-
1
-
-
12344305145
-
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
-
Apionishev, S., Katanayeva, N. M., Marks, S. A., Kalderon, D. and Tomlinson, A. (2005). Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat. Cell Biol. 7, 86-92.
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 86-92
-
-
Apionishev, S.1
Katanayeva, N.M.2
Marks, S.A.3
Kalderon, D.4
Tomlinson, A.5
-
2
-
-
0347764480
-
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
-
Bai, C. B., Stephen, D. and Joyner, A. L. (2004). All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6, 103-115.
-
(2004)
Dev. Cell
, vol.6
, pp. 103-115
-
-
Bai, C.B.1
Stephen, D.2
Joyner, A.L.3
-
3
-
-
72449171640
-
Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base
-
Barzi, M., Berenguer, J., Menendez, A., Alvarez-Rodriguez, R. and Pons, S. (2010). Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base. J. Cell Sci. 123, 62-69.
-
(2010)
J. Cell Sci
, vol.123
, pp. 62-69
-
-
Barzi, M.1
Berenguer, J.2
Menendez, A.3
Alvarez-Rodriguez, R.4
Pons, S.5
-
4
-
-
74449086803
-
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation
-
Besschetnova, T. Y., Kolpakova-Hart, E., Guan, Y., Zhou, J., Olsen, B. R. and Shah, J. V. (2010). Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr. Biol. 20, 182-187.
-
(2010)
Curr. Biol
, vol.20
, pp. 182-187
-
-
Besschetnova, T.Y.1
Kolpakova-Hart, E.2
Guan, Y.3
Zhou, J.4
Olsen, B.R.5
Shah, J.V.6
-
5
-
-
69249216479
-
EPAC proteins transduce diverse cellular actions of cAMP
-
Borland, G., Smith, B. O. and Yarwood, S. J. (2009). EPAC proteins transduce diverse cellular actions of cAMP. Br. J. Pharmacol. 158, 70-78.
-
(2009)
Br. J. Pharmacol
, vol.158
, pp. 70-78
-
-
Borland, G.1
Smith, B.O.2
Yarwood, S.J.3
-
6
-
-
20444385880
-
Regulation of cyclic nucleotide-gated channels
-
Bradley, J., Reisert, J. and Frings, S. (2005). Regulation of cyclic nucleotide-gated channels. Curr. Opin. Neurobiol. 15, 343-349.
-
(2005)
Curr. Opin. Neurobiol
, vol.15
, pp. 343-349
-
-
Bradley, J.1
Reisert, J.2
Frings, S.3
-
7
-
-
0029791854
-
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning
-
Concordet, J. P., Lewis, K. E., Moore, J. W., Goodrich, L. V., Johnson, R. L., Scott, M. P. and Ingham, P. W. (1996). Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122, 2835-2846.
-
(1996)
Development
, vol.122
, pp. 2835-2846
-
-
Concordet, J.P.1
Lewis, K.E.2
Moore, J.W.3
Goodrich, L.V.4
Johnson, R.L.5
Scott, M.P.6
Ingham, P.W.7
-
8
-
-
27644584608
-
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
-
Cooper, A. F., Yu, K. P., Brueckner, M., Brailey, L. L., Johnson, L., McGrath, J. M. and Bale, A. E. (2005). Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132, 4407-4417.
-
(2005)
Development
, vol.132
, pp. 4407-4417
-
-
Cooper, A.F.1
Yu, K.P.2
Brueckner, M.3
Brailey, L.L.4
Johnson, L.5
McGrath, J.M.6
Bale, A.E.7
-
9
-
-
69249245332
-
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
-
Chen, M. H., Wilson, C. W., Li, Y. J., Law, K. K., Lu, C. S., Gacayan, R., Zhang, X., Hui, C. C. and Chuang, P. T. (2009). Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23, 1910-1928.
