-
1
-
-
51949085076
-
Hedgehog: functions and mechanisms
-
Varjosalo M., Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008, 22:2454-2472.
-
(2008)
Genes Dev.
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
2
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev. Cell 2008, 15:801-812.
-
(2008)
Dev. Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
3
-
-
0033711384
-
Hedgehog signalling in cancer
-
Toftgard R. Hedgehog signalling in cancer. Cell. Mol. Life Sci. 2000, 57:1720-1731.
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1720-1731
-
-
Toftgard, R.1
-
5
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
6
-
-
0028077841
-
Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos
-
Hooper J.E. Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature 1994, 372:461-464.
-
(1994)
Nature
, vol.372
, pp. 461-464
-
-
Hooper, J.E.1
-
7
-
-
0030602796
-
The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
-
Alcedo J., et al. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232.
-
(1996)
Cell
, vol.86
, pp. 221-232
-
-
Alcedo, J.1
-
8
-
-
0029784223
-
Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
-
van den Heuvel M, Ingham P.W. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 1996, 382:547-551.
-
(1996)
Nature
, vol.382
, pp. 547-551
-
-
van den Heuvel, M.1
Ingham, P.W.2
-
9
-
-
0029948270
-
Biochemical evidence that patched is the Hedgehog receptor
-
Marigo V., et al. Biochemical evidence that patched is the Hedgehog receptor. Nature 1996, 384:176-179.
-
(1996)
Nature
, vol.384
, pp. 176-179
-
-
Marigo, V.1
-
10
-
-
0030838880
-
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
-
Robbins D.J., et al. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 1997, 90:225-234.
-
(1997)
Cell
, vol.90
, pp. 225-234
-
-
Robbins, D.J.1
-
11
-
-
0030754171
-
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
-
Sisson J.C., et al. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 1997, 90:235-245.
-
(1997)
Cell
, vol.90
, pp. 235-245
-
-
Sisson, J.C.1
-
12
-
-
0031647941
-
Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs
-
Alves G., et al. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech. Dev. 1998, 78:17-31.
-
(1998)
Mech. Dev.
, vol.78
, pp. 17-31
-
-
Alves, G.1
-
13
-
-
0034721665
-
Transducing the hedgehog signal
-
Kalderon D. Transducing the hedgehog signal. Cell 2000, 103:371-374.
-
(2000)
Cell
, vol.103
, pp. 371-374
-
-
Kalderon, D.1
-
14
-
-
0036830126
-
Ligand receptor interactions in the Wnt signaling pathway in Drosophila
-
Wu C.H., Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J. Biol. Chem. 2002, 277:41762-41769.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41762-41769
-
-
Wu, C.H.1
Nusse, R.2
-
15
-
-
0033616573
-
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
-
Hsieh J.C., et al. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3546-3551.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3546-3551
-
-
Hsieh, J.C.1
-
16
-
-
1142289021
-
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
-
Nakano Y., et al. Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech Dev. 2004, 121:507-518.
-
(2004)
Mech Dev.
, vol.121
, pp. 507-518
-
-
Nakano, Y.1
-
17
-
-
67449094358
-
The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling
-
Aanstad P., et al. The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr. Biol. 2009, 19:1034-1039.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1034-1039
-
-
Aanstad, P.1
-
18
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen J.K., et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 2002, 16:2743-2748.
-
(2002)
Genes Dev.
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
-
19
-
-
0037195074
-
Small molecule modulation of Smoothened activity
-
Chen J.K., et al. Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:14071-14076.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 14071-14076
-
-
Chen, J.K.1
-
20
-
-
10644247627
-
The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices
-
Lawson Z., Wheatley M. The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices. Biochem. Soc. Trans. 2004, 32:1048-1050.
-
(2004)
Biochem. Soc. Trans.
, vol.32
, pp. 1048-1050
-
-
Lawson, Z.1
Wheatley, M.2
-
21
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
Xie J., et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998, 391:90-92.
-
(1998)
Nature
, vol.391
, pp. 90-92
-
-
Xie, J.1
-
22
-
-
0033590605
-
A frequent activated smoothened mutation in sporadic basal cell carcinomas
-
Lam C.W., et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 1999, 18:833-836.
