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Volumn 10, Issue 8, 2004, Pages 789-799

Cancer genes and the pathways they control

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AXIN; FAS LIGAND; GENE PRODUCT; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; SMAD PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UVOMORULIN;

EID: 4043181214     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1087     Document Type: Review
Times cited : (3506)

References (118)
  • 1
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002).
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 2
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan, P.T. et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855-867 (2004).
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1
  • 3
    • 2542432915 scopus 로고    scopus 로고
    • Haploinsufficiency for tumour suppressor genes: When you don't need to go all the way
    • Santarosa, M. & Ashworth, A. Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way. Biochim. Biophys. Acta 1654, 105-122 (2004).
    • (2004) Biochim. Biophys. Acta , vol.1654 , pp. 105-122
    • Santarosa, M.1    Ashworth, A.2
  • 4
  • 5
    • 85015066476 scopus 로고    scopus 로고
    • DNA damage and repair
    • Friedberg, E.C. DNA damage and repair. Nature 421, 436-440 (2003).
    • (2003) Nature , vol.421 , pp. 436-440
    • Friedberg, E.C.1
  • 6
    • 0036376720 scopus 로고    scopus 로고
    • Tumor progression: A brief historical perspective
    • Nowell, P.C. Tumor progression: a brief historical perspective. Semin. Cancer Biol. 12, 261-266 (2002).
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 261-266
    • Nowell, P.C.1
  • 7
    • 2442649306 scopus 로고    scopus 로고
    • Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus
    • Maley, C.C. et al. Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res. 64, 3414-3427 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3414-3427
    • Maley, C.C.1
  • 8
    • 0037169361 scopus 로고    scopus 로고
    • Cancer modeling in the modern era: Progress and challenges
    • Van Dyke, T. & Jacks, T. Cancer modeling in the modern era: progress and challenges. Cell 108, 135-144 (2002).
    • (2002) Cell , vol.108 , pp. 135-144
    • Van Dyke, T.1    Jacks, T.2
  • 9
    • 0042469295 scopus 로고    scopus 로고
    • Worms, life, and death
    • Horvitz, H.R. Worms, life, and death. Chembiochem 4, 697-711 (2003).
    • (2003) Chembiochem , vol.4 , pp. 697-711
    • Horvitz, H.R.1
  • 10
    • 0034660892 scopus 로고    scopus 로고
    • Cancer cell cycles revisited
    • Sherr, C.J. Cancer cell cycles revisited. Cancer Res. 60, 3689-3695 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 11
    • 0037075887 scopus 로고    scopus 로고
    • Cyclin D-dependent kinases, INK4 inhibitors and cancer
    • Ortega, S., Malumbres, M. & Barbacid, M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim. Biophys. Acta 1602, 73-87 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 73-87
    • Ortega, S.1    Malumbres, M.2    Barbacid, M.3
  • 12
    • 0036884829 scopus 로고    scopus 로고
    • The retinoblastoma tumour suppressor in development and cancer
    • Classon, M. & Harlow, E. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2, 910-917 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 910-917
    • Classon, M.1    Harlow, E.2
  • 13
    • 0034649787 scopus 로고    scopus 로고
    • Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
    • Ichimura, K. et al. Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. 60, 417-424 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 417-424
    • Ichimura, K.1
  • 14
  • 15
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren, M. Decision making by p53: life, death and cancer. Cell Death Differ. 10, 431-442 (2003).
    • (2003) Cell Death Differ. , vol.10 , pp. 431-442
    • Oren, M.1
  • 16
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives, C. & Hall, P.A. The p53 pathway. J. Pathol. 187, 112-126 (1999).
    • (1999) J. Pathol. , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 17
    • 0036364945 scopus 로고    scopus 로고
    • Perspectives in studies of human tumor viruses
    • Klein, G. Perspectives in studies of human tumor viruses. Front. Biosci. 7, d268-d274 (2002).
    • (2002) Front. Biosci. , vol.7
    • Klein, G.1
  • 18
    • 0036849734 scopus 로고    scopus 로고
    • Human papillomavirus immortalization and transformation functions
    • Munger, K. & Howley, P.M. Human papillomavirus immortalization and transformation functions. Virus Res. 89, 213-228 (2002).
    • (2002) Virus Res. , vol.89 , pp. 213-228
    • Munger, K.1    Howley, P.M.2
  • 19
    • 0035956211 scopus 로고    scopus 로고
    • Oncogenic DNA viruses
    • zur Hausen, H. Oncogenic DNA viruses. Oncogene 20, 7820-7823 (2001).
    • (2001) Oncogene , vol.20 , pp. 7820-7823
    • Zur Hausen, H.1
  • 20
    • 0034614490 scopus 로고    scopus 로고
    • Signaling-2000 and beyond
    • Hunter, T. Signaling-2000 and beyond. Cell 100, 113-127 (2000).
    • (2000) Cell , vol.100 , pp. 113-127
    • Hunter, T.1
  • 21
    • 0003291373 scopus 로고    scopus 로고
    • Mutation-selection networks of cancer initiation: Tumor suppressor genes and chromosomal instability
    • Komarova, N.L., Sengupta, A. & Nowak, M.A. Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223, 433-450 (2003).
    • (2003) J. Theor. Biol. , vol.223 , pp. 433-450
    • Komarova, N.L.1    Sengupta, A.2    Nowak, M.A.3
  • 22
    • 0032411481 scopus 로고    scopus 로고
    • The critical role of chromosome translocations in human leukemias
    • Rowley, J.D. The critical role of chromosome translocations in human leukemias. Annu. Rev. Genet. 32, 495-519 (1998).
    • (1998) Annu. Rev. Genet. , vol.32 , pp. 495-519
    • Rowley, J.D.1
  • 23
    • 0034125650 scopus 로고    scopus 로고
    • Recurrent chromosome aberrations in cancer