-
(2009)
Genes Dev
, vol.23
, pp. 1910-1928
-
-
Chen, M.H.1
Wilson, C.W.2
Li, Y.J.3
Law, K.K.4
Lu, C.S.5
Gacayan, R.6
Zhang, X.7
Hui, C.C.8
Chuang, P.T.9
-
10
-
-
0032478107
-
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
-
USA
-
Chen, Y., Gallaher, N., Goodman, R. H. and Smolik, S. M. (1998). Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. USA 95, 2349-2354.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 2349-2354
-
-
Chen, Y.1
Gallaher, N.2
Goodman, R.H.3
Smolik, S.M.4
-
11
-
-
0032873774
-
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
-
Chen, Y., Cardinaux, J. R., Goodman, R. H. and Smolik, S. M. (1999). Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development 126, 3607-3616.
-
(1999)
Development
, vol.126
, pp. 3607-3616
-
-
Chen, Y.1
Cardinaux, J.R.2
Goodman, R.H.3
Smolik, S.M.4
-
12
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened
-
Chen, Y., Sasai, N., Ma, G., Yue, T., Jia, J., Briscoe, J. and Jiang, J. (2011). Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of Smoothened. PLoS Biol. 9, e1001083.
-
(2011)
PLoS Biol
, vol.9
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
Briscoe, J.6
Jiang, J.7
-
13
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. and Reiter, J. F. (2005). Vertebrate Smoothened functions at the primary cilium. Nature 13, 1018-1021.
-
(2005)
Nature
, vol.13
, pp. 1018-1021
-
-
Corbit, K.C.1
Aanstad, P.2
Singla, V.3
Norman, A.R.4
Stainier, D.Y.5
Reiter, J.F.6
-
14
-
-
0033583035
-
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3
-
Dai, P., Akimaru, H., Tanaka, Y., Maekawa, T., Nakafuku, M. and Ishii, S. (1999). Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 8143-8152
-
-
Dai, P.1
Akimaru, H.2
Tanaka, Y.3
Maekawa, T.4
Nakafuku, M.5
Ishii, S.6
-
15
-
-
0022534294
-
Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: Evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex
-
De Camilli, P., Moretti, M., Donini, S. D., Walter, U. and Lohmann, S. M. (1986). Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex. J. Cell Biol. 103, 189-203.
-
(1986)
J. Cell Biol
, vol.103
, pp. 189-203
-
-
de Camilli, P.1
Moretti, M.2
Donini, S.D.3
Walter, U.4
Lohmann, S.M.5
-
16
-
-
0031855859
-
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
-
Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.
-
(1998)
Development
, vol.125
, pp. 2533-2543
-
-
Ding, Q.1
Motoyama, J.2
Gasca, S.3
Mo, R.4
Sasaki, H.5
Rossant, J.6
Hui, C.C.7
-
17
-
-
0035849901
-
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
-
Eggenschwiler, J. T., Espinoza, E. and Anderson, K. V. (2001). Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature 412, 194-198.
-
(2001)
Nature
, vol.412
, pp. 194-198
-
-
Eggenschwiler, J.T.1
Espinoza, E.2
Anderson, K.V.3
-
18
-
-
70449709536
-
Intraflagellar transport particle size scales inversely with flagellar length: Revisiting the balance-point length control model
-
Engel, B. D., Ludington, W. B. and Marshall, W. F. (2009). Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model. J. Cell Biol. 187, 81-89.
-
(2009)
J. Cell Biol
, vol.187
, pp. 81-89
-
-
Engel, B.D.1
Ludington, W.B.2
Marshall, W.F.3
-
19
-
-
0029821890
-
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
-
Epstein, D. J., Marti, E., Scott, M. P. and McMahon, A. P. (1996). Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-9284.
