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Volumn 10, Issue 1, 2012, Pages

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; CASEIN KINASE I; CYCLIC AMP DEPENDENT PROTEIN KINASE; LYSINE; PROTEASOME; PROTEIN KURTZ; PROTEIN UBA1; PROTEIN UBPY; PROTEIN USP8; PROTEINASE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

EID: 84863012714     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001239     Document Type: Article
Times cited : (96)

References (53)
  • 1
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui C. C, (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-812.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 2
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham P. W, Nakano Y, Seger C, (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12: 393-406.
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 3
    • 0033754122 scopus 로고    scopus 로고
    • The sonic hedgehog-patched-gli pathway in human development and disease
    • Villavicencio E. H, Walterhouse D. O, Iannaccone P. M, (2000) The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 67: 1047-1054.
    • (2000) Am J Hum Genet , vol.67 , pp. 1047-1054
    • Villavicencio, E.H.1    Walterhouse, D.O.2    Iannaccone, P.M.3
  • 4
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy P. A, (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature 411: 349-354.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 5
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y, Struhl G, (1996) Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 6
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone D. M, Hynes M, Armanini M, Swanson T. A, Gu Q, et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3    Swanson, T.A.4    Gu, Q.5
  • 7
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N, Neubuser D, Perez L, Cohen S. M, (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 8
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • Zhao Y, Tong C, Jiang J, (2007) Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450: 252-258.
    • (2007) Nature , vol.450 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 10
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott M. P, (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 11
    • 0038625111 scopus 로고    scopus 로고
    • Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
    • Zhu A. J, Zheng L, Suyama K, Scott M. P, (2003) Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev 17: 1240-1252.
    • (2003) Genes Dev , vol.17 , pp. 1240-1252
    • Zhu, A.J.1    Zheng, L.2    Suyama, K.3    Scott, M.P.4
  • 12
    • 12344305145 scopus 로고    scopus 로고
    • Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    • Apionishev S, Katanayeva N. M, Marks S. A, Kalderon D, Tomlinson A, (2005) Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol 7: 86-92.
    • (2005) Nat Cell Biol , vol.7 , pp. 86-92
    • Apionishev, S.1    Katanayeva, N.M.2    Marks, S.A.3    Kalderon, D.4    Tomlinson, A.5
  • 13
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of smoothened requires phosphorylation by protein kinase A and casein kinase I
    • Jia J, Tong C, Wang B, Luo L, Jiang J, (2004) Hedgehog signalling activity of smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432: 1045-1050.
    • (2004) Nature , vol.432 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 14
    • 11144248964 scopus 로고    scopus 로고
    • Extensive phosphorylation of Smoothened in Hedgehog pathway activation
    • Zhang C, Williams E. H, Guo Y, Lum L, Beachy P. A, (2004) Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A 101: 17900-17907.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17900-17907
    • Zhang, C.1    Williams, E.H.2    Guo, Y.3    Lum, L.4    Beachy, P.A.5
  • 15
    • 1142289021 scopus 로고    scopus 로고
    • Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
    • Nakano Y, Nystedt S, Shivdasani A. A, Strutt H, Thomas C, et al. (2004) Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech Dev 121: 507-518.
    • (2004) Mech Dev , vol.121 , pp. 507-518
    • Nakano, Y.1    Nystedt, S.2    Shivdasani, A.A.3    Strutt, H.4    Thomas, C.5
  • 16
    • 0038795645 scopus 로고    scopus 로고
    • Signals for sorting of transmembrane proteins to endosomes and lysosomes
    • Bonifacino J. S, Traub L. M, (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 72: 395-447.
    • (2003) Annu Rev Biochem , vol.72 , pp. 395-447
    • Bonifacino, J.S.1    Traub, L.M.2
  • 17
    • 19644384744 scopus 로고    scopus 로고
    • E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation
    • d'Azzo A, Bongiovanni A, Nastasi T, (2005) E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation. Traffic 6: 429-441.
