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Volumn 10, Issue 24, 2011, Pages 4230-4236

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

Author keywords

Aging; Gerosuppressants; Longevity; mTOR; Rapamycin

Indexed keywords

RAPAMYCIN;

EID: 83755165458     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.24.18486     Document Type: Article
Times cited : (301)

References (51)
  • 1
  • 2
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogenous mice
    • PMID:19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460:392-5; PMID:19587680.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 3
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging: Four years later
    • PMID:20436272
    • Blagosklonny MV. Rapamycin and quasi-programmed aging: Four years later. Cell Cycle 2010; 9:1859-62; PMID:20436272; http://dx.doi.org/10.4161/cc.9.10. 11872.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 4
    • 27744511769 scopus 로고    scopus 로고
    • Regulation of yeast replicative lifespan by TOR and Sch9 in response to nutrients
    • PMID:16293764
    • Kaeberlein M, Powers RW, 3rd, Steffen KK, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative lifespan by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6; PMID:16293764; http://dx.doi.org/10.1126/ science.1115535.
    • (2005) Science , vol.310 , pp. 1193-1196
    • Kaeberlein, M.1    Powers III, R.W.2    Steffen, K.K.3    Westman, E.A.4    Hu, D.5    Dang, N.6
  • 5
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological lifespan in yeast by decreased TOR pathway signaling
    • PMID:16418483
    • Powers RW, 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological lifespan in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20:174-84; PMID:16418483; http://dx.doi.org/10.1101/gad. 1381406.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers III, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 6
    • 68049109688 scopus 로고    scopus 로고
    • Extension of chronological lifespan by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density
    • PMID:20157595
    • Pan Y, Shadel GS. Extension of chronological lifespan by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 2009; 1:131-45; PMID:20157595.
    • (2009) Aging , vol.1 , pp. 131-145
    • Pan, Y.1    Shadel, G.S.2
  • 7
    • 77951020823 scopus 로고    scopus 로고
    • The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
    • PMID:20157544
    • Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kossler S, Klinger H, et al. The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging 2009; 1:622-36; PMID:20157544.
    • (2009) Aging , vol.1 , pp. 622-636
    • Heeren, G.1    Rinnerthaler, M.2    Laun, P.3    Von Seyerl, P.4    Kossler, S.5    Klinger, H.6
  • 8
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • PMID:18948731
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61; PMID:18948731; http://dx.doi.org/10.4161/cc.7.21.6919.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 10
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
    • PMID:20157583
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 2009; 1:1008-16; PMID:20157583.
    • (2009) Aging , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 11
    • 67649369064 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
    • PMID:19478560
    • Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-900; PMID:19478560; http://dx.doi.org/10. 4161/cc.8.12.8809.
    • (2009) Cell Cycle , vol.8 , pp. 1896-1900
    • Demidenko, Z.N.1    Shtutman, M.2    Blagosklonny, M.V.3
  • 14
  • 15
    • 78349286289 scopus 로고    scopus 로고
    • Weak p53 permits senescence during cell cycle arrest
    • PMID:21051933
    • Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-7; PMID:21051933; http://dx.doi.org/10.4161/cc.9.21.13584.
    • (2010) Cell Cycle , vol.9 , pp. 4323-4327
    • Leontieva, O.V.1    Gudkov, A.V.2    Blagosklonny, M.V.3
  • 16
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • PMID:21212465
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging 2010; 2:924-35; PMID:21212465.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 17
