Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels

Journal of Agricultural and Food Chemistry

Volumn 52, Issue 24, 2004, Pages 7264-7271

  Olsson, Marie E ^a   Gustavsson, Karl Erik ^a   Andersson, Staffan ^a   Nilsson, Åke ^b   Duan, Rui Dong ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Anthocyanin; Ascorbate; Cancer cell proliferation; Correlation; Dehydroascorbate; Ellagic acid; Flavonol; Hydroxycinnamic acids; Phenolics

Indexed keywords

ANTHOCYANIN; ANTIOXIDANT; ASCORBIC ACID; DEHYDROASCORBIC ACID;

ARTICLE; BERRY; CANCER CELL; CANCER RISK; CELL PROLIFERATION; CELL STRAIN MCF 7; COLON CANCER; CONCENTRATION RESPONSE; EXTRACTION; FRUIT; GROWTH INHIBITION; SPECIES DIFFERENTIATION;

ANTIOXIDANTS; BREAST NEOPLASMS; CELL DIVISION; COLONIC NEOPLASMS; FRUIT; NEOPLASMS; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

MALUS X DOMESTICA; MINK CELL FOCUS-FORMING VIRUS; PHOTINIA MELANOCARPA; PRUNUS DOMESTICA; RHAMNACEAE; RIBES; RIBES HUDSONIANUM; VACCINIUM;

EID: 9344256065     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf030479p     Document Type: Article

References (51)

