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Volumn 4, Issue 12, 2012, Pages 899-916

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

Author keywords

Aging; Growth; MTOR; mTOR target of rapamycin

Indexed keywords


EID: 84874807522     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100528     Document Type: Article
Times cited : (48)

References (239)
  • 2
    • 18244393163 scopus 로고    scopus 로고
    • Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds
    • Vina J, Borras C, Gambini J, Sastre J, Pallardo FV. Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. FEBS Lett. 2005; 579: 2541-2545.
    • (2005) FEBS Lett , vol.579 , pp. 2541-2545
    • Vina, J.1    Borras, C.2    Gambini, J.3    Sastre, J.4    Pallardo, F.V.5
  • 3
    • 36849075408 scopus 로고    scopus 로고
    • Sex differences in ageing in natural populations of vertebrates
    • Clutton-Brock TH, Isvaran K. Sex differences in ageing in natural populations of vertebrates. Proc Biol Sci. 2007; 274: 3097-3104.
    • (2007) Proc Biol Sci , vol.274 , pp. 3097-3104
    • Clutton-Brock, T.H.1    Isvaran, K.2
  • 5
    • 33745960190 scopus 로고    scopus 로고
    • Why women live longer than men: sex differences in longevity
    • Austad SN. Why women live longer than men: sex differences in longevity. Gend Med. 2006; 3: 79-92.
    • (2006) Gend Med , vol.3 , pp. 79-92
    • Austad, S.N.1
  • 6
    • 79952118505 scopus 로고    scopus 로고
    • Joint influence of small-effect genetic variants on human longevity
    • Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Joint influence of small-effect genetic variants on human longevity. Aging (Albany NY). 2010; 2: 612-620.
    • (2010) Aging (Albany NY) , vol.2 , pp. 612-620
    • Yashin, A.I.1    Wu, D.2    Arbeev, K.G.3    Ukraintseva, S.V.4
  • 7
    • 84862820802 scopus 로고    scopus 로고
    • Gender and the regulation of longevity: implications for autoimmunity
    • Pan Z, Chang C. Gender and the regulation of longevity: implications for autoimmunity. Autoimmun Rev. 2012; 11: A393-403.
    • (2012) Autoimmun Rev , vol.11
    • Pan, Z.1    Chang, C.2
  • 8
    • 0036984941 scopus 로고    scopus 로고
    • Life with and without disease: women experience more of both
    • Crimmins EM, Kim JK, Hagedorn A. Life with and without disease: women experience more of both. J Women Aging. 2002; 14: 47-59.
    • (2002) J Women Aging , vol.14 , pp. 47-59
    • Crimmins, E.M.1    Kim, J.K.2    Hagedorn, A.3
  • 9
    • 37449031983 scopus 로고    scopus 로고
    • Sex differences in ageing in natural populations of mammals and birds
    • Gowaty PA. Sex differences in ageing in natural populations of mammals and birds. J Biosci. 2007; 32: 1221-1222.
    • (2007) J Biosci , vol.32 , pp. 1221-1222
    • Gowaty, P.A.1
  • 11
    • 79952264996 scopus 로고    scopus 로고
    • Why the disposable soma theory cannot explain why women live longer and why we age
    • Blagosklonny MV. Why the disposable soma theory cannot explain why women live longer and why we age. Aging (Albany NY). 2010; 2: 884-887.
    • (2010) Aging (Albany NY) , vol.2 , pp. 884-887
    • Blagosklonny, M.V.1
  • 12
    • 77955739991 scopus 로고    scopus 로고
    • Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
    • Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging (Albany NY). 2010; 2: 265-273.
    • (2010) Aging (Albany NY) , vol.2 , pp. 265-273
    • Blagosklonny, M.V.1
  • 13
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000; 103: 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 14
    • 36749047009 scopus 로고    scopus 로고
    • Amino acids and mTOR signalling in anabolic function
    • Proud CG. Amino acids and mTOR signalling in anabolic function. Biochem Soc Trans. 2007; 35: 1187-1190.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1187-1190
    • Proud, C.G.1
  • 17
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 18
    • 77951898362 scopus 로고    scopus 로고
    • Double trouble: when sonic hedgehog signaling meets TSC inactivation
    • Bhatia B, Nahle Z, Kenney AM. Double trouble: when sonic hedgehog signaling meets TSC inactivation. Cell Cycle. 2010; 9: 456-459.
    • (2010) Cell Cycle , vol.9 , pp. 456-459
    • Bhatia, B.1    Nahle, Z.2    Kenney, A.M.3
  • 19
    • 77953512889 scopus 로고    scopus 로고
    • mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes
    • Tsang CK, Liu H, Zheng XF. mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes. Cell Cycle. 2010; 9: 953-957.
    • (2010) Cell Cycle , vol.9 , pp. 953-957
    • Tsang, C.K.1    Liu, H.2    Zheng, X.F.3
  • 21
    • 77955463146 scopus 로고    scopus 로고
    • Nutrient regulation of mTORC1 and cell growth
    • Yan L, Mieulet V, Lamb RF. Nutrient regulation of mTORC1 and cell growth. Cell Cycle. 2010; 9: 2473-2474.
    • (2010) Cell Cycle , vol.9 , pp. 2473-2474
    • Yan, L.1    Mieulet, V.2    Lamb, R.F.3
  • 23
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: a common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging (Albany NY). 2009; 1: 357-362.
    • (2009) Aging (Albany NY) , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 26
    • 82855170875 scopus 로고    scopus 로고
    • TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy
    • Pena-Llopis S, Brugarolas J. TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy. Cell Cycle. 2011; 10: 3987-3988.
    • (2011) Cell Cycle , vol.10 , pp. 3987-3988
    • Pena-Llopis, S.1    Brugarolas, J.2
  • 27
    • 79957880743 scopus 로고    scopus 로고
    • Cell cycle arrest is not senescence
    • Blagosklonny MV. Cell cycle arrest is not senescence. Aging (Albany NY). 2011; 3: 94-101.