    • 0642367846 scopus 로고    scopus 로고
    • Genetics: Influence of TOR kinase on lifespan in C. elegans
    • PMID:14668850
    • Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID:14668850; http://dx.doi.org/10.1038/426620a.
    • (2003) Nature , vol.426 , pp. 620
    • Vellai, T.1    Takacs-Vellai, K.2    Zhang, Y.3    Kovacs, A.L.4    Orosz, L.5    Muller, F.6
  • 18
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • PMID:15186745
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90; PMID:15186745; http://dx.doi.org/10.1016/j.cub.2004.03. 059.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 19
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan
    • PMID:19797661
    • Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1    Tullet, J.M.2    Wieser, D.3    Irvine, E.4    Lingard, S.J.5    Choudhury, A.I.6
  • 20
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
    • PMID:20519118
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11:453-65; PMID:20519118; http://dx.doi.org/10.1016/j. cmet.2010.05.001.
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6
  • 21
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster
    • PMID:20017609
    • Moskalev AA, Shaposhnikov MV. Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster. Rejuvenation Res 2010; 13:246-7; PMID:20017609; http://dx.doi.org/10.1089/rej. 2009.0903.
    • (2010) Rejuvenation Res , vol.13 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 22
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of lifespan extension by rapamycin in the fruit fly Drosophila melanogaster
    • PMID:20074526
    • Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of lifespan extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010; 11:35-46; PMID:20074526; http://dx.doi.org/10. 1016/j.cmet.2009.11.010.
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3    Slack, C.4    Jacobson, J.5    Foley, A.6
  • 23
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy lifespan - From yeast to humans
    • PMID:20395504
    • Fontana L, Partridge L, Longo VD. Extending healthy lifespan - from yeast to humans. Science 2010; 328:321-6; PMID:20395504; http://dx.doi.org/10.1126/ science.1172539.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 24
    • 79953231709 scopus 로고    scopus 로고
    • A longer and healthier life with TOR downregulation: Genetics and drugs
    • PMID:21428920
    • Bjedov I, Partridge L. A longer and healthier life with TOR downregulation: genetics and drugs. Biochem Soc Trans 2011; 39:460-5; PMID:21428920; http://dx.doi.org/10.1042/BST0390460.
    • (2011) Biochem Soc Trans , vol.39 , pp. 460-465
    • Bjedov, I.1    Partridge, L.2
  • 25
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
    • PMID:20849947
    • Partridge L, Alic N, Bjedov I, Piper MD. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol 2011; 46:376-81; PMID:20849947; http://dx.doi.org/10.1016/j.exger.2010.09.003.
    • (2011) Exp Gerontol , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.4
  • 26
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • PMID:16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84; PMID:16469695; http://dx.doi.org/10.1016/j. cell.2006.01.016.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 27
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • PMID:20157523
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging 2009; 1:357-62; PMID:20157523.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 28
    • 77953577017 scopus 로고    scopus 로고
    • mTOR's role in ageing: Protein synthesis or autophagy?
    • PMID:20157541
    • Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging 2009; 1:586-97; PMID:20157541.
    • (2009) Aging , vol.1 , pp. 586-597
    • Hands, S.L.1    Proud, C.G.2    Wyttenbach, A.3
  • 29
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in hutchinson-gilford progeria syndrome cells
    • PMID:21715679
    • Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, et al. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in hutchinson-gilford progeria syndrome cells. Sci Transl Med 2011; 3:89; PMID:21715679; http://dx.doi.org/10.1126/scitranslmed.3002346.
