Genome-wide association analysis identifies 20 loci that influence adult height

Nature Genetics

Volumn 40, Issue 5, 2008, Pages 575-583

  Weedon, Michael N ^a   Lango, Hana ^a   Lindgren, Cecilia M ^b,c   Wallace, Chris ^d   Evans, David M ^e   Mangino, Massimo ^f   Freathy, Rachel M ^a   Perry, John R B ^a   Stevens, Suzanne ^f   Hall, Alistair S ^g   Samani, Nilesh J ^f   Shields, Beverly ^a   Prokopenko, Inga ^b,c   Farrall, Martin ^b   Dominiczak, Anna ^h   Johnson, Toby ^i,j,k   Bergmann, Sven ^i,j   Beckmann, Jacques S ^i,l   Vollenweider, Peter ^l   Waterworth, Dawn M ^m   Mooser, Vincent ^m   Palmer, Colin N A ⁿ   Morris, Andrew D ⁿ   Ouwehand, Willem H ^o,p   Zhao, Jing Hua ^q   Li, Shengxu ^q   Loos, Ruth J F ^q   Barroso, Inês ^r   Deloukas, Panagiotis ^r   Sandhu, Manjinder S ^s   Wheeler, Eleanor ^r   Soranzo, Nicole ^r   Inouye, Michael ^r   Wareham, Nicholas J ^q   Caulfield, Mark ^d   Munroe, Patricia B ^d   Hattersley, Andrew T ^a   McCarthy, Mark I ^b,c   Frayling, Timothy M ^a   more..

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

^g UNIVERSITY OF LEEDS   (United Kingdom)

^h UNIVERSITY OF GLASGOW   (United Kingdom)

ⁱ UNIVERSITY OF LAUSANNE   (Switzerland)

^j SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^k UNIVERSITY OF LAUSANNE   (Switzerland)

^l LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^m GLAXOSMITHKLINE   (United States)

ⁿ UNIVERSITY OF DUNDEE   (United Kingdom)

^o UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^p NHS BLOOD AND TRANSPLANT   (United Kingdom)

^q ADDENBROOKE S HOSPITAL   (United Kingdom)

^r WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^s UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; HIGH MOBILITY GROUP A2 PROTEIN; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

ACAN GENE; ADAMTSL3 GENE; ADULT; ADULTHOOD; AGED; ALLELE; ARTICLE; BODY HEIGHT; CONTROLLED STUDY; DLEU7 GENE; EFEMP1 GENE; EXTRACELLULAR MATRIX; FEMALE; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC TRAIT; GENETIC VARIABILITY; GENOME ANALYSIS; GENOTYPE; HHIP GENE; HUMAN; HUMAN DEVELOPMENT; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PRIORITY JOURNAL; REGULATOR GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BODY HEIGHT; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENOME, HUMAN; GENOTYPE; HEDGEHOG PROTEINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

ERINACEIDAE;

EID: 42649139571     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.121     Document Type: Article

References (27)

1. Macgregor, S., Cornes, B.K., Martin, N.G. & Visscher, P.M. Bias, precision and heritability of self-reported and clinically measured height in Australian twins. Hum. Genet. 120, 571-580 (2006).
2. Preece, M.A. The genetic contribution to stature. Horm. Res. 45, 56-58 (1996).
3. Silventoinen, K., Kaprio, J., Lahelma, E. & Koskenvuo, M. Relative effect of genetic and environmental factors on body height: differences across birth cohorts among Finnish men and women. Am. J. Public Health 90, 627-630 (2000).
4. Silventoinen, K. et al. Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res. 6, 399-408 (2003).
5. Perola, M. et al. Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet. 3, e97 (2007).
6. Palmert, M.R. & Hirschhorn, J.N. Genetic approaches to stature, pubertal timing, and other complex traits. Mol. Genet. Metab. 80, 1-10 (2003).
7. Weedon, M.N. et al. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat. Genet. 39, 1245-1250 (2007).
8. Price, A.L. et al. Principal components analysis corrects for stratification in genomewide association studies. Nat. Genet. 38, 904-909 (2006).
9. Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
10. Freedman, M.L. et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36, 388-393 (2004).
11. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
12. Dixon, A.L. et al. A genome-wide association study of global gene expression. Nat. Genet. 39, 1202-1207 (2007).
13. Malumbres, M. & Barbacid, M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630-641 (2005).
14. Southam, L. et al. An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage. Hum. Mol. Genet. 16, 2226-2232 (2007).
15. Miyamoto, Y. et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat. Genet. 39, 529-533 (2007).
16. Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S. & Hirschhorn, J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33, 177-182 (2003).
17. Fisher, R.A. The correlation between relatives on the supposition of Mendelian inheritance. Philosoph. Trans. Royal Soc. Edinburgh 52, 399-433 (1918).
18. Lettre, G. et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat. Genet. advance online publication, doi:10.1038/ng.125 (6 April 2008).
19. Diabetes Genetics Initiative of Broad Institute of Harvard and M.I.T. et al. Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331-1336 (2007).
20. Zeggini, E. et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336-1341 (2007).
21. Knight, B., Shields, B.M. & Hattersley, A.T. The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology. Paediatr. Perinat. Epidemiol. 20, 172-179 (2006).
22. Caulfield, M. et al. Genome-wide mapping of human loci for essential hypertension. Lancet 361, 2118-2123 (2003).
23. Marques-Vidal, P. et al. Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland: the CoLaus study. Eur. J. Clin. Nutr. advance online publication, doi: 10.1038/sj.ejcn.1602932 (17 October 2007).
24. Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
25. Stirling, W.D. Enhancements to aid interpretation of probability plots. Statistician 31, 211-220 (1982).
26. Gauderman, W.J. Sample size requirements for association studies of gene-gene interaction. Am. J. Epidemiol. 155, 478-484 (2002).
27. Sandhu, M.S. et al. LDL-cholesterol concentrations: a genome-wide association study. Lancet 371, 483-491 (2008).