-
1
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124:471-484.
-
(2006)
Cell.
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
2
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010; 40:310-322.
-
(2010)
Mol Cell.
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
3
-
-
0038441503
-
Cell senescence and hypermitogenic arrest
-
Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep. 2003; 4:358-362.
-
(2003)
EMBO Rep.
, vol.4
, pp. 358-362
-
-
Blagosklonny, M.V.1
-
4
-
-
33750499504
-
Cell senescence: hypertrophic arrest beyond restriction point
-
Blagosklonny MV. Cell senescence: hypertrophic arrest beyond restriction point. J Cell Physiol. 2006; 209:592-597.
-
(2006)
J Cell Physiol.
, vol.209
, pp. 592-597
-
-
Blagosklonny, M.V.1
-
5
-
-
0034682721
-
Cellular senescence: mitotic clock or culture shock?
-
Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell. 2000; 102:407-410.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
7
-
-
0034832956
-
Regulation of cellular senescence by p53
-
Itahana K, Dimri G, Campisi J. Regulation of cellular senescence by p53. Eur J Biochem. 2001; 268:2784-2791.
-
(2001)
Eur J Biochem.
, vol.268
, pp. 2784-2791
-
-
Itahana, K.1
Dimri, G.2
Campisi, J.3
-
8
-
-
1542781659
-
When cells get stressed: an integrative view of cellular senescence
-
Ben-Porath I, Weinberg RA. When cells get stressed: an integrative view of cellular senescence. J Clin Invest. 2004; 113:8-13.
-
(2004)
J Clin Invest.
, vol.113
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
9
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007; 130:223-233.
-
(2007)
Cell.
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
10
-
-
0027332123
-
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes
-
Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc Natl Acad Sci U S A. 1993; 90:11034-11038.
-
(1993)
Proc Natl Acad Sci U S A.
, vol.90
, pp. 11034-11038
-
-
Dulic, V.1
Drullinger, L.F.2
Lees, E.3
Reed, S.I.4
Stein, G.H.5
-
11
-
-
0029944622
-
Differential CDK-inhibitor gene expression in aging human diploid fibroblasts
-
Wong H, Riabowol K. Differential CDK-inhibitor gene expression in aging human diploid fibroblasts. Exp Gerontol. 1996; 31:311-325.
-
(1996)
Exp Gerontol.
, vol.31
, pp. 311-325
-
-
Wong, H.1
Riabowol, K.2
-
12
-
-
36549020608
-
Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells
-
Burton DG, Sheerin AN, Ostler EL, Smith K, Giles PJ, Lowe J, Rhys-Williams W, Kipling DG, Faragher RG. Cyclin D1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells. Ann N Y Acad Sci. 2007; 1119:20-31.
-
(2007)
Ann N Y Acad Sci.
, vol.1119
, pp. 20-31
-
-
Burton, D.G.1
Sheerin, A.N.2
Ostler, E.L.3
Smith, K.4
Giles, P.J.5
Lowe, J.6
Rhys-Williams, W.7
Kipling, D.G.8
Faragher, R.G.9
-
13
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355-3361.
-
(2008)
Cell Cycle.
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
14
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle. 2009; 8:4112-4118.
-
(2009)
Cell Cycle.
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
Demidenko, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
15
-
-
78651104478
-
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
-
Rodier F, Munoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppe JP, Campeau E, Beausejour CM, Kim SH, Davalos AR, Campisi J. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci. 2011; 124:68-81.
-
(2011)
J Cell Sci.
, vol.124
, pp. 68-81
-
-
Rodier, F.1
Munoz, D.P.2
Teachenor, R.3
Chu, V.4
Le, O.5
Bhaumik, D.6
Coppe, J.P.7
Campeau, E.8
Beausejour, C.M.9
Kim, S.H.10
Davalos, A.R.11
Campisi, J.12
-
16
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
-
Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A. 2001; 98:12072-12077.
-
(2001)
Proc Natl Acad Sci U S A.
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
17
-
-
13944260728
-
Stromalepithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
-
Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromalepithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci. 2005; 118:485-496.
-
(2005)
J Cell Sci.
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
18
-
-
33749549246
-
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
-
CoppŽ JP, Kauser K, Campisi J, BeausŽjour CM. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem. 2006; 281:29568-29574.
-
(2006)
J Biol Chem.
, vol.281
, pp. 29568-29574
-
-
CoppŽ, J.P.1
Kauser, K.2
Campisi, J.3
BeausŽjour, C.M.4
-
19
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
CoppŽ JP, Patil CK, Rodier F, Sun Y, Mu-oz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008; 6:2853-2868.
-
(2008)
PLoS Biol.
, vol.6
, pp. 2853-2868
-
-
CoppŽ, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Mu-oz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
20
-
-
68249096784
-
Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion
-
Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion. Nat Cell Biol. 2009; 11:973-979.