    • (2011) Aging (Albany NY) , vol.3 , pp. 94-101
    • Blagosklonny, M.V.1
  • 31
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7: 3355-3361.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 33
    • 67649369064 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
    • Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle. 2009; 8: 1896-1900.
    • (2009) Cell Cycle , vol.8 , pp. 1896-1900
    • Demidenko, Z.N.1    Shtutman, M.2    Blagosklonny, M.V.3
  • 35
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY). 2009; 1: 1008-1016.
    • (2009) Aging (Albany NY) , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 36
    • 78349286289 scopus 로고    scopus 로고
    • Weak p53 permits senescence during cell cycle arrest
    • Leontieva O, Gudkov A, Blagosklonny M. Weak p53 permits senescence during cell cycle arrest. Cell Cycle. 2010; 9: 4323-4327.
    • (2010) Cell Cycle , vol.9 , pp. 4323-4327
    • Leontieva, O.1    Gudkov, A.2    Blagosklonny, M.3
  • 37
    • 79961099905 scopus 로고    scopus 로고
    • From growing to secreting: new roles for mTOR in aging cells
    • Pani G. From growing to secreting: new roles for mTOR in aging cells. Cell Cycle. 2011; 10: 2450-2453.
    • (2011) Cell Cycle , vol.10 , pp. 2450-2453
    • Pani, G.1
  • 38
    • 84862891914 scopus 로고    scopus 로고
    • Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
    • Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY). 2012; 4: 159-165.
    • (2012) Aging (Albany NY) , vol.4 , pp. 159-165
    • Blagosklonny, M.V.1
  • 40
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY). 2010; 2: 924-935.
    • (2010) Aging (Albany NY) , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 41
    • 84871503188 scopus 로고    scopus 로고
    • Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
    • Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle. 2012; 11: 4642-4649.
    • (2012) Cell Cycle , vol.11 , pp. 4642-4649
    • Leontieva, O.V.1    Lenzo, F.2    Demidenko, Z.N.3    Blagosklonny, M.V.4
  • 43
    • 75549090275 scopus 로고    scopus 로고
    • mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009; 2: ra75.
    • (2009) Sci Signal , vol.2
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 44
    • 84855518671 scopus 로고    scopus 로고
    • A new path to longevity
    • Stipp D. A new path to longevity. Sci Am. 2012; 306: 32-39.
    • (2012) Sci Am , vol.306 , pp. 32-39
    • Stipp, D.1
  • 46
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004; 14: 885-890.47.
    • (2004) Curr Biol. 2004; , vol.14 , Issue.47 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 47
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development. 2004; 131: 3897-3906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 48
    • 38349093613 scopus 로고    scopus 로고
    • Remarkable longevity and stress resistance of nematode PI3Knull mutants
    • Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3Knull mutants. Aging Cell. 2008; 7: 13-22.
    • (2008) Aging Cell , vol.7 , pp. 13-22
    • Ayyadevara, S.1    Alla, R.2    Thaden, J.J.3    Shmookler Reis, R.J.4
  • 50
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010; 11: 453-465.
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6    Kockel, L.7
  • 54
    • 79954632599 scopus 로고    scopus 로고
    • Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
    • Katewa SD, Kapahi P. Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp Gerontol. 2011; 46: 382-390.
    • (2011) Exp Gerontol , vol.46 , pp. 382-390
    • Katewa, S.D.1    Kapahi, P.2
  • 56
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    • Partridge L, Alic N, Bjedov I, Piper MD. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol. 2011; 46: 376-381.
    • (2011) Exp Gerontol , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.4
  • 57
    • 84055184879 scopus 로고    scopus 로고
    • Rapamycin for life: a step to immortality
    • Demidenko ZN. Rapamycin for life: a step to immortality. Cell Cycle. 2011; 10: 4206.
    • (2011) Cell Cycle , vol.10 , pp. 4206
    • Demidenko, Z.N.1
  • 59
    • 77956821499 scopus 로고    scopus 로고
    • Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance
    • Haselton A, Sharmin E, Schrader J, Sah M, Poon P, Fridell YW. Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance. Cell Cycle. 2010; 9: 3063-3071.
    • (2010) Cell Cycle , vol.9 , pp. 3063-3071
    • Haselton, A.1    Sharmin, E.2    Schrader, J.3    Sah, M.4    Poon, P.5    Fridell, Y.W.6
  • 60
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5: 2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 61
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today. 2007; 12: 112-124.
    • (2007) Drug Disc Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 62
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSCmTOR pathway in human disease
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSCmTOR pathway in human disease. Nat Genet. 2005; 37: 19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 63
    • 67650602355 scopus 로고    scopus 로고
    • Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
    • Chen WQ, Zhong L, Zhang L, Ji XP, Zhang M, Zhao YX, Zhang C, Zhang Y. Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels. Br J Pharmacol. 2009; 156: 941-951.
    • (2009) Br J Pharmacol , vol.156 , pp. 941-951
    • Chen, W.Q.1    Zhong, L.2    Zhang, L.3    Ji, X.P.4    Zhang, M.5    Zhao, Y.X.6    Zhang, C.7    Zhang, Y.8
  • 64
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging (Allbany NY). 2009; 1: 281-288.
    • (2009) Aging (Allbany NY) , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 65
    • 84866494334 scopus 로고    scopus 로고
    • Prospective treatment of age-related diseases by slowing down aging
    • Blagosklonny MV. Prospective treatment of age-related diseases by slowing down aging. Am J Pathol. 2012; 181: 1142-1146.
