-
1
-
-
0027370186
-
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line
-
Albers MW, Williams RT, Brown EJ, Tanaka A, Hall FL, Schreiber SL. (1993). FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. J Biol Chem 268: 22825-22829.
-
(1993)
J Biol Chem
, vol.268
, pp. 22825-22829
-
-
Albers, M.W.1
Williams, R.T.2
Brown, E.J.3
Tanaka, A.4
Hall, F.L.5
Schreiber, S.L.6
-
2
-
-
18144388714
-
Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3′UTR
-
Averous J, Maurin AC, Bruhat A, Jousse C, Arliguie C, Fafournoux P. (2005). Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3′UTR. FEBS Lett 579: 2609-2614.
-
(2005)
FEBS Lett
, vol.579
, pp. 2609-2614
-
-
Averous, J.1
Maurin, A.C.2
Bruhat, A.3
Jousse, C.4
Arliguie, C.5
Fafournoux, P.6
-
3
-
-
33750044299
-
When translation meets transformation: The mTOR story
-
Averous J, Proud CG. (2006). When translation meets transformation: the mTOR story. Oncogene 25: 6423-6435.
-
(2006)
Oncogene
, vol.25
, pp. 6423-6435
-
-
Averous, J.1
Proud, C.G.2
-
4
-
-
0030814110
-
Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels
-
Bruhat A, Jousse C, Wang XZ, Ron D, Ferrara M, Fafournoux P. (1997). Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem 272: 17588-17593.
-
(1997)
J Biol Chem
, vol.272
, pp. 17588-17593
-
-
Bruhat, A.1
Jousse, C.2
Wang, X.Z.3
Ron, D.4
Ferrara, M.5
Fafournoux, P.6
-
5
-
-
33750058023
-
Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
-
Corradetti MN, Guan KL. (2006). Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25: 6347-6360.
-
(2006)
Oncogene
, vol.25
, pp. 6347-6360
-
-
Corradetti, M.N.1
Guan, K.L.2
-
6
-
-
2342489456
-
eIF-4E expression and its role in malignancies and metastases
-
De Benedetti A, Graff JR. (2004). eIF-4E expression and its role in malignancies and metastases. Oncogene 23: 3189-3199.
-
(2004)
Oncogene
, vol.23
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
7
-
-
0034660062
-
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, eIF4E
-
Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. (2000). A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5′ cap-binding protein, eIF4E. EMBO J 19: 3142-3156.
-
(2000)
EMBO J
, vol.19
, pp. 3142-3156
-
-
Dostie, J.1
Ferraiuolo, M.2
Pause, A.3
Adam, S.A.4
Sonenberg, N.5
-
8
-
-
33750072949
-
mTOR and cancer therapy
-
Easton JB, Houghton PJ. (2006). mTOR and cancer therapy. Oncogene 25: 6436-6446.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
9
-
-
1642535431
-
AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
-
Gera JF, Mellinghoff IK, Shi Y, Rettig MB, Tran C, Hsu JH et al. (2004). AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem 279: 2737-2746.
-
(2004)
J Biol Chem
, vol.279
, pp. 2737-2746
-
-
Gera, J.F.1
Mellinghoff, I.K.2
Shi, Y.3
Rettig, M.B.4
Tran, C.5
Hsu, J.H.6
-
10
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras A-C, Raught B, Gygi SP, Niedzwieka A, Miron M, Burley SK et al. (2001). Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 15: 2852-2864.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.-C.1
Raught, B.2
Gygi, S.P.3
Niedzwieka, A.4
Miron, M.5
Burley, S.K.6
-
11
-
-
34250635347
-
Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/ Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells
-
Guan L, Song K, Pysz MA, Curry KJ, Hizli AA, Danielpour D et al. (2007). Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/ Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. J Biol Chem 282: 14213-14225.
-
(2007)
J Biol Chem
, vol.282
, pp. 14213-14225
-
-
Guan, L.1
Song, K.2
Pysz, M.A.3
Curry, K.J.4
Hizli, A.A.5
Danielpour, D.6
-
12
-
-
0032485937
-
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin d1 mRNA and protein stability
-
Hashemolhosseini S, Nagamine Y, Morley SJ, Desrivieres S, Mercep L, Ferrari S. (1998). Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin d1 mRNA and protein stability. J Biol Chem 273: 14424-14429.
-
(1998)
J Biol Chem
, vol.273
, pp. 14424-14429
-
-
Hashemolhosseini, S.1
Nagamine, Y.2
Morley, S.J.3
Desrivieres, S.4
Mercep, L.5
Ferrari, S.6
-
13
-
-
33744963882
-
Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells
-
Hizli AA, Black AR, Pysz MA, Black JD. (2006). Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. J Biol Chem 281: 14596-14603.
