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Volumn 10, Issue 24, 2011, Pages 4217-4224

Rapamycin-induced glucose intolerance: Hunger or starvation diabetes

Author keywords

Hunger; Insulin; mTOR; Starvation

Indexed keywords

INSULIN; KETONE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; RAPAMYCIN;

EID: 84055190702     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.24.18595     Document Type: Review
Times cited : (54)

References (149)
  • 1
    • 67650074206 scopus 로고    scopus 로고
    • mTOR regulates memory CD8 T-cell differentiation
    • PMID:19543266
    • Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009; 460:108-12; PMID:19543266; http://dx.doi.org/10.1038/nature08155.
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3    Gangappa, S.4    Keller, S.A.5    Bachmann, M.F.6
  • 2
    • 75549090275 scopus 로고    scopus 로고
    • mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • PMID:19934433
    • Chen C, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009; 2:75; PMID:19934433; http://dx.doi.org/10.1126/scisignal.2000559.
    • (2009) Sci Signal , vol.2 , pp. 75
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 3
    • 79951670258 scopus 로고    scopus 로고
    • Temsirolimus, an mTOR inhibitor, enhances antitumour effects of heat shock protein cancer vaccines
    • PMID:21285988
    • Wang Y, Wang XY, Subjeck JR, Shrikant PA, Kim HL. Temsirolimus, an mTOR inhibitor, enhances antitumour effects of heat shock protein cancer vaccines. Br J Cancer 2011; 104:643-52; PMID:21285988; http://dx.doi.org/10.1038/bjc.2011. 15.
    • (2011) Br J Cancer , vol.104 , pp. 643-652
    • Wang, Y.1    Wang, X.Y.2    Subjeck, J.R.3    Shrikant, P.A.4    Kim, H.L.5
  • 4
    • 50849110457 scopus 로고    scopus 로고
    • Prevention of cancer by inhibiting aging
    • PMID:18769112
    • Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther 2008; 7:1520-4; PMID:18769112; http://dx.doi.org/10.4161/cbt.7.10.6663.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1520-1524
    • Blagosklonny, M.V.1
  • 5
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    • PMID:15800227
    • Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352:1317-23; PMID:15800227; http://dx.doi.org/10.1056/NEJMoa042831.
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3    Di Paolo, S.4    Loverre, A.5    Maggio, G.6
  • 6
    • 0344687374 scopus 로고    scopus 로고
    • Teaching old drugs new tricks: Reincarnating immunosuppressants as antifungal drugs
    • PMID:12669381
    • Blankenship JR, Steinbach WJ, Perfect JR, Heitman J. Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. Curr Opin Investig Drugs 2003; 4:192-9; PMID:12669381.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 192-199
    • Blankenship, J.R.1    Steinbach, W.J.2    Perfect, J.R.3    Heitman, J.4
  • 7
    • 77149139107 scopus 로고    scopus 로고
    • Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
    • PMID:20086156
    • Krakauer T, Buckley M, Issaq HJ, Fox SD. Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo. Antimicrob Agents Chemother 2010; 54:1125-31; PMID:20086156; http://dx.doi.org/10.1128/AAC.01015-09.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1125-1131
    • Krakauer, T.1    Buckley, M.2    Issaq, H.J.3    Fox, S.D.4
  • 8
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Tokyo PMID:1102508
    • Vézina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975; 28:721-6; PMID:1102508.
    • (1975) J Antibiot , vol.28 , pp. 721-726
    • Vézina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 9
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • PMID:1715094
    • Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991; 253:905-9; PMID:1715094; http://dx.doi.org/10.1126/science.1715094.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 10
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological lifespan in yeast by decreased TOR pathway signaling
    • PMID:16418483
    • Powers RW, 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological lifespan in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20:174-84; PMID:16418483; http://dx.doi.org/10.1101/gad. 1381406.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers III, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 11
    • 68049109688 scopus 로고    scopus 로고
    • Extension of chronological lifespan by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density
    • PMID:20157595
    • Pan Y, Shadel GS. Extension of chronological lifespan by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 2009; 1:131-5; PMID:20157595.
    • (2009) Aging , vol.1 , pp. 131-135
    • Pan, Y.1    Shadel, G.S.2
  • 12
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • PMID:20157523
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging 2009; 1:357-62; PMID:20157523.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 13
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • PMID:18948731
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61; PMID:18948731; http://dx.doi.org/10.4161/cc.7.21.6919.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 15
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
    • PMID:20157583
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 2009; 1:1008-16; PMID:20157583.
    • (2009) Aging , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 17
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • PMID:21212465
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging 2010; 2:924-35; PMID:21212465.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 19
    • 77958449473 scopus 로고    scopus 로고
    • p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate
    • PMID:20935470
    • Romanov VS, Abramova MV, Svetlikova SB, Bykova TV, Zubova SG, Aksenov ND, et al. p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate. Cell Cycle 2010; 9:3945-55; PMID:20935470; http://dx.doi.org/10.4161/cc.9.19.13160.
    • (2010) Cell Cycle , vol.9 , pp. 3945-3955
    • Romanov, V.S.1    Abramova, M.V.2    Svetlikova, S.B.3    Bykova, T.V.4    Zubova, S.G.5    Aksenov, N.D.6
  • 20
    • 27544500981 scopus 로고    scopus 로고
    • Growing roles for the mTOR pathway
    • PMID:16226444
    • Sarbassov DD, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol 2005; 17:596-603; PMID:16226444; http://dx.doi.org/10.1016/ j.ceb.2005.09.009.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 596-603
    • Sarbassov, D.D.1    Ali, S.M.2    Sabatini, D.M.3
  • 21
    • 12344262762 scopus 로고    scopus 로고
    • mTOR, translational control and human disease
    • PMID:15659337
    • Tee AR, Blenis J. mTOR, translational control and human disease. Semin Cell Dev Biol 2005; 16:29-37; PMID:15659337; http://dx.doi.org/10.1016/j.semcdb. 2004.11.005.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 29-37
    • Tee, A.R.1    Blenis, J.2
  • 22
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • PMID:16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84; PMID:16469695; http://dx.doi.org/10.1016/j. cell.2006.01.016.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 23
    • 77953577017 scopus 로고    scopus 로고
    • mTOR's role in ageing: Protein synthesis or autophagy?
    • PMID:20157541
    • Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging 2009; 1:586-97; PMID:20157541.
    • (2009) Aging , vol.1 , pp. 586-597
    • Hands, S.L.1    Proud, C.G.2    Wyttenbach, A.3
  • 24
    • 66749130276 scopus 로고    scopus 로고
    • Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
    • PMID:19395857
    • Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 2009; 8:1738-46; PMID:19395857; http://dx.doi.org/10.4161/ cc.8.11.8619.
    • (2009) Cell Cycle , vol.8 , pp. 1738-1746
    • Glazer, H.P.1    Osipov, R.M.2    Clements, R.T.3    Sellke, F.W.4    Bianchi, C.5
  • 25
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
    • PMID:20519118
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11:453-65; PMID:20519118; http://dx.doi.org/10.1016/j. cmet.2010.05.001.
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6
  • 26
    • 67649316034 scopus 로고    scopus 로고
    • Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacologic deceleration
    • PMID:19448395
    • Blagosklonny MV. Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration. Cell Cycle 2009; 8:1883-7; PMID:19448395; http://dx.doi.org/10.4161/cc.8.12.8815.
    • (2009) Cell Cycle , vol.8 , pp. 1883-1887
    • Blagosklonny, M.V.1
  • 27
    • 79957880743 scopus 로고    scopus 로고
    • Cell cycle arrest is not senescence
    • PMID:21297220
    • Blagosklonny MV. Cell cycle arrest is not senescence. Aging 2011; 3:94-101; PMID:21297220.