-
(1999)
Oncogene
, vol.18
, pp. 833-836
-
-
Lam, C.W.1
-
23
-
-
0032080853
-
Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
-
Reifenberger J., et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 1998, 58:1798-1803.
-
(1998)
Cancer Res.
, vol.58
, pp. 1798-1803
-
-
Reifenberger, J.1
-
24
-
-
36049033946
-
Hedgehog regulates smoothened activity by inducing a conformational switch
-
Zhao Y., et al. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 2007, 450:252-258.
-
(2007)
Nature
, vol.450
, pp. 252-258
-
-
Zhao, Y.1
-
25
-
-
33748611621
-
Targeting the hedgehog signaling pathway with small molecules
-
Kiselyov A.S. Targeting the hedgehog signaling pathway with small molecules. Anticancer Agents Med. Chem. 2006, 6:445-449.
-
(2006)
Anticancer Agents Med. Chem.
, vol.6
, pp. 445-449
-
-
Kiselyov, A.S.1
-
26
-
-
0037158748
-
Patched acts catalytically to suppress the activity of Smoothened
-
Taipale J., et al. Patched acts catalytically to suppress the activity of Smoothened. Nature 2002, 418:892-897.
-
(2002)
Nature
, vol.418
, pp. 892-897
-
-
Taipale, J.1
-
27
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion
-
Bijlsma M.F., et al. Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol. 2006, 4:e232.
-
(2006)
PLoS Biol.
, vol.4
-
-
Bijlsma, M.F.1
-
28
-
-
65249123996
-
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
-
Wilson C.W., et al. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 2009, 4:e5182.
-
(2009)
PLoS ONE
, vol.4
-
-
Wilson, C.W.1
-
29
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran R.B., Scott M.P. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:8408-8413.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
30
-
-
34247844371
-
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells
-
Dwyer J.R., et al. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J. Biol. Chem. 2007, 282:8959-8968.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 8959-8968
-
-
Dwyer, J.R.1
-
31
-
-
44349159118
-
Multiple roles for lipids in the Hedgehog signalling pathway
-
Eaton S. Multiple roles for lipids in the Hedgehog signalling pathway. Nat. Rev. Mol. Cell Biol. 2008, 9:437-445.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 437-445
-
-
Eaton, S.1
-
32
-
-
18344378499
-
Lipoprotein particles are required for Hedgehog and Wingless signalling
-
Panakova D., et al. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005, 435:58-65.
-
(2005)
Nature
, vol.435
, pp. 58-65
-
-
Panakova, D.1
-
33
-
-
38949218488
-
Patched, the receptor of Hedgehog, is a lipoprotein receptor
-
Callejo A., et al. Patched, the receptor of Hedgehog, is a lipoprotein receptor. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:912-917.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 912-917
-
-
Callejo, A.1
-
34
-
-
71449084811
-
Patched regulates Smoothened trafficking using lipoprotein-derived lipids
-
Khaliullina H., et al. Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development 2009, 136:4111-4121.
-
(2009)
Development
, vol.136
, pp. 4111-4121
-
-
Khaliullina, H.1
-
35
-
-
67349185911
-
Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila
-
Ayers K.L., et al. Tow (Target of Wingless), a novel repressor of the Hedgehog pathway in Drosophila. Dev. Biol. 2009, 329:280-293.
-
(2009)
Dev. Biol.
, vol.329
, pp. 280-293
-
-
Ayers, K.L.1
-
36
-
-
12344305145
-
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
-
Apionishev S., et al. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat. Cell Biol. 2005, 7:86-92.
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 86-92
-
-
Apionishev, S.1
-
37
-
-
11144237279
-
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
-
Jia J., et al. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 2004, 432:1045-1050.
-
(2004)
Nature
, vol.432
, pp. 1045-1050
-
-
Jia, J.1
-
38
-
-
11144248964
-
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
-
Zhang C., et al. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:17900-17907.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 17900-17907
-
-
Zhang, C.1
-
39
-
-
48749098903
-
The role of kinases in the Hedgehog signalling pathway
-
Aikin R.A., et al. The role of kinases in the Hedgehog signalling pathway. EMBO Rep. 2008, 9:330-336.
-
(2008)
EMBO Rep.