    • (2012) Am J Pathol , vol.181 , pp. 1142-1146
    • Blagosklonny, M.V.1
  • 67
    • 80052084689 scopus 로고    scopus 로고
    • mTOR pathway activation in age-related retinal disease
    • Zhao C, Vollrath D. mTOR pathway activation in age-related retinal disease. Aging (Albany NY). 2011; 3: 346-347.
    • (2011) Aging (Albany NY) , vol.3 , pp. 346-347
    • Zhao, C.1    Vollrath, D.2
  • 70
    • 79959539851 scopus 로고    scopus 로고
    • Normalizing a hyperactive mTOR initiates muscle growth during obesity
    • Williamson DL. Normalizing a hyperactive mTOR initiates muscle growth during obesity. Aging (Albany NY). 2011; 3: 83-84.
    • (2011) Aging (Albany NY) , vol.3 , pp. 83-84
    • Williamson, D.L.1
  • 73
    • 84862881961 scopus 로고    scopus 로고
    • Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
    • Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012; 11: 2391-2401.
    • (2012) Cell Cycle , vol.11 , pp. 2391-2401
    • Kolesnichenko, M.1    Hong, L.2    Liao, R.3    Vogt, P.K.4    Sun, P.5
  • 75
    • 79952260219 scopus 로고    scopus 로고
    • mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging
    • Wesierska-Gadek J. mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging. Aging (Albany NY). 2010; 2: 892-893.
    • (2010) Aging (Albany NY) , vol.2 , pp. 892-893
    • Wesierska-Gadek, J.1
  • 77
    • 77957012074 scopus 로고    scopus 로고
    • Decision-making by p53 and mTOR
    • Maki CG. Decision-making by p53 and mTOR. Aging (Albany NY). 2010; 2: 324-326.
    • (2010) Aging (Albany NY) , vol.2 , pp. 324-326
    • Maki, C.G.1
  • 78
    • 78349246236 scopus 로고    scopus 로고
    • Shifting senescence into quiescence by turning up p53
    • Serrano M. Shifting senescence into quiescence by turning up p53. Cell Cycle. 2010; 9: 4256-4257.
    • (2010) Cell Cycle , vol.9 , pp. 4256-4257
    • Serrano, M.1
  • 79
    • 84863430906 scopus 로고    scopus 로고
    • Status of mTOR activity may phenotypically differentiate senescence and quiescence
    • Cho S, Hwang ES. Status of mTOR activity may phenotypically differentiate senescence and quiescence. Mol Cells. 2012; 33: 597-604.
    • (2012) Mol Cells , vol.33 , pp. 597-604
    • Cho, S.1    Hwang, E.S.2
  • 80
    • 80655140600 scopus 로고    scopus 로고
    • mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging
    • Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez-Martin A. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle. 2011; 10: 3658-3677.
    • (2011) Cell Cycle , vol.10 , pp. 3658-3677
    • Menendez, J.A.1    Vellon, L.2    Oliveras-Ferraros, C.3    Cufi, S.4    Vazquez-Martin, A.5
  • 81
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers RWr, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006; 20: 174-184.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 82
    • 83755206860 scopus 로고    scopus 로고
    • Rapamycin: killing two birds with one stone
    • Khanna A, Kapahi P. Rapamycin: killing two birds with one stone. Aging (Albany NY). 2011; 3: 1043-1044.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1043-1044
    • Khanna, A.1    Kapahi, P.2
  • 83
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival ofDrosophila melanogaster
    • Moskalev AA, Shaposhnikov MV. Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival ofDrosophila melanogaster. Rejuvenation Res. 2010; 13: 246-247.
    • (2010) Rejuvenation Res , vol.13 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 84
    • 54849431380 scopus 로고    scopus 로고
    • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
    • Polak P, Cybulski N, Feige JN, Auwerx J, RŸegg MA, Hall MN. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 2008; 8: 399-410.
    • (2008) Cell Metab , vol.8 , pp. 399-410
    • Polak, P.1    Cybulski, N.2    Feige, J.N.3    Auwerx, J.4    Rÿegg, M.A.5    Hall, M.N.6
  • 91
    • 83755186591 scopus 로고    scopus 로고
    • Intermittent supplementation with rapamycin as a dietary restriction mimetic
    • Longo VD, Fontana L. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY). 2011; 3: 1039-1040.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1039-1040
    • Longo, V.D.1    Fontana, L.2
  • 92
    • 32044435126 scopus 로고    scopus 로고
    • Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
    • Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev. 2006; 20: 267-275.
    • (2006) Genes Dev , vol.20 , pp. 267-275
    • Levine, A.J.1    Feng, Z.2    Mak, T.W.3    You, H.4    Jin, S.5
  • 93
    • 79952691843 scopus 로고    scopus 로고
    • The p53 inducing drug dosage may determine quiescence or senescence
    • Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY). 2010; 2: 748.
    • (2010) Aging (Albany NY) , vol.2 , pp. 748
    • Lane, D.P.1    Verma, C.2    Fang, C.C.3
  • 94
    • 77958491663 scopus 로고    scopus 로고
    • p53 and senescence: a little goes a long way
    • Long JS, Ryan KM. p53 and senescence: a little goes a long way. Cell Cycle. 2010; 9: 4050-4051.
    • (2010) Cell Cycle , vol.9 , pp. 4050-4051
    • Long, J.S.1    Ryan, K.M.2
  • 95
    • 79952116991 scopus 로고    scopus 로고
    • TP53 and MTOR crosstalk to regulate cellular senescence
    • Galluzzi L, Kepp O, Kroemer G. TP53 and MTOR crosstalk to regulate cellular senescence. Aging (Albany NY). 2010; 2: 535-537.
    • (2010) Aging (Albany NY) , vol.2 , pp. 535-537
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 98
    • 79959238659 scopus 로고    scopus 로고
    • Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
    • Chao SK, Horwitz SB, McDaid HM. Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget. 2011; 2: 89-98.
