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Volumn 3, Issue 8-9, 2004, Pages 927-934

The multifaceted role of mTOR in cellular stress responses

Author keywords

Amino acids; Apoptosis; DNA damage; Hypoxia; mTOR; Signaling

Indexed keywords

RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

EID: 3242892160     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2004.03.012     Document Type: Review
Times cited : (76)

References (65)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2001;2177-2196
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 5
    • 0037623417 scopus 로고    scopus 로고
    • GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • Kim D.H., Sarbassov D., Ali S.M., Latek R.R., Guntur K.V., Erdjument-Bromage H., Tempst P., Sabatini D. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell. 11:2002;895-904
    • (2002) Mol. Cell , vol.11 , pp. 895-904
    • Kim, D.H.1    Sarbassov, D.2    Ali, S.M.3    Latek, R.R.4    Guntur, K.V.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.8
  • 7
    • 0038482156 scopus 로고    scopus 로고
    • Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
    • Choi K.-M., McMahon L.P., Lawrence J.C. Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J. Biol. Chem. 278:2003;19667-19673
    • (2003) J. Biol. Chem. , vol.278 , pp. 19667-19673
    • Choi, K.-M.1    McMahon, L.P.2    Lawrence, J.C.3
  • 10
    • 0037007014 scopus 로고    scopus 로고
    • FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
    • Desai B.N., Myers B.R., Schreiber S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. U.S.A. 99:2002;4319-4324
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 4319-4324
    • Desai, B.N.1    Myers, B.R.2    Schreiber, S.L.3
  • 11
    • 0037008730 scopus 로고    scopus 로고
    • Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture
    • Zhang X., Shu L., Hosoi H., Murti K.G., Houghton P.J. Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. J. Biol. Chem. 277:2002;28127-28134
    • (2002) J. Biol. Chem. , vol.277 , pp. 28127-28134
    • Zhang, X.1    Shu, L.2    Hosoi, H.3    Murti, K.G.4    Houghton, P.J.5
  • 12
    • 0036837863 scopus 로고    scopus 로고
    • The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin
    • McMahon L.P., Choi K.-M., Lin T.A., Abraham R.T., Lawrence J.C. The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol. Cell Biol. 22:2002;7428-7438
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7428-7438
    • McMahon, L.P.1    Choi, K.-M.2    Lin, T.A.3    Abraham, R.T.4    Lawrence, J.C.5
  • 13
    • 0142071830 scopus 로고    scopus 로고
    • The TOR-signaling and RAIP motifs play distinct roles in the mTOR-dependent phosphorylation of initiation factor 4E-binding protein 1 in vivo
    • Beugnet A., Wang X., Proud C.G. The TOR-signaling and RAIP motifs play distinct roles in the mTOR-dependent phosphorylation of initiation factor 4E-binding protein 1 in vivo. J. Biol. Chem. 278:2003;40717-40722
    • (2003) J. Biol. Chem. , vol.278 , pp. 40717-40722
    • Beugnet, A.1    Wang, X.2    Proud, C.G.3
  • 14
    • 0002921709 scopus 로고    scopus 로고
    • Translational control of TOP mRNAs
    • N. Sonenberg, J.W.B. Hershey, M.B. Mathews (Eds.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • O. Meyuhas, E. Hornstein, Translational control of TOP mRNAs, in: N. Sonenberg, J.W.B. Hershey, M.B. Mathews (Eds.), Translational control of gene expression, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2000, pp. 671-693.
    • (2000) Translational Control of Gene Expression , pp. 671-693
    • Meyuhas, O.1    Hornstein, E.2
  • 15
    • 11144356304 scopus 로고    scopus 로고
    • S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    • Pende M., Um S.H., Mieulet V., Sticker M., Goss V.L., Mestan J., Mueller M., Fumagalli S., Kozma S.C., Thomas G. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell Biol. 24:2004;3112-3124
    • (2004) Mol. Cell Biol. , vol.24 , pp. 3112-3124
    • Pende, M.1    Um, S.H.2    Mieulet, V.3    Sticker, M.4    Goss, V.L.5    Mestan, J.6    Mueller, M.7    Fumagalli, S.8    Kozma, S.C.9    Thomas, G.10
  • 16
    • 0035200856 scopus 로고    scopus 로고
    • Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