, vol.9
, pp. 330-336
-
-
Aikin, R.A.1
-
40
-
-
31744436876
-
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
-
Varjosalo M., et al. Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev. Cell 2006, 10:177-186.
-
(2006)
Dev. Cell
, vol.10
, pp. 177-186
-
-
Varjosalo, M.1
-
41
-
-
31644442906
-
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
-
Huangfu D., Anderson K.V. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 2006, 133:3-14.
-
(2006)
Development
, vol.133
, pp. 3-14
-
-
Huangfu, D.1
Anderson, K.V.2
-
42
-
-
75549090700
-
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
-
Milenkovic L., et al. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biol. 2009, 187:365-374.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 365-374
-
-
Milenkovic, L.1
-
43
-
-
34247146469
-
Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling
-
Tiecke E., et al. Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling. Dev. Biol. 2007, 305:312-324.
-
(2007)
Dev. Biol.
, vol.305
, pp. 312-324
-
-
Tiecke, E.1
-
44
-
-
0031747997
-
The role of receptor kinases and arrestins in G protein-coupled receptor regulation
-
Krupnick J.G., Benovic J.L. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu. Rev. Pharmacol. Toxicol. 1998, 38:289-319.
-
(1998)
Annu. Rev. Pharmacol. Toxicol.
, vol.38
, pp. 289-319
-
-
Krupnick, J.G.1
Benovic, J.L.2
-
45
-
-
62349102527
-
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
-
Jia H., et al. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 2009, 136:307-316.
-
(2009)
Development
, vol.136
, pp. 307-316
-
-
Jia, H.1
-
46
-
-
3042798261
-
Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
-
Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol. Ther. 2004, 103:21-80.
-
(2004)
Pharmacol. Ther.
, vol.103
, pp. 21-80
-
-
Kristiansen, K.1
-
47
-
-
0035577854
-
Hedgehog signaling in animal development: paradigms and principles
-
Ingham P.W., McMahon A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001, 15:3059-3087.
-
(2001)
Genes Dev.
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
48
-
-
0034713934
-
Smoothened activates Galphai-mediated signaling in frog melanophores
-
DeCamp D.L., et al. Smoothened activates Galphai-mediated signaling in frog melanophores. J. Biol. Chem. 2000, 275:26322-26327.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26322-26327
-
-
DeCamp, D.L.1
-
49
-
-
33747614580
-
Activation of heterotrimeric G proteins by Smoothened
-
Riobo N.A., et al. Activation of heterotrimeric G proteins by Smoothened. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12607-12612.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 12607-12612
-
-
Riobo, N.A.1
-
50
-
-
0032519906
-
The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling
-
Hammerschmidt M., McMahon A.P. The effect of pertussis toxin on zebrafish development: a possible role for inhibitory G-proteins in hedgehog signaling. Dev. Biol. 1998, 194:166-171.
-
(1998)
Dev. Biol.
, vol.194
, pp. 166-171
-
-
Hammerschmidt, M.1
McMahon, A.P.2
-
51
-
-
49049108307
-
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
-
Low W.C., et al. The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev. Biol. 2008, 321:188-196.
-
(2008)
Dev. Biol.
, vol.321
, pp. 188-196
-
-
Low, W.C.1
-
52
-
-
0037470952
-
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
-
Lum L., et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science 2003, 299:2039-2045.
-
(2003)
Science
, vol.299
, pp. 2039-2045
-
-
Lum, L.1
-
53
-
-
34247857432
-
Pathways of signal transduction employed by vertebrate Hedgehogs
-
Riobo N.A., Manning D.R. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem. J. 2007, 403:369-379.
-
(2007)
Biochem. J.
, vol.403
, pp. 369-379
-
-
Riobo, N.A.1
Manning, D.R.2
-
54
-
-
57049085407
-
G protein Galpha(i) functions immediately downstream of Smoothened in Hedgehog signalling
-
Ogden S.K., et al. G protein Galpha(i) functions immediately downstream of Smoothened in Hedgehog signalling. Nature 2008, 456:967-970.
-
(2008)
Nature
, vol.456
, pp. 967-970
-
-
Ogden, S.K.1
-
55
-
-
0023062991
-
G proteins: transducers of receptor-generated signals
-
Gilman A.G. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 1987, 56:615-649.