    • (2011) Aging , vol.3 , pp. 94-101
    • Blagosklonny, M.V.1
  • 28
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
    • PMID:17012837
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102; PMID:17012837; http://dx.doi.org/10.4161/cc.5.18.3288.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 29
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • PMID:17275731
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007; 12:112-24; PMID:17275731; http://dx.doi.org/10.1016/j.drudis.2006.12.008.
    • (2007) Drug Discov Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 30
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • PMID:20157517
    • Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging 2009; 1:281-8; PMID:20157517.
    • (2009) Aging , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 31
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • PMID:21157483
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID:21157483; http://dx.doi.org/10.1038/nrm3025.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 32
    • 78049499910 scopus 로고    scopus 로고
    • Why human lifespan is rapidly increasing: Solving "longevity riddle" with "revealed-slow-aging"hypothesis
    • PMID:20404395
    • Blagosklonny MV. Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging"hypothesis. Aging 2010; 2:177-82; PMID:20404395.
    • (2010) Aging , vol.2 , pp. 177-182
    • Blagosklonny, M.V.1
  • 33
    • 77955739991 scopus 로고    scopus 로고
    • Why men age faster but reproduce longer than women: MTOR and evolutionary perspectives
    • PMID:20519781
    • Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging 2010; 2:265-73; PMID:20519781.
    • (2010) Aging , vol.2 , pp. 265-273
    • Blagosklonny, M.V.1
  • 34
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogenous mice
    • PMID:19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460:392-5; PMID:19587680.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 36
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological inhibition of Phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster
    • PMID:20017609
    • Moskalev AA, Shaposhnikov MV. Pharmacological inhibition of Phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res 2010; 13:246-7; PMID:20017609; http://dx.doi.org/10.1089/rej. 2009.0903.
    • (2010) Rejuvenation Res , vol.13 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 37
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of lifespan extension by rapamycin in the fruit fly Drosophila melanogaster
    • PMID:20074526
    • Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of lifespan extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010; 11:35-46; PMID:20074526; http://dx.doi.org/10. 1016/j.cmet.2009.11.010.
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3    Slack, C.4    Jacobson, J.5    Foley, A.6
  • 38
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • PMID:21659604
    • Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011; 332:1317-22; PMID:21659604; http://dx.doi.org/10.1126/science.1199498.
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3    Zhang, Y.4    Ottina, K.A.5    Lim, D.6
  • 39
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • PMID:21659605
    • Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villen J, et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011; 332:1322-6; PMID:21659605; http://dx.doi.org/10.1126/science.1199484.
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1    Yoon, S.O.2    Poulogiannis, G.3    Yang, Q.4    Ma, X.M.5    Villen, J.6
  • 40
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • PMID:17698034
    • Mordier S, Iynedjian PB. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem Biophys Res Commun 2007; 362:206-11; PMID:17698034; http://dx.doi.org/10.1016/j. bbrc.2007.08.004.
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 41
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • PMID:11287630
    • Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, et al. A phosphatidylinositol-3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 2001; 98:4640-5; PMID:11287630; http://dx.doi.org/10.1073/pnas.051042298.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6
  • 42
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • PMID:11498541
    • Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 2001; 276:38052-60; PMID:11498541.
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 43
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • PMID:16123357
    • Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005; 54:2674-84; PMID:16123357; http://dx.doi.org/10.2337/diabetes.54.9.2674.
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6
  • 44
    • 35348832340 scopus 로고    scopus 로고
    • Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
    • PMID:17709744
    • Tremblay F, Bržl Ž, Hee S, Um S, Li Y, Masuda K, et al. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci USA 2007; 104:14056-61; PMID:17709744; http://dx.doi.org/10.1073/pnas.0706517104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14056-14061
    • Tremblay, F.1    Bržl, Ž.2    Hee, S.3    Um, S.4    Li, Y.5    Masuda, K.6
  • 45
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol-3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • PMID:16354680
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol-3-kinase/ Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 2006; 26:63-76; PMID:16354680; http://dx.doi.org/10.1128/MCB.26.1.63-76.2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 46
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance and cell survival deficiencies
    • PMID:15380067
    • Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance and cell survival deficiencies. Curr Biol 2004; 14:1650-6; PMID:15380067; http://dx.doi.org/10.1016/j.cub.2004.08.026.
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 47
    • 33846015072 scopus 로고    scopus 로고
    • Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    • PMID:17077083
    • Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, et al. Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. J Biol Chem 2006; 281:40242-51; PMID:17077083; http://dx.doi.org/10.1074/jbc.M608116200.
    • (2006) J Biol Chem , vol.281 , pp. 40242-40251
    • Cao, Y.1    Kamioka, Y.2    Yokoi, N.3    Kobayashi, T.4    Hino, O.5    Onodera, M.6
  • 48
    • 45549092417 scopus 로고    scopus 로고
    • Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation
    • PMID:18303120
    • Robinson KA, Buse MG. Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation. Am J Physiol Endocrinol Metab 2008; 294:870-81; PMID:18303120; http://dx.doi.org/10.1152/ajpendo.00644.2007.
    • (2008) Am J Physiol Endocrinol Metab , vol.294 , pp. 870-881
    • Robinson, K.A.1    Buse, M.G.2
  • 49
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway downregulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • PMID:10847581
    • Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, et al. A rapamycin-sensitive pathway downregulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 2000; 14:783-94; PMID:10847581; http://dx.doi.org/10.1210/me.14.6.783.
    • (2000) Mol Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6
  • 50
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • PMID:15306821
    • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-5; PMID:15306821; http://dx.doi.org/ 10.1038/nature02866.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5    Sticker, M.6
  • 51
    • 0034700456 scopus 로고    scopus 로고
    • Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
    • PMID:11140689
    • Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, et al. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 2000; 408:994-7; PMID:11140689; http://dx.doi.org/10.1038/35050135.
    • (2000) Nature , vol.408 , pp. 994-997
    • Pende, M.1    Kozma, S.C.2    Jaquet, M.3    Oorschot, V.4    Burcelin, R.5    Le Marchand-Brustel, Y.6
  • 52
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan
    • PMID:19797661
    • Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1    Tullet, J.M.2    Wieser, D.3    Irvine, E.4    Lingard, S.J.5    Choudhury, A.I.6
  • 53
    • 55849132493 scopus 로고    scopus 로고
    • Insulin and aging
    • PMID:18948730
    • Bartke A. Insulin and aging. Cell Cycle 2008; 7:3338-43; PMID:18948730; http://dx.doi.org/10.4161/cc.7.21.7012.
    • (2008) Cell Cycle , vol.7 , pp. 3338-3343
    • Bartke, A.1
  • 54
    • 65549122452 scopus 로고    scopus 로고
    • Insulin sensitivity as a key mediator of growth hormone actions on longevity
    • PMID:19304940
    • Masternak MM, Panici JA, Bonkowski MS, Hughes LF, Bartke A. Insulin sensitivity as a key mediator of growth hormone actions on longevity. J Gerontol A Biol Sci Med Sci 2009; 64:516-21; PMID:19304940; http://dx.doi.org/10.1093/ gerona/glp024.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 516-521
    • Masternak, M.M.1    Panici, J.A.2    Bonkowski, M.S.3    Hughes, L.F.4    Bartke, A.5
  • 56
    • 27544460718 scopus 로고    scopus 로고
    • Extended longevity and insulin signaling in adipose tissue
    • PMID:16125891
    • Klöting N, Bluher M. Extended longevity and insulin signaling in adipose tissue. Exp Gerontol 2005; 40:878-83; PMID:16125891; http://dx.doi.org/10.1016/j.exger.2005.07.004.
