메뉴 건너뛰기




Volumn 2, Issue 12, 2010, Pages 897-899

Metformin and sex: Why suppression of aging may be harmful to young male mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; METFORMIN;

EID: 79952275086     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100264     Document Type: Note
Times cited : (14)

References (44)
  • 2
    • 0018895934 scopus 로고
    • Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice
    • Dilman VM and Anisimov VN. Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology. 1980; 26:241-246.
    • (1980) Gerontology , vol.26 , pp. 241-246
    • Dilman, V.M.1    Anisimov, V.N.2
  • 5
    • 66949126138 scopus 로고    scopus 로고
    • Metformin, insulin, breast cancer and more
    • Berstein LM. Metformin, insulin, breast cancer and more. Future Oncol. 2009; 5:309-312.
    • (2009) Future Oncol , vol.5 , pp. 309-312
    • Berstein, L.M.1
  • 6
    • 78650316639 scopus 로고    scopus 로고
    • Metformin for aging and cancer prevention
    • Anisimov VN. Metformin for aging and cancer prevention. Aging (Albany NY). 2010; 2: 760-774.
    • (2010) Aging (Albany NY) , vol.2 , pp. 760-774
    • Anisimov, V.N.1
  • 9
    • 3543008912 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    • Chan AY, Soltys CL, Young ME, Proud CG, Dyck JR. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem. 2004; 279:32771-32779.
    • (2004) J Biol Chem , vol.279 , pp. 32771-32779
    • Chan, A.Y.1    Soltys, C.L.2    Young, M.E.3    Proud, C.G.4    Dyck, J.R.5
  • 11
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTORmediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A and Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTORmediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006; 26:63-76.
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 12
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007; 67:10804-10812.
    • (2007) Cancer Res , vol.67 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 13
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • Mordier S and Iynedjian PB. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem Biophys Res Commun. 2007; 362:206-211.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 14
    • 60749108023 scopus 로고    scopus 로고
    • The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
    • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle. 2009; 8:88-96.
    • (2009) Cell Cycle , vol.8 , pp. 88-96
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 15
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, Lind SE, Thor AD. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle. 2009; 8:909-915.
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5    Lind, S.E.6    Thor, A.D.7
  • 16
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasiprogrammed senescence and its pharmacologic inhibition. CellCycle. 2006; 5:2087-2102.
    • (2006) CellCycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 17
    • 33847226657 scopus 로고    scopus 로고
    • An anti-aging drug today: from senescence-promoting genes to anti-aging pill
    • Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today. 2007; 12:218-224.
    • (2007) Drug Disc Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1
  • 18
    • 67649347537 scopus 로고    scopus 로고
    • Growth Aging: a common molecular mechanism
    • Blagosklonny MV and Hall MN. Growth and Aging: a common molecular mechanism. Aging. 2009; 1:357-362.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 19
    • 0034644525 scopus 로고    scopus 로고
    • TORa central controller of cell growth
    • Schmelzle T and Hall MN. TOR, a central controller of cell growth. Cell. 2000; 103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 20
    • 0035971180 scopus 로고    scopus 로고
    • The TOR kinases link nutrient sensing to cell growth
    • Rohde J, Heitman J, Cardenas ME. The TOR kinases link nutrient sensing to cell growth. J Biol Chem. 2001; 276:9583-9586.
    • (2001) J Biol Chem , vol.276 , pp. 9583-9586
    • Rohde, J.1    Heitman, J.2    Cardenas, M.E.3
  • 22
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 23
    • 33645738458 scopus 로고    scopus 로고
    • Complexity of the TOR signaling network
    • Inoki K and Guan KL. Complexity of the TOR signaling network. Trends Cell Biol. 2006; 16:206-212.
    • (2006) Trends Cell Biol , vol.16 , pp. 206-212
    • Inoki, K.1    Guan, K.L.2
  • 24
    • 77953577017 scopus 로고    scopus 로고
    • Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy?
    • Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging. 2009:586-597.
    • Aging , vol.2009 , pp. 586-597
    • Hands, S.L.1    Proud, C.G.2
  • 25
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger AL and Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell. 2002; 13:2276-2288.
    • (2002) Mol Biol Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 26
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
    • Huang J and Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008; 412:179-190.
    • (2008) Biochem J , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 27
    • 0347627139 scopus 로고    scopus 로고
    • mTOR-mediated regulation of translation factors by amino acids
    • Proud CG. mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun. 2004; 313:429-436.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 429-436
    • Proud, C.G.1
  • 28
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTORmediated translational control
    • Ma XM and Blenis J. Molecular mechanisms of mTORmediated translational control. Nat Rev Mol Cell Biol. 2009; 10:307-318.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 31
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN and Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355-3361.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 33
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential
    • Demidenko ZN and Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging. 2009; 1:1008-1016.
    • (2009) Aging , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 34
    • 78650352864 scopus 로고    scopus 로고
    • Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
    • Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal. Cell Cycle. 2010; 9: 4788-4794.
    • (2010) Cell Cycle , vol.9 , pp. 4788-4794
    • Blagosklonny, M.V.1
  • 35
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle. 2010; 9:3151-3156.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 36
    • 78049499910 scopus 로고    scopus 로고
    • Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis
    • Blagosklonny MV. Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging. 2010; 2:177-182.
    • (2010) Aging , vol.2 , pp. 177-182
    • Blagosklonny, M.V.1
  • 37
    • 77955739991 scopus 로고    scopus 로고
    • Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
    • Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging. 2010; 2:265-273.
    • (2010) Aging , vol.2 , pp. 265-273
    • Blagosklonny, M.V.1
  • 38
    • 26044442246 scopus 로고    scopus 로고
    • Cancer in rodents: does it tell us about cancer in humans?
    • Anisimov VN, Ukraintseva SV, Yashin AI. Cancer in rodents: does it tell us about cancer in humans? Nat Rev Cancer. 2005; 5:807-819.
    • (2005) Nat Rev Cancer , vol.5 , pp. 807-819
    • Anisimov, V.N.1    Ukraintseva, S.V.2    Yashin, A.I.3
  • 40
    • 77957281835 scopus 로고    scopus 로고
    • Testosteroneinduced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR
    • Wu Y, Bauman WA, Blitzer RD, Cardozo C. Testosteroneinduced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR. Biochem Biophys Res Commun. 2010; 400:679-683.
    • (2010) Biochem Biophys Res Commun , vol.400 , pp. 679-683
    • Wu, Y.1    Bauman, W.A.2    Blitzer, R.D.3    Cardozo, C.4
  • 42
    • 33847235398 scopus 로고    scopus 로고
    • Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
    • Huyghe E, Zairi A, Nohra J, Kamar N, Plante P, Rostaing L. Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transpl Int. 2007; 20:305-311.
    • (2007) Transpl Int , vol.20 , pp. 305-311
    • Huyghe, E.1    Zairi, A.2    Nohra, J.3    Kamar, N.4    Plante, P.5    Rostaing, L.6
  • 43
    • 35348920085 scopus 로고    scopus 로고
    • Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment
    • Skrzypek J and Krause W. Azoospermia in a renal transplant recipient during sirolimus (rapamycin) treatment. Andrologia. 2007; 39:198-199.
    • (2007) Andrologia , vol.39 , pp. 198-199
    • Skrzypek, J.1    Krause, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.