Sequential phosphorylation of smoothened transduces graded hedgehog signaling

Science Signaling

Volumn 4, Issue 180, 2011, Pages

  Su, Ying ^a   Ospina, Jason K ^a   Zhang, Junzheng ^a   Michelson, Andrew P ^a   Schoen, Adam M ^a   Zhu, Alan Jian ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; SMOOTHENED PROTEIN, DROSOPHILA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; DROSOPHILA MELANOGASTER; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING;

ERINACEIDAE;

ANIMALS; CASEIN KINASE I; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HEDGEHOG PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 79960084157     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001747     Document Type: Article

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82. Acknowledgments: We are grateful to S. Cohen, S. Eaton, R. Holmgren, D. Kalderon, G. Moorhead, M. Scott, A. Sehgal, K. Suyama, T. Tabata, P. Thérond, A. Vincent, the Bloomington Stock Center, the DSHB, the TRiP, and the VDRC for fly stocks, antibodies, PP2A, and other reagents. We thank A. Arif and L. Zhao for technical assistance, K. Nybakken for sharing unpublished results, and T. Blankenship, J. McDonald, A. Plessis, and M. A. Price for helpful discussions. Funding: This work was supported by a March of Dimes Basil O'Connor Starter Scholar Research Award (5-FY07-41), a Scott Hamilton CARES Initiative Award, an American Cancer Society Institutional Award (IRG-91-022-12), and an NIH/National Institute of General Medical Sciences grant (R01GM085175) to A.J.Z.; American Heart Association Postdoctoral Fellowship Awards (0825591D and 10POST4110011) to Y.S. and J.Z.; and an NIH/National Institute ofChild Health and Human Development Postdoctoral Training grant (T32HD007104) to J.K.O. Author contributions: A.J.Z.,Y.S., J.K.O., and J.Z. designed the experiments; Y.S., J.K.O., J.Z.,A.P.M., and A.M.S. performed the experiments; and A.J.Z., Y.S., J.K.O., and J.Z. analyzed the data and wrote the paper. Competing interests: The authors declare that they have no competing interests.