In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

Nature

Volumn 437, Issue 7060, 2005, Pages 894-897

  Ahn, Sohyun ^a,c   Joyner, Alexandra L ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; GENETIC ENGINEERING; NEUROLOGY;

EMBRYONIC STAGES; FOREBRAIN; NEUROGENESIS; STEM CELLS;

CELLS;

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

CELLS AND CELL COMPONENTS;

ANIMAL CELL; ARTICLE; BRAIN REGION; CELL FATE; CELL POPULATION; CELL RENEWAL; CELL TYPE; CONTROLLED STUDY; DENTATE GYRUS; FOREBRAIN; GENE MAPPING; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION;

ERINACEIDAE; RODENTIA;

EID: 27144487469     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature03994     Document Type: Article

References (27)

1. Lai, K., Kaspar, B. K., Gage, F. H. & Schaffer, D. V. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neurosci. 6, 21-27 (2003).
2. Machold, R. et al. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39, 937-950 (2003).
3. Doetsch, F. The glial identity of neural stem cells. Nature Neurosci. 6, 1127-1134 (2003).
4. Alvarez-Buylla, A. & Garcia-Verdugo, J. M. Neurogenesis in adult subventricular zone. J. Neurosci. 22, 629-634 (2002).
5. Gage, F. H. Mammalian neural stem cells. Science 287, 1433-1438 (2000).
6. Alvarez-Buylla, A. & Lim, D. A. For the long run: maintaining germinal niches in the adult brain. Neuron 41, 683-686 (2004).
7. Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D. & Joyner, A. L. Gli2, but not Gli1, is required for initial Shh signalling and ectopic activation of the Shh pathway. Development 129, 4753-4761 (2002).
8. Bai, C. B., Stephen, D. & Joyner, A. L. All mouse ventral spinal cord patterning by Hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6, 103-115 (2004).
9. Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716 (1999).
10. Seri, B., Garcia-Verdugo, J. M., McEwen, B. S. & Alvarez-Buylla, A. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J. Neurosci. 21, 7153-7160 (2001).
11. Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36, 1021-1034 (2002).
12. Hack, M. A., Sugimori, M., Lundberg, C., Nakafuku, M. & Gotz, M. Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6. Mol. Cell. Neurosci. 25, 664-678 (2004).
13. Ahn, S. & Joyner, A. L. Dynamic changes in the response of cells to positive hedgehog signalling during mouse limb patterning. Cell 118, 505-516 (2004).
14. Zervas, M., Millet, S., Ahn, S. & Joyner, A. L. Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron 43, 345-357 (2004).
15. Doetsch, F., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Regeneration of a germinal layer in the adult mammalian brain. Proc. Natl Acad. Sci. USA 96, 11619-11624 (1999).
16. Palmer, T. D., Takahashi, J. & Gage, F. H. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell. Neurosci. 8, 389-404 (1997).
17. Gage, F. H., Kempermann, G., Palmer, T. D., Peterson, D. A. & Ray, J. Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol. 36, 249-266 (1998).
18. Suhonen, J. O., Peterson, D. A., Ray, J. & Gage, F. H. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383, 624-627 (1996).
19. Herrera, D. G., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Adult-derived neural precursors transplanted into multiple regions in the adult brain. Ann. Neurol. 46, 867-877 (1999).
20. Yoon, S. O. et al. Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain. Proc. Natl Acad. Sci. USA 93, 11974-11979 (1996).
21. Doetsch, F., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17, 5046-5061 (1997).
22. Kuhn, H. G., Dickinson-Anson, H. & Gage, F. H. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16, 2027-2033 (1996).
23. Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M. & Gage, F. H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130, 391-399 (2003).
24. Berman, D. M. et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425, 846-851 (2003).
25. Karhadkar, S. S. et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431, 707-712 (2004).
26. Watkins, D. N. et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422, 313-317 (2003).
27. Arnett, H. A. et al. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306, 2111-2115 (2004).