-
2
-
-
22744452215
-
Food restriction, evolution and ageing
-
Kirkwood TB, Shanley DP. Food restriction, evolution and ageing. Mech Ageing Dev 2005; 126:1011-6.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1011-1016
-
-
Kirkwood, T.B.1
Shanley, D.P.2
-
3
-
-
34548293807
-
Protein synthesis and aging: EIF4E and the soma vs. germline distinction
-
Tavernarakis N. Protein synthesis and aging: eIF4E and the soma vs. germline distinction. Cell Cycle 2007; 6:1168-71.
-
(2007)
Cell Cycle
, vol.6
, pp. 1168-1171
-
-
Tavernarakis, N.1
-
4
-
-
33847199335
-
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
Syntichaki P, Troulinaki K, Tavernarakis N. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 2007; 445:922-6.
-
(2007)
Nature
, vol.445
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
5
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 2007; 6:111-9.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
6
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007; 6:95-110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
7
-
-
0027771804
-
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 461-4.
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 461-4.
-
-
-
-
8
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
Kenyon C. The plasticity of aging: Insights from long-lived mutants. Cell 2005; 120:449-60.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
9
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000; 408:255-62.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
10
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: Influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
11
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science 2003; 299:1346-51.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
12
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90.
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
13
-
-
0037470539
-
Genetics and the specificity of the aging process
-
Hekimi S, Guarente L. Genetics and the specificity of the aging process. Science 2003; 299:1351-4.
-
(2003)
Science
, vol.299
, pp. 1351-1354
-
-
Hekimi, S.1
Guarente, L.2
-
14
-
-
33751246173
-
A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins
-
Berdichevsky A, Guarente L. A stress response pathway involving sirtuins, forkhead and 14-3-3 proteins. Cell Cycle 2006; 5:2588-91.
-
(2006)
Cell Cycle
, vol.5
, pp. 2588-2591
-
-
Berdichevsky, A.1
Guarente, L.2
-
15
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 2007; 447:545-9.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
16
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120:437-47.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
17
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005; 120:483-95.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
19
-
-
25144510360
-
Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
-
Andziak B, O'Connor TP, Buffenstein R. Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mech Ageing Dev 2005; 126:1206-12.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1206-1212
-
-
Andziak, B.1
O'Connor, T.P.2
Buffenstein, R.3
-
20
-
-
33751242066
-
High oxidative damage levels in the longest-living rodent, the naked mole-rat
-
Andziak B, O'Connor TP, Qi W, DeWaal EM, Pierce A, Chaudhuri AR, Van Remmen H, Buffenstein R. High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell 2006; 5:463-71.
-
(2006)
Aging Cell
, vol.5
, pp. 463-471
-
-
Andziak, B.1
O'Connor, T.P.2
Qi, W.3
DeWaal, E.M.4
Pierce, A.5
Chaudhuri, A.R.6
Van Remmen, H.7
Buffenstein, R.8
-
21
-
-
29144506279
-
The naked mole-rat: A new long-living model for human aging research
-
Buffenstein R. The naked mole-rat: A new long-living model for human aging research. J Gerontol A Biol Sci Med Sci 2005; 60:1369-77.
-
(2005)
J Gerontol A Biol Sci Med Sci
, vol.60
, pp. 1369-1377
-
-
Buffenstein, R.1
-
22
-
-
1542408999
-
Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan
-
Parker JD, Parker KM, Sohal BH, Sohal RS, Keller L. Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan. Proc Natl Acad Sci USA 2004; 101:3486-9.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3486-3489
-
-
Parker, J.D.1
Parker, K.M.2
Sohal, B.H.3
Sohal, R.S.4
Keller, L.5
-
23
-
-
0035111620
-
Mouse cloning with nucleus donor cells of different age and type
-
Wakayama T, Yanagimachi R. Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev 2001; 58:376-83.