-
(1996)
Development
, vol.122
, pp. 2885-9284
-
-
Epstein, D.J.1
Marti, E.2
Scott, M.P.3
McMahon, A.P.4
-
20
-
-
0034614416
-
Activity and regulation of the centrosome-associated proteasome
-
Fabunmi, R. P., Wigley, W. C., Thomas, P. J. and DeMartino, G. N. (2000). Activity and regulation of the centrosome-associated proteasome. J. Biol. Chem. 275, 409- 413.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 409-413
-
-
Fabunmi, R.P.1
Wigley, W.C.2
Thomas, P.J.3
Demartino, G.N.4
-
21
-
-
0033200397
-
Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
-
Freed, E., Lacey, K. R., Huie, P., Lyapina, S. A., Deshaies, R. J., Stearns, T. and Jackson, P. K. (1999). Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes Dev. 13, 2242-2257.
-
(1999)
Genes Dev
, vol.13
, pp. 2242-2257
-
-
Freed, E.1
Lacey, K.R.2
Huie, P.3
Lyapina, S.A.4
Deshaies, R.J.5
Stearns, T.6
Jackson, P.K.7
-
22
-
-
77951101203
-
The primary cilium: A signalling centre during vertebrate development
-
Goetz, S. C. and Anderson, K. V. (2010). The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 11, 331-344.
-
(2010)
Nat. Rev. Genet
, vol.11
, pp. 331-344
-
-
Goetz, S.C.1
Anderson, K.V.2
-
23
-
-
0030866154
-
Altered neural cell fates and medulloblastoma in mouse patched mutants
-
Goodrich, L. V., Milenkovic, L., Higgins, K. M. and Scott, M. P. (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113.
-
(1997)
Science
, vol.277
, pp. 1109-1113
-
-
Goodrich, L.V.1
Milenkovic, L.2
Higgins, K.M.3
Scott, M.P.4
-
24
-
-
0029879687
-
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
-
Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P. (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev. 10, 647-658.
-
(1996)
Genes Dev
, vol.10
, pp. 647-658
-
-
Hammerschmidt, M.1
Bitgood, M.J.2
McMahon, A.P.3
-
25
-
-
0036351299
-
Molecular and behavioral effects of a null mutation in all PKA C beta isoforms
-
Howe, D. G., Wiley, J. C. and McKnight, G. S. (2002). Molecular and behavioral effects of a null mutation in all PKA C beta isoforms. Mol. Cell. Neurosci. 20, 515-524.
-
(2002)
Mol. Cell. Neurosci
, vol.20
, pp. 515-524
-
-
Howe, D.G.1
Wiley, J.C.2
McKnight, G.S.3
-
26
-
-
0037205428
-
Protein kinase A deficiency causes axially localized neural tube defects in mice
-
Huang, Y., Roelink, H. and McKnight, G. S. (2002). Protein kinase A deficiency causes axially localized neural tube defects in mice. J. Biol. Chem. 277, 19889-19896.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 19889-19896
-
-
Huang, Y.1
Roelink, H.2
McKnight, G.S.3
-
27
-
-
31644442906
-
Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
-
Huangfu, D. and Anderson, K. V. (2005). Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133, 3-14.
-
(2005)
Development
, vol.133
, pp. 3-14
-
-
Huangfu, D.1
Anderson, K.V.2
-
28
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L. and Anderson, K. V. (2003). Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426, 83-87.
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
Liu, A.2
Rakeman, A.S.3
Murcia, N.S.4
Niswander, L.5
Anderson, K.V.6
-
29
-
-
0027478216
-
A mouse model of greig cephalopolysyndactyly syndrome: The extra-toesJ mutation contains an intragenic deletion of the Gli3 gene
-
Hui, C. C. and Joyner, A. L. (1993). A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet. 3, 241-246.
-
(1993)
Nat. Genet
, vol.3
, pp. 241-246
-
-
Hui, C.C.1
Joyner, A.L.2
-
30
-
-
77950463564
-
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
-
Humke, E. W., Dorn, K. V., Milenkovic, L., Scott, M. P. and Rohatgi, R. (2010). The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24, 670-682.