-
(2006)
J Biol Chem
, vol.281
, pp. 14596-14603
-
-
Hizli, A.A.1
Black, A.R.2
Pysz, M.A.3
Black, J.D.4
-
14
-
-
27744569843
-
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
Holz MK, Ballif BA, Gygi SP, Blenis J. (2005). mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123: 569-580.
-
(2005)
Cell
, vol.123
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenis, J.4
-
15
-
-
2942515128
-
Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells
-
Jiang H, Coleman J, Miskimins R, Miskimins WK. (2003). Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells. Cancer Cell Int 3: 2.
-
(2003)
Cancer Cell Int
, vol.3
, pp. 2
-
-
Jiang, H.1
Coleman, J.2
Miskimins, R.3
Miskimins, W.K.4
-
16
-
-
31544466776
-
Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
-
Kimball SR, Jefferson LS. (2006). Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 136: 227S-231S.
-
(2006)
J Nutr
, vol.136
-
-
Kimball, S.R.1
Jefferson, L.S.2
-
17
-
-
9644303169
-
Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation
-
Koziczak M, Hynes NE. (2004). Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation. J Biol Chem 279: 50004-50011.
-
(2004)
J Biol Chem
, vol.279
, pp. 50004-50011
-
-
Koziczak, M.1
Hynes, N.E.2
-
18
-
-
0026583874
-
The mRNA 5′ cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
-
Lazaris-Karatzas A, Sonenberg N. (1992). The mRNA 5′ cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol Cell Biol 12: 1234-1238.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 1234-1238
-
-
Lazaris-Karatzas, A.1
Sonenberg, N.2
-
19
-
-
33750068623
-
mTOR, translation initiation and cancer
-
Mamane Y, Petroulakis E, Le Bacquer O, Sonenberg N. (2006). mTOR, translation initiation and cancer. Oncogene 25: 6416-6422.
-
(2006)
Oncogene
, vol.25
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
Le Bacquer, O.3
Sonenberg, N.4
-
20
-
-
33846449110
-
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
-
Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A et al. (2007). Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128: 257-267.
-
(2007)
Cell
, vol.128
, pp. 257-267
-
-
Moerke, N.J.1
Aktas, H.2
Chen, H.3
Cantel, S.4
Reibarkh, M.Y.5
Fahmy, A.6
-
21
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng T, Golub TR, Sabatini DM. (2002). The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 21: 5575-5584.
-
(2002)
Mol Cell Biol
, vol.21
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
23
-
-
0027365517
-
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E
-
Rosenwald IB, Lazaris-Karatzas A, Sonenberg N, Schmidt EV. (1993). Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol 13: 7358-7363.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7358-7363
-
-
Rosenwald, I.B.1
Lazaris-Karatzas, A.2
Sonenberg, N.3
Schmidt, E.V.4
-
24
-
-
0030041884
-
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 messenger-RNA are increased in cells overexpressing eukaryotic initiation factor 4E
-
Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N. (1996). Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 messenger-RNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci USA 93: 1065-1070.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1065-1070
-
-
Rousseau, D.1
Kaspar, R.2
Rosenwald, I.3
Gehrke, L.4
Sonenberg, N.5
-
25
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D, Montanaro L, Ma L, Xu W, Londei P et al. (2004). The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 10: 484-486.
-
(2004)
Nat Med
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
Xu, W.4
Londei, P.5
-
26
-
-
33747819801
-
mTOR and cancer: Insights into a complex relationship
-
Sabatini DM. (2006). mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6: 729-734.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 729-734
-
-
Sabatini, D.M.1
-
27
-
-
33745570504
-
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
-
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J et al. (2006). The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J 25: 2781-2791.
-
(2006)
EMBO J
, vol.25
, pp. 2781-2791
-
-
Shahbazian, D.1
Roux, P.P.2
Mieulet, V.3
Cohen, M.S.4
Raught, B.5
Taunton, J.6
-
28
-
-
0036181011
-
Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
-
Tee AR, Proud CG. (2002). Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol Cell Biol 22: 1674-1683.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1674-1683
-
-
Tee, A.R.1
Proud, C.G.2
-
29
-
-
15044340650
-
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
-
Wang X, Beugnet A, Murakami M, Yamanaka S, Proud CG. (2005). Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins. Mol Cell Biol 25: 2558-2572.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2558-2572
-
-
Wang, X.1
Beugnet, A.2
Murakami, M.3
Yamanaka, S.4
Proud, C.G.5
-
30
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. (2006). TOR signaling in growth and metabolism. Cell 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
|