-
(1987)
Annu. Rev. Biochem.
, vol.56
, pp. 615-649
-
-
Gilman, A.G.1
-
56
-
-
0028897883
-
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
-
Li W., et al. Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 1995, 80:553-562.
-
(1995)
Cell
, vol.80
, pp. 553-562
-
-
Li, W.1
-
57
-
-
0028918468
-
Protein kinase A and hedgehog signaling in Drosophila limb development
-
Jiang J., Struhl G. Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 1995, 80:563-572.
-
(1995)
Cell
, vol.80
, pp. 563-572
-
-
Jiang, J.1
Struhl, G.2
-
58
-
-
0030984470
-
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
-
Ohlmeyer J.T., Kalderon D. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 1997, 11:2250-2258.
-
(1997)
Genes Dev.
, vol.11
, pp. 2250-2258
-
-
Ohlmeyer, J.T.1
Kalderon, D.2
-
59
-
-
33645220566
-
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
-
Riobo N.A., et al. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:4505-4510.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 4505-4510
-
-
Riobo, N.A.1
-
60
-
-
31544461492
-
Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
-
Riobo N.A., et al. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res. 2006, 66:839-845.
-
(2006)
Cancer Res.
, vol.66
, pp. 839-845
-
-
Riobo, N.A.1
-
61
-
-
70450221494
-
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
-
Cheng S., et al. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev. Biol. 2009, 337:99-109.
-
(2009)
Dev. Biol.
, vol.337
, pp. 99-109
-
-
Cheng, S.1
-
62
-
-
34249950014
-
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
-
Molnar C., et al. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:7963-7968.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 7963-7968
-
-
Molnar, C.1
-
63
-
-
0035338997
-
Gprk2 controls cAMP levels in Drosophila development
-
Lannutti B.J., Schneider L.E. Gprk2 controls cAMP levels in Drosophila development. Dev. Biol. 2001, 233:174-185.
-
(2001)
Dev. Biol.
, vol.233
, pp. 174-185
-
-
Lannutti, B.J.1
Schneider, L.E.2
-
64
-
-
59349091148
-
Smoothened signaling in vertebrates is facilitated by a G Protein-coupled receptor kinase
-
Philipp M., et al. Smoothened signaling in vertebrates is facilitated by a G Protein-coupled receptor kinase. Mol. Biol. Cell 2008, 19:5478-5489.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5478-5489
-
-
Philipp, M.1
-
65
-
-
11144256194
-
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
-
Chen W., et al. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 2004, 306:2257-2260.
-
(2004)
Science
, vol.306
, pp. 2257-2260
-
-
Chen, W.1
-
66
-
-
33749590571
-
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
-
Meloni A.R., et al. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol. Cell. Biol. 2006, 26:7550-7560.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7550-7560
-
-
Meloni, A.R.1
-
67
-
-
61349202225
-
Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2
-
Atkinson P.J., et al. Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. J. Neurochem. 2009, 108:1539-1549.
-
(2009)
J. Neurochem.
, vol.108
, pp. 1539-1549
-
-
Atkinson, P.J.1
-
68
-
-
0038625111
-
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
-
Zhu A.J., et al. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 2003, 17:1240-1252.
-
(2003)
Genes Dev.
, vol.17
, pp. 1240-1252
-
-
Zhu, A.J.1
-
69
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
Denef N., et al. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000, 102:521-531.
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
-
70
-
-
0242361620
-
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
-
Jia J., et al. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 2003, 17:2709-2720.
-
(2003)
Genes Dev.
, vol.17
, pp. 2709-2720
-
-
Jia, J.1
-
71
-
-
0141728540
-
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
-
Ruel L., et al. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat. Cell Biol. 2003, 5:907-913.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 907-913
-
-
Ruel, L.1
-
72
-
-
0242625184
-
Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2
-
Ogden S.K., et al. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr. Biol. 2003, 13:1998-2003.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1998-2003
-
-
Ogden, S.K.1
-
73
-
-
0041470133
-
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
-
Chen W., et al. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 2003, 301:1391-1394.