    • (2011) Oncotarget , vol.2 , pp. 89-98
    • Chao, S.K.1    Horwitz, S.B.2    McDaid, H.M.3
  • 101
    • 77956416235 scopus 로고    scopus 로고
    • Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53? Cell Cycle
    • Roemer K. Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53? Cell Cycle. 2010; 9: 3438-3441.
    • (2010) , vol.9 , pp. 3438-3441
    • Roemer, K.1
  • 102
    • 80052102573 scopus 로고    scopus 로고
    • Pharmacological inhibition of NF-kappaB prolongs lifespan of Drosophila melanogaster
    • Moskalev A, Shaposhnikov M. Pharmacological inhibition of NF-kappaB prolongs lifespan of Drosophila melanogaster. Aging (Albany NY). 2011; 3: 391-394.
    • (2011) Aging (Albany NY) , vol.3 , pp. 391-394
    • Moskalev, A.1    Shaposhnikov, M.2
  • 108
    • 79952275086 scopus 로고    scopus 로고
    • Metformin and sex: Why suppression of aging may be harmful to young male mice
    • Blagosklonny MV. Metformin and sex: Why suppression of aging may be harmful to young male mice. Aging (Albany NY). 2010; 2: 897-899.
    • (2010) Aging (Albany NY) , vol.2 , pp. 897-899
    • Blagosklonny, M.V.1
  • 110
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle. 2010; 9: 3151-3156.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 111
    • 78049499910 scopus 로고    scopus 로고
    • Why human lifespan is rapidly increasing: solving longevity revealed-slow-aginghypothesis
    • Blagosklonny MV. Why human lifespan is rapidly increasing: solving longevity riddle" with revealed-slow-aging hypothesis. Aging (Albany NY). 2010; 9; 177-182.
    • (2010) Aging (Albany NY) , vol.9 , pp. 177-182
    • Blagosklonny, M.V.1
  • 112
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging: Four years later
    • Blagosklonny MV. Rapamycin and quasi-programmed aging: Four years later. Cell Cycle. 2010; 9: 1859-1862.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 113
    • 83755206847 scopus 로고    scopus 로고
    • Hormesis does not make sense except in the light of TOR-driven aging
    • Blagosklonny MV. Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY). 2011; 3: 1051-1062.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1051-1062
    • Blagosklonny, M.V.1
  • 114
    • 3242892160 scopus 로고    scopus 로고
    • The multifaceted role of mTOR in cellular stress responses
    • Proud CG. The multifaceted role of mTOR in cellular stress responses. DNA Repair. 2004; 3: 927-934.
    • (2004) DNA Repair , vol.3 , pp. 927-934
    • Proud, C.G.1
  • 116
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010; 40: 310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 117
    • 79960470913 scopus 로고    scopus 로고
    • mTOR complex 2 signaling and functions
    • Oh WJ, Jacinto E. mTOR complex 2 signaling and functions. Cell Cycle. 2011; 10: 2305-2316.
    • (2011) Cell Cycle , vol.10 , pp. 2305-2316
    • Oh, W.J.1    Jacinto, E.2
  • 118
    • 83455177213 scopus 로고    scopus 로고
    • Target of rapamycin (TOR) in nutrient signaling and growth control
    • Loewith R, Hall MN. Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics. 2011; 189: 1177-1201.
    • (2011) Genetics , vol.189 , pp. 1177-1201
    • Loewith, R.1    Hall, M.N.2
  • 119
    • 34249679614 scopus 로고    scopus 로고
    • Thomas G. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
    • Dann SG, Selvaraj A, Thomas G. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med. 2007; 13: 252-259.
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2
  • 120
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004; 18: 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 121
    • 34047095297 scopus 로고    scopus 로고
    • The Two TORCs and Akt
    • Bhaskar PT, Hay N. The Two TORCs and Akt. Dev Cell. 2007; 12: 487-502.
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 122
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 124
    • 80052915403 scopus 로고    scopus 로고
    • Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)
    • Vazquez-Martin A, Cufi S, Oliveras-Ferraros C, Menendez JA. Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs). Cell Cycle. 2011; 10: 3140-3152.
    • (2011) Cell Cycle , vol.10 , pp. 3140-3152
    • Vazquez-Martin, A.1    Cufi, S.2    Oliveras-Ferraros, C.3    Menendez, J.A.4
  • 126
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004; 24: 200-216.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 127
    • 11844304072 scopus 로고    scopus 로고
    • Restraining PI3K: mTOR signalling goes back to the membrane
    • Harrington LS, Findlay GM, Lamb RF. Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem Sci. 2005; 30: 35-42.
    • (2005) Trends Biochem Sci , vol.30 , pp. 35-42
    • Harrington, L.S.1    Findlay, G.M.2    Lamb, R.F.3
  • 129
    • 12344262762 scopus 로고    scopus 로고
    • mTOR, translational control and human disease
    • Tee AR, Blenis J. mTOR, translational control and human disease. Semin Cell Dev Biol. 2005; 16: 29-37.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 133
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
    • Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell. 2006; 11: 583-589.
    • (2006) Dev Cell , vol.11 , pp. 583-589
    • Shiota, C.1    Woo, J.T.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 135
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr Biol. 2009; 19: R1046-1052.
    • (2009) Curr Biol , vol.19
    • Laplante, M.1    Sabatini, D.M.2
  • 136
    • 77951917753 scopus 로고    scopus 로고
    • Regulation of Akt signaling activation by ubiquitination
    • Yang WL, Wu CY, Wu J, Lin HK. Regulation of Akt signaling activation by ubiquitination. Cell Cycle. 2010; 9: 487-497.
    • (2010) Cell Cycle , vol.9 , pp. 487-497
    • Yang, W.L.1    Wu, C.Y.2    Wu, J.3    Lin, H.K.4
  • 137
    • 0035112192 scopus 로고    scopus 로고
    • Evolution of the human menopause
    • Shanley DP, Kirkwood TB. Evolution of the human menopause. Bioessays. 2001; 23: 282-287.