    • (2005) Exp Gerontol , vol.40 , pp. 878-883
    • Klöting, N.1    Bluher, M.2
  • 57
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • PMID:15604215
    • Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 2005; 146:1473-81; PMID:15604215; http://dx.doi.org/10.1210/en.2004-0921.
    • (2005) Endocrinology , vol.146 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 58
    • 79955664598 scopus 로고    scopus 로고
    • Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance post-partum
    • PMID:21289241
    • Barbour LA, McCurdy CE, Hernandez TL, Friedman JE. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance post-partum. J Clin Endocrinol Metab 2011; 96:1431-41; PMID:21289241; http://dx.doi.org/10.1210/jc.2010-116.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1431-1441
    • Barbour, L.A.1    McCurdy, C.E.2    Hernandez, T.L.3    Friedman, J.E.4
  • 59
    • 1642341446 scopus 로고    scopus 로고
    • Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle
    • PMID:14656717
    • Liu Z, Wu Y, Nicklas EW, Jahn LA, Price WJ, Barrett EJ. Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. Am J Physiol Endocrinol Metab 2004; 286:523-8; PMID:14656717; http://dx.doi.org/10.1152/ajpendo.00146.2003.
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , pp. 523-528
    • Liu, Z.1    Wu, Y.2    Nicklas, E.W.3    Jahn, L.A.4    Price, W.J.5    Barrett, E.J.6
  • 60
    • 34249679233 scopus 로고    scopus 로고
    • The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    • PMID:17329620
    • Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P, et al. The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes 2007; 56:1600-7; PMID:17329620; http://dx.doi.org/10. 2337/db06-1016.
    • (2007) Diabetes , vol.56 , pp. 1600-1607
    • Krebs, M.1    Brunmair, B.2    Brehm, A.3    Artwohl, M.4    Szendroedi, J.5    Nowotny, P.6
  • 61
    • 16844370268 scopus 로고    scopus 로고
    • Regulation of insulin signalling by hyperinsulinaemia: Role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
    • PMID:15692808
    • Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, et al. Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Diabetologia 2005; 48:506-18; PMID:15692808; http://dx.doi.org/10.1007/s00125-004-1662-6.
    • (2005) Diabetologia , vol.48 , pp. 506-518
    • Ueno, M.1    Carvalheira, J.B.2    Tambascia, R.C.3    Bezerra, R.M.4    Amaral, M.E.5    Carneiro, E.M.6
  • 62
    • 9444228813 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes: Insulin resistance and beta-cell function
    • PMID:15561919
    • Chiasson JL, Rabasa-Lhoret R. Prevention of type 2 diabetes: insulin resistance and beta-cell function. Diabetes 2004; 53:34-8; PMID:15561919; http://dx.doi.org/10.2337/diabetes.53.suppl-3.S34.
    • (2004) Diabetes , vol.53 , pp. 34-38
    • Chiasson, J.L.1    Rabasa-Lhoret, R.2
  • 63
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • PMID:15823385
    • Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005; 365:1333-46; PMID:15823385; http://dx.doi.org/10.1016/S0140-6736(05)61032-X.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 64
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes-a matter of betacell life and death?
    • PMID:15662003
    • Rhodes CJ. Type 2 diabetes-a matter of betacell life and death? Science 2005; 307:380-4; PMID:15662003; http://dx.doi.org/10.1126/science.1104345.
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 65
    • 79959807374 scopus 로고    scopus 로고
    • Type 2 diabetes can be prevented with early pharmacological intervention
    • PMID:21525456
    • DeFronzo RA, Abdul-Ghani M. Type 2 diabetes can be prevented with early pharmacological intervention. Diabetes Care 2011; 34:202-9; PMID:21525456; http://dx.doi.org/10.2337/dc11-s221.
    • (2011) Diabetes Care , vol.34 , pp. 202-209
    • DeFronzo, R.A.1    Abdul-Ghani, M.2
  • 66
    • 0025856749 scopus 로고
    • Benefits and limitations of very-low-calorie diet therapy in obese NIDDM
    • PMID:1959474
    • Henry RR, Gumbiner B. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM. Diabetes Care 1991; 14:802-23; PMID:1959474; http://dx.doi.org/10.2337/diacare.14.9.802.
    • (1991) Diabetes Care , vol.14 , pp. 802-823
    • Henry, R.R.1    Gumbiner, B.2
  • 67
    • 0028147295 scopus 로고
    • Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients
    • PMID:8112186
    • Wing RR, Blair EH, Bononi P, Marcus MD, Watanabe R, Bergman RN. Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients. Diabetes Care 1994; 17:30-6; PMID:8112186; http://dx.doi.org/10.2337/diacare.17.1.30.
    • (1994) Diabetes Care , vol.17 , pp. 30-36
    • Wing, R.R.1    Blair, E.H.2    Bononi, P.3    Marcus, M.D.4    Watanabe, R.5    Bergman, R.N.6
  • 69
    • 48549091164 scopus 로고    scopus 로고
    • Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt and mammalian target of rapamycin in mammary carcinomas, mammary gland and liver
    • PMID:18593953
    • Jiang W, Zhu Z, Thompson HJ. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt and mammalian target of rapamycin in mammary carcinomas, mammary gland and liver. Cancer Res 2008; 68:5492-9; PMID:18593953; http://dx.doi.org/10.1158/0008-5472.CAN-07-6721.
    • (2008) Cancer Res , vol.68 , pp. 5492-5499
    • Jiang, W.1    Zhu, Z.2    Thompson, H.J.3
  • 70
    • 65349191234 scopus 로고    scopus 로고
    • Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways
    • PMID:19370158
    • Estep PW, 3rd, Warner JB, Bulyk ML. Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways. PLoS ONE 2009; 4:5242; PMID:19370158; http://dx.doi.org/ 10.1371/journal.pone.0005242.
    • (2009) PLoS ONE , vol.4 , pp. 5242
    • Estep III, P.W.1    Warner, J.B.2    Bulyk, M.L.3
  • 71
    • 39749190584 scopus 로고    scopus 로고
    • A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
    • PMID:18347658
    • Glynn EL, Lujan HL, Kramer VJ, Drummond MJ, DiCarlo SE, Rasmussen BB. A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. Appl Physiol Nutr Metab 2008; 33:93-101; PMID:18347658; http://dx.doi.org/10.1139/H07-149.
    • (2008) Appl Physiol Nutr Metab , vol.33 , pp. 93-101
    • Glynn, E.L.1    Lujan, H.L.2    Kramer, V.J.3    Drummond, M.J.4    DiCarlo, S.E.5    Rasmussen, B.B.6
  • 72
    • 33745476017 scopus 로고    scopus 로고
    • Diabetic microvascular complications - Can the presence of one predict the development of another
    • PMID:16798474
    • Girach A, Vignati L. Diabetic microvascular complications - can the presence of one predict the development of another. J Diabetes Complications 2006; 20:228-37; PMID:16798474; http://dx.doi.org/10.1016/j.jdiacomp.2006.03. 001.
    • (2006) J Diabetes Complications , vol.20 , pp. 228-237
    • Girach, A.1    Vignati, L.2
  • 73
    • 17644415720 scopus 로고    scopus 로고
    • Treating diabetic retinopathy by tackling growth factor pathways
    • PMID:15898347
    • Chiarelli F, Giannini C, Di Marzio D, Mohn A. Treating diabetic retinopathy by tackling growth factor pathways. Curr Opin Investig Drugs 2005; 6:395-409; PMID:15898347.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 395-409
    • Chiarelli, F.1    Giannini, C.2    Di Marzio, D.3    Mohn, A.4
  • 74
    • 77955585592 scopus 로고    scopus 로고
    • Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial
    • PMID:20594588
    • Ismail-Beigi F, Craven T, Banerji MA, Basile J, Calles J, Cohen RM, et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial. Lancet 2010; 376:419-30; PMID:20594588; http://dx.doi.org/10.1016/S0140-6736(10)60576-4.
