Impact of organic and conventional carrots on intestinal and peripheral immunity

Journal of the Science of Food and Agriculture

Volumn 92, Issue 14, 2012, Pages 2913-2922

  Roselli, Marianna ^a   Finamore, Alberto ^a   Brasili, Elisa ^a   Capuani, Giorgio ^b   Kristensen, Hanne L ^c   Micheloni, Cristina ^d   Mengheri, Elena ^a  

^a ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c AARHUS UNIVERSITY   (Denmark)

^d Associazione Italiana per l'Agricoltura Biologica (AIAB)   (Italy)

Author keywords

Immunity; Intraepithelial lymphocytes; Lamina propria lymphocytes; Organic carrots; Regulatory T cells

Indexed keywords

CYTOKINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CARROT; CELLULAR IMMUNITY; COLON; COMPARATIVE STUDY; CROP; CYTOLOGY; DENMARK; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; IMMUNOMODULATION; INTESTINE; INTESTINE MUCOSA; ITALY; LYMPHOCYTE COUNT; MOUSE; MUCOSAL IMMUNITY; ORGANIC FOOD; PLANT ROOT; REGULATORY T LYMPHOCYTE; REPRODUCIBILITY; SECRETION (PROCESS); SPLEEN;

ANIMALS; COLON; CROPS, AGRICULTURAL; CYTOKINES; DAUCUS CAROTA; DENMARK; FOOD, ORGANIC; IMMUNITY, CELLULAR; IMMUNITY, MUCOSAL; IMMUNOMODULATION; INTESTINAL MUCOSA; INTESTINES; ITALY; LYMPHOCYTE COUNT; MICE; MICE, INBRED BALB C; PLANT ROOTS; REPRODUCIBILITY OF RESULTS; SPLEEN; T-LYMPHOCYTES, REGULATORY;

DAUCUS CAROTA; MUS;

EID: 84872611263     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.5667     Document Type: Article

References (45)