    • (2001) Bioessays , vol.23 , pp. 282-287
    • Shanley, D.P.1    Kirkwood, T.B.2
  • 138
    • 38349151564 scopus 로고    scopus 로고
    • Understanding ageing from an evolutionary perspective
    • Kirkwood TB. Understanding ageing from an evolutionary perspective. J Intern Med. 2008; 263: 117-127.
    • (2008) J Intern Med , vol.263 , pp. 117-127
    • Kirkwood, T.B.1
  • 140
    • 0031012554 scopus 로고    scopus 로고
    • Postmenopausal acceleration of age-related mortality increase
    • Horiuchi S. Postmenopausal acceleration of age-related mortality increase. J Gerontol A Biol Sci Med Sci. 1997; 52: B78-92.
    • (1997) J Gerontol A Biol Sci Med Sci , vol.52
    • Horiuchi, S.1
  • 142
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. Understanding the odd science of aging. Cell. 2005; 120: 437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 143
    • 84863863145 scopus 로고    scopus 로고
    • The free-radical theory of ageing-older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support
    • Kirkwood TB, Kowald A. The free-radical theory of ageing-older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support. Bioessays. 2012; 34: 692-700.
    • (2012) Bioessays , vol.34 , pp. 692-700
    • Kirkwood, T.B.1    Kowald, A.2
  • 146
    • 79952201966 scopus 로고    scopus 로고
    • Revisiting the free radical theory using next-generation sequencing technology
    • Burhans WC, Weinberger M. Revisiting the free radical theory using next-generation sequencing technology. Aging (Albany NY). 2010; 2: 459-460.
    • (2010) Aging (Albany NY) , vol.2 , pp. 459-460
    • Burhans, W.C.1    Weinberger, M.2
  • 147
    • 79956032310 scopus 로고    scopus 로고
    • Mitochondrial complex I: a central regulator of the aging process
    • Stefanatos R, Sanz A. Mitochondrial complex I: a central regulator of the aging process. Cell Cycle. 2011; 10: 1528-1532.
    • (2011) Cell Cycle , vol.10 , pp. 1528-1532
    • Stefanatos, R.1    Sanz, A.2
  • 151
    • 79952260454 scopus 로고    scopus 로고
    • The DNA damage response: Balancing the scale between cancer and ageing
    • Seviour EG, Lin SY. The DNA damage response: Balancing the scale between cancer and ageing. Aging (Albany NY). 2010; 2: 900-907.
    • (2010) Aging (Albany NY) , vol.2 , pp. 900-907
    • Seviour, E.G.1    Lin, S.Y.2
  • 152
    • 80855144458 scopus 로고    scopus 로고
    • 'Relax and Repair' to restrain aging
    • Krishnan V, Liu B, Zhou Z. 'Relax and Repair' to restrain aging. Aging (Albany NY). 2011; 3: 943-954.
    • (2011) Aging (Albany NY) , vol.3 , pp. 943-954
    • Krishnan, V.1    Liu, B.2    Zhou, Z.3
  • 154
    • 79952327702 scopus 로고    scopus 로고
    • SAHF, to senesce or not to senesce? Cell Cycle
    • Kocylowski MK, Halazonetis TD. SAHF, to senesce or not to senesce? Cell Cycle. 2011; 10: 738-739.
    • (2011) , vol.10 , pp. 738-739
    • Kocylowski, M.K.1    Halazonetis, T.D.2
  • 155
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny MV. Aging: ROS or TOR. Cell Cycle. 2008; 7: 3344-3354.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 156
    • 57749095081 scopus 로고    scopus 로고
    • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    • Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR, Gems D. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 2008; 22: 3236-3241.
    • (2008) Genes Dev , vol.22 , pp. 3236-3241
    • Doonan, R.1    McElwee, J.J.2    Matthijssens, F.3    Walker, G.A.4    Houthoofd, K.5    Back, P.6    Matscheski, A.7    Vanfleteren, J.R.8    Gems, D.9
  • 157
    • 66749126389 scopus 로고    scopus 로고
    • Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
    • Gems D, Doonan R. Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? Cell Cycle. 2009; 8: 1681-1687.
    • (2009) Cell Cycle , vol.8 , pp. 1681-1687
    • Gems, D.1    Doonan, R.2
  • 158
    • 84874802960 scopus 로고    scopus 로고
    • Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
    • Gems D, Partridge L. Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts. Annu Rev Physiol. 2012.
    • (2012) Annu Rev Physiol
    • Gems, D.1    Partridge, L.2
  • 159
    • 84874802637 scopus 로고    scopus 로고
    • Alternative Perspectives on Aging in C. elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal
    • Gems DHde la Guardia YI. Alternative Perspectives on Aging in C. elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal. 2012.
    • 2012
    • Gems, D.H.1    de la Guardia, Y.I.2
  • 162
    • 84860390185 scopus 로고    scopus 로고
    • Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
    • Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, Braeckman BP, Gems D. Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med. 2011; 51: 1575-1582.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1575-1582
    • Cabreiro, F.1    Ackerman, D.2    Doonan, R.3    Araiz, C.4    Back, P.5    Papp, D.6    Braeckman, B.P.7    Gems, D.8
  • 163
    • 73749085674 scopus 로고    scopus 로고
    • When a theory of aging ages badly
    • Lapointe J, Hekimi S. When a theory of aging ages badly. Cell Mol Life Sci. 2009; 67: 1-8.
    • (2009) Cell Mol Life Sci , vol.67 , pp. 1-8
    • Lapointe, J.1    Hekimi, S.2
  • 164
    • 61449184625 scopus 로고    scopus 로고
    • Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
    • Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 2009; 5: e1000361.
