Antipsychotic drugs regulate Hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels

Molecular Pharmacology

Volumn 78, Issue 3, 2010, Pages 486-496

  Lauth, Matthias ^a,b   Rohnalter, Verena ^a   Bergström, Åsa ^b   Kooshesh, Mahsa ^b   Svenningsson, Per ^b   Toftgård, Rune ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(2 CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE; 7 DEHYDROCHOLESTEROL; 7 DEHYDROCHOLESTEROL REDUCTASE; CHLORPROMAZINE; CLOZAPINE; DIAMINE; GLI ANTAGONIST 61; HALOPERIDOL; IMIPRAMINE; NEUROLEPTIC AGENT; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; 7-DEHYDROCHOLESTEROL; 7-DEHYDROCHOLESTEROL REDUCTASE; G PROTEIN COUPLED RECEPTOR; GLI1 PROTEIN, HUMAN; OXIDOREDUCTASE; SMO PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; 3T3 CELL LINE; ANIMAL; C57BL MOUSE; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIPSYCHOTIC AGENTS; DEHYDROCHOLESTEROLS; MALE; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANS-1,4-BIS(2-CHLOROBENZAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 77956241933     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.066431     Document Type: Article

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