    • (2011) Sci Transl Med , vol.3 , pp. 89
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    Mazzulli, J.R.4    Erdos, M.R.5    Krainc, D.6
  • 30
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • PMID:20157517
    • Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging 2009; 1:281-8; PMID:20157517.
    • (2009) Aging , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 31
    • 79960635284 scopus 로고    scopus 로고
    • Fighting neurodegeneration with rapamycin: Mechanistic insights
    • PMID:21772323
    • Bové J, Martinez-Vicente M, Vila M. Fighting neurodegeneration with rapamycin: mechanistic insights. Nat Rev Neurosci 2011; 12:437-52; PMID:21772323; http://dx.doi.org/10.1038/nrn3068.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 437-452
    • Bové, J.1    Martinez-Vicente, M.2    Vila, M.3
  • 33
    • 80052084689 scopus 로고    scopus 로고
    • mTOR pathway activation in age-related retinal disease
    • PMID:21483039
    • Zhao C, Vollrath D. mTOR pathway activation in age-related retinal disease. Aging 2011; 3:346-7; PMID:21483039.
    • (2011) Aging , vol.3 , pp. 346-347
    • Zhao, C.1    Vollrath, D.2
  • 34
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
    • PMID:17012837
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102; PMID:17012837; http://dx.doi.org/10.4161/cc.5.18.3288.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 36
    • 0345237923 scopus 로고    scopus 로고
    • Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: Correlation to extended longevity
    • PMID:12663691
    • Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci 2003; 58:291-6; PMID:12663691; http://dx.doi.org/10.1093/gerona/58.4.B291.
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 , pp. 291-296
    • Ikeno, Y.1    Bronson, R.T.2    Hubbard, G.B.3    Lee, S.4    Bartke, A.5
  • 37
    • 65549149453 scopus 로고    scopus 로고
    • Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice
    • PMID:19228785
    • Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR, et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 2009; 64:522-9; PMID:19228785; http://dx.doi.org/10.1093/gerona/glp017.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 522-529
    • Ikeno, Y.1    Hubbard, G.B.2    Lee, S.3    Cortez, L.A.4    Lew, C.M.5    Webb, C.R.6
  • 38
    • 50849110457 scopus 로고    scopus 로고
    • Prevention of cancer by inhibiting aging
    • PMID:18769112
    • Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther 2008; 7:1520-4; PMID:18769112; http://dx.doi.org/10.4161/cbt.7.10.6663.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1520-1524
    • Blagosklonny, M.V.1
  • 39
    • 78650316639 scopus 로고    scopus 로고
    • Metformin for aging and cancer prevention
    • PMID:21084729
    • Anisimov VN. Metformin for aging and cancer prevention. Aging 2010; 2:760-74; PMID:21084729.
    • (2010) Aging , vol.2 , pp. 760-774
    • Anisimov, V.N.1
  • 40
    • 75249094454 scopus 로고    scopus 로고
    • Calorie restriction and cancer prevention: Metabolic and molecular mechanisms
    • PMID:20097433
    • Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci 2010; 31:89-98; PMID:20097433; http://dx.doi.org/10.1016/j.tips.2009.11.004.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 89-98
    • Longo, V.D.1    Fontana, L.2
  • 41
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)
    • PMID:20139716
    • Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle 2010; 9:683-8; PMID:20139716; http://dx.doi.org/10.4161/cc.9.4.10766.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 42
    • 77953635101 scopus 로고    scopus 로고
    • At the crossroad of lifespan, calorie restriction, chromatin and disease: Meeting on sirtuins
    • PMID:20458180
    • Mostoslavsky R, Esteller M, Vaquero A. At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. Cell Cycle 2010; 9:1907-12; PMID:20458180; http://dx.doi.org/10.4161/cc.9.10.11481.
    • (2010) Cell Cycle , vol.9 , pp. 1907-1912
    • Mostoslavsky, R.1    Esteller, M.2    Vaquero, A.3
  • 44
    • 79952265105 scopus 로고    scopus 로고