    • (2010) Lancet , vol.376 , pp. 419-430
    • Ismail-Beigi, F.1    Craven, T.2    Banerji, M.A.3    Basile, J.4    Calles, J.5    Cohen, R.M.6
  • 75
    • 78049492722 scopus 로고    scopus 로고
    • Mixed messages on systemic therapies for diabetic retinopathy
    • PMID:21036265
    • Lim LS, Liew G, Cheung N, Mitchell P, Wong TY. Mixed messages on systemic therapies for diabetic retinopathy. Lancet 2010; 376:1461; PMID:21036265; http://dx.doi.org/10.1016/S0140-6736(10)61984-8.
    • (2010) Lancet , vol.376 , pp. 1461
    • Lim, L.S.1    Liew, G.2    Cheung, N.3    Mitchell, P.4    Wong, T.Y.5
  • 76
    • 0028865515 scopus 로고
    • Progression of retinopathy after change of treatment from oral antihyperglycemic agents to insulin in patients with NIDDM
    • PMID:8722053
    • Henricsson M, Janzon L, Groop L. Progression of retinopathy after change of treatment from oral antihyperglycemic agents to insulin in patients with NIDDM. Diabetes Care 1995; 18:1571-6; PMID:8722053; http://dx.doi.org/10.2337/ diacare.18.12.1571.
    • (1995) Diabetes Care , vol.18 , pp. 1571-1576
    • Henricsson, M.1    Janzon, L.2    Groop, L.3
  • 77
    • 0031972613 scopus 로고    scopus 로고
    • Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM)
    • PMID:9427226
    • Cohen JA, Jeffers BW, Faldut D, Marcoux M, Schrier RW. Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM). Muscle Nerve 1998; 21:72-80; PMID:9427226; http://dx.doi.org/10.1002/(SICI)1097-4598(199801)21:1〈72:: AID-MUS10〉3.0.CO;2-2.
    • (1998) Muscle Nerve , vol.21 , pp. 72-80
    • Cohen, J.A.1    Jeffers, B.W.2    Faldut, D.3    Marcoux, M.4    Schrier, R.W.5
  • 78
    • 0026469208 scopus 로고
    • Effect of rapid glycemic control on progression of diabetic retinopathy
    • PMID:1464975
    • Funatsu H, Yamashita H, Ohashi Y, Ishigaki T. Effect of rapid glycemic control on progression of diabetic retinopathy. Jpn J Ophthalmol 1992; 36:356-67; PMID:1464975.
    • (1992) Jpn J Ophthalmol , vol.36 , pp. 356-367
    • Funatsu, H.1    Yamashita, H.2    Ohashi, Y.3    Ishigaki, T.4
  • 79
    • 77951730299 scopus 로고    scopus 로고
    • Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy
    • PMID:20437589
    • Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol 2010; 67:534-41; PMID:20437589; http://dx.doi.org/10.1002/ana.21952.
    • (2010) Ann Neurol , vol.67 , pp. 534-541
    • Gibbons, C.H.1    Freeman, R.2
  • 80
    • 79951968328 scopus 로고    scopus 로고
    • Fasting C-peptide levels and death resulting from all causes and breast cancer: The health, eating, activity and lifestyle study
    • PMID:21115859
    • Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, et al. Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity and lifestyle study. J Clin Oncol 2011; 29:47-53; PMID:21115859; http://dx.doi.org/10.1200/JCO.2010.28.4752.
    • (2011) J Clin Oncol , vol.29 , pp. 47-53
    • Irwin, M.L.1    Duggan, C.2    Wang, C.Y.3    Smith, A.W.4    McTiernan, A.5    Baumgartner, R.N.6
  • 81
    • 32244431832 scopus 로고    scopus 로고
    • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: Antidiabetic drugs as geroprotectors and anticarcinogens
    • PMID:16399897
    • Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, Tyndyk ML, et al. Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. Ann N Y Acad Sci 2005; 1057:220-34; PMID:16399897; http://dx.doi.org/10.1196/annals. 1356.017.
    • (2005) Ann N Y Acad Sci , vol.1057 , pp. 220-234
    • Anisimov, V.N.1    Berstein, L.M.2    Popovich, I.G.3    Zabezhinski, M.A.4    Egormin, P.A.5    Tyndyk, M.L.6
  • 82
    • 78650316639 scopus 로고    scopus 로고
    • Metformin for aging and cancer prevention
    • PMID:21084729
    • Anisimov VN. Metformin for aging and cancer prevention. Aging 2010; 2:760-74; PMID:21084729.
    • (2010) Aging , vol.2 , pp. 760-774
    • Anisimov, V.N.1
  • 83
    • 84055208519 scopus 로고    scopus 로고
    • Insulin resistance, complications, diabetes and mTOR: Surprising sequence of events and therapeutic opportunities
    • In press
    • Blagosklonny MV. Insulin resistance, complications, diabetes and mTOR: Surprising sequence of events and therapeutic opportunities. Aging 2011; 3; In press.
    • (2011) Aging , vol.3
    • Blagosklonny, M.V.1
  • 84
    • 11944263528 scopus 로고
    • Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis
    • PMID:1516497
    • Harris MI, Klein R, Welborn TA, Knuiman MW. Onset of NIDDM occurs at least 4-7 yr before clinical diagnosis. Diabetes Care 1992; 15:815-9; PMID:1516497; http://dx.doi.org/10.2337/diacare.15.7.815.
    • (1992) Diabetes Care , vol.15 , pp. 815-819
    • Harris, M.I.1    Klein, R.2    Welborn, T.A.3    Knuiman, M.W.4
  • 85
    • 79951711413 scopus 로고    scopus 로고
    • Glycemic thresholds for diabetes-specific retinopathy: Implications for diagnostic criteria for diabetes
    • PMID:20978099
    • Colagiuri S, Lee CM, Wong TY, Balkau B, Shaw JE, Borch-Johnsen K. Glycemic thresholds for diabetes-specific retinopathy: implications for diagnostic criteria for diabetes. Diabetes Care 2011; 34:145-50; PMID:20978099; http://dx.doi.org/10.2337/dc10-1206.
    • (2011) Diabetes Care , vol.34 , pp. 145-150
    • Colagiuri, S.1    Lee, C.M.2    Wong, T.Y.3    Balkau, B.4    Shaw, J.E.5    Borch-Johnsen, K.6
  • 86
    • 80052120069 scopus 로고    scopus 로고
    • Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: A cross-sectional study
    • PMID:21183519
    • Ellis JD, Zvandasara T, Leese G, McAlpine R, Macewen CJ, Baines PS, et al. Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: a cross-sectional study. Br J Ophthalmol 2011; 95:1229-33; PMID:21183519; http://dx.doi.org/10.1136/bjo.2010.196204.
    • (2011) Br J Ophthalmol , vol.95 , pp. 1229-1233
    • Ellis, J.D.1    Zvandasara, T.2    Leese, G.3    McAlpine, R.4    Macewen, C.J.5    Baines, P.S.6
  • 87
    • 33646269278 scopus 로고    scopus 로고
    • Therapy insight: Neurological complications of prediabetes
    • PMID:16932564
    • Singleton JR, Smith AG. Therapy insight: neurological complications of prediabetes. Nat Clin Pract Neurol 2006; 2:276-82; PMID:16932564; http://dx.doi.org/10.1038/ncpneuro0172.
