Inhibition of neuroepithelial patched-induced apoptosis by Sonic hedgehog

Science

Volumn 301, Issue 5634, 2003, Pages 843-846

  Thibert, Chantal ^a   Teillet, Marie Aimée ^b   Lapointe, Françoise ^b   Mazelin, Laetitia ^a   Le Douarin, Nicole M ^b   Mehlen, Patrick ^a,c  

^a UNIVERSITÉ DE LYON   (France)

^b CNRS   (France)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CELLS;

CELL DEATH;

NEUROLOGY;

CASPASE; PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

DEVELOPMENTAL BIOLOGY; VERTEBRATE;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; GENE OVEREXPRESSION; NEURAL TUBE; NEUROEPITHELIUM; NICK END LABELING; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VERTEBRATE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIFFERENTIATION; CELL LINE; CENTRAL NERVOUS SYSTEM; CHICK EMBRYO; ELECTROPORATION; EPITHELIAL CELLS; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPINAL CORD; TRANS-ACTIVATORS; TRANSFECTION;

ERINACEIDAE; VERTEBRATA;

EID: 0041853572     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085405     Document Type: Article

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31. We thank G. S. Salvesen, F. de Sauvage, C. C. Hui, P. A. Beachy, and J. L. Duband for reagents. We also thank C. Guix for technical assistance. Supported by the Ligue Contre le Cancer (P.M.), the Schlumberger foundation (P.M.), NIH (P.M), the CNRS (P.M.), and the Association pour ta Recherche contre le Cancer (P.M. and M.-A.T.).