Mammalian Notum induces the release of glypicans and other GPI-anchored proteins from the cell surface

Biochemical Journal

Volumn 410, Issue 3, 2008, Pages 503-511

  Traister, Alexandra ^a,b   Shi, Wen ^a,b   Filmus, Jorge ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Glycosylphosphatidylinositol (GPI) anchor; Glypican family of proteins; Heparan sulfate proteoglycan; Mammalian notum; Phospholipase; Wnt

Indexed keywords

EXTRACELLULAR ENVIRONMENT; GLYCOSYLPHOSPHATIDYLINOSITOL (GPI) ANCHOR; HEPARAN SULFATE PROTEOGLYCAN; MAMMALIAN GLYPICANS; MAMMALIAN NOTUM;

BONE; CELL GROWTH; ENZYME ACTIVITY; FIBROBLASTS;

PROTEINS;

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; GLYPICAN; GLYPICAN 3; MAMMALIAN NOTUM; PROTEOHEPARAN SULFATE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CELL SURFACE; ENZYME PURIFICATION; ENZYME REGULATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ANIMALS; CELL MEMBRANE; DROSOPHILA; DROSOPHILA PROTEINS; EXTRACELLULAR SPACE; GLYCOSYLPHOSPHATIDYLINOSITOLS; GLYPICANS; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; MICE; RABBITS; TRANSFECTION; WNT PROTEINS;

ERINACEIDAE; MAMMALIA;

EID: 41149161142     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070511     Document Type: Article

References (44)