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 276-282
    • Singleton, J.R.1    Smith, A.G.2
  • 88
    • 37349105692 scopus 로고    scopus 로고
    • Neuropathy associated with prediabetes: What is new in 2007?
    • PMID:18255003
    • Singleton JR, Smith AG. Neuropathy associated with prediabetes: what is new in 2007? Curr Diab Rep 2007; 7:420-4; PMID:18255003; http://dx.doi.org/10. 1007/s11892-007-0070-y.
    • (2007) Curr Diab Rep , vol.7 , pp. 420-424
    • Singleton, J.R.1    Smith, A.G.2
  • 89
    • 38349063153 scopus 로고    scopus 로고
    • Impaired glucose tolerance and neuropathy
    • PMID:18195653
    • Smith AG, Singleton JR. Impaired glucose tolerance and neuropathy. Neurologist 2008; 14:23-9; PMID:18195653; http://dx.doi.org/10.1097/NRL. 0b013e31815a3956.
    • (2008) Neurologist , vol.14 , pp. 23-29
    • Smith, A.G.1    Singleton, J.R.2
  • 90
    • 0345707525 scopus 로고    scopus 로고
    • Microvascular complications of impaired glucose tolerance
    • PMID:14633845
    • Singleton JR, Smith AG, Russell JW, Feldman EL. Microvascular complications of impaired glucose tolerance. Diabetes 2003; 52:2867-73; PMID:14633845; http://dx.doi.org/10.2337/diabetes.52.12.2867.
    • (2003) Diabetes , vol.52 , pp. 2867-2873
    • Singleton, J.R.1    Smith, A.G.2    Russell, J.W.3    Feldman, E.L.4
  • 91
    • 33750596002 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes
    • PMID:16929378
    • Groop PH, Forsblom C, Thomas MC. Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab 2005; 1:100-10; PMID:16929378; http://dx.doi.org/10.1038/ ncpendmet0046.
    • (2005) Nat Clin Pract Endocrinol Metab , vol.1 , pp. 100-110
    • Groop, P.H.1    Forsblom, C.2    Thomas, M.C.3
  • 92
    • 33846626478 scopus 로고    scopus 로고
    • The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program
    • Diabetes Prevention Program Research Group. PMID:17257275
    • Diabetes Prevention Program Research Group. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program. Diabet Med 2007; 24:137-44; PMID:17257275; http://dx.doi.org/10.1111/j.1464-5491.2007.02043.x.
    • (2007) Diabet Med , vol.24 , pp. 137-144
  • 93
    • 0036598583 scopus 로고    scopus 로고
    • Longitudinal association of glycemia and microalbuminuria: The Framingham Offspring Study
    • PMID:12032102
    • Meigs JB, D'Agostino RBS, Nathan DM, Rifai N, Wilson PW. Longitudinal association of glycemia and microalbuminuria: the Framingham Offspring Study. Diabetes Care 2002; 25:977-83; PMID:12032102; http://dx.doi.org/10.2337/diacare. 25.6.977.
    • (2002) Diabetes Care , vol.25 , pp. 977-983
    • Meigs, J.B.1    D'Agostino, R.B.S.2    Nathan, D.M.3    Rifai, N.4    Wilson, P.W.5
  • 94
    • 0036276294 scopus 로고    scopus 로고
    • Obesity, diabetes and risk of cardiovascular disease in the elderly
    • PMID:11872970
    • Wilson PW, Kannel WB. Obesity, diabetes and risk of cardiovascular disease in the elderly. Am J Geriatr Cardiol 2002; 11:119-23; PMID:11872970; http://dx.doi.org/10.1111/j.1076-7460.2002.00998.x.
    • (2002) Am J Geriatr Cardiol , vol.11 , pp. 119-123
    • Wilson, P.W.1    Kannel, W.B.2
  • 95
    • 79960959816 scopus 로고    scopus 로고
    • Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials
    • PMID:21791495
    • Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 2011; 343:4169; PMID:21791495; http://dx.doi.org/10.1136/bmj.d4169.
    • (2011) BMJ , vol.343 , pp. 4169
    • Boussageon, R.1    Bejan-Angoulvant, T.2    Saadatian-Elahi, M.3    Lafont, S.4    Bergeonneau, C.5    Kassai, B.6
  • 96
    • 33646352217 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
    • PMID:16597691
    • Lloberas N, Cruzado JM, Franquesa M, Herrero-Fresneda I, Torras J, Alperovich G, et al. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 2006; 17:1395-404; PMID:16597691; http://dx.doi.org/10.1681/ASN.2005050549.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1395-1404
    • Lloberas, N.1    Cruzado, J.M.2    Franquesa, M.3    Herrero-Fresneda, I.4    Torras, J.5    Alperovich, G.6
  • 97
    • 29244486472 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
    • PMID:16364254
    • Sakaguchi M, Isono M, Isshiki K, Sugimoto T, Koya D, Kashiwagi A. Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. Biochem Biophys Res Commun 2006; 340:296-301; PMID:16364254; http://dx.doi.org/10.1016/j.bbrc.2005.12.012.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 296-301
    • Sakaguchi, M.1    Isono, M.2    Isshiki, K.3    Sugimoto, T.4    Koya, D.5    Kashiwagi, A.6
  • 98
    • 34748880045 scopus 로고    scopus 로고
    • Rapamycin prevents early steps of the development of diabetic nephropathy in rats
    • PMID:17671379
    • Yang Y, Wang J, Qin L, Shou Z, Zhao J, Wang H, et al. Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol 2007; 27:495-502; PMID:17671379; http://dx.doi.org/10.1159/000106782.
    • (2007) Am J Nephrol , vol.27 , pp. 495-502
    • Yang, Y.1    Wang, J.2    Qin, L.3    Shou, Z.4    Zhao, J.5    Wang, H.6
  • 99
    • 67649616517 scopus 로고    scopus 로고
    • Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat
    • PMID:19424027
    • Wittmann S, Daniel C, Stief A, Vogelbacher R, Amann K, Hugo C. Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat. Transplantation 2009; 87:1290-9; PMID:19424027; http://dx.doi.org/10. 1097/TP.0b013e3181a192bd.
    • (2009) Transplantation , vol.87 , pp. 1290-1299
    • Wittmann, S.1    Daniel, C.2    Stief, A.3    Vogelbacher, R.4    Amann, K.5    Hugo, C.6
  • 100
    • 67651087241 scopus 로고    scopus 로고
    • Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)
    • PMID:19321761
    • Zafar I, Belibi FA, He Z, Edelstein CL. Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD). Nephrol Dial Transplant 2009; 24:2349-53; PMID:19321761; http://dx.doi.org/10.1093/ndt/ gfp129.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2349-2353
    • Zafar, I.1    Belibi, F.A.2    He, Z.3    Edelstein, C.L.4
  • 101
    • 27744489524 scopus 로고    scopus 로고
    • Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
    • PMID:15917339
    • Bonegio RG, Fuhro R, Wang Z, Valeri CR, Andry C, Salant DJ, et al. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J Am Soc Nephrol 2005; 16:2063-72; PMID:15917339; http://dx.doi.org/10.1681/ASN.2004030180.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2063-2072
    • Bonegio, R.G.1    Fuhro, R.2    Wang, Z.3    Valeri, C.R.4    Andry, C.5    Salant, D.J.6
  • 102
    • 33847713330 scopus 로고    scopus 로고
    • Five-year follow-up after late conversion from calcineurin inhibitors to sirolimus in patients with chronic renal allograft dysfunction
    • PMID:17362772
    • Krüger B, Fischereder M, Jauch KW, Graeb C, Hoffmann U, Boger CA, et al. Five-year follow-up after late conversion from calcineurin inhibitors to sirolimus in patients with chronic renal allograft dysfunction. Transplant Proc 2007; 39:518-21; PMID:17362772; http://dx.doi.org/10.1016/j.transproceed.2006. 12.004.
