Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 50, 2009, Pages 21191-21196

  Zhang, Qing ^a,c   Shi, Qing ^a   Chen, Yongbin ^a   Yue, Tao ^a   Li, Shuang ^a   Wang, Bing ^a   Jiang, Jin ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NANJING UNIVERSITY   (China)

Author keywords

BTB; E3 ligase; Gli2; Gli3; Hedgehog

Indexed keywords

DIMER; OLIGOMER; SERINE; SONIC HEDGEHOG PROTEIN; THREONINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CUBITUS INTERRUPTUS; TRANSCRIPTION FACTOR GLI; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME SUBSTRATE; IN VIVO STUDY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF;

3T3 CELLS; ANIMALS; CULLIN PROTEINS; DROSOPHILA PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; NUCLEAR PROTEINS; PROTEIN STABILITY; REPRESSOR PROTEINS; SERINE; THREONINE; UBIQUITIN-PROTEIN LIGASES;

CUBITUS INTERRUPTUS; ERINACEIDAE;

EID: 75849129292     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912008106     Document Type: Article

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