-
(2001)
Mol Reprod Dev
, vol.58
, pp. 376-383
-
-
Wakayama, T.1
Yanagimachi, R.2
-
25
-
-
34047116291
-
Mitochondrial point mutations do not limit the natural lifespan of mice
-
Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 2007; 39:540-3.
-
(2007)
Nat Genet
, vol.39
, pp. 540-543
-
-
Vermulst, M.1
Bielas, J.H.2
Kujoth, G.C.3
Ladiges, W.C.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
26
-
-
33744494572
-
The free radical fantasy: A panoply of paradoxes
-
Howes RM. The free radical fantasy: A panoply of paradoxes. Ann NY Acad Sci 2006; 1067:22-6.
-
(2006)
Ann NY Acad Sci
, vol.1067
, pp. 22-26
-
-
Howes, R.M.1
-
27
-
-
33847378451
-
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 2007; 297:842-57.
-
(2007)
JAMA
, vol.297
, pp. 842-857
-
-
Bjelakovic, G.1
Nikolova, D.2
Gluud, L.L.3
Simonetti, R.G.4
Gluud, C.5
-
28
-
-
0036236634
-
Programmed death phenomena: From organelle to organism
-
Skulachev VP. Programmed death phenomena: From organelle to organism. Ann NY Acad Sci 2002; 959:214-37.
-
(2002)
Ann NY Acad Sci
, vol.959
, pp. 214-237
-
-
Skulachev, V.P.1
-
30
-
-
24744440811
-
Programmed ageing: The theory of maximal metabolic scope
-
Prinzinger R. Programmed ageing: The theory of maximal metabolic scope. EMBO Rep 2005; 6:S14-9.
-
(2005)
EMBO Rep
, vol.6
-
-
Prinzinger, R.1
-
31
-
-
0036245337
-
Mechanisms of ageing: Public or private?
-
Partridge L, Gems D. Mechanisms of ageing: Public or private? Nat Rev Genet 2002; 3:165-75.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 165-175
-
-
Partridge, L.1
Gems, D.2
-
32
-
-
0000055057
-
Pleiotropy, natural selection, and the evolution of senescence
-
Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957; 11:398-411.
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
33
-
-
24744454199
-
Time of our lives. What controls the length of life?
-
Kirkwood TB. Time of our lives. What controls the length of life? EMBO Rep 2005; 6:S4-8.
-
(2005)
EMBO Rep
, vol.6
-
-
Kirkwood, T.B.1
-
34
-
-
33750029285
-
Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
-
Blagosklonny MV. Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102.
-
(2006)
Cell Cycle
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
35
-
-
27744511769
-
-
Kaeberlein M, Powers RWR, KKS, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6.
-
Kaeberlein M, Powers RWR, KKS, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6.
-
-
-
-
36
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers RWR, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20:174-184.
-
(2006)
Genes Dev
, vol.20
, pp. 174-184
-
-
Powers, R.W.R.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
37
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897-906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
38
-
-
0034644525
-
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103:253-262.
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103:253-262.
-
-
-
-
39
-
-
0033540030
-
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
-
Beck T, Hall MN. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 1999; 402:689-92.
-
(1999)
Nature
, vol.402
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
40
-
-
0037076314
-
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
-
Crespo JL, Powers T, Fowler B, Hall MN. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci USA 2002; 99:6784-9.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6784-6789
-
-
Crespo, J.L.1
Powers, T.2
Fowler, B.3
Hall, M.N.4
-
41
-
-
33645738458
-
Complexity of the TOR signaling network
-
Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol 2006; 16:206-12.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 206-212
-
-
Inoki, K.1
Guan, K.L.2
-
42
-
-
13844249825
-
Is aging programed?
-
Austad SN. Is aging programed? Aging Cell 2004; 3:249-51.