    • (2007) Transplant Proc , vol.39 , pp. 518-521
    • Krüger, B.1    Fischereder, M.2    Jauch, K.W.3    Graeb, C.4    Hoffmann, U.5    Boger, C.A.6
  • 103
    • 25444435486 scopus 로고    scopus 로고
    • Systemic rapamycin inhibits retinal and choroidal neovascularization in mice
    • PMID:15623986
    • Dejneka NS, Kuroki AM, Fosnot J, Tang W, Tolentino MJ, Bennett J. Systemic rapamycin inhibits retinal and choroidal neovascularization in mice. Mol Vis 2004; 10:964-72; PMID:15623986.
    • (2004) Mol Vis , vol.10 , pp. 964-972
    • Dejneka, N.S.1    Kuroki, A.M.2    Fosnot, J.3    Tang, W.4    Tolentino, M.J.5    Bennett, J.6
  • 104
    • 78650799667 scopus 로고    scopus 로고
    • A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization
    • PMID:20847709
    • Nussenblatt RB, Byrnes G, Sen HN, Yeh S, Faia L, Meyerle C, et al. A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization. Retina 2010; 30:1579-87; PMID:20847709; http://dx.doi.org/10.1097/IAE.0b013e3181e7978e.
    • (2010) Retina , vol.30 , pp. 1579-1587
    • Nussenblatt, R.B.1    Byrnes, G.2    Sen, H.N.3    Yeh, S.4    Faia, L.5    Meyerle, C.6
  • 105
    • 0038585135 scopus 로고    scopus 로고
    • Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice
    • PMID:12752312
    • Elloso MM, Azrolan N, Sehgal SN, Hsu PL, Phiel KL, Kopec CA, et al. Protective effect of the immunosuppressant sirolimus against aortic atherosclerosis in apo E-deficient mice. Am J Transplant 2003; 3:562-9; PMID:12752312; http://dx.doi.org/10.1034/j.1600-6143.2003.00094.x.
    • (2003) Am J Transplant , vol.3 , pp. 562-569
    • Elloso, M.M.1    Azrolan, N.2    Sehgal, S.N.3    Hsu, P.L.4    Phiel, K.L.5    Kopec, C.A.6
  • 106
    • 26044448312 scopus 로고    scopus 로고
    • Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein e knockout mice: Inhibitory effect on monocyte chemotaxis
    • PMID:16160601
    • Pakala R, Stabile E, Jang GJ, Clavijo L, Waksman R. Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis. J Cardiovasc Pharmacol 2005; 46:481-6; PMID:16160601; http://dx.doi.org/10.1097/01.fjc.0000177985.14305.15.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 481-486
    • Pakala, R.1    Stabile, E.2    Jang, G.J.3    Clavijo, L.4    Waksman, R.5
  • 107
    • 40949111498 scopus 로고    scopus 로고
    • Prevention of atherosclerosis by the mTOR inhibitor everolimis in LDLR-/- Mice despite hypercholesterolemia
    • PMID:17980369
    • Mueller MA, Beutner F, Teupser d, Ceglarek U, Thiery J. Prevention of atherosclerosis by the mTOR inhibitor everolimis in LDLR-/- mice despite hypercholesterolemia. Atherosclerosis 2008; 198:39-48; PMID:17980369; http://dx.doi.org/10.1016/j.atherosclerosis.2007.09.019.
    • (2008) Atherosclerosis , vol.198 , pp. 39-48
    • Mueller, M.A.1    Beutner, F.2    Teupser, D.3    Ceglarek, U.4    Thiery, J.5
  • 108
    • 33646056392 scopus 로고    scopus 로고
    • Oral Rapamycin after Coronary Bare-Metal Stent Implantation to Prevent Restenosis the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study
    • PMID:16630986
    • Rodriguez AE, Granada JF, Rodriguez-Alemparte M, Vigo CF, Delgado J, Fernandez-Pereira C, et al. Oral Rapamycin After Coronary Bare-Metal Stent Implantation to Prevent Restenosis The Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study. J Am Coll Cardiol 2006; 47:1522-9; PMID:16630986; http://dx.doi.org/10.1016/j.jacc.2005.12.052.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1522-1529
    • Rodriguez, A.E.1    Granada, J.F.2    Rodriguez-Alemparte, M.3    Vigo, C.F.4    Delgado, J.5    Fernandez-Pereira, C.6
  • 109
    • 78649816080 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
    • PMID:20801951
    • Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes. Endocr Relat Cancer 2010; 17:941-51; PMID:20801951; http://dx.doi.org/10.1677/ERC-10-0091.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 941-951
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    LeRoith, D.5
  • 110
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and beta-cell dysfunction
    • PMID:18048763
    • Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 2008; 29:351-66; PMID:18048763; http://dx.doi.org/10. 1210/er.2007-0023.
    • (2008) Endocr Rev , vol.29 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 111
    • 0036738398 scopus 로고    scopus 로고
    • Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
    • PMID:12235117
    • Maedler K, Sergeev P, Ris F, Oberholzer J, Joller- Jemelka HI, Spinas GA, et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110:851-60; PMID:12235117.
    • (2002) J Clin Invest , vol.110 , pp. 851-860
    • Maedler, K.1    Sergeev, P.2    Ris, F.3    Oberholzer, J.4    Joller-Jemelka, H.I.5    Spinas, G.A.6
  • 112
    • 63349109171 scopus 로고    scopus 로고
    • Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1
    • PMID:19305497
    • Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS ONE 2009; 4:4954; PMID:19305497; http://dx.doi.org/10.1371/journal.pone.0004954.
    • (2009) PLoS ONE , vol.4 , pp. 4954
    • Bachar, E.1    Ariav, Y.2    Ketzinel-Gilad, M.3    Cerasi, E.4    Kaiser, N.5    Leibowitz, G.6
  • 113
    • 77957579650 scopus 로고    scopus 로고
    • Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in betacells
    • PMID:20622167
    • Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Meneur C, Fatrai S, Gould AP, et al. Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in betacells. Diabetes 2010; 59:2390-9; PMID:20622167; http://dx.doi.org/10.2337/db09-0851.
    • (2010) Diabetes , vol.59 , pp. 2390-2399
    • Elghazi, L.1    Balcazar, N.2    Blandino-Rosano, M.3    Cras-Meneur, C.4    Fatrai, S.5    Gould, A.P.6
  • 114
    • 12544252740 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback downregulates protein kinase B-mediated signaling pathway in beta-cells
    • PMID:15537654
    • Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback downregulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem 2005; 280:2282-93; PMID:15537654; http://dx.doi.org/10.1074/jbc.M412179200.
    • (2005) J Biol Chem , vol.280 , pp. 2282-2293
    • Briaud, I.1    Dickson, L.M.2    Lingohr, M.K.3    McCuaig, J.F.4    Lawrence, J.C.5    Rhodes, C.J.6
  • 115
    • 42449104351 scopus 로고    scopus 로고
    • mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • PMID:18174523
    • Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 2008; 57:945-57; PMID:18174523; http://dx.doi.org/10.2337/db07-0922.