    • Gender differences in metformin effect on aging, lifespan and spontaneous tumorigenesis in 129/Sv mice
    • PMID:21164223
    • Anisimov VN, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Egormin PA, et al. Gender differences in metformin effect on aging, lifespan and spontaneous tumorigenesis in 129/Sv mice. Aging 2010; 2:945-58; PMID:21164223.
    • (2010) Aging , vol.2 , pp. 945-958
    • Anisimov, V.N.1    Piskunova, T.S.2    Popovich, I.G.3    Zabezhinski, M.A.4    Tyndyk, M.L.5    Egormin, P.A.6
  • 45
    • 79959564452 scopus 로고    scopus 로고
    • If started early in life, metformin treatment increases lifespan and postpones tumors in female SHR mice
    • PMID:21386129
    • Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, Piskunova TS, et al. If started early in life, metformin treatment increases lifespan and postpones tumors in female SHR mice. Aging 2011; 3:148-57; PMID:21386129.
    • (2011) Aging , vol.3 , pp. 148-157
    • Anisimov, V.N.1    Berstein, L.M.2    Popovich, I.G.3    Zabezhinski, M.A.4    Egormin, P.A.5    Piskunova, T.S.6
  • 46
    • 74549131244 scopus 로고    scopus 로고
    • Metformin extends lifespan of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
    • PMID:20016287
    • Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, Yurova MN, et al. Metformin extends lifespan of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle 2010; 9:188-97; PMID:20016287; http://dx.doi.org/10.4161/cc.9.1. 10407.
    • (2010) Cell Cycle , vol.9 , pp. 188-197
    • Anisimov, V.N.1    Egormin, P.A.2    Piskunova, T.S.3    Popovich, I.G.4    Tyndyk, M.L.5    Yurova, M.N.6
  • 47
    • 25444462729 scopus 로고    scopus 로고
    • Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice
    • PMID:16224592
    • Anisimov VN, Egormin PA, Bershtein LM, Zabezhinskii MA, Piskunova TS, Popovich IG, et al. Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. Bull Exp Biol Med 2005; 139:721-3; PMID:16224592; http://dx.doi.org/10.1007/s10517-005-0389-9.
    • (2005) Bull Exp Biol Med , vol.139 , pp. 721-723
    • Anisimov, V.N.1    Egormin, P.A.2    Bershtein, L.M.3    Zabezhinskii, M.A.4    Piskunova, T.S.5    Popovich, I.G.6
  • 48
    • 24644475793 scopus 로고    scopus 로고
    • Effect of metformin on lifespan and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • PMID:16125352
    • Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, et al. Effect of metformin on lifespan and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 2005; 40:685-93; PMID:16125352; http://dx.doi.org/10.1016/j.exger.2005.07.007.
    • (2005) Exp Gerontol , vol.40 , pp. 685-693
    • Anisimov, V.N.1    Berstein, L.M.2    Egormin, P.A.3    Piskunova, T.S.4    Popovich, I.G.5    Zabezhinski, M.A.6
  • 49
    • 79952275086 scopus 로고    scopus 로고
    • Metformin and sex: Why suppression of aging may be harmful to young male mice
    • PMID:21212463
    • Blagosklonny MV. Metformin and sex: Why suppression of aging may be harmful to young male mice. Aging 2010; 2:897-9; PMID:21212463.
    • (2010) Aging , vol.2 , pp. 897-899
    • Blagosklonny, M.V.1
  • 50
    • 0036722946 scopus 로고    scopus 로고
    • Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    • PMID:12209581
    • Anisimov VN, Khavinson VK, Provinciali M, Alimova IN, Baturin DA, Popovich IG, et al. Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer 2002; 101:7-10; PMID:12209581; http://dx.doi.org/10.1002/ijc.10570.
    • (2002) Int J Cancer , vol.101 , pp. 7-10
    • Anisimov, V.N.1    Khavinson, V.K.2    Provinciali, M.3    Alimova, I.N.4    Baturin, D.A.5    Popovich, I.G.6
  • 51
    • 0036695321 scopus 로고    scopus 로고
    • Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice
    • PMID:12360351
    • Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, Khavinson V, Anisimov VN. Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. Bull Exp Biol Med 2002; 133:274-6; PMID:12360351; http://dx.doi.org/10.1023/A:1015899003974.
    • (2002) Bull Exp Biol Med , vol.133 , pp. 274-276
    • Rosenfeld, S.V.1    Togo, E.F.2    Mikheev, V.S.3    Popovich, I.G.4    Khavinson, V.5    Anisimov, V.N.6


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