    • Tang H., Hornstein E., Stolovich M., Levy G., Livingstone M., Templeton D., Avruch J., Meyuhas O. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol. Cell Biol. 21:2001;8671-8683
    • (2001) Mol. Cell Biol. , vol.21 , pp. 8671-8683
    • Tang, H.1    Hornstein, E.2    Stolovich, M.3    Levy, G.4    Livingstone, M.5    Templeton, D.6    Avruch, J.7    Meyuhas, O.8
  • 18
    • 0032538890 scopus 로고    scopus 로고
    • Disruption of the p70S6k/p85S6k gene reveals a small mouse phenotype and a new functional S6 kinase
    • Shima H., Pende M., Chen Y., Fumagalli S., Thomas G., Kozma S.C. Disruption of the p70S6k/p85S6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17:1998;6649-6659
    • (1998) EMBO J. , vol.17 , pp. 6649-6659
    • Shima, H.1    Pende, M.2    Chen, Y.3    Fumagalli, S.4    Thomas, G.5    Kozma, S.C.6
  • 19
    • 0030883848 scopus 로고    scopus 로고
    • PHAS/4E-BPs as regulators of mRNA translation and cell proliferation
    • Lawrence J.C., Abraham R.T. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem. Sci. 22:1997;345-349
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 345-349
    • Lawrence, J.C.1    Abraham, R.T.2
  • 20
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras A.-C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:2001;807-826
    • (2001) Genes Dev. , vol.15 , pp. 807-826
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 21
    • 0034660062 scopus 로고    scopus 로고
    • A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, eIF4E
    • Dostie J., Ferraiuolo M., Pause A., Adam S.A., Sonenberg N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, eIF4E. EMBO J. 19:2000;3142-3156
    • (2000) EMBO J. , vol.19 , pp. 3142-3156
    • Dostie, J.1    Ferraiuolo, M.2    Pause, A.3    Adam, S.A.4    Sonenberg, N.5
  • 22
    • 0025314596 scopus 로고
    • Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
    • Lazaris-Karatzas A., Montine K.S., Sonenberg N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature. 345:1990;544-547
    • (1990) Nature , vol.345 , pp. 544-547
    • Lazaris-Karatzas, A.1    Montine, K.S.2    Sonenberg, N.3
  • 23
    • 0025107684 scopus 로고
    • Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology
    • De Benedetti A., Rhoads R.E. Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. Proc. Natl. Acad. Sci. U.S.A. 87:1990;8212-8216
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 8212-8216
    • De Benedetti, A.1    Rhoads, R.E.2
  • 24
    • 0030443685 scopus 로고    scopus 로고
    • The eIF4E-binding protein-1 and protein-2 are negative regulators of cell growth
    • Rousseau D., Gingras A.-C., Pause A., Sonenberg N. The eIF4E-binding protein-1 and protein-2 are negative regulators of cell growth. Oncogene. 13:1996;2415-2420
    • (1996) Oncogene , vol.13 , pp. 2415-2420
    • Rousseau, D.1    Gingras, A.-C.2    Pause, A.3    Sonenberg, N.4
  • 26
    • 1542751639 scopus 로고    scopus 로고
    • The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
    • Mita M.M., Mita A., Rowinsky E.K. The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol. Ther. 2:2003;S169-S177
    • (2003) Cancer Biol. Ther. , vol.2 , pp. 169-S177
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 27
    • 0030041884 scopus 로고    scopus 로고
    • Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 messenger-RNA are increased in cells overexpressing eukaryotic initiation factor 4E
    • Rousseau D., Kaspar R., Rosenwald I., Gehrke L., Sonenberg N. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 messenger-RNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc. Natl. Acad. Sci. U.S.A. 93:1996;1065-1070
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1065-1070
    • Rousseau, D.1    Kaspar, R.2    Rosenwald, I.3    Gehrke, L.4    Sonenberg, N.5
  • 28
  • 29
    • 0034624746 scopus 로고    scopus 로고
    • Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1
    • Tan A., Bitterman P., Sonenberg N., Peterson M., Polunovsky V. Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1. Oncogene. 19:2000;1437-1447
    • (2000) Oncogene , vol.19 , pp. 1437-1447
    • Tan, A.1    Bitterman, P.2    Sonenberg, N.3    Peterson, M.4    Polunovsky, V.5
  • 30
    • 0343167422 scopus 로고    scopus 로고
