Enhanced potency of human Sonic hedgehog by hydrophobic modification

Biochemistry

Volumn 40, Issue 14, 2001, Pages 4359-4371

  Taylor, F R ^a   Wen, D ^a   Garber, E A ^a   Carmillo, A N ^a   Baker, D P ^a   Arduini, R M ^a   Williams, K P ^a   Weinreb, P H ^a   Rayhorn, P ^a   Hronowski, X ^a   Whitty, A ^a   Day, E S ^a   Boriack Sjodin, A ^a   Shapiro, R I ^a   Galdes, A ^a   Pepinsky, R B ^a  

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SIGNALING ASSAYS;

CHOLESTEROL; FATTY ACIDS; HYDROPHILICITY; HYDROPHOBICITY;

PROTEINS;

SONIC HEDGEHOG PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CIRCULAR DICHROISM; HYDROPHOBICITY; INTERNALIZATION; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

ACYL COENZYME A; AMIDES; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CIRCULAR DICHROISM; CYSTEINE; ETHYLMALEIMIDE; FATTY ACIDS; FORMALDEHYDE; HEDGEHOG PROTEINS; HUMANS; INDICATORS AND REAGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IODOACETAMIDE; MEMBRANE PROTEINS; MICE; MICE, INBRED C3H; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFHYDRYL COMPOUNDS; THIAZOLES; THIAZOLIDINES; TRANS-ACTIVATORS; UP-REGULATION;

ERINACEIDAE;

EID: 0035836505     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi002487u     Document Type: Article

References (56)