-
(2004)
Aging Cell
, vol.3
, pp. 249-251
-
-
Austad, S.N.1
-
43
-
-
12744275052
-
Genetic basis of variation in morphological and life-history traits of a wild population of Pink Salmon
-
Funk WC, Tyburczy AJ, et al. Genetic basis of variation in morphological and life-history traits of a wild population of Pink Salmon. J Heredity 2005; 24-31.
-
(2005)
J Heredity
, pp. 24-31
-
-
Funk, W.C.1
Tyburczy, A.J.2
-
44
-
-
0034626769
-
-
DePinho RA. The age of cancer. Nature 2000; 408:248-.
-
DePinho RA. The age of cancer. Nature 2000; 408:248-.
-
-
-
-
45
-
-
33846548099
-
Biology of aging and cancer
-
Anisimov VN. Biology of aging and cancer. Cancer Control 2007; 14:23-31.
-
(2007)
Cancer Control
, vol.14
, pp. 23-31
-
-
Anisimov, V.N.1
-
46
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994; 4:1-7.
-
(1994)
Curr Biol
, vol.4
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
Schmitt, E.M.4
Halachmi, S.5
Bronson, R.T.6
Weinberg, R.A.7
-
47
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee Park S, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Hee Park, S.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
48
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, Sutherland A, Thorner M, Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004; 18:306-19.
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
49
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 2007; 448:375-9.
-
(2007)
Nature
, vol.448
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Viña, J.8
Blasco, M.A.9
Serrano, M.10
-
50
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 2005; 120:513-22.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
51
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol 2002; 12:1448-61.
-
(2002)
Curr Biol
, vol.12
, pp. 1448-1461
-
-
Long, X.1
Spycher, C.2
Han, Z.S.3
Rose, A.M.4
Muller, F.5
Avruch, J.6
-
52
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004; 24:9508-16.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
Um, S.H.7
Brown, E.J.8
Cereghini, S.9
Thomas, G.10
Kozma, S.C.11
-
53
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, Kiyama H, Yonezawa K, Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 2004; 24:6710-8.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
54
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 2006; 11:583-9.
-
(2006)
Dev Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
55
-
-
33947574775
-
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
-
Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 2007; 5:265-77.
-
(2007)
Cell Metab
, vol.5
, pp. 265-277
-
-
Bonawitz, N.D.1
Chatenay-Lapointe, M.2
Pan, Y.3
Shadel, G.S.4
-
56
-
-
33947581886
-
TOR and aging: Less is more
-
Schieke SM, Finkel T. TOR and aging: Less is more. Cell Metab 2007; 5:233-5.
-
(2007)
Cell Metab
, vol.5
, pp. 233-235
-
-
Schieke, S.M.1
Finkel, T.2
-
57
-
-
20044379872
-
Exercise and hormesis: Oxidative stress-related adaptation for successful aging
-
Radak Z, Chung HY, Goto S. Exercise and hormesis: Oxidative stress-related adaptation for successful aging. Biogerontology 2005; 6:71-5.
-
(2005)
Biogerontology
, vol.6
, pp. 71-75
-
-
Radak, Z.1
Chung, H.Y.2
Goto, S.3
-
58
-
-
3242892160
-
The multifaceted role of mTOR in cellular stress responses
-
Proud CG. The multifaceted role of mTOR in cellular stress responses. DNA Repair 2004; 3:927-34.
-
(2004)
DNA Repair
, vol.3
, pp. 927-934
-
-
Proud, C.G.1
-
59
-
-
13944276748
-
TOR signaling: An odyssey from cellular stress to the cell growth machinery
-
Abraham RT. TOR signaling: An odyssey from cellular stress to the cell growth machinery. Curr Biol 2005; 15:r139-41.
-
(2005)
Curr Biol
, vol.15
-
-
Abraham, R.T.1
-
60
-
-
0037701899
-
The most pressing problem of our age
-
Kirkwood TB. The most pressing problem of our age. BMJ 2003; 326:1-3.