    • Rapid induction of apoptosis mediated through peptides that bind initiation factor eIF4E
    • Herbert T.P., Fahraeus R., Prescott A., Lane D.P., Proud C.G. Rapid induction of apoptosis mediated through peptides that bind initiation factor eIF4E. Curr. Biol. 10:2000;793-796
    • (2000) Curr. Biol. , vol.10 , pp. 793-796
    • Herbert, T.P.1    Fahraeus, R.2    Prescott, A.3    Lane, D.P.4    Proud, C.G.5
  • 31
    • 0036438894 scopus 로고    scopus 로고
    • Regulation of peptide-chain elongation in mammalian cells
    • Browne G.J., Proud C.G. Regulation of peptide-chain elongation in mammalian cells. Eur. J. Biochem. 269:2002;5360-5368
    • (2002) Eur. J. Biochem. , vol.269 , pp. 5360-5368
    • Browne, G.J.1    Proud, C.G.2
  • 33
    • 0036310982 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
    • Peng T., Golub T.R., Sabatini D.M. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell Biol. 21:2002;5575-5584
    • (2002) Mol. Cell Biol. , vol.21 , pp. 5575-5584
    • Peng, T.1    Golub, T.R.2    Sabatini, D.M.3
  • 35
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus E.J., Alessi D.R. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat. Cell Biol. 4:2002;E214-E216
    • (2002) Nat. Cell Biol. , vol.4 , pp. 214-E216
    • McManus, E.J.1    Alessi, D.R.2
  • 36
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/mTOR signalling network
    • Saucedo L.J., Gao X., Chiarelli D.A., Li L., Pan D., Edgar B.A. Rheb promotes cell growth as a component of the insulin/mTOR signalling network. Nat. Cell Biol. 5:2003;566-571
    • (2003) Nat. Cell Biol. , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 38
    • 0036440779 scopus 로고    scopus 로고
    • Regulation of mammalian translation factors by nutrients
    • Proud C.G. Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 269:2002;5338-5349
    • (2002) Eur. J. Biochem. , vol.269 , pp. 5338-5349
    • Proud, C.G.1
  • 39
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E BP1 through a common effector mechanism
    • Hara K., Yonezawa K., Weng Q.-P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E BP1 through a common effector mechanism. J. Biol. Chem. 273:1998;14484-14494
    • (1998) J. Biol. Chem. , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.-P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 40
    • 0037155888 scopus 로고    scopus 로고
    • Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a TOR-dependent manner
    • Christie G.R., Hajduch E., Hundal H.S., Proud C.G., Taylor P.M. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a TOR-dependent manner. J. Biol. Chem. 277:2002;9952-9957
    • (2002) J. Biol. Chem. , vol.277 , pp. 9952-9957
    • Christie, G.R.1    Hajduch, E.2    Hundal, H.S.3    Proud, C.G.4    Taylor, P.M.5
  • 43
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through downregulated mTOR signaling
    • D.R. Bolster, S.J. Crozier, S.R. Kimball, L.S. Jefferson, AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through downregulated mTOR signaling, J. Biol. Chem. 277, 2002.
    • (2002) J. Biol. Chem. , vol.277
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 44
    • 0036364274 scopus 로고    scopus 로고
    • Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
    • Krause U., Bertrand L., Hue L. Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur. J. Biochem. 269:2002;3751-3759
    • (2002) Eur. J. Biochem. , vol.269 , pp. 3751-3759
    • Krause, U.1    Bertrand, L.2    Hue, L.3
  • 46
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 115:2003;577-590
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 48
    • 0037145807 scopus 로고    scopus 로고
    • ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling
    • McLeod L.E., Proud C.G. ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. FEBS Lett. 531:2002;448-452
    • (2002) FEBS Lett. , vol.531 , pp. 448-452
    • McLeod, L.E.1    Proud, C.G.2
  • 49
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham A.M., Howell J.J., Simon M.C. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 278:2003;29655-29660
    • (2003) J. Biol. Chem. , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 50
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