1. Steinmetz, K. A.; Potter, J. D. Vegetables, fruit and cancer prevention: A review. J. Am. Diet. Assoc. 1996, 96, 1027-1039.
2. Block, G.; Patterson, B.; Subar, A. Fruit, vegetables and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer 1992, 18, 1-29.
3. Kris-Etherton, P. M.; Hecker, K. D.; Bonanome, A.; Coval, S. M.; Binkoski, A. E.; Hilpert, K. F.; Griel, A. E.; Etherton, T. D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002, 113, 71S-88S.
4. Matés, J. M.; Sánchez-Jiménez, F. M. Role of oxygen species in apoptosis: implications for cancer therapy. Int. J. Biochem. Cell Biol. 2000, 32, 157-170.
5. Fosslien, E. Molecular pathology of cyclooxygenase-2 in neoplasia. Ann. Clin. Lab. Sci. 2000, 30, 3-21.
6. Ranelletti, F. O.; Maggiano, N.; Serra, F. G.; Ricci, R.; Larocca, L. M.; Lanza, P.; Scambia, G.; Fattorossi, A.; Capelli, A.; Piantelli, M. Quercetin inhibits p21-ras expression in human colon cancer cell lines and in primary colorectal tumors. Int. J. Cancer 2000, 85, 438-445.
7. Evan, G. I.; Vousden, K. H. Proliferation, cell cycle and apoptosis in cancer. Nature 2001, 411, 342-348.
8. Kuntz, S.; Wenzel, U.; Daniel, H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 1999, 38, 133-142.
9. Prakash, P.; Russel, R. M.; Krinsky, N. I. In vitro inhibition of estrogen-dependent and estrogen-independent human breast cancer cells treated with carotenoids or retinoids. J. Nutr. 2001, 131, 1574-1580.
10. Block, G. Epidemiological evidence regarding vitamin C and cancer. Am. J. Clin. Nutr. 1991, 54, 1310S-1314S.
11. Haegele, A. D.; Gillette, C.; O'Neill, C.; Wolfe, P.; Heimendinger, J.; Sedlacek, S.; Thompson, H. J. Plasma xanthophyll carotenoids correlate inversely with indices of oxidative DNA damage and lipid peroxidation. Cancer Epidemiol. Biomark., Prev. 2000, 9, 421-425.
12. Birt, D. B.; Hendrich, S.; Wang, W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001, 90, 157-177.
13. Narayana, B. A.; Geoffroy, O.; Willinham, M. C.; Re, G. G.; Nixon, D. W. P53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999, 136, 215-221.
14. Liu, J.-J.; Nilsson, A.; Oredsson, S.; Badmaev, V.; Zhao, W.-Z.; Duan, R.-D. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002, 23, 2087-2093.
15. Wimalasiri, P.; Wills, R. B. H. Simultaneous analysis of ascorbic acid and dehydroascorbic acid in fruit and vegetables by high-performance liquid chromatography. J. Chromatogr. A 1983, 256, 368-371.
16. Esteve, M. J.; Farré, R.; Frigola, A.; Garcia-Cantabella, J. M. Determination of ascorbic and dehydroascorbic acids in blood plasma and serum by liquid chromatography. J. Chromatogr. A 1997, 688, 345-349.
17. Khachik, F.; Beecher, G. R.; Lusby, W. R. Separation, identification, and quantification of the major carotenoids in extracts of apricots, peaches, cantaloupe, and pink grapefruit by liquid chromatography. J. Agric. Food Chem. 1989, 37, 1465-1473.
18. Madhavi, D. L.; Bomser, J.; Smith, M. A. L.; Singletary, K. Isolation of bioactive constituents from Vaccinium myrtillus (bilberry) fruits and cell cultures. J. Plant Sci. 1998, 131, 95-103.
19. Schieber, A.; Keller, P.; Carle, R. Determination of phenolics of apple and pear by high-performance liquid chromatography. J. Chromatogr. A 2001, 910, 265-273.
20. Giusti, M. M.; Rodriguez-Saona, L. E.; Wrolstad, R. E. Molar absorptivity and color characteristics of acylated and non-acylated pelargonidin-based anthocyanins. J. Agric. Food Chem. 1999, 47, 4631-4637.
21. Milbury, P. M.; Cao, G.; Prior, R. L.; Blumberg, J. Bioavailability of elderberry anthocyanins. Mech. Ageing Dev. 2002, 123, 997-1006.
22. Mertens-Talcott, S. U.; Talcott, S. T.; Percival, S. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr. 2003, 133, 2669-2674.
23. Halliwell, B. Vitamin C and genomic stability (review). Mutat. Res. 2001, 475, 29-35.
24. Lonnrot, K.; Metsa-Ketek, T.; Molnar, G.; Ahonen, J. P.; Latvala, M.; Petola, J.; Pietila, T.; Alho, H. The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity. Free Radical Biol. Med. 1996, 21, 211-217.
25. Waring, A. J.; Drake, I. M.; Scorah, C. J.; White, K. L.; Lynch, D. A.; Axon, A. D.; Dixon, M. F. Asorbic acid and total vitamin C concentrations in plasma, gastric juice and gastrointestinal muscosa: effects of gastritis and oral supplementation. Gut 1996, 38, 171-176.
26. Levine, M.; Rumsey, S. C.; Daruwala, S.; Park, J. B.; Wang, Y. Criteria and recommendations for vitamin C intake. JAMA 1999, 281, 1415-1423.
