Dual roles for patched in sequestering and transducing Hedgehog

Cell

Volumn 87, Issue 3, 1996, Pages 553-563

  Chen, Yu ^a   Struhl, Gary ^a  

^a Columbia Univ Coll of Phys and S ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEVELOPMENT; DROSOPHILA; EMBRYO; FORELIMB; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALIA; ERINACEIDAE;

EID: 0030297553     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81374-4     Document Type: Article

References (51)

1. Alcedo, J., Ayzenzon, M., von Ohlen, T., Noll, M., and Hooper, J.E. (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell 86, 221-232.
2. Basler, K., and Struhl, G. (1994). Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368, 208-214.
3. Bhanot, P., Brink, M., Samos, C.H., Hsieh, J., Wang, Y., Macke, J.P., Andrew, D., Nathans, J., and Nusse, R. (1996). A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225-230.
4. Blackman, R.K., Sanicola, M., Raftery, L.A., Gillevet, T., and Gelbart, W.M. (1991). An extensive 3′ cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-β family in Drosophila. Development 111, 657-666.
5. Capdevila, J., Estrada, M.P., Sanchez-Herrero, E., and Guerrero, I. (1994). The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J. 13, 71-82.
6. Capdevila, J. and Guerrero, I. (1994). Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
7. Casanova, J., Furriols, M., McCormick, C.A., and Struhl, G. (1995). Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila. Genes Dev. 9, 2539-2544.
8. Casanova, J., and Struhl, G. (1993). The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila. Nature 362, 152-155.
9. Chou, T.-B., and Perrimon, N. (1992). Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila. Genetics 131, 643-653.
10. Fan, C.H., Porter, J., Chiang, C., Chang, D.T., Beachy, P.A., and Tessier-Lavigne, M. (1995). Long-range sclerotome induction by Sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic amp signaling pathway. Cell 81, 457-465.
11. Golic, K. (1991). Site-specific recombination between homologous chromosomes in Drosophila. Science 252, 958-961.
12. Goodrich, L.V., Johnson, R.L., Milenkovic, L., McMahon, J., and Scott, M. (1996). Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10, 301-312.
13. Hooper, J.E. (1994). Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 372, 461-464.
14. Hooper, J.E., and Scott, M.P. (1989). The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765.
15. Ingham, P.W. (1991). Segment polarity genes and cell patterning within the Drosophila body segment. Curr. Opin. Genet. Dev. 1, 261-267.
16. Ingham, P.W. (1993). Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 366, 560-562.
17. Ingham, P.W. (1994). Hedgehog points the way. Curr. Biol. 4, 347-350.
18. Ingham, P.W., and Higalgo, A. (1993). Regulation of wingless transcription in the Drosophila embryo. Development 117, 283-291.
19. Ingham, P.W., Taylor, A.M., and Nakano, Y. (1991). Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187.
20. Jiang, J., and Struhl, G. (1995). Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80, 563-572.
21. Johnson, R.L., Grenier, J.K., and Scott, M.P. (1995).patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121, 4161-4170.
22. Kingsley, D.M. (1994). The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146.
23. Lecuit, T., Brook, W.J., Ng, M., Callega, M., Sun, H., and Cohen, S.M. (1996). Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381, 387-393.
24. Lepage, T., Cohen, S.M., Diaz-Benjumea, F.J., and Parkhurst, S.M. (1995). Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715.
25. Li, W., Ohlmeyer, J.T., Lane, M.E., and Kalderon, D. (1995). Function of protein kinase A in hedghehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
26. Marigo, V., Scott, M.P., Johnson, R.L., Goodrich, L.V., and Tabin, C.J. (1996). Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 122, 1225-1233.
27. Massagué, J. (1992). Receptors for the TGF-β family. Cell 69, 1067-1070.
28. Mathews, L.S., and Vale, W.W. (1991). Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65, 973-982.
29. Morisato, D., and Anderson, K.V. (1994). The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsoventral pattern of the Drosophila embryo. Cell 76, 677-688.
30. Motzny, C.K., and Holmgren, R. (1995). The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-150.
31. Nakano, Y., Guerrero, I., Hidalgo, A., Taylor, A., Whittle, J.R., and Ingham, P.W. (1989). A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513.
32. Nellen, D., Burke, R., Struhl, G., and Basler, K. (1996). Direct and long-range action of a DPP morphogen gradient. Cell 85, 357-368.
33. Nusse, R., and Varmus, H.E. (1992). Wnt genes. Cell 69, 1073-1087.
34. Nüsslein-Volhard, C., and Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801.
35. Nüsslein-Volhard, C., Wieschaus, E., and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster: zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193, 267-282.
36. Pan, D., and Rubin, G.M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552.
37. Perrimon, N. (1996). Serpentine proteins slither into the Wingless and Hedgehog fields. Cell 86, 513-516.
38. Phillips, R.G., Roberts, I.J., Ingham, P.W., and Whittle, J.R. (1990). The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development 110, 105-114.
39. Posakony, L.G., Raftery, L.A., and Gelbart, W.M. (1991). Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary. Mech. Dev. 33, 69-82.
40. Roelink, H. (1995). Tripartite signaling of pattern: interactions between Hedgehogs, BMPs and Wnts in the control of vertebrate development. Curr. Opin. Neurobiol. 6, 33-40.
41. Roelink, H., Porter, J.A., Chiang, C., Tanabe, Y., Chang, D.T., Beachy, P.A., and Jessell, T.M. (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81, 445-455.
42. Sprenger, F., and Nüsslein-Volhard, C. (1992). Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg. Cell 71, 987-1001.
43. Stein, D., Roth, S., Vogelsang, E., and Nüsslein-Volhard, C. (1991). The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell 65, 725-735.
44. Struhl, G., and Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.
45. Tabata, T., and Kornberg, T.B. (1994). Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102.
46. van den Heuvel, M., and Ingham, P.W. (1996). smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547-551.
47. van den Heuvel, M., Klingensmith, J., Perrimon, N., and Nusse, R. (1993). Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos. Development supp, 105-114.
48. Vincent, J., Girdham, C., and O'Farrell, P. (1994). A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics. Dev. Biol. 164, 328-331.
49. Vortkamp, A., Lee, K., Lanske, B., Segre, G.V., Kronenberg, H.M., and Tabin, C.J. (1996). Regulation of rate of cartilage differentiation by Indian Hedgehog and PTH-related protein. Science 273, 613-622.
50. Xu, T., and Rubin, G.M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
51. Zecca, M., Basler, K., and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.