-
(2009)
Nat Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
21
-
-
67649318940
-
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
-
Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging. 2009; 1: 402-411.
-
(2009)
Aging.
, vol.1
, pp. 402-411
-
-
Bhaumik, D.1
Scott, G.K.2
Schokrpur, S.3
Patil, C.K.4
Orjalo, A.V.5
Rodier, F.6
Lithgow, G.J.7
Campisi, J.8
-
22
-
-
77952105389
-
Inflammatory networks during cellular senescence: causes and consequences
-
Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010:238-246.
-
(2010)
Trends Mol Med.
, pp. 238-246
-
-
Freund, A.1
Orjalo, A.V.2
Desprez, P.Y.3
Campisi, J.4
-
23
-
-
0037214472
-
Induction of senescenceassociated growth inhibitors in the tumor-suppressive function of retinoids
-
Roninson IB, Dokmanovic M. Induction of senescenceassociated growth inhibitors in the tumor-suppressive function of retinoids. J Cell Biochem. 2003; 88:83-94.
-
(2003)
J Cell Biochem.
, vol.88
, pp. 83-94
-
-
Roninson, I.B.1
Dokmanovic, M.2
-
24
-
-
31544479046
-
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
-
Bavik C, Coleman I, Dean JP, Knudsen B, Plymate S, Nelson PS. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res. 2006; 66:794-802.
-
(2006)
Cancer Res.
, vol.66
, pp. 794-802
-
-
Bavik, C.1
Coleman, I.2
Dean, J.P.3
Knudsen, B.4
Plymate, S.5
Nelson, P.S.6
-
25
-
-
44649101304
-
Oncogene-induced senescence relayed by an interleukindependent inflammatory network
-
Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS. Oncogene-induced senescence relayed by an interleukindependent inflammatory network. Cell. 2008; 133:1019-1031.
-
(2008)
Cell.
, vol.133
, pp. 1019-1031
-
-
Kuilman, T.1
Michaloglou, C.2
Vredeveld, L.C.3
Douma, S.4
van Doorn, R.5
Desmet, C.J.6
Aarden, L.A.7
Mooi, W.J.8
Peeper, D.S.9
-
26
-
-
33845292259
-
A negative feedback signaling network underlies oncogene-induced senescence
-
Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell. 2006; 10:459-472.
-
(2006)
Cancer Cell.
, vol.10
, pp. 459-472
-
-
Courtois-Cox, S.1
Genther Williams, S.M.2
Reczek, E.E.3
Johnson, B.W.4
McGillicuddy, L.T.5
Johannessen, C.M.6
Hollstein, P.E.7
MacCollin, M.8
Cichowski, K.9
-
27
-
-
44649120132
-
Chemokine signaling via the CXCR2 receptor reinforces senescence
-
Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008; 133:1006-1018.
-
(2008)
Cell.
, vol.133
, pp. 1006-1018
-
-
Acosta, J.C.1
O'Loghlen, A.2
Banito, A.3
Guijarro, M.V.4
Augert, A.5
Raguz, S.6
Fumagalli, M.7
Da Costa, M.8
Brown, C.9
Popov, N.10
Takatsu, Y.11
Melamed, J.12
d'Adda di Fagagna, F.13
Bernard, D.14
Hernando, E.15
Gil, J.16
-
28
-
-
0034689774
-
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
-
Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene. 2000; 19:2165-2170.
-
(2000)
Oncogene.
, vol.19
, pp. 2165-2170
-
-
Chang, B.D.1
Broude, E.V.2
Fang, J.3
Kalinichenko, T.V.4
Abdryashitov, R.5
Poole, J.C.6
Roninson, I.B.7
-
29
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle. 2009; 8:1888-1895.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
30
-
-
50549090486
-
Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
-
Blagosklonny MV. Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res. 2008; 11:801-808.
-
(2008)
Rejuvenation Res.
, vol.11
, pp. 801-808
-
-
Blagosklonny, M.V.1
-
31
-
-
24344438713
-
The thorny path linking cellular senescence to organismal aging
-
Patil CK, Mian IS, Campisi J. The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev. 2005; 126:1040-1045.
-
(2005)
Mech Ageing Dev.
, vol.126
, pp. 1040-1045
-
-
Patil, C.K.1
Mian, I.S.2
Campisi, J.3
-
32
-
-
33750029285
-
Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition
-
Blagosklonny MV. Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087-2102.
-
(2006)
Cell Cycle.
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
33
-
-
74849115774
-
mTOR-driven aging: speeding car without brakes
-
Blagosklonny MV. mTOR-driven aging: speeding car without brakes. Cell Cycle. 2009; 8:4055-4059.
-
(2009)
Cell Cycle.