27. Smith-Warner, S. A.; Elmer, P. J.; Tharp, T. M.; Fosdick, L.; Randall, B.; Gross, M.; Wood, J.; Potter, J. D. Increasing vegetable and fruit intake: randomised intervention and monitoring in an at-risk population. Cancer Epidemiol. Biomarkers Prev. 2000, 9, 307-317.
28. Lee, K. W.; Lee, H. J.; Surh, Y.-J.; Lee, C. Y. Vitamin C and cancer chemoprevention: reappraisal. Am. J. Clin. Nutr. 2003, 78, 1074-1078.
29. Byers, T.; Guerrero, N. Epidemiological evidence for vitamin C and vitamin E in cancer prevention. Am. J. Clin. Nutr. 1995, 62, 1385S-1392S.
30. Block, G.; Norkus, E.; Hudes, M.; Mandel, S.; Helzlsouer, K. Which plasma antioxidants are mostly related to fruit and vegetable consumption? Am. J. Epidemiol. 2001, 154, 1113-1118.
31. Podmore, I. D.; Griffiths, H. R.; Herbert, K. E.; Mistry, N.; Mistry, N.; Lunec, J. Vitamin C exhibits pro-oxidant properties. Nature 1998, 392, 559.
32. Griffiths, H. R.; Lunec, J. Ascorbic acid in the 21st century-more than a simple antioxidant. Environ. Toxicol. Pharmacol. 2001, 10, 173-182.
33. Halliwell, B. Vitamin C: poison, prophylactic or pancrea? Trends Biochem. Sci. 1999, 7, 255-259.
34. Rehman, A.; Collis, C. S.; Yang, M.; Kelly, M.; Diplock, A. T.; Halliwell, B.; Rice-Evans, C. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem. Biophys. Res. Commun. 1998, 246, 293-298.
35. Osmak, M.; Kovak, I.; Ljubenkov, I.; Spaventi, R.; Eckert-Maksic, M. Ascorbic acid and 6-deoxy-6-chloro-ascorbic acid: potential anticancer drugs. Neoplasma 1997, 44, 101-107.
36. Kageyama, K.; Yamada, R.; Otani, S.; Hasuma, T.; Yoshimata, T.; Seto, C.; Takada, Y.; Yamaguchi, Y.; Kogawa, H.; Miwa, N. Abnormal cell morphology and cytotoxic effect are induced by 6-O-palmitoyl-ascorbate 2-O-phosphate, but not by ascorbic acid or hyperthermia alone. Anticancer Res. 1999, 19, 4321-4326.
37. Kandaswami, C.; Perkins, E.; Soloniuk, D. S.; Drzewiecki, G.; Middleton, E., Jr. Ascorbic acid-enhanced effect of flavonoids on squamous cell carcinoma in vitro. Anticancer Drugs 1993, 4, 91-96.
38. Kurbacher, C. M.; Wagner, U.; Roister, B.; Andreotti, P. E.; Krebs, D.; Bruckner, H. W. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubin, cisplatin, and pactitaxel in human breast carcinoma cells in vitro. Cancer Lett. 1996, 103, 183-189.
39. Van Poppel, G. Epidemiological evidence for β-carotene in cancer prevention and cardiovascular disease. Eur. J. Clin. Nutr. 1996, 50, S57-S61.
40. Toniolo, P.; Van Kappel, A. L.; Akhmedkhanov, A.; Ferrari, P.; Kato, I.; Shore, R. E.; Riboli, E. Serum carotenoids and breast cancer. Am. J. Epidemiol. 2001, 153, 1142-1147.
41. Kim, M. K.; Ahn, S. H.; Lee-Kim, Y. C. Relationship of serum α-tocopherol, carotenoids and retinal with the risk of breast cancer. Nutr. Res. 2001, 21, 797-809.
42. The α-Tocopherol, β-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancers in male smokers. N. Engl. J. Med. 1994, 330, 1029-1035.
43. Taylor, P. R.; Li, B.; Dawsey, S. M.; Yang, C. S.; Guo, W.; Blot, W. J. Prevention of esophageal cancer: the nutrition trials in Linxian, China. Linxian Intervention Trials Study Group. Cancer Res. 1994, 54, 2029S-2031S.
44. Omenn, G. S.; Goodman, G. E.; Thornquist, M. D.; Balmes, J.; Cullen, M. R.; Glass, A.; Keogh, J. P.; Meyskens, F. L.; Valanis, B.; Williams, J. H.; Barnhart, S.; Hammar, S. Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 1996, 334, 1150-1155.
45. Lee, I. M.; Cook, N. R.; Manson, J. E. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: Women's Health Study. J. Natl. Cancer Inst. 1999, 91, 2102-2106.
46. Wang, X. D.; Russell, R. M. Procarconogenic and anticarcinogenic effects of β-carotene; Nutr. prev.; International Life Sciences Institute, ILSI Press: Washington, DC, 1999; Vol. 57, pp 263-272.
47. Eastwood, M. A. Interaction of dietary antioxidants in vivo: How fruit and vegetables prevent disease? Q. J. Med. 1999, 92, 527-530.
48. Lopaczynski, W.; Zeisel, S. H. Antioxidants, programmed cell death and cancer. Nutr. Res. 2001, 21, 295-307.
49. Min mice and reduce proliferation of human colon cancer cells. Cancer Lett. 2003, 194, 13-19.
50. Liu, M.; Li, X. Q.; Weber, C.; Lee, C. Y.; Brown, J.; Liu, R. H. Antioxidant and antiproliferative activities of raspberries. J. Agric. Food Chem. 2002, 50, 2926-2930.
51. Meyers, K. J.; Watkins, C. B.; Pritts, M. P.; Liu, R. H. Antioxidant and antiproliferative activities of strawberries. J. Agric. Food Chem. 2003, 51, 6887-6892.