Joint influence of small-effect genetic variants on human longevity

Aging

Volumn 2, Issue 9, 2010, Pages 612-620

  Yashin, Anatoliy I ^a,b   Wu, Deqing ^a   Arbeev, Konstantin G ^a   Ukraintseva, Svetlana V ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE CANCER INSTITUTE   (United States)

Author keywords

Aging; Framingham heart study; Genome wide association studies; Longevity

Indexed keywords

AGING; ALLELE; ARTICLE; GENETIC VARIABILITY; GENETICS; HUMAN; HUMAN GENOME; LONGEVITY; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

AGING; ALLELES; GENETIC VARIATION; GENOME, HUMAN; HUMANS; LONGEVITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79952118505     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100191     Document Type: Article

References (11)

1. Hardy J, Singleton A. Genomewide Association Studies and Human Disease. New Engl J Med 2009; 360:1759-1768.
2. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TFC, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753.
3. Slatkin M. Epigenetic Inheritance and the Missing Heritability Problem. Genetics 2009; 182:845-850.
4. Visscher PM, Hill WG, Wray NR. Heritability in the genomics era - concepts and misconceptions. Nat Rev Genet 2008; 9:255-266.
5. Maher B. Personal genomes: The case of the missing heritability. Nature 2008; 456:18-21.
6. Goldstein DB. Common Genetic Variation and Human Traits. New Engl J Med 2009; 360:1696-1698.
7. Gravina S, Lescai F, Hurteau G, Brock GJ, Saramaki A, Salvioli S, Franceschi C, Roninson IB. Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging. 2009; 5:470-80.
8. Vijg J. SNP'ing for longevity. Aging. 2009; 5:442-443.
9. Lunetta KL, D'Agostino RB, Sr., Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet 2007; 8:S13.
10. Herskind AM, McGue M, Holm NV, Sorensen TIA, Harvald B, Vaupel JW. The heritability of human longevity: A populationbased study of 2872 Danish twin pairs born 1870-1900. Hum Genet 1996; 97:319-323.
11. Nyholt DR. A simple correction for multiple testing for singlenucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74:765-769.