, vol.8
, pp. 4055-4059
-
-
Blagosklonny, M.V.1
-
34
-
-
58049196780
-
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
-
Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A. 2008; 105:19384-19389.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 19384-19389
-
-
Gan, B.1
Sahin, E.2
Jiang, S.3
Sanchez-Aguilera, A.4
Scott, K.L.5
Chin, L.6
Williams, D.A.7
Kwiatkowski, D.J.8
DePinho, R.A.9
-
35
-
-
65949104286
-
mTORC1 signaling governs hematopoietic stem cell quiescence
-
Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle. 2009; 8:1003-1006.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1003-1006
-
-
Gan, B.1
DePinho, R.A.2
-
36
-
-
53349091768
-
TSCmTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Zheng P. TSCmTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008; 205:2397-2408.
-
(2008)
J Exp Med.
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Zheng, P.6
-
37
-
-
75549090275
-
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
-
Chen C, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009; 2:ra75.
-
(2009)
Sci Signal.
, vol.2
-
-
Chen, C.1
Liu, Y.2
Zheng, P.3
-
38
-
-
77949898034
-
Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
-
Adhikari D, Zheng W, Shen Y, Gorre N, Hamalainen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K. Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet. 2010; 19:397-410.
-
(2010)
Hum Mol Genet.
, vol.19
, pp. 397-410
-
-
Adhikari, D.1
Zheng, W.2
Shen, Y.3
Gorre, N.4
Hamalainen, T.5
Cooney, A.J.6
Huhtaniemi, I.7
Lan, Z.J.8
Liu, K.9
-
39
-
-
79952269372
-
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
-
Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging. 2010; 2:924-935.
-
(2010)
Aging.
, vol.2
, pp. 924-935
-
-
Leontieva, O.V.1
Blagosklonny, M.V.2
-
41
-
-
77955351672
-
DNA replication is intrinsically hindered in terminally differentiated myotubes
-
Pajalunga D, Puggioni EM, Mazzola A, Leva V, Montecucco A, Crescenzi M. DNA replication is intrinsically hindered in terminally differentiated myotubes. PLoS One. 2010; 5:e11559.
-
(2010)
PLoS One.
, vol.5
-
-
Pajalunga, D.1
Puggioni, E.M.2
Mazzola, A.3
Leva, V.4
Montecucco, A.5
Crescenzi, M.6
-
42
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000; 100:57-70.
-
(2000)
Cell.
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
44
-
-
77955747085
-
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
-
Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging. 2010; 2:344-352.
-
(2010)
Aging.
, vol.2
, pp. 344-352
-
-
Korotchkina, L.G.1
Leontieva, O.V.2
Bukreeva, E.I.3
Demidenko, Z.N.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
45
-
-
78349286289
-
Weak p53 permits senescence during cell cycle arrest
-
Leontieva O, Gudkov A, Blagosklonny M. Weak p53 permits senescence during cell cycle arrest. Cell Cycle. 2010; 9:4323-4327.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4323-4327
-
-
Leontieva, O.1
Gudkov, A.2
Blagosklonny, M.3
-
46
-
-
78650093044
-
P53 and aging: A fresh look at an old paradigm
-
Poyurovsky MV, Prives C. P53 and aging: A fresh look at an old paradigm. Aging . 2010; 2:380-382.
-
(2010)
Aging .
, vol.2
, pp. 380-382
-
-
Poyurovsky, M.V.1
Prives, C.2
-
47
-
-
78650152988
-
p53, ROS and senescence in the control of aging
-
Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging. 2010; 2:471-474.
-
(2010)
Aging.
, vol.2
, pp. 471-474
-
-
Vigneron, A.1
Vousden, K.H.2
-
48
-
-
78349246236
-
Shifting senescence into quiescence by turning up p53
-
Serrano M. Shifting senescence into quiescence by turning up p53. Cell Cycle. 2010; 9: 4256-4257.
-
(2010)
Cell Cycle.
, vol.9
, pp. 4256-4257
-
-
Serrano, M.1
-
49
-
-
79952116991
-
TP53 and MTOR crosstalk to regulate cellular senescence
-
Galluzzi L, Kepp O, Kroemer G. TP53 and MTOR crosstalk to regulate cellular senescence. Aging. 2010; 2:535-537.
-
(2010)
Aging.
, vol.2
, pp. 535-537
-
-
Galluzzi, L.1
Kepp, O.2
Kroemer, G.3
-
50
-
-
79952691843
-
The p53 inducing drug dosage may determine quiescence or senescence
-
Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging. 2010; 2:748.
-
(2010)
Aging.
, vol.2
, pp. 748
-
-
Lane, D.P.1
Verma, C.2
Fang, C.C.3
-
51
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW. Regulation of PTEN transcription by p53. Mol Cell. 2001; 8:317-325.
-
(2001)
Mol Cell.
