Prospective treatment of age-related diseases by slowing down aging

American Journal of Pathology

Volumn 181, Issue 4, 2012, Pages 1142-1146

  Blagosklonny, Mikhail V ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

ADIPOCYTE; AGING; ALZHEIMER DISEASE; ATHEROSCLEROSIS; CALORIC RESTRICTION; CELL AGING; CELL MIGRATION; DRUG EFFECT; DRUG EFFICACY; ENDOTHELIUM CELL; GERIATRIC DISORDER; HEART MUSCLE FIBROSIS; HUMAN; HUNTINGTON CHOREA; KIDNEY FIBROSIS; LIFESPAN; LIVER CELL; LIVER FIBROSIS; LONGEVITY; MACROPHAGE; MOLECULAR PATHOLOGY; MOLECULARLY TARGETED THERAPY; NEOPLASM; NONHUMAN; OBESITY; OSTEOARTHRITIS; OSTEOPOROSIS; PALLIATIVE THERAPY; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SPINOCEREBELLAR DEGENERATION; SURVIVAL; THROMBOCYTE; TREATMENT INDICATION;

EID: 84866494334     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.06.024     Document Type: Short Survey

References (63)

1. L.M. Berstein Metformin, insulin, breast cancer and more Future Oncol 5 2009 309 312
2. M. Henricsson, L. Janzon, L. Groop Progression of retinopathy after change of treatment from oral antihyperglycemic agents to insulin in patients with NIDDM Diabetes Care 18 1995 1571 1576
3. A. Bartke Insulin and aging Cell Cycle 7 2008 3338 3343
4. N. Barzilai, D.M. Huffman, R.H. Muzumdar, A. Bartke The critical role of metabolic pathways in aging Diabetes 61 2012 1315 1322
5. S. Wullschleger, R. Loewith, M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484 (Pubitemid 43199434)
6. Z.N. Demidenko, M.V. Blagosklonny Growth stimulation leads to cellular senescence when the cell cycle is blocked Cell Cycle 7 2008 3355 3361
7. Z.N. Demidenko, S.G. Zubova, E.I. Bukreeva, V.A. Pospelov, T.V. Pospelova, M.V. Blagosklonny Rapamycin decelerates cellular senescence Cell Cycle 8 2009 1888 1895
8. O.V. Leontieva, M.V. Blagosklonny DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence Aging (Albany NY) 2 2010 924 935
9. M.V. Blagosklonny Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging Aging (Albany NY) 4 2012 159 165
10. Z.N. Demidenko, L.G. Korotchkina, A.V. Gudkov, M.V. Blagosklonny Paradoxical suppression of cellular senescence by p53 Proc Natl Acad Sci U S A 107 2010 9660 9664
11. O. Leontieva, A. Gudkov, M. Blagosklonny Weak p53 permits senescence during cell cycle arrest Cell Cycle 9 2010 4323 4327
12. B. Gan, E. Sahin, S. Jiang, A. Sanchez-Aguilera, K.L. Scott, L. Chin, D.A. Williams, D.J. Kwiatkowski, R.A. DePinho mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization Proc Natl Acad Sci U S A 105 2008 19384 19389
13. C. Chen, Y. Liu, P. Zheng mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells Sci Signal 2 2009 ra75
14. K. Cao, J.J. Graziotto, C.D. Blair, J.R. Mazzulli, M.R. Erdos, D. Krainc, F.S. Collins Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells Sci Transl Med 3 2011 89ra58
15. M. Narita, A.R. Young, S. Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S. Hong, L.S. Berry, S. Reichelt, M. Ferreira, S. Tavare, K. Inoki, S. Shimizu Spatial coupling of mTOR and autophagy augments secretory phenotypes Science 332 2011 966 970
16. A. Orlandi, M.L. Bochaton-Piallat, G. Gabbiani, L.G. Spagnoli Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis Atherosclerosis 188 2006 221 230 (Pubitemid 44301147)
17. D. Siegel-Axel, K. Daub, P. Seizer, S. Lindemann, M. Gawaz Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis Cardiovasc Res 78 2008 8 17 (Pubitemid 351430965)
18. R. Baetta, A. Granata, M. Canavesi, N. Ferri, L. Arnaboldi, S. Bellosta, P. Pfister, A. Corsini Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits J Pharmacol Exp Ther 328 2009 419 425
19. R. Pakala, E. Stabile, G.J. Jang, L. Clavijo, R. Waksman Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis J Cardiovasc Pharmacol 46 2005 481 486 (Pubitemid 41407577)
20. M.A. Mueller, F. Beutner, D. Teupser, U. Ceglarek, J. Thiery Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR-/- mice despite severe hypercholesterolemia Atherosclerosis 198 2008 39 48 (Pubitemid 351406366)