-
(2010)
Genes Dev
, vol.24
, pp. 670-682
-
-
Humke, E.W.1
Dorn, K.V.2
Milenkovic, L.3
Scott, M.P.4
Rohatgi, R.5
-
31
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham, P. W. and McMahon, A. P. (2001). Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
32
-
-
79956308325
-
Mechanisms and functions of Hedgehog signalling across the metazoa
-
Ingham, P. W., Nakano, Y. and Seger, C. (2011). Mechanisms and functions of Hedgehog signalling across the metazoa. Nat. Rev. Genet.12, 393-406.
-
(2011)
Nat. Rev. Genet
, vol.12
, pp. 393-406
-
-
Ingham, P.W.1
Nakano, Y.2
Seger, C.3
-
33
-
-
11144237279
-
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
-
Jia, J., Tong, C., Wang, B., Luo, L. and Jiang, J. (2004). Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432, 1045-1050.
-
(2004)
Nature
, vol.432
, pp. 1045-1050
-
-
Jia, J.1
Tong, C.2
Wang, B.3
Luo, L.4
Jiang, J.5
-
34
-
-
28444449828
-
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
-
Jia, J., Zhang, L., Zhang, Q., Tong, C., Wang, B., Hou, F., Amanai, K. and Jiang, J. (2005). Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev. Cell 9, 819-830.
-
(2005)
Dev. Cell
, vol.9
, pp. 819-830
-
-
Jia, J.1
Zhang, L.2
Zhang, Q.3
Tong, C.4
Wang, B.5
Hou, F.6
Amanai, K.7
Jiang, J.8
-
35
-
-
67349198593
-
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
-
Jia, J., Kolterud, A., Zeng, H., Hoover, A., Teglund, S., Toftgard, R. and Liu, A. (2009). Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev. Biol. 330, 452-460.
-
(2009)
Dev. Biol
, vol.330
, pp. 452-460
-
-
Jia, J.1
Kolterud, A.2
Zeng, H.3
Hoover, A.4
Teglund, S.5
Toftgard, R.6
Liu, A.7
-
36
-
-
0028918468
-
Protein kinase A and hedgehog signaling in Drosophila limb development
-
Jiang, J. and Struhl, G. (1995). Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
-
(1995)
Cell
, vol.80
, pp. 563-572
-
-
Jiang, J.1
Struhl, G.2
-
37
-
-
0032576777
-
Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
-
Jiang, J. and Struhl, G. (1998). Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496.
-
(1998)
Nature
, vol.391
, pp. 493-496
-
-
Jiang, J.1
Struhl, G.2
-
38
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang, J. and Hui, C. C. (2008). Hedgehog signaling in development and cancer. Dev. Cell 15, 801-812.
-
(2008)
Dev. Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
39
-
-
4444220296
-
Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
-
Lei, Q., Zelman, A. K., Kuang, E., Li, S. and Matise, M. P. (2004). Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131, 3593-3604.
-
(2004)
Development
, vol.131
, pp. 3593-3604
-
-
Lei, Q.1
Zelman, A.K.2
Kuang, E.3
Li, S.4
Matise, M.P.5
-
40
-
-
0028897883
-
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
-
Li, W., Ohlmeyer, J. T., Lane, M. E. and Kaldero, D. (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-562.
-
(1995)
Cell
, vol.80
, pp. 553-562
-
-
Li, W.1
Ohlmeyer, J.T.2
Lane, M.E.3
Kaldero, D.4
-
41
-
-
69449099121
-
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
-
USA
-
Liem, K. F., Jr, He, M., Ocbina, P. J. and Anderson, K. V. (2009). Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 106, 13377-13382.