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
Benchimol, S.7
Mak, T.W.8
-
52
-
-
34248194200
-
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKTmTOR pathways
-
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKTmTOR pathways. Cancer Res. 2007; 67:3043-3053.
-
(2007)
Cancer Res.
, vol.67
, pp. 3043-3053
-
-
Feng, Z.1
Hu, W.2
de Stanchina, E.3
Teresky, A.K.4
Jin, S.5
Lowe, S.6
Levine, A.J.7
-
53
-
-
50049087380
-
p53 strikes mTORC1 by employing sestrins
-
Hay N. p53 strikes mTORC1 by employing sestrins. Cell Metab. 2008; 8:184-185.
-
(2008)
Cell Metab.
, vol.8
, pp. 184-185
-
-
Hay, N.1
-
54
-
-
77954310492
-
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
-
Feng Z, Levine AJ. The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol. 2010; 20:427-434.
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 427-434
-
-
Feng, Z.1
Levine, A.J.2
-
55
-
-
77952212178
-
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
-
Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010; 107:7455-7460.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 7455-7460
-
-
Hu, W.1
Zhang, C.2
Wu, R.3
Sun, Y.4
Levine, A.5
Feng, Z.6
-
56
-
-
77952227625
-
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
-
Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc Natl Acad Sci U S A. 2010; 107:7461-7466.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 7461-7466
-
-
Suzuki, S.1
Tanaka, T.2
Poyurovsky, M.V.3
Nagano, H.4
Mayama, T.5
Ohkubo, S.6
Lokshin, M.7
Hosokawa, H.8
Nakayama, T.9
Suzuki, Y.10
Sugano, S.11
Sato, E.12
Nagao, T.13
Yokote, K.14
Tatsuno, I.15
Prives, C.16
-
57
-
-
77957009531
-
apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53
-
Ashur-Fabian O, Har-Zahav A, Shaish A, Amram HW, Margalit O, Weizer-Stern O, Dominissini D, Harats D, Amariglio N, Rechavi G. apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53. Cell Cycle. 2010; 9:3761-3770.
-
(2010)
Cell Cycle.
, vol.9
, pp. 3761-3770
-
-
Ashur-Fabian, O.1
Har-Zahav, A.2
Shaish, A.3
Amram, H.W.4
Margalit, O.5
Weizer-Stern, O.6
Dominissini, D.7
Harats, D.8
Amariglio, N.9
Rechavi, G.10
-
58
-
-
77953587752
-
GAMT joins the p53 network: branching into metabolism
-
Ide T, Chu K, Aaronson SA, Lee SW. GAMT joins the p53 network: branching into metabolism. Cell Cycle. 2010; 9:1706-1710.
-
(2010)
Cell Cycle.
, vol.9
, pp. 1706-1710
-
-
Ide, T.1
Chu, K.2
Aaronson, S.A.3
Lee, S.W.4
-
60
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Vina J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature. 2007; 448:375-379.
-
(2007)
Nature.
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Vina, J.8
Blasco, M.A.9
Serrano, M.10
-
61
-
-
67649369064
-
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
-
Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle. 2009; 8:1896-1900.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1896-1900
-
-
Demidenko, Z.N.1
Shtutman, M.2
Blagosklonny, M.V.3
-
62
-
-
67649369072
-
At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
-
Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle. 2009; 8:1901-1904.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1901-1904
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
63
-
-
77953111224
-
Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential
-
Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging. 2009; 1:1008-1016.
-
(2009)
Aging.
, vol.1
, pp. 1008-1016
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
64
-
-
67649316034
-
Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration
-
Blagosklonny MV. Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration. Cell Cycle. 2009; 8:1883-1887.
-
(2009)
Cell Cycle.
, vol.8
, pp. 1883-1887
-
-
Blagosklonny, M.V.1
-
65
-
-
50849110457
-
Prevention of cancer by inhibiting aging
-
Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther. 2008; 7:1520-1524.
-
(2008)
Cancer Biol Ther.
, vol.7
, pp. 1520-1524
-
-
Blagosklonny, M.V.1
-
66
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi J, D'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8:729-740.
-
(2007)
Nat Rev Mol Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'Adda di Fagagna, F.2
-
67
-
-
34547941973
-
The common biology of cancer and ageing
-
Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007; 448:767-774.
-
(2007)
Nature.
, vol.448
, pp. 767-774
-
-
Finkel, T.1
Serrano, M.2
Blasco, M.A.3
-
68
-
-
34548179310
-
Cancer and ageing: convergent and divergent mechanisms
-
Serrano M, Blasco MA. Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol. 2007; 8:715-722.
-
(2007)
Nat Rev Mol Cell Biol.
, vol.8
, pp. 715-722
-
-
Serrano, M.1
Blasco, M.A.2
|