    • (2009) PLoS Genet , vol.5
    • Van Raamsdonk, J.M.1    Hekimi, S.2
  • 165
    • 79952659906 scopus 로고    scopus 로고
    • The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
    • Speakman JR, Selman C. The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan. Bioessays. 2011; 33: 255-259.
    • (2011) Bioessays , vol.33 , pp. 255-259
    • Speakman, J.R.1    Selman, C.2
  • 166
    • 79959350253 scopus 로고    scopus 로고
    • Extending life span by increasing oxidative stress
    • Ristow M, Schmeisser S. Extending life span by increasing oxidative stress. Free Radic Biol Med. 2011; 51: 327-336.
    • (2011) Free Radic Biol Med , vol.51 , pp. 327-336
    • Ristow, M.1    Schmeisser, S.2
  • 168
    • 84859489680 scopus 로고    scopus 로고
    • Molecular damage in cancer: an argument for mTOR-driven aging
    • Blagosklonny MV. Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY). 2011; 3: 1130-1141.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1130-1141
    • Blagosklonny, M.V.1
  • 169
    • 34247103512 scopus 로고    scopus 로고
    • Hormetic modulation of aging and longevity by mild heat stress
    • Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2006; 3: 533-546.
    • (2006) Dose Response , vol.3 , pp. 533-546
    • Rattan, S.I.1
  • 170
    • 33746652227 scopus 로고    scopus 로고
    • Can dietary restriction increase longevity in all species, particularly in human beings? Introduction to a debate among experts
    • Le Bourg E, Rattan SI. Can dietary restriction increase longevity in all species, particularly in human beings? Introduction to a debate among experts. Biogerontology. 2006; 7: 123-125.
    • (2006) Biogerontology , vol.7 , pp. 123-125
    • Le Bourg, E.1    Rattan, S.I.2
  • 171
    • 33747726263 scopus 로고    scopus 로고
    • Anti-ageing strategies: prevention or therapy
    • Rattan SIS. Anti-ageing strategies: prevention or therapy. EMBO Rep. 2005; 6: S25-29.
    • (2005) EMBO Rep , vol.6
    • Rattan, S.I.S.1
  • 172
    • 39649110574 scopus 로고    scopus 로고
    • Stress-response hormesis and aging: that which does not kill us makes us stronger
    • Gems D, Partridge L. Stress-response hormesis and aging: that which does not kill us makes us strongerCell Metab. 2008; 7: 200-203.
    • (2008) Cell Metab , vol.7 , pp. 200-203
    • Gems, D.1    Partridge, L.2
  • 173
    • 84055190702 scopus 로고    scopus 로고
    • Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
    • Blagosklonny MV. Rapamycin-induced glucose intolerance: Hunger or starvation diabetes. Cell Cycle. 2011; 10: 4217-4224.
    • (2011) Cell Cycle , vol.10 , pp. 4217-4224
    • Blagosklonny, M.V.1
  • 174
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans)
    • Blagosklonny MV. Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans). Cell Cycle. 2010; 9: 683-688.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 175
    • 64549083295 scopus 로고    scopus 로고
    • The scientific basis of caloric restriction leading to longer life
    • Fontana L. The scientific basis of caloric restriction leading to longer life. Curr Opin Gastroenterol. 2009; 25: 144-150.
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 144-150
    • Fontana, L.1
  • 176
    • 0025856749 scopus 로고
    • Benefits and limitations of very-lowcalorie diet therapy in obese NIDDM
    • Henry RR, Gumbiner B. Benefits and limitations of very-lowcalorie diet therapy in obese NIDDM. Diabetes Care. 1991; 14: 802-823.
    • (1991) Diabetes Care , vol.14 , pp. 802-823
    • Henry, R.R.1    Gumbiner, B.2
  • 177
    • 77953635101 scopus 로고    scopus 로고
    • At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins
    • Mostoslavsky R, Esteller M, Vaquero A. At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. Cell Cycle. 2010; 9: 1907-1912.
    • (2010) Cell Cycle , vol.9 , pp. 1907-1912
    • Mostoslavsky, R.1    Esteller, M.2    Vaquero, A.3
  • 182
    • 79952257025 scopus 로고    scopus 로고
    • Perspectives on cellular senescence and short term dietary restriction in adults
    • Kirkland JL. Perspectives on cellular senescence and short term dietary restriction in adults. Aging (Albany NY). 2010; 2: 542-544.
    • (2010) Aging (Albany NY) , vol.2 , pp. 542-544
    • Kirkland, J.L.1
  • 183
    • 79952007405 scopus 로고    scopus 로고
    • Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout
    • Galikova M, Flatt T. Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout. Aging (Albany NY). 2010; 2: 387-389.
    • (2010) Aging (Albany NY) , vol.2 , pp. 387-389
    • Galikova, M.1    Flatt, T.2
  • 184
    • 14644390872 scopus 로고    scopus 로고
    • Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
    • Mattson MP, Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem. 2005; 16: 129-137.
    • (2005) J Nutr Biochem , vol.16 , pp. 129-137
    • Mattson, M.P.1    Wan, R.2
  • 185
    • 0037338615 scopus 로고    scopus 로고
    • Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction
    • Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci. 2003; 58: 212-219.
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 , pp. 212-219
    • Bodkin, N.L.1    Alexander, T.M.2    Ortmeyer, H.K.3    Johnson, E.4    Hansen, B.C.5
  • 188
    • 84860920123 scopus 로고    scopus 로고
    • Krzysik-Walker SM, de Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics
    • Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev. 2012; 11: 390-398.
    • (2012) Ageing Res Rev , vol.11 , pp. 390-398
    • Mercken, E.M.1    Carboneau, B.A.2
  • 189
    • 38149107357 scopus 로고    scopus 로고
    • Paradoxes of aging
    • Blagosklonny MV. Paradoxes of aging. Cell Cycle. 2007; 6: 2997-3003.