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3    Pappo, O.4    Karaca, M.5    Castel, J.6
  • 116
    • 53549129190 scopus 로고    scopus 로고
    • The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes
    • PMID:18834443
    • Leibowitz G, Cerasi E, Ketzinel-Gilad M. The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes. Diabetes Obes Metab 2008; 10:157-69; PMID:18834443; http://dx.doi.org/10.1111/j.1463-326.2008.00952. x.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 157-169
    • Leibowitz, G.1    Cerasi, E.2    Ketzinel-Gilad, M.3
  • 117
    • 48249146208 scopus 로고    scopus 로고
    • Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
    • PMID:18587048
    • Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci USA 2008; 105:9250-5; PMID:18587048; http://dx.doi.org/10.1073/pnas.0803047105.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9250-9255
    • Rachdi, L.1    Balcazar, N.2    Osorio-Duque, F.3    Elghazi, L.4    Weiss, A.5    Gould, A.6
  • 118
    • 42349086872 scopus 로고    scopus 로고
    • Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
    • PMID:18316403
    • Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, et al. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol 2008; 28:2971-9; PMID:18316403; http://dx.doi.org/10.1128/MCB.01695-07.
    • (2008) Mol Cell Biol , vol.28 , pp. 2971-2979
    • Shigeyama, Y.1    Kobayashi, T.2    Kido, Y.3    Hashimoto, N.4    Asahara, S.5    Matsuda, T.6
  • 119
    • 68949215897 scopus 로고    scopus 로고
    • Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice
    • PMID:19496779
    • Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Hsu HM, et al. Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice. Basic Clin Pharmacol Toxicol 2009; 105:188-98; PMID:19496779; http://dx.doi.org/10.1111/j.1742-7843.2009.00427.x.
    • (2009) Basic Clin Pharmacol Toxicol , vol.105 , pp. 188-198
    • Chang, G.R.1    Wu, Y.Y.2    Chiu, Y.S.3    Chen, W.Y.4    Liao, J.W.5    Hsu, H.M.6
  • 120
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • PMID:20299475
    • Houde VP, Brule S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y, et al. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 2010; 59:1338-48; PMID:20299475; http://dx.doi.org/10. 2337/db09-1324.
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3    Blanchard, P.G.4    Bellmann, K.5    Deshaies, Y.6
  • 121
    • 32844474879 scopus 로고    scopus 로고
    • Glucose metabolism in renal transplant recipients: Effect of calcineurin inhibitor withdrawal and conversion to sirolimus
    • PMID:16107580
    • Teutonico A, Schena PF, Di Paolo S. Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus. J Am Soc Nephrol 2005; 16:3128-35; PMID:16107580; http://dx.doi.org/10.1681/ASN.2005050487.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3128-3135
    • Teutonico, A.1    Schena, P.F.2    Di Paolo, S.3
  • 122
    • 67949084959 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and diabetes: What does the current evidence tell us?
    • PMID:19651294
    • Vodenik B, Rovira J, Campistol JM. Mammalian target of rapamycin and diabetes: what does the current evidence tell us? Transplant Proc 2009; 41:31-8; PMID:19651294; http://dx.doi.org/10.1016/j.transproceed.2009.06.159.
    • (2009) Transplant Proc , vol.41 , pp. 31-38
    • Vodenik, B.1    Rovira, J.2    Campistol, J.M.3
  • 123
    • 0013695015 scopus 로고
    • Metabolic abnormalities in starvation diabetes
    • PMID:18872320
    • Lundbaek K. Metabolic abnormalities in starvation diabetes. Yale J Biol Med 1948; 20:533-44; PMID:18872320.
    • (1948) Yale J Biol Med , vol.20 , pp. 533-544
    • Lundbaek, K.1
  • 124
    • 0023734690 scopus 로고
    • Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
    • PMID:3069395
    • Randle PJ, Kerbey AL, Espinal J. Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 1988; 4:623-38; PMID:3069395; http://dx.doi.org/10.1002/dmr.5610040702.
    • (1988) Diabetes Metab Rev , vol.4 , pp. 623-638
    • Randle, P.J.1    Kerbey, A.L.2    Espinal, J.3
  • 125
    • 0025633806 scopus 로고
    • Mechanisms of starvation diabetes: A study with double tracer and indirect calorimetry
    • PMID:2260646
    • Fery F, d'Attellis NP, Balasse EO. Mechanisms of starvation diabetes: a study with double tracer and indirect calorimetry. Am J Physiol 1990; 259:770-7; PMID:2260646.
    • (1990) Am J Physiol , vol.259 , pp. 770-777
    • Fery, F.1    D'Attellis, N.P.2    Balasse, E.O.3
  • 126
    • 0037983739 scopus 로고    scopus 로고
    • Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney
    • PMID:12765946
    • Huang B, Wu P, Popov KM, Harris RA. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes 2003; 52:1371-6; PMID:12765946; http://dx.doi.org/10.2337/diabetes.52.6.1371.
    • (2003) Diabetes , vol.52 , pp. 1371-1376
    • Huang, B.1    Wu, P.2    Popov, K.M.3    Harris, R.A.4
  • 127
    • 0018144194 scopus 로고
    • Muscle metabolism during exercise in diabetics and in obese during starvation
    • PMID:680626
    • Dieterle P, Bachl I, Bachl G, Henner J, Frommeld D, Minkus P, et al. Muscle metabolism during exercise in diabetics and in obese during starvation. Horm Metab Res 1978; 10:263-8; PMID:680626; http://dx.doi.org/10.1055/s-0028- 1093411.
    • (1978) Horm Metab Res , vol.10 , pp. 263-268
    • Dieterle, P.1    Bachl, I.2    Bachl, G.3    Henner, J.4    Frommeld, D.5    Minkus, P.6
  • 128
    • 28944455613 scopus 로고    scopus 로고
    • Effects of acute starvation on insulin resistance in obese patients with and without type 2 diabetes mellitus
    • PMID:16185788
    • Duska F, Andel M, Kubena A, Macdonald IA. Effects of acute starvation on insulin resistance in obese patients with and without type 2 diabetes mellitus. Clin Nutr 2005; 24:1056-64; PMID:16185788; http://dx.doi.org/10.1016/j.clnu. 2005.08.008.
    • (2005) Clin Nutr , vol.24 , pp. 1056-1064
    • Duska, F.1    Andel, M.2    Kubena, A.3    Macdonald, I.A.4
  • 129
    • 0018760738 scopus 로고
    • Starvation diabetes in the rat: Onset, recovery and specificity of reduced responsiveness of pancreatic beta-cells
    • PMID:374069
    • Zawalich WS, Dye ES, Pagliara AS, Rognstad R, Matschinsky FM. Starvation diabetes in the rat: onset, recovery and specificity of reduced responsiveness of pancreatic beta-cells. Endocrinology 1979; 104:1344-51; PMID:374069; http://dx.doi.org/10.1210/endo-104-5-1344.
    • (1979) Endocrinology , vol.104 , pp. 1344-1351
    • Zawalich, W.S.1    Dye, E.S.2    Pagliara, A.S.3    Rognstad, R.4    Matschinsky, F.M.5
  • 130
    • 0018912679 scopus 로고
    • On the relation of glucose and insulin secretion in the fasting state
    • PMID:6986011
    • Joost HG, Beckmann J. On the relation of glucose and insulin secretion in the fasting state. Metabolism 1980; 29:23-7; PMID:6986011; http://dx.doi.org/ 10.1016/0026-0495(80)90093-1.
    • (1980) Metabolism , vol.29 , pp. 23-27
    • Joost, H.G.1    Beckmann, J.2
  • 131
    • 0017572807 scopus 로고
    • Insulin secretion reactivation of pancreatic islets from starved rats in vitro
    • PMID:356495
    • Hahn HJ, Gottschling HD. Insulin secretion reactivation of pancreatic islets from starved rats in vitro. Acta Biol Med Ger 1977; 36:1423-7; PMID:356495.