-
(2003)
Science
, vol.301
, pp. 1391-1394
-
-
Chen, W.1
-
74
-
-
0034725650
-
The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits
-
Laporte S.A., et al. The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. J. Biol. Chem. 2000, 275:23120-23126.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23120-23126
-
-
Laporte, S.A.1
-
75
-
-
0033616494
-
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
-
Laporte S.A., et al. The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:3712-3717.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3712-3717
-
-
Laporte, S.A.1
-
76
-
-
11144285406
-
Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
-
Wilbanks A.M., et al. Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. Science 2004, 306:2264-2267.
-
(2004)
Science
, vol.306
, pp. 2264-2267
-
-
Wilbanks, A.M.1
-
77
-
-
0035852697
-
Beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
-
Kohout T.A., et al. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:1601-1606.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 1601-1606
-
-
Kohout, T.A.1
-
78
-
-
0242581681
-
Hedgehog signalling in the mouse requires intraflagellar transport proteins
-
Huangfu D., et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 2003, 426:83-87.
-
(2003)
Nature
, vol.426
, pp. 83-87
-
-
Huangfu, D.1
-
79
-
-
26644460824
-
Vertebrate Smoothened functions at the primary cilium
-
Corbit K.C., et al. Vertebrate Smoothened functions at the primary cilium. Nature 2005, 437:1018-1021.
-
(2005)
Nature
, vol.437
, pp. 1018-1021
-
-
Corbit, K.C.1
-
80
-
-
62549159642
-
Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process
-
Rohatgi R., et al. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:3196-3201.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 3196-3201
-
-
Rohatgi, R.1
-
81
-
-
62449174504
-
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
-
Wang Y., et al. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2623-2628.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2623-2628
-
-
Wang, Y.1
-
82
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium
-
Rohatgi R., et al. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007, 317:372-376.
-
(2007)
Science
, vol.317
, pp. 372-376
-
-
Rohatgi, R.1
-
83
-
-
40749144679
-
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
-
Haycraft C.J., et al. Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 2005, 1:e53.
-
(2005)
PLoS Genet.
, vol.1
-
-
Haycraft, C.J.1
-
84
-
-
46449127054
-
Beta-arrestin-mediated localization of smoothened to the primary cilium
-
Kovacs J.J., et al. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 2008, 320:1777-1781.
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
-
85
-
-
44449106038
-
Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors
-
Berbari N.F., et al. Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors. Mol. Biol. Cell 2008, 19:1540-1547.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 1540-1547
-
-
Berbari, N.F.1
-
86
-
-
33745255998
-
Flies without centrioles
-
Basto R., et al. Flies without centrioles. Cell 2006, 125:1375-1386.
-
(2006)
Cell
, vol.125
, pp. 1375-1386
-
-
Basto, R.1
-
87
-
-
49849093519
-
Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway
-
Farzan S.F., et al. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr. Biol. 2008, 18:1215-1220.
-
(2008)
Curr. Biol.
, vol.18
, pp. 1215-1220
-
-
Farzan, S.F.1
-
88
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch R.L., et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009, 326:572-574.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
-
89
-
-
0037172658
-
Sonic hedgehog induces the segregation of patched and smoothened in endosomes
-
Incardona J.P., et al. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr. Biol. 2002, 12:983-995.
-
(2002)
Curr. Biol.
, vol.12
, pp. 983-995
-
-
Incardona, J.P.1
-
90
-
-
33947383373
-
The cell biology of Smo signalling and its relationships with GPCRs
-
Ruiz-Gomez A., et al. The cell biology of Smo signalling and its relationships with GPCRs. Biochim. Biophys. Acta 2007, 1768:901-912.
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 901-912
-
-
Ruiz-Gomez, A.1
-
91
-
-
0036729484
-
Seven-transmembrane receptors
-
Pierce K.L., et al. Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 2002, 3:639-650.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 639-650
-
-
Pierce, K.L.1
-
92
-
-
33947424008
-
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling
-
Ribas C., et al. The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim. Biophys. Acta 2007, 1768:913-922.
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 913-922
-
-
Ribas, C.1
-
93
-
-
58449102096
-
The primary cilium: a small yet mighty organelle
-
DeRouen M.C., Oro A.E. The primary cilium: a small yet mighty organelle. J. Invest. Dermatol. 2009, 129:264-265.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 264-265
-
-
DeRouen, M.C.1
Oro, A.E.2
-
95
-
-
33746171099
-
The primary cilium in cell signaling and cancer
-
Michaud E.J., Yoder B.K. The primary cilium in cell signaling and cancer. Cancer Res. 2006, 66:6463-6467.