    • (2007) Cell Cycle , vol.6 , pp. 2997-3003
    • Blagosklonny, M.V.1
  • 190
    • 0345237923 scopus 로고    scopus 로고
    • Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity
    • Ikeno Y, Bronson RT, Hubbard GB, Lee SB, A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci. 2003; 58: 291-296.
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 , pp. 291-296
    • Ikeno, Y.1    Bronson, R.T.2    Hubbard, G.B.3    Lee, S.B.A.4
  • 191
    • 13944276264 scopus 로고    scopus 로고
    • Life extension in the dwarf mouse
    • Bartke A, Brown-Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol. 2004; 63: 189-225.
    • (2004) Curr Top Dev Biol , vol.63 , pp. 189-225
    • Bartke, A.1    Brown-Borg, H.2
  • 192
    • 18244379033 scopus 로고    scopus 로고
    • Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
    • Sharp ZD, Bartke A. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci. 2005; 60: 293-300.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 293-300
    • Sharp, Z.D.1    Bartke, A.2
  • 193
    • 55849132493 scopus 로고    scopus 로고
    • Insulin and aging
    • Bartke A. Insulin and aging. Cell Cycle. 2008; 7: 3338-3343.
    • (2008) Cell Cycle , vol.7 , pp. 3338-3343
    • Bartke, A.1
  • 194
    • 33644507693 scopus 로고    scopus 로고
    • Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
    • Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab. 2006; 17: 33-35.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 33-35
    • Bartke, A.1
  • 196
    • 84863323282 scopus 로고    scopus 로고
    • Healthy aging: is smaller better? - a mini-review
    • Bartke A. Healthy aging: is smaller better? - a mini-review. Gerontology. 2012; 58: 337-343.
    • (2012) Gerontology , vol.58 , pp. 337-343
    • Bartke, A.1
  • 198
    • 84857926653 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice
    • Spong A, Bartke A. Rapamycin slows aging in mice. Cell Cycle. 2012; 11: 845.
    • (2012) Cell Cycle , vol.11 , pp. 845
    • Spong, A.1    Bartke, A.2
  • 199
    • 0013056730 scopus 로고    scopus 로고
    • Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice
    • Miller RA, Harper JM, Galecki A, Burke DT. Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice. Aging Cell. 2002; 1: 22-29.
    • (2002) Aging Cell , vol.1 , pp. 22-29
    • Miller, R.A.1    Harper, J.M.2    Galecki, A.3    Burke, D.T.4
  • 200
    • 78649719816 scopus 로고    scopus 로고
    • Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice
    • Panici JA, Harper JM, Miller RA, Bartke A, Spong A, Masternak MM. Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. Faseb J. 2010; 24: 5073-5079.
    • (2010) Faseb J , vol.24 , pp. 5073-5079
    • Panici, J.A.1    Harper, J.M.2    Miller, R.A.3    Bartke, A.4    Spong, A.5    Masternak, M.M.6
  • 201
    • 0242490056 scopus 로고    scopus 로고
    • Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
    • Bartke A. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology. 2003; 78: 210-216.
    • (2003) Neuroendocrinology , vol.78 , pp. 210-216
    • Bartke, A.1
  • 202
    • 80655133978 scopus 로고    scopus 로고
    • GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells
    • Siejka A, Barabutis N, Schally AV. GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells. Cell Cycle. 2011; 10: 3714-3718.
    • (2011) Cell Cycle , vol.10 , pp. 3714-3718
    • Siejka, A.1    Barabutis, N.2    Schally, A.V.3
  • 203
    • 77958507818 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology
    • Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010; 9: 4110-4116.
    • (2010) Cell Cycle , vol.9 , pp. 4110-4116
    • Barabutis, N.1    Schally, A.V.2
  • 205
    • 84868624948 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers
    • Perez R, Schally AV, Vidaurre I, Rincon R, Block NL, Rick FG. Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers. Oncotarget. 2012; 3: 988-997.
    • (2012) Oncotarget , vol.3 , pp. 988-997
    • Perez, R.1    Schally, A.V.2    Vidaurre, I.3    Rincon, R.4    Block, N.L.5    Rick, F.G.6
  • 206
    • 77953555625 scopus 로고    scopus 로고
    • Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer
    • Hohla F, Schally AV. Targeting gastrin releasing peptide receptors: New options for the therapy and diagnosis of cancer. Cell Cycle. 2010; 9: 1738-1741.
    • (2010) Cell Cycle , vol.9 , pp. 1738-1741
    • Hohla, F.1    Schally, A.V.2
  • 207
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004; 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 209
    • 32044445067 scopus 로고    scopus 로고
    • TORgeting oncogene addiction for cancer therapy
    • Choo AY, Blenis J. TORgeting oncogene addiction for cancer therapy. Cancer Cell. 2006; 9: 77-79.
    • (2006) Cancer Cell , vol.9 , pp. 77-79
    • Choo, A.Y.1    Blenis, J.2
  • 211
    • 33751162384 scopus 로고    scopus 로고
    • Therapeutic targets: MTOR and related pathways
    • Dancey JE. Therapeutic targets: MTOR and related pathways. Cancer Biol Ther. 2006; 5: 1065-1073.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1065-1073
    • Dancey, J.E.1
  • 213
    • 79953668112 scopus 로고    scopus 로고
    • The physiology and pathophysiology of rapamycin resistance: implications for cancer
    • Gruppuso PA, Boylan JM, Sanders JA. The physiology and pathophysiology of rapamycin resistance: implications for cancer. Cell Cycle. 2011; 10: 1050-1058.
    • (2011) Cell Cycle , vol.10 , pp. 1050-1058
    • Gruppuso, P.A.1    Boylan, J.M.2    Sanders, J.A.3
  • 214
    • 39149093333 scopus 로고    scopus 로고
    • Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1
    • Averous J, Fonseca BD, Proud CG. Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Oncogene. 2008; 27: 1106-1113.