    • (1977) Acta Biol Med Ger , vol.36 , pp. 1423-1427
    • Hahn, H.J.1    Gottschling, H.D.2
  • 132
    • 0033948888 scopus 로고    scopus 로고
    • Glucose-induced insulin secretion from islets of fasted rats: Modulation by alternate fuel and neurohumoral agonists
    • PMID:10856889
    • Zawalich WS, Zawalich KC. Glucose-induced insulin secretion from islets of fasted rats: modulation by alternate fuel and neurohumoral agonists. J Endocrinol 2000; 166:111-20; PMID:10856889; http://dx.doi.org/10.1677/joe.0. 1660111.
    • (2000) J Endocrinol , vol.166 , pp. 111-120
    • Zawalich, W.S.1    Zawalich, K.C.2
  • 133
    • 77952090325 scopus 로고    scopus 로고
    • Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats
    • PMID:20960173
    • Shivaswamy V, McClure M, Passer J, Frahm C, Ochsner L, Erickson J, et al. Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats. Endocrine 2010; 37:489-96; PMID:20960173; http://dx.doi.org/10.1007/s12020-010-9332-6.
    • (2010) Endocrine , vol.37 , pp. 489-496
    • Shivaswamy, V.1    McClure, M.2    Passer, J.3    Frahm, C.4    Ochsner, L.5    Erickson, J.6
  • 134
    • 34447316421 scopus 로고    scopus 로고
    • Caloric restriction in humans
    • PMID:17482403
    • Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007; 42:709-12; PMID:17482403; http://dx.doi.org/10.1016/j.exger.2007.03.009.
    • (2007) Exp Gerontol , vol.42 , pp. 709-712
    • Holloszy, J.O.1    Fontana, L.2
  • 135
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • PMID:21656330
    • Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011; 54:2506-14; PMID:21656330; http://dx.doi.org/10.1007/s00125-011-2204-7.
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3    Chen, M.J.4    Mathers, J.C.5    Taylor, R.6
  • 136
    • 33750908045 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial
    • PMID:17093155
    • Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, et al. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 2006; 84:1033-42; PMID:17093155.
    • (2006) Am J Clin Nutr , vol.84 , pp. 1033-1042
    • Weiss, E.P.1    Racette, S.B.2    Villareal, D.T.3    Fontana, L.4    Steger-May, K.5    Schechtman, K.B.6
  • 137
    • 2342647592 scopus 로고    scopus 로고
    • Longterm calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • PMID:15096581
    • Fontana L, Meyer TE, Klein S, Holloszy JO. Longterm calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 2004; 101:6659-63; PMID:15096581; http://dx.doi.org/10.1073/ pnas.0308291101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 138
    • 0036265047 scopus 로고    scopus 로고
    • Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice
    • PMID:12016155
    • Berrigan D, Perkins SN, Haines DC, Hursting SD. Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis 2002; 23:817-22; PMID:12016155; http://dx.doi.org/10.1093/carcin/ 23.5.817.
    • (2002) Carcinogenesis , vol.23 , pp. 817-822
    • Berrigan, D.1    Perkins, S.N.2    Haines, D.C.3    Hursting, S.D.4
  • 140
    • 60649110218 scopus 로고    scopus 로고
    • Caloric restriction alone and with exercise improves CVD risk in healthy nonobese individuals
    • PMID:18602635
    • Lefevre M, Redman LM, Heilbronn LK, Smith JV, Martin CK, Rood JC, et al. Caloric restriction alone and with exercise improves CVD risk in healthy nonobese individuals. Atherosclerosis 2009; 203:206-13; PMID:18602635; http://dx.doi.org/10.1016/j.atherosclerosis.2008.05.036.
    • (2009) Atherosclerosis , vol.203 , pp. 206-213
    • Lefevre, M.1    Redman, L.M.2    Heilbronn, L.K.3    Smith, J.V.4    Martin, C.K.5    Rood, J.C.6
  • 141
    • 0013072999 scopus 로고    scopus 로고
    • Calorie restriction, aging and cancer prevention: Mechanisms of action and applicability to humans
    • PMID:12525670
    • Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC. Calorie restriction, aging and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 2003; 54:131-52; PMID:12525670; http://dx.doi.org/10. 1146/annurev.med.54.101601.152156.
    • (2003) Annu Rev Med , vol.54 , pp. 131-152
    • Hursting, S.D.1    Lavigne, J.A.2    Berrigan, D.3    Perkins, S.N.4    Barrett, J.C.5
  • 142
    • 66149165913 scopus 로고    scopus 로고
    • Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster
    • PMID:19627272
    • Edman U, Garcia AM, Busuttil RA, Sorensen D, Lundell M, Kapahi P, et al. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster. Aging Cell 2009; 8:331-8; PMID:19627272; http://dx.doi.org/10.1111/j.1474-9726.2009.00480.x.
    • (2009) Aging Cell , vol.8 , pp. 331-338
    • Edman, U.1    Garcia, A.M.2    Busuttil, R.A.3    Sorensen, D.4    Lundell, M.5    Kapahi, P.6
  • 143
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)
    • PMID:20139716
    • Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle 2010; 9:683-8; PMID:20139716; http://dx.doi.org/10.4161/cc.9.4.10766.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 144
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy lifespan - From yeast to humans
    • PMID:20395504
    • Fontana L, Partridge L, Longo VD. Extending healthy lifespan - from yeast to humans. Science 2010; 328:321-6; PMID:20395504; http://dx.doi.org/10.1126/ science.1172539.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 145
    • 78650848337 scopus 로고    scopus 로고
    • mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • PMID:21179166
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 2010; 468:1100-4; PMID:21179166; http://dx.doi.org/10.1038/nature09584.
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 146
    • 79955383670 scopus 로고    scopus 로고
    • Reversal of diabetic nephropathy by a ketogenic diet
    • PMID:21533091
    • Poplawski MM, Mastaitis JW, Isoda F, Grosjean F, Zheng F, Mobbs CV. Reversal of diabetic nephropathy by a ketogenic diet. PLoS ONE 2011; 6:18604; PMID:21533091; http://dx.doi.org/10.1371/journal.pone.0018604.
    • (2011) PLoS ONE , vol.6 , pp. 18604
    • Poplawski, M.M.1    Mastaitis, J.W.2    Isoda, F.3    Grosjean, F.4    Zheng, F.5    Mobbs, C.V.6
  • 147
    • 77952549736 scopus 로고    scopus 로고
    • Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain
    • PMID:20188215
    • Balietti M, Casoli T, Di Stefano G, Giorgetti B, Aicardi G, Fattoretti P. Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain. Ageing Res Rev 2010; 9:273-9; PMID:20188215; http://dx.doi.org/10.1016/j.arr.2010.02.003.
    • (2010) Ageing Res Rev , vol.9 , pp. 273-279
    • Balietti, M.1    Casoli, T.2    Di Stefano, G.3    Giorgetti, B.4    Aicardi, G.5    Fattoretti, P.6
  • 148
    • 30344462964 scopus 로고    scopus 로고
    • A low-carbohydrate, ketogenic diet to treat type 2 diabetes
    • Lond PMID:16318637
    • Yancy WS Jr, Foy M, Chalecki AM, Vernon MC, Westman EC. A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutr Metab (Lond) 2005; 2:34; PMID:16318637; http://dx.doi.org/10.1186/1743-7075-2-34.
    • (2005) Nutr Metab , vol.2 , pp. 34
    • Yancy Jr., W.S.1    Foy, M.2    Chalecki, A.M.3    Vernon, M.C.4    Westman, E.C.5
  • 149
    • 38149107357 scopus 로고    scopus 로고
    • Paradoxes of aging
    • PMID:18156807
    • Blagosklonny MV. Paradoxes of aging. Cell Cycle 2007; 6:2997-3003; PMID:18156807; http://dx.doi.org/10.4161/cc.6.24.5124.
    • (2007) Cell Cycle , vol.6 , pp. 2997-3003
    • Blagosklonny, M.V.1


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