    • Humar R., Kiefer F.N., Berns H., Resink T.J., Battegay E.J. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J. 16:2002;771-780
    • (2002) FASEB J. , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3    Resink, T.J.4    Battegay, E.J.5
  • 51
    • 0033571682 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., Simons J.W. Modulation of hypoxia-inducible factor 1a expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 59:1999;5830-5835
    • (1999) Cancer Res. , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3    Lim, M.4    Hilton, D.A.5    Zagzag, D.6    Buechler, P.7    Isaacs, W.B.8    Semenza, G.L.9    Simons, J.W.10
  • 55
    • 0034659730 scopus 로고    scopus 로고
    • DNA damage causes inactivation of translational regulators linked to mTOR signalling
    • Tee A.R., Proud C.G. DNA damage causes inactivation of translational regulators linked to mTOR signalling. Oncogene. 19:2000;3021-3031
    • (2000) Oncogene , vol.19 , pp. 3021-3031
    • Tee, A.R.1    Proud, C.G.2
  • 57
    • 0037043851 scopus 로고    scopus 로고
    • P53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation
    • Horton L.E., Bushell M., Barth-Baus D., Tilleray V.J., Clemens M.J., Hensold J.O. p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene. 21:2002;5325-5334
    • (2002) Oncogene , vol.21 , pp. 5325-5334
    • Horton, L.E.1    Bushell, M.2    Barth-Baus, D.3    Tilleray, V.J.4    Clemens, M.J.5    Hensold, J.O.6
  • 58
    • 0032100624 scopus 로고    scopus 로고
    • P53 is a general repressor of RNA polymerase III transcription
    • Cairns C.A., White R.J. p53 is a general repressor of RNA polymerase III transcription. EMBO J. 17:2003;3112-3123
    • (2003) EMBO J. , vol.17 , pp. 3112-3123
    • Cairns, C.A.1    White, R.J.2
  • 60
    • 0030694253 scopus 로고    scopus 로고
    • Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells
    • Metcalfe S.M., Canman C.E., Milner J., Morris R.E., Goldman S., Kastan M.B. Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. Oncogene. 15:1997;1635-1642
    • (1997) Oncogene , vol.15 , pp. 1635-1642
    • Metcalfe, S.M.1    Canman, C.E.2    Milner, J.3    Morris, R.E.4    Goldman, S.5    Kastan, M.B.6
  • 61
    • 0033662156 scopus 로고    scopus 로고
    • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang D.-Q., Kastan M.B. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat. Cell Biol. 2:2000;893-898
    • (2000) Nat. Cell Biol. , vol.2 , pp. 893-898
    • Yang, D.-Q.1    Kastan, M.B.2
  • 62
    • 0037373346 scopus 로고    scopus 로고
    • The C-terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
    • Wang X., Li W., Parra J.-L., Beugnet A., Proud C.G. The C-terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol. Cell Biol. 23:2003;1546-1557
    • (2003) Mol. Cell Biol. , vol.23 , pp. 1546-1557
    • Wang, X.1    Li, W.2    Parra, J.-L.3    Beugnet, A.4    Proud, C.G.5
  • 63
    • 0035877641 scopus 로고    scopus 로고
    • Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA radiation
    • Zhang Y., Dong Z., Nomura M., Zhong S., Chen N., Bode A.M. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA radiation. J. Biol. Chem. 276:2001;20913-20923
    • (2001) J. Biol. Chem. , vol.276 , pp. 20913-20923
    • Zhang, Y.1    Dong, Z.2    Nomura, M.3    Zhong, S.4    Chen, N.5    Bode, A.M.6
  • 64
    • 0034635444 scopus 로고    scopus 로고
    • Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts
    • Brenneisen P., Wenk J., Wlaschek M., Krieg T., Scharffetter-Kochanek K. Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts. J. Biol. Chem. 275:2000;4336-4344
    • (2000) J. Biol. Chem. , vol.275 , pp. 4336-4344
    • Brenneisen, P.1    Wenk, J.2    Wlaschek, M.3    Krieg, T.4    Scharffetter-Kochanek, K.5
  • 65
    • 0035870281 scopus 로고    scopus 로고
    • P53/p21CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin
    • Huang S., Liu L.N., Hosoi H., Dilling M.B., Shikata T., Houghton P.J. p53/p21CIP1 cooperate in enforcing rapamycin-induced G1 arrest and determine the cellular response to rapamycin. Cancer Res. 61:2001;3373-3381
    • (2001) Cancer Res. , vol.61 , pp. 3373-3381
    • Huang, S.1    Liu, L.N.2    Hosoi, H.3    Dilling, M.B.4    Shikata, T.5    Houghton, P.J.6


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