    • (2008) Oncogene , vol.27 , pp. 1106-1113
    • Averous, J.1    Fonseca, B.D.2    Proud, C.G.3
  • 215
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer. 2006; 6: 184-192.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 216
    • 79959998541 scopus 로고    scopus 로고
    • LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology
    • Green AS, Chapuis N, Lacombe C, Mayeux P, Bouscary D, Tamburini J. LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology. Cell Cycle. 2011; 10: 2115-2120.
    • (2011) Cell Cycle , vol.10 , pp. 2115-2120
    • Green, A.S.1    Chapuis, N.2    Lacombe, C.3    Mayeux, P.4    Bouscary, D.5    Tamburini, J.6
  • 218
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: insights into a complex relationship
    • Sabatini DM. mTOR and cancer: insights into a complex relationship. Nat Rev Cancer. 2006.
    • Nat Rev Cancer. 2006.
    • Sabatini, D.M.1
  • 220
    • 79957983577 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs
    • Markman B, Dienstmann R, Tabernero J. Targeting the PI3K/Akt/mTOR pathway-beyond rapalogs. Oncotarget. 2010; 1: 530-543.
    • (2010) Oncotarget , vol.1 , pp. 530-543
    • Markman, B.1    Dienstmann, R.2    Tabernero, J.3
  • 221
    • 77958459431 scopus 로고    scopus 로고
    • eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways
    • Shahbazian D, Parsyan A, Petroulakis E, Hershey J, Sonenberg N. eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell Cycle. 2010; 9: 4106-4109.
    • (2010) Cell Cycle , vol.9 , pp. 4106-4109
    • Shahbazian, D.1    Parsyan, A.2    Petroulakis, E.3    Hershey, J.4    Sonenberg, N.5
  • 222
    • 81855212711 scopus 로고    scopus 로고
    • The expanding relevance of nuclear mTOR in carcinogenesis
    • Back JH, Kim AL. The expanding relevance of nuclear mTOR in carcinogenesis. Cell Cycle. 2011; 10: 3849-3852.
    • (2011) Cell Cycle , vol.10 , pp. 3849-3852
    • Back, J.H.1    Kim, A.L.2
  • 223
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A. 2005; 102: 8204-8209.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 224
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 2007; 67: 3043-3053.
    • (2007) Cancer Res , vol.67 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    de Stanchina, E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6    Levine, A.J.7
  • 226
    • 77953567566 scopus 로고    scopus 로고
    • Eph receptor and mTOR pathway crosstalk: implications for cancer
    • Sahin M. Eph receptor and mTOR pathway crosstalk: implications for cancer. Cell Cycle. 2010; 9: 2053-2054.
    • (2010) Cell Cycle , vol.9 , pp. 2053-2054
    • Sahin, M.1
  • 227
    • 79956014865 scopus 로고    scopus 로고
    • The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1alpha
    • Demidenko ZN, Blagosklonny MV. The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1alpha. Cell Cycle. 2011; 10: 1557-1562.
    • (2011) Cell Cycle , vol.10 , pp. 1557-1562
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 230
    • 80555154907 scopus 로고    scopus 로고
    • Phosphorylation of AKT: a mutational analysis
    • Hart JR, Vogt PK. Phosphorylation of AKT: a mutational analysis. Oncotarget. 2011; 2: 467-476.
    • (2011) Oncotarget , vol.2 , pp. 467-476
    • Hart, J.R.1    Vogt, P.K.2
  • 231
    • 84857204726 scopus 로고    scopus 로고
    • Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells
    • Weber GL, Parat MO, Binder ZA, Gallia GL, Riggins GJ. Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells. Oncotarget. 2011; 2: 833-849.
    • (2011) Oncotarget , vol.2 , pp. 833-849
    • Weber, G.L.1    Parat, M.O.2    Binder, Z.A.3    Gallia, G.L.4    Riggins, G.J.5
  • 232
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007; 12: 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 234
    • 79958011128 scopus 로고    scopus 로고
    • Role of dual PI3/Akt andmTOR inhibition in Waldenstrom's Macroglobulinemia
    • Sacco A, Roccaro A, Ghobrial IM. Role of dual PI3/Akt andmTOR inhibition in Waldenstrom's Macroglobulinemia. Oncotarget. 2010; 1: 578-582.
    • (2010) Oncotarget , vol.1 , pp. 578-582
    • Sacco, A.1    Roccaro, A.2    Ghobrial, I.M.3
  • 236
    • 0034635444 scopus 로고    scopus 로고
    • Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts
    • Brenneisen P, Wenk J, Wlaschek M, Krieg T, Scharffetter-Kochanek K. Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. J Biol Chem. 2000; 275: 4336-4344.
    • (2000) J Biol Chem , vol.275 , pp. 4336-4344
    • Brenneisen, P.1    Wenk, J.2    Wlaschek, M.3    Krieg, T.4    Scharffetter-Kochanek, K.5
  • 237
    • 77953593619 scopus 로고    scopus 로고
    • Dual-targeting of mTOR and HSP90 for cancer therapy: facing oncogenic feed-back-loops and acquired mTOR resistance
    • Stoeltzing O. Dual-targeting of mTOR and HSP90 for cancer therapy: facing oncogenic feed-back-loops and acquired mTOR resistance. Cell Cycle. 2010; 9: 2051-2052.
    • (2010) Cell Cycle , vol.9 , pp. 2051-2052
    • Stoeltzing, O.1
  • 239
    • 77951884299 scopus 로고    scopus 로고
    • Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS
    • Zhao L, Vogt PK. Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS. Cell Cycle. 2010; 9: 596-600.
    • (2010) Cell Cycle , vol.9 , pp. 596-600
    • Zhao, L.1    Vogt, P.K.2


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