21. A. Keogh, M. Richardson, P. Ruygrok, P. Spratt, A. Galbraith, G. O'Driscoll, P. Macdonald, D. Esmore, D. Muller, S. Faddy Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial Circulation 110 2004 2694 2700 (Pubitemid 39453021)
22. A.E. Rodriguez, J.F. Granada, M. Rodriguez-Alemparte, C.F. Vigo, J. Delgado, C. Fernandez-Pereira, A. Pocovi, A.M. Rodriguez-Granillo, D. Schulz, A.E. Raizner, I. Palacios, W. O'Neill, G.L. Kaluza, G. Stone ORAR II Investigators Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study J Am Coll Cardiol 47 2006 1522 1529
23. T. Mathew, H. Kreis, P. Friend Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies Clin Transplant 18 2004 446 449 (Pubitemid 39077081)
24. H.M. Kauffman, W.S. Cherikh, Y. Cheng, D.W. Hanto, B.D. Kahan Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies Transplantation 80 2005 883 889 (Pubitemid 41552882)
25. J.M. Campistol, J. Eris, R. Oberbauer, P. Friend, B. Hutchison, J.M. Morales, K. Claesson, G. Stallone, G. Russ, L. Rostaing, H. Kreis, J.T. Burke, Y. Brault, J.A. Scarola, J.F. Neylan Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation J Am Soc Nephrol 17 2006 581 589
26. G. Stallone, A. Schena, B. Infante, S. Di Paolo, A. Loverre, G. Maggio, E. Ranieri, L. Gesualdo, F.P. Schena, G. Grandaliano Sirolimus for Kaposi's sarcoma in renal-transplant recipients N Engl J Med 352 2005 1317 1323 (Pubitemid 40411498)
27. C.A. Granville, N. Warfel, J. Tsurutani, M.C. Hollander, M. Robertson, S.D. Fox, T.D. Veenstra, H.J. Issaq, R.I. Linnoila, P.A. Dennis Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors Clin Cancer Res 13 2007 2281 2289 (Pubitemid 46649898)
28. M.V. Blagosklonny Prevention of cancer by inhibiting aging Cancer Biol Ther 7 2008 1520 1524
29. M.V. Blagosklonny Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans) Cell Cycle 9 2010 683 688
30. M. Kneissel, N.H. Luong-Nguyen, M. Baptist, R. Cortesi, S. Zumstein-Mecker, S. Kossida, T. O'Reilly, H. Lane, M. Susa Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts Bone 35 2004 1144 1156 (Pubitemid 39487361)
31. J. Rovira, E. Marcelo Arellano, J.T. Burke, Y. Brault, D. Moya-Rull, E. Bañón-Maneus, M.J. Ramírez-Bajo, A. Gutiérrez-Dalmau, I. Revuelta, L.F. Quintana, J.M. Campistol, F. Diekmann Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients Transpl Int 21 2008 992 998
32. G.R. Chang, Y.S. Chiu, Y.Y. Wu, W.Y. Chen, J.W. Liao, T.H. Chao, F.C. Mao Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice J Pharmacol Sci 109 2009 496 503
33. J. Bove, M. Martinez-Vicente, M. Vila Fighting neurodegeneration with rapamycin: mechanistic insights Nat Rev Neurosci 12 2011 437 452
34. B. Carames, A. Hasegawa, N. Taniguchi, S. Miyaki, F.J. Blanco, M. Lotz Autophagy activation by rapamycin reduces severity of experimental osteoarthritis Ann Rheum Dis 71 2012 575 581
35. M. Neef, M. Ledermann, H. Saegesser, V. Schneider, J. Reichen Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis J Hepatol 45 2006 786 796 (Pubitemid 44646687)
36. X.M. Gao, G. Wong, B. Wang, H. Kiriazis, X.L. Moore, Y.D. Su, A. Dart, X.J. Du Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis J Hypertens 24 2006 1663 1670 (Pubitemid 44162470)
37. M.V. Blagosklonny Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition Cell Cycle 5 2006 2087 2102 (Pubitemid 44566240)
38. M.V. Blagosklonny Rapamycin-induced glucose intolerance: hunger or starvation diabetes Cell Cycle 10 2011 4217 4224
39. S. Majumder, A. Caccamo, D.X. Medina, A.D. Benavides, M.A. Javors, E. Kraig, R. Strong, A. Richardson, S. Oddo Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling Aging Cell 11 2012 326 335
40. L. Khamzina, A. Veilleux, S. Bergeron, A. Marette Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance Endocrinology 146 2005 1473 1481 (Pubitemid 40289337)
41. D. Stipp A new path to longevity Sci Am 306 2012 32 39
42. P. Kapahi, B.M. Zid, T. Harper, D. Koslover, V. Sapin, S. Benzer Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway Curr Biol 14 2004 885 890 (Pubitemid 38800910)