-
(2009)
Proc. Natl. Acad. Sci
, vol.106
, pp. 13377-13382
-
-
Liem Jr., K.F.1
He, M.2
Ocbina, P.J.3
Anderson, K.V.4
-
42
-
-
23144466931
-
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
-
Liu, A., Wang, B. and Niswander, L. A. (2005). Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132, 3103-3111.
-
(2005)
Development
, vol.132
, pp. 3103-3111
-
-
Liu, A.1
Wang, B.2
Niswander, L.A.3
-
43
-
-
0001203866
-
Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells
-
Low, S. H., Roche, P. A., Anderson, H. A., van Ijzendoorn, S. C., Zhang, M., Mostov, K. E. and Weimbs, T. (1998). Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. J. Biol. Chem. 273, 3422-3430.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 3422-3430
-
-
Low, S.H.1
Roche, P.A.2
Anderson, H.A.3
van Ijzendoorn, S.C.4
Zhang, M.5
Mostov, K.E.6
Weimbs, T.7
-
44
-
-
79957637188
-
Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation
-
Marks, S. A. and Kalderon, D. (2011). Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. Development 138, 2533-2542.
-
(2011)
Development
, vol.138
, pp. 2533-2542
-
-
Marks, S.A.1
Kalderon, D.2
-
45
-
-
0031679850
-
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
-
Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.
-
(1998)
Development
, vol.125
, pp. 2759-2770
-
-
Matise, M.P.1
Epstein, D.J.2
Park, H.L.3
Platt, K.A.4
Joyner, A.L.5
-
46
-
-
27744484694
-
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
-
May, S. R., Ashique, A. M., Karlen, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J., Ericson, J. and Peterson, A. S. (2005). Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287, 378-389.
-
(2005)
Dev. Biol
, vol.287
, pp. 378-389
-
-
May, S.R.1
Ashique, A.M.2
Karlen, M.3
Wang, B.4
Shen, Y.5
Zarbalis, K.6
Reiter, J.7
Ericson, J.8
Peterson, A.S.9
-
47
-
-
77953943126
-
Not lost in space: Trafficking in the hedgehog signaling pathway
-
Milenkovic, L. and Scott, M. P. (2010). Not lost in space: trafficking in the hedgehog signaling pathway. Sci. Signal. 13, pe14.
-
(2010)
Sci. Signal.
, vol.13
-
-
Milenkovic, L.1
Scott, M.P.2
-
48
-
-
75549090700
-
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
-
Milenkovic, L., Scott, M. P. and Rohatgi, R. (2009). Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biol. 187, 365-374.
-
(2009)
J. Cell Biol
, vol.187
, pp. 365-374
-
-
Milenkovic, L.1
Scott, M.P.2
Rohatgi, R.3
-
49
-
-
0037706929
-
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
-
Motoyama, J., Milenkovic, L., Iwama, M., Shikata, Y., Scott, M. P. and Hui, C. C. (2003). Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 259, 150-161.
-
(2003)
Dev. Biol
, vol.259
, pp. 150-161
-
-
Motoyama, J.1
Milenkovic, L.2
Iwama, M.3
Shikata, Y.4
Scott, M.P.5
Hui, C.C.6
-
50
-
-
48849116430
-
Pharmacological PKA inhibition: All may not be what it seems
-
Murray, A. J. (2008). Pharmacological PKA inhibition: all may not be what it seems. Sci. Signal. 1, re4.
-
(2008)
Sci. Signal.
, vol.1
-
-
Murray, A.J.1
-
51
-
-
0012315579
-
-
Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
-
Nagy, A., Gertsenstein, M., Vintersten, K. and Behringer, R. (2003). Manipulating the Mouse Embryo: A Laboratory Manual (Third Edition). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
-
(2003)
Manipulating the Mouse Embryo: A Laboratory Manual
-
-
Nagy, A.1
Gertsenstein, M.2
Vintersten, K.3
Behringer, R.4
-
52
-
-
0022363913
-
Cyclic-AMPdependent protein kinase type II is associated with the Golgi complex and with centrosomes
-
Nigg, E. A., Schafer, G., Hilz, H. and Eppenberger, H. M. (1985). Cyclic-AMPdependent protein kinase type II is associated with the Golgi complex and with centrosomes. Cell 41, 1039-1051.