-
(2003)
BMJ
, vol.326
, pp. 1-3
-
-
Kirkwood, T.B.1
-
61
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004; 14:1650-6.
-
(2004)
Curr Biol
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
62
-
-
22844438330
-
Tuberous sclerosis and insulin resistance: Unlikely bedfellows reveal a TORrid affair
-
Shah OJ, Hunter T. Tuberous sclerosis and insulin resistance: Unlikely bedfellows reveal a TORrid affair. Cell Cycle 2005; 4:46-51.
-
(2005)
Cell Cycle
, vol.4
, pp. 46-51
-
-
Shah, O.J.1
Hunter, T.2
-
63
-
-
14244256097
-
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
-
Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance. Endocrinology 2005; 146:1473-81.
-
(2005)
Endocrinology
, vol.146
, pp. 1473-1481
-
-
Khamzina, L.1
Veilleux, A.2
Bergeron, S.3
Marette, A.4
-
64
-
-
33747726263
-
Anti-ageing strategies: Prevention or therapy
-
Rattan SIS. Anti-ageing strategies: Prevention or therapy. EMBO Rep 2005; 6:S25-9.
-
(2005)
EMBO Rep
, vol.6
-
-
Rattan, S.I.S.1
-
65
-
-
0141720388
-
Calorie restriction and aging: Review of the literature and implications for studies in humans
-
Heilbronn LK, Ravussin E. Calorie restriction and aging: Review of the literature and implications for studies in humans. Am J Clin Nutr 2003; 78:361-9.
-
(2003)
Am J Clin Nutr
, vol.78
, pp. 361-369
-
-
Heilbronn, L.K.1
Ravussin, E.2
-
66
-
-
33746628186
-
Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans
-
Shanley DP, Kirkwood TB. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology 2006; 7:165-8.
-
(2006)
Biogerontology
, vol.7
, pp. 165-168
-
-
Shanley, D.P.1
Kirkwood, T.B.2
-
67
-
-
0036276294
-
Obesity, diabetes, and risk of cardiovascular disease in the elderly
-
Wilson PW, Kannel WB. Obesity, diabetes, and risk of cardiovascular disease in the elderly. Am J Geriatr Cardiol 2002; 11:119-23.
-
(2002)
Am J Geriatr Cardiol
, vol.11
, pp. 119-123
-
-
Wilson, P.W.1
Kannel, W.B.2
-
68
-
-
23944444300
-
Health consequences of obesity in the elderly: A review of four unresolved questions
-
Zamboni M, Mazzali G, Zoico E, Harris TB, Meigs JB, Di Francesco V, Fantin F, Bissoli L, Bosello O. Health consequences of obesity in the elderly: A review of four unresolved questions. Int J Obes 2005; 29:1011-29.
-
(2005)
Int J Obes
, vol.29
, pp. 1011-1029
-
-
Zamboni, M.1
Mazzali, G.2
Zoico, E.3
Harris, T.B.4
Meigs, J.B.5
Di Francesco, V.6
Fantin, F.7
Bissoli, L.8
Bosello, O.9
-
69
-
-
2342647592
-
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
-
Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 2004; 101:6659-63.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6659-6663
-
-
Fontana, L.1
Meyer, T.E.2
Klein, S.3
Holloszy, J.O.4
-
70
-
-
34447316421
-
Caloric restriction in humans
-
Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007; 42:709-12.
-
(2007)
Exp Gerontol
, vol.42
, pp. 709-712
-
-
Holloszy, J.O.1
Fontana, L.2
-
71
-
-
33847226657
-
An anti-aging drug today: From senescence-promoting genes to anti-aging pill
-
Blagosklonny MV. An anti-aging drug today: From senescence-promoting genes to anti-aging pill. Drug Discov Today 2007; 12:218-24.
-
(2007)
Drug Discov Today
, vol.12
, pp. 218-224
-
-
Blagosklonny, M.V.1
|