43. D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, N.L. Nadon, J.E. Wilkinson, K. Frenkel, C.S. Carter, M. Pahor, M.A. Javors, E. Fernandezr, R.A. Miller Rapamycin fed late in life extends lifespan in genetically heterogenous mice Nature 460 2009 392 396
44. C. Selman, J.M. Tullet, D. Wieser, E. Irvine, S.J. Lingard, A.I. Choudhury, M. Claret, H. Al-Qassab, D. Carmignac, F. Ramadani, A. Woods, I.C. Robinson, E. Schuster, R.L. Batterham, S.C. Kozma, G. Thomas, D. Carling, K. Okkenhaug, J.M. Thornton, L. Partridge, D. Gems, D.J. Withers Ribosomal protein S6 kinase 1 signaling regulates mammalian life span Science 326 2009 140 144
45. A.A. Moskalev, M.V. Shaposhnikov Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster Rejuvenation Res 13 2010 246 247
46. I. Bjedov, J.M. Toivonen, F. Kerr, C. Slack, J. Jacobson, A. Foley, L. Partridge Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster Cell Metab 11 2010 35 46
47. R.A. Miller, D.E. Harrison, C.M. Astle, J.A. Baur, A.R. Boyd, R. DE Cabo, E. Fernandez, K. Flurkey, M.A. Javors, J.F. Nelson, C.J. Orihuela, S. Pletcher, Z.D. Sharp, D. Sinclair, J.W. Starnes, J.E. Wilkinson, N.L. Nadon, R. Strong Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice J Gerontol A Biol Sci Med Sci 66 2011 191 201
48. V.N. Anisimov, M.A. Zabezhinski, I.G. Popovich, T.S. Piskunova, A.V. Semenchenko, M.L. Tyndyk, M.N. Yurova, M.P. Antoch, M.V. Blagosklonny Rapamycin extends maximal lifespan in cancer-prone mice Am J Pathol 176 2010 2092 2097
49. V.N. Anisimov, M.A. Zabezhinski, I.G. Popovich, T.S. Piskunova, A.V. Semenchenko, M.L. Tyndyk, M.N. Yurova, S.V. Rosenfeld, M.V. Blagosklonny Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice Cell Cycle 10 2011 4230 4236
50. D.W. Lamming, L. Ye, P. Katajisto, M.D. Goncalves, M. Saitoh, D.M. Stevens, J.G. Davis, A.B. Salmon, A. Richardson, R.S. Ahima, D.A. Guertin, D.M. Sabatini, J.A. Baur Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity Science 335 2012 1638 1643
51. L. Fontana, L. Partridge, V.D. Longo Extending healthy life span: from yeast to humans Science 328 2010 321 326
52. J.O. Holloszy, L. Fontana Caloric restriction in humans Exp Gerontol 42 2007 709 712 (Pubitemid 47058857)
53. R.J. Colman, R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, T.M. Beasley, D.B. Allison, C. Cruzen, H.A. Simmons, J.W. Kemnitz, R. Weindruch Caloric restriction delays disease onset and mortality in rhesus monkeys Science 325 2009 201 204
54. L. Fontana, T.E. Meyer, S. Klein, J.O. Holloszy Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans Proc Natl Acad Sci U S A 101 2004 6659 6663 (Pubitemid 38586030)
55. A. Soare, R. Cangemi, D. Omodei, J.O. Holloszy, L. Fontana Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans Aging (Albany NY) 3 2010 374 379
56. A.V. Witte, M. Fobker, R. Gellner, S. Knecht, A. Floel Caloric restriction improves memory in elderly humans Proc Natl Acad Sci U S A 106 2009 1255 1260
57. D.L. Williamson Normalizing a hyperactive mTOR initiates muscle growth during obesity Aging (Albany NY) 3 2011 83 84
58. E. Marzetti, H.A. Lees, S.E. Wohlgemuth, C. Leeuwenburgh Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction Biofactors 35 2009 28 35
59. Z. Li, D. Heber Sarcopenic obesity in the elderly and strategies for weight management Nutr Rev 70 2012 57 64
60. R. Muzumdar, D.B. Allison, D.M. Huffman, X. Ma, G. Atzmon, F.H. Einstein, S. Fishman, A.D. Poduval, T. McVei, S.W. Keith, N. Barzilai Visceral adipose tissue modulates mammalian longevity Aging Cell 7 2008 438 440 (Pubitemid 351663912)
61. F. Tremblay, M. Krebs, L. Dombrowski, A. Brehm, E. Bernroider, E. Roth, P. Nowotny, W. Waldhäusl, A. Marette, M. Roden Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability Diabetes 54 2005 2674 2684 (Pubitemid 41233590)
62. S. Sengupta, T.R. Peterson, M. Laplante, S. Oh, D.M. Sabatini mTORC1 controls fasting-induced ketogenesis and its modulation by ageing Nature 468 2010 1100 1104
63. C. Wang, M. Maddick, S. Miwa, D. Jurk, R. Czapiewski, G. Saretzki, S.A. Langie, R.W. Godschalk, K. Cameron, T. von Zglinicki Adult-onset, short-term dietary restriction reduces cell senescence in mice Aging (Albany NY) 2 2010 555 566