-
(1985)
Cell
, vol.41
, pp. 1039-1051
-
-
Nigg, E.A.1
Schafer, G.2
Hilz, H.3
Eppenberger, H.M.4
-
53
-
-
49449086772
-
Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts
-
Ocbina, P. J. and Anderson, K. V. (2008). Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev. Dyn. 237, 2030-2038.
-
(2008)
Dev. Dyn
, vol.237
, pp. 2030-2038
-
-
Ocbina, P.J.1
Anderson, K.V.2
-
54
-
-
79957611891
-
Complex interactions between genes controlling trafficking in primary cilia
-
Ocbina, P. J., Eggenschwiler, J. T., Moskowitz, I. and Anderson, K. V. (2011). Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43, 547-553.
-
(2011)
Nat. Genet
, vol.43
, pp. 547-553
-
-
Ocbina, P.J.1
Eggenschwiler, J.T.2
Moskowitz, I.3
Anderson, K.V.4
-
55
-
-
0030984470
-
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
-
Ohlmeyer, J. T. and Kalderon, D. (1997). Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250-2258.
-
(1997)
Genes Dev
, vol.11
, pp. 2250-2258
-
-
Ohlmeyer, J.T.1
Kalderon, D.2
-
56
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Pan, Y., Bai, C. B., Joyner, A. L. and Wang, B. (2006). Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26, 3365-3377.
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
57
-
-
58549117286
-
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
-
Pan, Y., Wang, C. and Wang, B. (2009). Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326, 177-189.
-
(2009)
Dev. Biol
, vol.326
, pp. 177-189
-
-
Pan, Y.1
Wang, C.2
Wang, B.3
-
58
-
-
0037111829
-
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
-
Persson, M., Stamataki, D., te, Welscher, P., Andersson, E., Bose, J., Ruther, U., Ericson, J. and Briscoe, J. (2002). Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 16, 2865-2878.
-
(2002)
Genes Dev
, vol.16
, pp. 2865-2878
-
-
Persson, M.1
Stamataki, D.2
te Welscher, P.3
Andersson, E.4
Bose, J.5
Ruther, U.6
Ericson, J.7
Briscoe, J.8
-
59
-
-
0032756914
-
Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
-
Price, M. A. and Kalderon, D. (1999). Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 126, 4331-4339.
-
(1999)
Development
, vol.126
, pp. 4331-4339
-
-
Price, M.A.1
Kalderon, D.2
-
60
-
-
58849146635
-
Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells
-
Raychowdhury, M. K., Ramos, A. J., Zhang, P., McLaughin, M., Dai, X.-Q., Chen, X.-Z., Montalbetti, N., del Rocío Cantero, M., Ausiello, D. A. and Cantiello, H. F. (2009). Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. Am. J. Physiol. Renal. Physiol. 296, F87-F97.
-
(2009)
Am. J. Physiol. Renal. Physiol
, vol.296
-
-
Raychowdhury, M.K.1
Ramos, A.J.2
Zhang, P.3
McLaughin, M.4
Dai, X.-Q.5
Chen, X.-Z.6
Montalbetti, N.7
del Rocío, C.M.8
Ausiello, D.A.9
Cantiello, H.F.10
-
61
-
-
51349104215
-
A multicomponent assembly pathway contributes to the formation of acentrosomal microtubule arrays in interphase Drosophila cells
-
Rogers, G. C., Rusan, N. M., Peifer, M. and Rogers, S. L. (2008). A multicomponent assembly pathway contributes to the formation of acentrosomal microtubule arrays in interphase Drosophila cells. Mol. Biol. Cell 19, 3163-3178.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 3163-3178
-
-
Rogers, G.C.1
Rusan, N.M.2
Peifer, M.3
Rogers, S.L.4
-
62
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
Rohatgi, R., Milenkovic, L. and Scott, M. P. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372-376.