-
(2006)
Cancer Res.
, vol.66
, pp. 6463-6467
-
-
Michaud, E.J.1
Yoder, B.K.2
-
96
-
-
36849008176
-
The primary cilia, a 'Rab-id' transit system for hedgehog signaling
-
Oro A.E. The primary cilia, a 'Rab-id' transit system for hedgehog signaling. Curr. Opin. Cell Biol. 2007, 19:691-696.
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 691-696
-
-
Oro, A.E.1
-
97
-
-
58749105340
-
Modeling ciliopathies: Primary cilia in development and disease
-
Quinlan R.J., et al. Modeling ciliopathies: Primary cilia in development and disease. Curr. Top. Dev. Biol. 2008, 84:249-310.
-
(2008)
Curr. Top. Dev. Biol.
, vol.84
, pp. 249-310
-
-
Quinlan, R.J.1
-
98
-
-
61649116183
-
Primary cilia and signaling pathways in mammalian development, health and disease
-
Veland I.R., et al. Primary cilia and signaling pathways in mammalian development, health and disease. Nephron. Physiol. 2009, 111:39-53.
-
(2009)
Nephron. Physiol.
, vol.111
, pp. 39-53
-
-
Veland, I.R.1
-
99
-
-
58149333235
-
The primary cilium at the crossroads of mammalian hedgehog signaling
-
Wong S.Y., Reiter J.F. The primary cilium at the crossroads of mammalian hedgehog signaling. Curr. Top. Dev. Biol. 2008, 85:225-260.
-
(2008)
Curr. Top. Dev. Biol.
, vol.85
, pp. 225-260
-
-
Wong, S.Y.1
Reiter, J.F.2
-
100
-
-
58149326846
-
Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling
-
Pedersen L.B., Rosenbaum J.L. Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr. Top. Dev. Biol. 2008, 85:23-61.
-
(2008)
Curr. Top. Dev. Biol.
, vol.85
, pp. 23-61
-
-
Pedersen, L.B.1
Rosenbaum, J.L.2
-
101
-
-
34548306769
-
Patching the gaps in Hedgehog signalling
-
Rohatgi R., Scott M.P. Patching the gaps in Hedgehog signalling. Nat. Cell Biol. 2007, 9:1005-1009.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1005-1009
-
-
Rohatgi, R.1
Scott, M.P.2
-
102
-
-
65549170297
-
Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
-
Wilson C.W., et al. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature 2009, 459:98-102.
-
(2009)
Nature
, vol.459
, pp. 98-102
-
-
Wilson, C.W.1
-
103
-
-
69449084098
-
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
-
Cheung H.O., et al. The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci. Signal. 2009, 2:ra29.
-
(2009)
Sci. Signal.
, vol.2
-
-
Cheung, H.O.1
-
104
-
-
68149178664
-
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development
-
Endoh-Yamagami S., et al. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 2009, 19:1320-1326.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1320-1326
-
-
Endoh-Yamagami, S.1
-
105
-
-
69449099121
-
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
-
Liem K.F., et al. Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:13377-13382.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 13377-13382
-
-
Liem, K.F.1
-
106
-
-
0026761497
-
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster
-
Preat T. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics 1992, 132:725-736.
-
(1992)
Genetics
, vol.132
, pp. 725-736
-
-
Preat, T.1
-
107
-
-
0033789068
-
Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
-
Methot N., Basler K. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development 2000, 127:4001-4010.
-
(2000)
Development
, vol.127
, pp. 4001-4010
-
-
Methot, N.1
Basler, K.2
-
108
-
-
31744451535
-
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
-
Svard J., et al. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev. Cell 2006, 10:187-197.
-
(2006)
Dev. Cell
, vol.10
, pp. 187-197
-
-
Svard, J.1
-
109
-
-
27644584608
-
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
-
Cooper A.F., et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 2005, 132:4407-4417.
-
(2005)
Development
, vol.132
, pp. 4407-4417
-
-
Cooper, A.F.1
|