents? Food Res. Int. 2011, 44, 2545-2554.
167. Brown, E.M.; Gill, C.I.R.; McDougall, G.J.; Stewart, D. Mechanisms underlying the anti-proliferative effects of berry components in in vitro models of colon cancer. Curr. Pharm. Biotechnol. 2012, 13, 200-209.