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
63
-
-
0032808138
-
Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
-
Ruiz i Altaba, A. (1999). Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126, 3205-3216.
-
(1999)
Development
, vol.126
, pp. 3205-3216
-
-
Ruiz i, A.A.1
-
64
-
-
0036008839
-
Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction
-
Skalhegg, B. S., Huang, Y., Su, T., Idzerda, R. L., McKnight, G. S. and Burton, K. A. (2002). Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol. Endocrinol. 16, 630-639.
-
(2002)
Mol. Endocrinol
, vol.16
, pp. 630-639
-
-
Skalhegg, B.S.1
Huang, Y.2
Su, T.3
Idzerda, R.L.4
McKnight, G.S.5
Burton, K.A.6
-
65
-
-
30044442183
-
Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
-
Smelkinson, M. G. and Kalderon, D. (2006). Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr. Biol. 16, 110-116.
-
(2006)
Curr. Biol
, vol.16
, pp. 110-116
-
-
Smelkinson, M.G.1
Kalderon, D.2
-
66
-
-
31744451535
-
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svard, J., Heby-Henricson, K., Persson-Lek, M., Rozell, B., Lauth, M., Bergstrom, A., Ericson, J., Toftgard, R. and Teglund, S. (2006). Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 10, 187-197.
-
(2006)
Dev. Cell
, vol.10
, pp. 187-197
-
-
Svard, J.1
Heby-Henricson, K.2
Persson-Lek, M.3
Rozell, B.4
Lauth, M.5
Bergstrom, A.6
Ericson, J.7
Toftgard, R.8
Teglund, S.9
-
67
-
-
77649337790
-
Hedgehog beyond medulloblastoma and basal cell carcinoma
-
Teglund, S. and Toftgard, R. (2010). Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim. Biophys. Acta. 1805, 181-208.
-
(2010)
Biochim. Biophys. Acta
, vol.1805
, pp. 181-208
-
-
Teglund, S.1
Toftgard, R.2
-
68
-
-
68049128117
-
Paracrine Hedgehog signaling in cancer
-
Theunissen, J. W. and de Sauvage, F. J. (2009). Paracrine Hedgehog signaling in cancer. Cancer Res. 69, 6007-6010.
-
(2009)
Cancer Res
, vol.69
, pp. 6007-6010
-
-
Theunissen, J.W.1
de Sauvage, F.J.2
-
69
-
-
34247146469
-
Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling
-
Tiecke, E., Turner, R., Sanz-Ezquerro, J. J., Warner, A. and Tickle, C. (2007). Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling. Dev. Biol. 305, 312-324.
-
(2007)
Dev. Biol
, vol.305
, pp. 312-324
-
-
Tiecke, E.1
Turner, R.2
Sanz-Ezquerro, J.J.3
Warner, A.4
Tickle, C.5
-
70
-
-
0033711384
-
Hedgehog signalling in cancer
-
Toftgard, R. (2000). Hedgehog signalling in cancer. Cell Mol. Life Sci. 57, 1720-1731.
-
(2000)
Cell Mol. Life Sci
, vol.57
, pp. 1720-1731
-
-
Toftgard, R.1
-
71
-
-
77958508124
-
A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
-
Tukachinsky, H., Lopez, L. V. and Salic, A. (2010). A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J. Cell Biol. 191, 415-428.
-
(2010)
J. Cell Biol
, vol.191
, pp. 415-428
-
-
Tukachinsky, H.1
Lopez, L.V.2
Salic, A.3
-
72
-
-
0030601349
-
Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos
-
Ungar, A. R. and Moon, R. T. (1996). Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. Dev. Biol. 178, 186-191.