    • (2005) Traffic , vol.6 , pp. 429-441
    • d'Azzo, A.1    Bongiovanni, A.2    Nastasi, T.3
  • 18
    • 0346655115 scopus 로고    scopus 로고
    • Regulated ubiquitination of proteins in GPCR-initiated signaling pathways
    • Wojcikiewicz R. J, (2004) Regulated ubiquitination of proteins in GPCR-initiated signaling pathways. Trends Pharmacol Sci 25: 35-41.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 35-41
    • Wojcikiewicz, R.J.1
  • 19
    • 38849112545 scopus 로고    scopus 로고
    • The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously
    • Lee T. V, Ding T, Chen Z, Rajendran V, Scherr H, et al. (2008) The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development 135: 43-52.
    • (2008) Development , vol.135 , pp. 43-52
    • Lee, T.V.1    Ding, T.2    Chen, Z.3    Rajendran, V.4    Scherr, H.5
  • 20
    • 52949084018 scopus 로고    scopus 로고
    • Mutation of the gene encoding the ubiquitin activating enzyme Uba1 causes tissue overgrowth in Drosophila
    • Pfleger C. M, Harvey K. F, Yan H, Hariharan I. K, (2007) Mutation of the gene encoding the ubiquitin activating enzyme Uba1 causes tissue overgrowth in Drosophila. Fly (Austin) 1: 95-105.
    • (2007) Fly (Austin) , vol.1 , pp. 95-105
    • Pfleger, C.M.1    Harvey, K.F.2    Yan, H.3    Hariharan, I.K.4
  • 21
    • 33646893705 scopus 로고    scopus 로고
    • A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    • Zhang Q, Zhang L, Wang B, Ou C. Y, Chien C. T, et al. (2006) A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell 10: 719-729.
    • (2006) Dev Cell , vol.10 , pp. 719-729
    • Zhang, Q.1    Zhang, L.2    Wang, B.3    Ou, C.Y.4    Chien, C.T.5
  • 22
    • 35148886143 scopus 로고    scopus 로고
    • Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
    • Yang Y, Kitagaki J, Dai R. M, Tsai Y. C, Lorick K. L, et al. (2007) Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res 67: 9472-9481.
    • (2007) Cancer Res , vol.67 , pp. 9472-9481
    • Yang, Y.1    Kitagaki, J.2    Dai, R.M.3    Tsai, Y.C.4    Lorick, K.L.5
  • 23
    • 0037169336 scopus 로고    scopus 로고
    • Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila
    • Lloyd T. E, Atkinson R, Wu M. N, Zhou Y, Pennetta G, et al. (2002) Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108: 261-269.
    • (2002) Cell , vol.108 , pp. 261-269
    • Lloyd, T.E.1    Atkinson, R.2    Wu, M.N.3    Zhou, Y.4    Pennetta, G.5
  • 24
    • 27644593284 scopus 로고    scopus 로고
    • Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    • Moberg K. H, Schelble S, Burdick S. K, Hariharan I. K, (2005) Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell 9: 699-710.
    • (2005) Dev Cell , vol.9 , pp. 699-710
    • Moberg, K.H.1    Schelble, S.2    Burdick, S.K.3    Hariharan, I.K.4
  • 25
    • 28544438939 scopus 로고    scopus 로고
    • Endocytic control of epithelial polarity and proliferation in Drosophila
    • Lu H, Bilder D, (2005) Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol 7: 1232-1239.
    • (2005) Nat Cell Biol , vol.7 , pp. 1232-1239
    • Lu, H.1    Bilder, D.2
  • 26
    • 33847660443 scopus 로고    scopus 로고
    • An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    • Bischof J, Maeda R. K, Hediger M, Karch F, Basler K, (2007) An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A 104: 3312-3317.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3312-3317
    • Bischof, J.1    Maeda, R.K.2    Hediger, M.3    Karch, F.4    Basler, K.5
  • 27
    • 0035834428 scopus 로고    scopus 로고
    • Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin
    • Shenoy S. K, McDonald P. H, Kohout T. A, Lefkowitz R. J, (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294: 1307-1313.
    • (2001) Science , vol.294 , pp. 1307-1313
    • Shenoy, S.K.1    McDonald, P.H.2    Kohout, T.A.3    Lefkowitz, R.J.4
  • 28
    • 67149106146 scopus 로고    scopus 로고
    • Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia
    • Sulahian R, Cleaver O, Huang L. J, (2009) Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia. Blood 113: 5287-5297.