1. Crinnion WJ, Organic foods contain higher levels of certain nutrients, lower levels of pesticides, and may provide health benefits for the consumer. Altern Med Rev 15: 4-12 (2010).
2. Woese K, Lange D, Bo C and Bogl KW, A comparison of organically and conventionally grown foods. results of a review of the relevant literature. J Sci Food Agric 74: 281-293 (1997).
3. Rembialkowska E, Quality of plant products from organic agriculture. J Sci Food Agric 87: 2757-2762 (2007).
4. Torjusen H, Sangstad L, O'Doherty J, Ensen K and Kjærnes U, European consumers' conceptions of organic food: a review of available research. Processional report 4, National Institute for Consumer Research (SIFO), Oslo (2004).
5. International Foundation for Organic Agriculture, IFOAM: Organic Standards and Certification (2009). [Online]. Available: http://www.ifoam.org/about_ifoam/standards/index.html [4 January 2009].
6. Magkos F, Arvaniti F and Zampelas A, Organic food: buying more safety or just peace of mind? A critical review of the literature. Crit Rev Food Sci Nutr 46: 23-56 (2006).
7. Hoefkens C, Sioen I, Baert K, De Meulenaer B, De Henauw S, Vandekinderen I, et al, Consuming organic versus conventional vegetables: the effect on nutrient and contaminant intakes. Food Chem Toxicol 48: 3058-3066 (2010).
8. Williams CM, Nutritional quality of organic food: shades of grey or shades of green? Proc Nutr Soc 61: 19-24 (2002).
9. Perera CO and Yen GM, Functional properties of carotenoids in human health. Int J Food Prop 10: 201-230 (2007).
10. Mora JR, Iwata M and von Andrian UH, Vitamin effects on the immune system: vitamin A and D take centre stage. Nat Rev Immunol 8: 685-698 (2008).
11. Metzger BT, Barnes DM and Reed JD, Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. J Agric Food Chem 56: 3554-3560 (2008).
12. Young JF, Christensen LP, Theil PK and Oksbjerg N, The polyacetylenes falcarinol and falcarindiol affect stress responses in myotube cultures in a biphasic manner. Dose Response 6: 239-251 (2008).
13. Mercadante A and Rodriguez-Amaya DB, Carotenoid composition of a leafy vegetable in relation to some agriculture variables. J Agric Food Chem 39: 1094-1097 (1991).
14. Sikora M, Hallmann E and Rembialkowska E, The content of bioactive compounds in carrots from organic and conventional production in the context of health prevention. Rocz Panstw Zakl Hig 60: 217-220 (2009).
15. Warman PR and Havard KA, Yield, vitamin and mineral contents of organically and conventionally grown carrots and cabbage. Agric Ecosyst Environ 61: 155-162 (1997).
16. Søltoft M, Bysted A, Madsen KH, Mark AB, Bügel SG, Nielsen J, et al, Effects of organic and conventional growth systems on the content of carotenoids in carrot roots, and on intake and plasma status of carotenoids in humans. J Sci Food Agric 91: 767-775 (2011).
17. Stracke BA, Rüfer CE, Bub A, Briviba K, Seifert S, Kunz C, et al, Bioavailability and nutritional effects of carotenoids from organically and conventionally produced carrots in healthy men. Br J Nutr 101: 1664-1672 (2008).
18. Søltoft M, Eriksen MR, Träger AW, Nielsen J, Laursen KH, Husted S, et al, Comparison of polyacetylene content in organically and conventionally grown carrots using a fast ultrasonic liquid extraction method. J Agric Food Chem 58: 7673-7679 (2010).
19. Jorgensen H, Brandt K and Lauridsen C, Year rather than farming system influences protein utilization and energy value of vegetables when measured in a rat model. Nutr Res 28: 866-878 (2008).
20. Abreu-Martin MT and Targan SR, Regulation of immune responses of the intestinal mucosa. Crit Rev Immunol 16: 277-309 (1996).
21. Tamura A, Soga H, Yaguchi K, Yamagishi M, Toyota T, Sato J, et al, Distribution of two types of lymphocytes (intraepithelial and lamina-propria-associated) in the murine small intestine. Cell Tissue Res 313: 47-53 (2003).
22. Ishikawa H, Naito T, Iwanaga T, Takahashi-Iwanaga H, Suematsu M, Hibi T, et al, Curriculum vitae of intestinal intraepithelial T cells: their developmental and behavioural characteristics. Immunol Rev 215: 154-165 (2007).
23. Izcue A and Powrie F, Special regulatory T-cell review: regulatory T cells and the intestinal tract-patrolling the frontier. Immunology 123: 6-10 (2008).
24. + regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 10: 689-695 (2009).
25. Thorup-Kristensen K, Dresbøll DB and Kristensen HL, Crop yield, root growth, and nutrient dynamics in a conventional and three organic cropping systems with different levels of external inputs and N re-cycling through fertility building crops. Eur J Agron 37: 66-82 (2012).
26. Di Renzo L, Di Pierro D, Bigioni M, Sodi V, Galvano F, Cianci R, et al, Is antioxidant plasma status in humans a consequence of the antioxidant food content influence? Eur Rev Med Pharmacol Sci 11: 185-192 (2007).
27. Lauridsen C, Yong C, Halekoh U, Højbjerg Bügel S, Brandt K, Porskjær Christensen L, et al, Rats show differences in some biomarkers of health when eating diets based on ingredients produced with three different cultivation strategies. J Sci Food Agric 88: 720-732 (2008).
28. Huber M, van de Vijver LP, Parmentier H, Savelkoul H, Coulier L, Wopereis S, et al, Effects of organically and conventionally produced feed on biomarkers of health in a chicken model. Br J Nutr 103: 663-676 (2010).
29. Ramsdell F, Foxp3 and natural regulatory T cells, key to a cell lineage? Immunity 19: 165-168 (2003).
30. Hansen W, Westendorf AM and Buer J, Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation. Inflamm Allergy Drug Targets 7: 217-223 (2008).
31. Leech MD and Anderton SM, Antigen-based therapies targeting the expansion of regulatory T cells in autoimmune and allergic disease. Chem Immunol Allergy 94: 201-210 (2008).
32. Khattar M, Chen W and Stepkowski SM, Expanding and converting regulatory T cells: a horizon for immunotherapy. Arch Immunol Ther Exp (Warsz) 57: 199-204 (2009).
33. + regulatory T-cell activation and expansion. J Allergy Clin Immunol 123: 749-755 (2009).
34. Chassy AW, Bui L, Renaud EN, Van Horn M and Mitchell AE, Three-year comparison of the content of antioxidant microconstituents and several quality characteristics in organic and conventionally managed tomatoes and bell peppers. J Agric Food Chem 54: 8244-8252 (2006).
35. Hanada T and Yoshimura A, Regulation of cytokine signalling and inflammation. Cytokine Growth Factor Rev 13: 413-421 (2002).
36. Pussemier L, Piérard JY, Anselme M, Tangni EK, Motte JC and Larondelle Y, Development and application of analytical methods for the determination of mycotoxins in organic and conventional wheat. Food Addit Contam 23: 1208-1218 (2006).
37. Harcz P, De Temmerman L, De Voghel S, Waegeneers N, Wilmart O, Vromman V, et al, Contaminants in organically and conventionally produced winter wheat (Triticum aestivum) in Belgium. Food Addit Contam 24: 713-720 (2007).
38. Gottschalk C, Barthel J, Engelhardt G, Bauer J and Meyer K, Occurrence of type A trichothecenes in conventionally and organically produced oats and oat products. Mol Nutr Food Res 51: 1547-1553 (2007).
39. Sharma RP, Immunotoxicity of mycotoxins. J Dairy Sci 76: 892-897 (1993).
40. Bouhet S and Oswald IP, The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Vet Immunol Immunopathol 108: 199-209 (2005).
41. Finamore A, Britti MS, Roselli M, Bellovino D, Gaetani S and Mengheri E, A novel approach for food safety evaluation: results of a pilot experiment to evaluate organic and conventional food. J Agric Food Chem 52: 7425-7431 (2004).
42. Maiani G, Castón MJ, Catasta G, Toti E, Cambrodón IG, Bysted A, et al, Carotenoids: actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Mol Nutr Food Res 53: S194-S218 (2009).
43. Paoletti et al, (submitted for publication).
44. Yoshikawa M, Nishida N, Ninomiya K, Ohgushi T, Kubo M, Morikawa T et al, Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Bioorg Med Chem 14: 456-463 (2006).
45. Edelenbos et al, (manuscript in preparation).