rasp, a putative transmembrane acyltransferase, is required for Hedgehog

Development

Volumn 129, Issue 4, 2002, Pages 843-851

  Micchelli, Craig A ^a   The, Inge ^a   Selva, Erica ^a   Mogila, Vladic ^a   Perrimon, Norbert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Acyltransferase; Drosophila; Hedgehog; rasp; Wing imaginal disc

Indexed keywords

ACYLTRANSFERASE; CYSTEINE; MEMBRANE PROTEIN; RASP PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO POLARITY; FEMALE; FORELIMB; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC SCREENING; GENETIC TRANSCRIPTION; IMAGINAL DISC; INVERTEBRATE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE; ZYGOTE;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHENOTYPE; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS);

ANIMALIA; ERINACEIDAE; EUKARYOTA; INVERTEBRATA; VERTEBRATA;

EID: 0036339605     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Transcription of the segment polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupal-lethal wg mutant
2. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
3. Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila
4. Shaggy (zeste-white 3) and the formation of supernumerary bristle precursors in the developing wing blade of Drosophila
5. Imaginal discs
6. Smoothened-mediated Hedgehog signaling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila
7. Roles of wingless in patterning the larval epidermis of Drosophila
8. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
9. Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
10. Dispatched, a novel sterol-sensinng domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
11. The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
12. Protein lipidation in cell signaling
13. Skinny hedgehog, an acyltransferase for palmitoylation and activity of the hedgehog signal
14. Dual roles for patched in sequestering and transducing hedgehog
15. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster
16. On the range of Hedgehog signaling
17. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis
18. Repression of ci-D in the posterior compartment of Drosophila by engrailed
19. Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-nediated signaling which is spatially controlled through wingless
20. Type 1 repressors of P element mobility
21. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis
22. The world according to hedgehog
23. One-, two-, and three-color whole-mount in situ hybridization to Drosophila embryos
24. A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling
25. Role of Drosophila patched gene in positional signaling
26. The segment polarity gene procupine encodes a putative multitransmembrane protein involved in Wingless processing
27. N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
28. Morphogens, compartments, and pattern: Lessons from Drosophila?
29. Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
30. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
31. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
32. Secretion and localized transcription suggests a role in positional signaling for products of the segmentation gene hedghog
33. Autoproteolysis in hedgehog protein biogenesis
34. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
35. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
36. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
37. Pattern specific expression of the Drosophila decapentapalegic gene in imaginal disks is regulated by 3′ cis-regulatory elements
38. Maternal products of two new genes, rasp and grater are required for the segmentation of the Drosophila embryo
39. Reversible palmitoylation of signaling proteins
40. Direct and long-range action of a DPP morphogen gradient
41. A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
42. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
43. Identification of a palmitic acid-modified form of human sonic hedgehog
44. The Drosophila segment polarity gene patched is involved in a positional signaling mechanism in imaginal discs
45. Wingless expressing mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development
46. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
47. Hedgehog patterning activity: Role of a lipophillic modification medicated by the carboxy-terminal autoprocessing domain
48. Cholesterol modification of hedgehog signaling proteins in animal development
49. Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins
50. Control of compartmental affinity boundaries by Hedgehog
51. Drawing a stripe in Drosophila imaginal disks: Regative regulation of decapentaplegic and patched expression by engrailed
52. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
53. Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen
54. Hedgehog acts by distinct gradint and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen
55. Creating a Drosophila wing de novo, the role of engrailed and the compartment border hypothesis
56. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
57. Genetic analysis of chomosome region 63 of Drosophila melanogaster
58. Evidence for engrailed-independent wingless autoregulation in Drosophila
59. Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing
60. Direct and long-range action of a wingless morphogen gradient