    • (2009) Blood , vol.113 , pp. 5287-5297
    • Sulahian, R.1    Cleaver, O.2    Huang, L.J.3
  • 29
    • 11144256194 scopus 로고    scopus 로고
    • Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
    • Chen W, Ren X. R, Nelson C. D, Barak L. S, Chen J. K, et al. (2004) Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306: 2257-2260.
    • (2004) Science , vol.306 , pp. 2257-2260
    • Chen, W.1    Ren, X.R.2    Nelson, C.D.3    Barak, L.S.4    Chen, J.K.5
  • 30
    • 0033927390 scopus 로고    scopus 로고
    • kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila
    • Roman G, He J, Davis R. L, (2000) kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila. Genetics 155: 1281-1295.
    • (2000) Genetics , vol.155 , pp. 1281-1295
    • Roman, G.1    He, J.2    Davis, R.L.3
  • 31
    • 79953754361 scopus 로고    scopus 로고
    • Role of the Drosophila non-visual ss-arrestin kurtz in hedgehog signalling
    • doi:10.1371/journal.pgen.1001335
    • Molnar C, Ruiz-Gomez A, Martin M, Rojo-Berciano S, Mayor F, et al. (2011) Role of the Drosophila non-visual ss-arrestin kurtz in hedgehog signalling. PLoS Genet 7: e1001335 doi:10.1371/journal.pgen.1001335.
    • (2011) PLoS Genet , vol.7
    • Molnar, C.1    Ruiz-Gomez, A.2    Martin, M.3    Rojo-Berciano, S.4    Mayor, F.5
  • 33
    • 0030054178 scopus 로고    scopus 로고
    • Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis
    • Hicke L, Riezman H, (1996) Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84: 277-287.
    • (1996) Cell , vol.84 , pp. 277-287
    • Hicke, L.1    Riezman, H.2
  • 34
    • 0029781462 scopus 로고    scopus 로고
    • Ubiquitination of the yeast a-factor receptor
    • Roth A. F, Davis N. G, (1996) Ubiquitination of the yeast a-factor receptor. J Cell Biol 134: 661-674.
    • (1996) J Cell Biol , vol.134 , pp. 661-674
    • Roth, A.F.1    Davis, N.G.2
  • 35
    • 0038394715 scopus 로고    scopus 로고
    • Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
    • Haglund K, Sigismund S, Polo S, Szymkiewicz I, Di Fiore P. P, et al. (2003) Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol 5: 461-466.
    • (2003) Nat Cell Biol , vol.5 , pp. 461-466
    • Haglund, K.1    Sigismund, S.2    Polo, S.3    Szymkiewicz, I.4    Di Fiore, P.P.5
  • 36
    • 0037677208 scopus 로고    scopus 로고
    • Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation
    • Mosesson Y, Shtiegman K, Katz M, Zwang Y, Vereb G, et al. (2003) Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation. J Biol Chem 278: 21323-21326.
    • (2003) J Biol Chem , vol.278 , pp. 21323-21326
    • Mosesson, Y.1    Shtiegman, K.2    Katz, M.3    Zwang, Y.4    Vereb, G.5
  • 37
    • 52049117442 scopus 로고    scopus 로고
    • Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
    • Shenoy S. K, Xiao K, Venkataramanan V, Snyder P. M, Freedman N. J, et al. (2008) Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem 283: 22166-22176.
    • (2008) J Biol Chem , vol.283 , pp. 22166-22176
    • Shenoy, S.K.1    Xiao, K.2    Venkataramanan, V.3    Snyder, P.M.4    Freedman, N.J.5
  • 38
    • 34249950014 scopus 로고    scopus 로고
    • The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
    • Molnar C, Holguin H, Mayor F Jr, Ruiz-Gomez A, de Celis J. F, (2007) The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A 104: 7963-7968.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7963-7968
    • Molnar, C.1    Holguin, H.2    Mayor Jr., F.3    Ruiz-Gomez, A.4    de Celis, J.F.5
  • 39
    • 70450221494 scopus 로고    scopus 로고
    • Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
    • Cheng S, Maier D, Neubueser D, Hipfner D. R, (2010) Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol 337: 99-109.
    • (2010) Dev Biol , vol.337 , pp. 99-109
    • Cheng, S.1    Maier, D.2    Neubueser, D.3    Hipfner, D.R.4
  • 40
    • 77956805860 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    • Chen Y, Li S, Tong C, Zhao Y, Wang B, et al. (2010) G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev 24: 2054-2067.