-
(1996)
Dev. Biol
, vol.178
, pp. 186-191
-
-
Ungar, A.R.1
Moon, R.T.2
-
73
-
-
30444437000
-
Evidence for the direct involvement of βTrCP in Gli3 protein processing
-
USA
-
Wang, B. and Li, Y. (2006). Evidence for the direct involvement of βTrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. USA 103, 33-38.
-
(2006)
Proc. Natl. Acad. Sci
, vol.103
, pp. 33-38
-
-
Wang, B.1
Li, Y.2
-
74
-
-
0034681266
-
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
-
Wang, B., Fallon, J. F. and Beachy, P. A. (2000). Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434.
-
(2000)
Cell
, vol.100
, pp. 423-434
-
-
Wang, B.1
Fallon, J.F.2
Beachy, P.A.3
-
75
-
-
77953050811
-
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
-
Wang, C., Pan, Y. and Wang, B. (2010). Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development 137, 2001-2009.
-
(2010)
Development
, vol.137
, pp. 2001-2009
-
-
Wang, C.1
Pan, Y.2
Wang, B.3
-
76
-
-
0032728958
-
Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
-
Wang, G., Wang, B. and Jiang, J. (1999). Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev. 13, 2828-2837.
-
(1999)
Genes Dev
, vol.13
, pp. 2828-2837
-
-
Wang, G.1
Wang, B.2
Jiang, J.3
-
77
-
-
77950671813
-
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
-
Wen, X., Lai, C. K., Evangelista, M., Hongo, J. A., de Sauvage, F. J. and Scales, S. J. (2010). Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol. Cell. Biol. 30, 1910-1922.
-
(2010)
Mol. Cell. Biol
, vol.30
, pp. 1910-1922
-
-
Wen, X.1
Lai, C.K.2
Evangelista, M.3
Hongo, J.A.4
de Sauvage, F.J.5
Scales, S.J.6
-
78
-
-
79954544984
-
Cell-type specific expression of a dominant negative PKA mutation in mice
-
Willis, B. S., Niswender, C. M., Su, T., Amieux, P. S. and McKnight, G. S. (2011). Cell-type specific expression of a dominant negative PKA mutation in mice. PLoS One 6, e18772.
-
(2011)
PLoS One
, vol.6
-
-
Willis, B.S.1
Niswender, C.M.2
Su, T.3
Amieux, P.S.4
McKnight, G.S.5
-
79
-
-
65249123996
-
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
-
Wilson, C. W., Chen, M. H. and Chuang, P. T. (2009). Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One 4, e5182.
-
(2009)
PLoS One
, vol.4
-
-
Wilson, C.W.1
Chen, M.H.2
Chuang, P.T.3
-
80
-
-
79958717871
-
Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme
-
Wirschell, M., Yamamoto, R., Alford, L., Gokhale, A., Gaillard, A. and Sale, W. S. (2011). Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme. Arch. Biochem. Biophys. 510, 93-100.
-
(2011)
Arch. Biochem. Biophys
, vol.510
, pp. 93-100
-
-
Wirschell, M.1
Yamamoto, R.2
Alford, L.3
Gokhale, A.4
Gaillard, A.5
Sale, W.S.6
-
81
-
-
78650808301
-
Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium
-
Zeng, H., Jia, J. and Liu, A. (2010). Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium. PLoS One 5, e15900.
-
(2010)
PLoS One
, vol.5
-
-
Zeng, H.1
Jia, J.2
Liu, A.3
-
82
-
-
11144248964
-
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
-
USA
-
Zhang, C., Williams, E. H., Guo, Y., Lum, L. and Beachy, P. A. (2004). Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc. Natl. Acad. Sci. USA 101, 17900-17907.
-
(2004)
Proc. Natl. Acad. Sci
, vol.101
, pp. 17900-17907
-
-
Zhang, C.1
Williams, E.H.2
Guo, Y.3
Lum, L.4
Beachy, P.A.5
|