1. Udenfriend, S. and Kodukula, K. (1995) How glycosylphosphatidylinositol- anchored membrane proteins are made. Annu. Rev. Biochem. 64, 563-591
2. Ferguson, M. A. J. (1999) The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J. Cell Sci. 112, 2799-2809
3. Elortza, F., Mohammed, S., Bunkenborg, J., Foster, L. J., Nuhse, T. S., Brodbeck, U., Peck, S. C. and Jensen, O. N. (2006) Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment. J. Proteome Res. 5, 935-943
4. Sharom, F. J. and Radeva, G. (2004) GPI-anchored protein cleavage in the regulation of transmembrane signals. In Membrane Dynamics and Domains (Quinn, P. J., ed.), pp. 285-316, Kluwer Academic, New York
5. Lander, A. D., Stipp, C. S. and Ivins, J. K. (1998) The glypican family of heparan sulfate proteoglycans: major cell-surface proteoglycans of the developing nervous system. Perspect. Dev. Neurobiol. 3, 347-358
6. Veugelers, M. and David, G. (1998) The glypicans: a family of GPI-anchored heparan sulfate proteoglycans with a potential role in the control of cell division. Trends Glycosci. Glycotechnol. 10, 145-152
7. Filmus, J. and Song, H. H. (2000) Glypicans. In Proteoglycans (Iozzo, R. V., ed.), pp. 161-176, Marcel Dekker, New York
8. Nakato, H., Futch, T. A. and Selleck, S. B. (1995) The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan reguired for cell division patterning during postembryonic development of the nervous system in Drosophila. Development 121, 3687-3702
9. Baeg, G. H., Lin, X., Khare, N., Baumgartner, S. and Perrimon, N. (2001) Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development 128, 87-94
10. Veugelers, M., De Cat, B., Ceulemans, H., Bruystens, A. M., Coomans, C., Durr, J., Vermeesch, J., Marynen, P. and David, G. (1999) Glypican-6, a new member of the glypican family of cell surface proteoglycans. J.Biol. Chem. 274, 26968-26977
11. Song, H. H. and Filmus, J. (2002) The role of glypicans in mammalian development. Biochim. Biophys. Acta 1573, 241-246
12. Jackson, S. M., Nakato, H., Sugiura, M., Jannuzi, A., Oakes, R., Kaluza, V., Golden, C. and Selleck, S. B. (1997) dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen Dpp. Development 124, 4113-4120
13. Baeg, G. H. and Perrimon, N. (2000) Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Curr. Opin. Cell Biol. 12, 575-580
14. Perrimon, N. and Bernfield, M. (2000) Specificities of heparan sulphate proteoglycans in developmental processes. Nature 404, 725-728
15. Paine-Saunders, S., Viviano, B. L., Zupicich, J., Skarnes, W. C. and Saunders, S. (2000) Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev. Biol. 225, 179-187
16. Lum, L., Yao, S., Mozer, B., Rovescalli, A., Von Kessler, D., Nirenberg, M. and Beachy, P. A. (2003) Identification of hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299, 2039-2045
17. Desbordes, S. C. and Sanson, B. (2003) The glypican Dally-like is required for hedgehog signalling in the embryonic epidermis of Drosophila. Development 130, 6245-6255
18. Topczewsky, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J. and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Dev. Cell 1, 251-264
19. Ohkawara, B., Yamamoto, T. S., Tada, M. and Ueno, N. (2003) Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 130, 2129-2138
20. De Cat, B., Muyldermans, S. Y., Coomans, C., Degeest, G., Vanderschueren, B., Creemers, J., Biemar, F., Peers, B. and David, G. (2003) Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signalling, and gastrulation movements. J. Cell Biol. 163, 625-635
21. Kramer, K. L. and Yost, H. J. (2003) Heparan sulfate core proteins in cell-cell signaling. Annu. Rev. Genet. 37, 461-484
22. Ai, X., Do, A. T., Lozynska, O., Kusche-Gullberg, M., Lindhal, U. and Emerson, C. P. (2003) QSulf1 remodels the 6-O sulfation states of cell surface proteoglycans to promote Wnt signaling. J. Cell Biol. 162, 341-351
23. Capurro, M., Xiang, Y. Y., Lobe, C. and Filmus, J. (2005) Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. Cancer Res. 65, 6245-6254
24. Song, H. H., Shi, W., Xiang, Y. and Filmus, J. (2005) The loss of glypican-3 induces alterations in Wnt signaling. J. Biol. Chem. 280, 2116-2125
25. Han, C., Yan, D., Belenkaya, T. Y. and Lin, X. (2005) Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development 132, 667-679
26. Kirkpatrick, C. A., Dimitroff, B. D., Rawson, J. M. and Selleck, S. B. (2004) Spatial regulation of wingless morphogen distribution and signaling by Dally-like protein. Dev. Cell 7, 513-523
27. Franch-Marro, X., Marchand, O., Piddini, E., Ricardo, S., Alexandre, C. and Vincent, J. P. (2005) Glypicans shunt the wingless signal between local signalling and further transport. Development 132, 659-666
28. Giraldez, A. J., Copley, R. R. and Cohen, S. M. (2002) HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Dev. Cell 2, 667-676
29. Gerlitz, O. and Basler, K. (2002) Wingful, an extracellular feedback inhibitor of Wingless. Genes Dev. 16, 1055-1059
30. Kreuger, J., Perez, L., Giraldez, A. J. and Cohen, S. M. (2004) Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev. Cell 7, 503-512
31. Duenas Gonzales, A., Kaya, M., Shi, W., Song, H., Testa, J. R., Penn, L. Z. and Filmus, J. (1998) OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner. J. Cell Biol. 141, 1407-1414
32. Hagihara, K., Watanabe, K., Chun, J. and Yamaguchi, Y. (2000) Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells. Dev. Dyn. 219, 353-367
33. Screaton, R. A., DeMarte, L., Draber, P. and Stanners, C. P. (2000) The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor. J. Cell Biol. 150, 613-625
34. Aguirre Ghiso, J. A., Kovalski, K. and Ossowski, L. (1999) Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J. Cell Biol. 147, 89-103
35. Gouvaeva, F., Giardina, S., Yiu, K., Parfyonova, Y., Tkachuk, V. A. and Yang, J. (2005) T-cadherin GPI-anchor is insufficient for apical targeting in MDCK cells. Biochem. Biophys. Res. Commun. 329, 624-631
36. Capurro, M., Wanless, I. R., Sherman, M., Deboer, G., Shi, W., Miyoshi, E. and Filmus, J. (2003) Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 125, 81-90
37. -/- colon carcinoma. Science 275, 1784-1787
38. 2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. Cancer Res. 64, 2418-2423
39. Walter, E. I., Roberts, W. L., Rosenberry, T. L., Ratnoff, W. D. and Medof, M. E. (1990) Structural basis for variations in the sensitivity of human decay accelerating factor to phosphatidylinositol-specific phospholipase C cleavage. J. Immunol. 144, 1030-1036
40. Brunner, G., Metz, C. N., Nguyen, H., Gabrilove, J., Patel, S. R., Davitz, M. A., Rifkin, D. B. and Wilson, E. L. (1994) An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures. Blood 83, 2115-2125
41. Wilhelm, O. G., Wilhelm, S., Escott, G. M., Lutz, V., Magdolen, V., Schmitt, M., Rifkin, D. B., Wilson, E. L., Graeff, H. and Brunner, G. (1999) Cellular glycosylphosphalidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J. Cell. Physiol. 180, 225-235
42. Tujioka, H., Misumi, Y., Takami, N. and Ikehara, Y. (1998) Posttranslational modification of glycosylphosphatidylinositol (GPI)-specific phospholipase D and its activity in cleavage of GPI anchors. Biochem. Biophys. Res. Commun. 251, 737-743
43. Kondoh, G., Tojo, H., Nakatami, Y., Komazawa, N., Murata, C., Yamagata, K., Maeda, Y., Kinoshita, T., Okabe, M. and Taguchi, R. et al (2005) Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat. Med. 11, 160-166
44. Leisle, L., Parkin, E. T., Turner, A. J. and Hooper, N. M. (2006) Angiotensin-converting enzyme as a GPIase: a critical reevaluation. Nat. Med. 11, 1139-1140