    • (2010) Genes Dev , vol.24 , pp. 2054-2067
    • Chen, Y.1    Li, S.2    Tong, C.3    Zhao, Y.4    Wang, B.5
  • 41
    • 11144285406 scopus 로고    scopus 로고
    • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
    • Wilbanks A. M, Fralish G. B, Kirby M. L, Barak L. S, Li Y. X, et al. (2004) Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 306: 2264-2267.
    • (2004) Science , vol.306 , pp. 2264-2267
    • Wilbanks, A.M.1    Fralish, G.B.2    Kirby, M.L.3    Barak, L.S.4    Li, Y.X.5
  • 42
    • 46449127054 scopus 로고    scopus 로고
    • Beta-arrestin-mediated localization of smoothened to the primary cilium
    • Kovacs J. J, Whalen E. J, Liu R, Xiao K, Kim J, et al. (2008) Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 320: 1777-1781.
    • (2008) Science , vol.320 , pp. 1777-1781
    • Kovacs, J.J.1    Whalen, E.J.2    Liu, R.3    Xiao, K.4    Kim, J.5
  • 43
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened
    • doi:10.1371/journal.pbio.1001083
    • Chen Y, Sasai N, Ma G, Yue T, Jia J, et al. (2011) Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol 9: e1001083 doi:10.1371/journal.pbio.1001083.
    • (2011) PLoS Biol , vol.9
    • Chen, Y.1    Sasai, N.2    Ma, G.3    Yue, T.4    Jia, J.5
  • 44
    • 0034713934 scopus 로고    scopus 로고
    • Smoothened activates Galphai-mediated signaling in frog melanophores
    • DeCamp D. L, Thompson T. M, de Sauvage F. J, Lerner M. R, (2000) Smoothened activates Galphai-mediated signaling in frog melanophores. J Biol Chem 275: 26322-26327.
    • (2000) J Biol Chem , vol.275 , pp. 26322-26327
    • DeCamp, D.L.1    Thompson, T.M.2    de Sauvage, F.J.3    Lerner, M.R.4
  • 45
    • 57049085407 scopus 로고    scopus 로고
    • G protein Galpha(i) functions immediately downstream of Smoothened in Hedgehog signalling
    • Ogden S. K, Fei D. L, Schilling N. S, Ahmed Y. F, Hwa J, et al. (2008) G protein Galpha(i) functions immediately downstream of Smoothened in Hedgehog signalling. Nature.
    • (2008) Nature
    • Ogden, S.K.1    Fei, D.L.2    Schilling, N.S.3    Ahmed, Y.F.4    Hwa, J.5
  • 48
    • 77954903507 scopus 로고    scopus 로고
    • Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
    • Mukai A, Yamamoto-Hino M, Awano W, Watanabe W, Komada M, et al. (2010) Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. EMBO J 29: 2114-2125.
    • (2010) EMBO J , vol.29 , pp. 2114-2125
    • Mukai, A.1    Yamamoto-Hino, M.2    Awano, W.3    Watanabe, W.4    Komada, M.5
  • 49
    • 0028918468 scopus 로고
    • Protein kinase A and Hedgehog signalling in Drosophila limb development
    • Jiang J, Struhl G, (1995) Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell 80: 563-572.
    • (1995) Cell , vol.80 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 50
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • Jia J, Tong C, Jiang J, (2003) Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 17: 2709-2720.
    • (2003) Genes Dev , vol.17 , pp. 2709-2720
    • Jia, J.1    Tong, C.2    Jiang, J.3
  • 51
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, et al. (2003) Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 299: 2039-2045.
    • (2003) Science , vol.299 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    von Kessler, D.5
  • 52
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus
    • Zhang W, Zhao Y, Tong C, Wang G, Wang B, et al. (2005) Hedgehog-regulated costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus. Dev Cell 8: 267-278.
    • (2005) Dev Cell , vol.8 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5
  • 53
    • 0029126148 scopus 로고
    • The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
    • Motzny C. K, Holmgren R, (1995) The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech Dev 52: 137-150.
    • (1995) Mech Dev , vol.52 , pp. 137-150
    • Motzny, C.K.1    Holmgren, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.