    • Mitelman, F. Recurrent chromosome aberrations in cancer. Mutat. Res. 462, 247-253 (2000).
    • (2000) Mutat. Res. , vol.462 , pp. 247-253
    • Mitelman, F.1
  • 25
    • 0035253742 scopus 로고    scopus 로고
    • Know thy neighbor: Stromal cells can contribute oncogenic signals
    • Tlsty, T.D. & Hein, P.W. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev. 11, 54-59 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 54-59
    • Tlsty, T.D.1    Hein, P.W.2
  • 26
    • 1042292614 scopus 로고    scopus 로고
    • Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes
    • Fata, J.E., Werb, Z. & Bissell, M.J. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 6, 1-11 (2004).
    • (2004) Breast Cancer Res. , vol.6 , pp. 1-11
    • Fata, J.E.1    Werb, Z.2    Bissell, M.J.3
  • 27
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 28
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29, 15-18 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 15-18
    • Folkman, J.1
  • 29
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K.J., Gerber, H.P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391-400 (2004).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 30
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo, K., Klco, J., Nakamura, E., Lechpammer, M. & Kaelin, W.G. Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237-246 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 31
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 32
    • 0038102259 scopus 로고    scopus 로고
    • Sequence-based cancer genomics: Progress, lessons and opportunities
    • Strausberg, R.L., Simpson, A.J. & Wooster, R. Sequence-based cancer genomics: progress, lessons and opportunities. Nat. Rev. Genet. 4, 409-418 (2003).
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 409-418
    • Strausberg, R.L.1    Simpson, A.J.2    Wooster, R.3
  • 35
  • 36
    • 18344378411 scopus 로고    scopus 로고
    • Prevalence of somatic alterations in the colorectal cancer cell genome
    • Wang, T.L. et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc. Natl. Acad. Sci. USA 99, 3076-3080 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3076-3080
    • Wang, T.L.1
  • 37
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer, C., Kinzler, K.W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 38
    • 85078507894 scopus 로고    scopus 로고
    • Multistep carcinogenesis: A chain reaction of aneuploidizations
    • Duesberg, P. & Li, R. Multistep carcinogenesis: a chain reaction of aneuploidizations. Cell Cycle 2, 202-210 (2003).
    • (2003) Cell Cycle , vol.2 , pp. 202-210
    • Duesberg, P.1    Li, R.2
  • 39
    • 0141994858 scopus 로고    scopus 로고
    • Genomic microarrays in human genetic disease and cancer
    • Albertson, D.G. & Pinkel, D. Genomic microarrays in human genetic disease and cancer. Hum. Mol. Genet. 12 (spec. no. 2), R145-R152 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , Issue.SPEC. NO. 2
    • Albertson, D.G.1    Pinkel, D.2
  • 40
    • 0034798285 scopus 로고    scopus 로고
    • ATM genome stability, neuronal development, and cancer cross paths
    • Shiloh, Y. & Kastan, M.B. ATM: genome stability, neuronal development, and cancer cross paths. Adv. Cancer Res. 83, 209-254 (2001).
    • (2001) Adv. Cancer Res. , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 41
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully, R. & Livingston, D.M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432 (2000).
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2
  • 42
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis, and cancer
    • Maser, R.S. & DePinho, R.A. Connecting chromosomes, crisis, and cancer. Science 297, 565-569 (2002).
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, R.S.1    DePinho, R.A.2
  • 43
    • 0041883657 scopus 로고    scopus 로고
    • Mutations and aneuploidy: Co-conspirators in cancer?
    • Pihan, G. & Doxsey, S.J. Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell 4, 89-94 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 89-94
    • Pihan, G.1    Doxsey, S.J.2
  • 44
    • 1542377277 scopus 로고    scopus 로고
    • Inactivation of hCDC4 can cause chromosomal instability
    • Rajagopalan, H. et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 428, 77-81 (2004).
    • (2004) Nature , vol.428 , pp. 77-81
    • Rajagopalan, H.1
  • 45
    • 2342570379 scopus 로고    scopus 로고
    • Hallmarks of senescence in carcinogenesis and cancer therapy
    • Shay, J.W. & Roninson, I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23, 2919-2933 (2004).
    • (2004) Oncogene , vol.23 , pp. 2919-2933
    • Shay, J.W.1    Roninson, I.B.2
  • 46
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers, A.F., Groom, A.C. & MacDonald, I.C. Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer 2, 563-572 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 47
    • 0035999133 scopus 로고    scopus 로고
    • Critical determinants of metastasis
    • Fidler, I.J. Critical determinants of metastasis. Semin. Cancer Biol. 12, 89-96 (2002).
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 89-96
    • Fidler, I.J.1
  • 48
    • 1642391048 scopus 로고    scopus 로고
    • Host genetics and tumour metastasis
    • Hunter, K.W. Host genetics and tumour metastasis. Br. J. Cancer 90, 752-755 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 752-755
    • Hunter, K.W.1
  • 50
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre, A.J. et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 17, 3112-3126 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 3112-3126
    • Aguirre, A.J.1
  • 51
    • 0027973077 scopus 로고
    • Molecular determinants of dysplasia in colorectal lesions
    • Jen, J. et al. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54, 5523-5526 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 5523-5526
    • Jen, J.1
  • 52
    • 0028931923 scopus 로고
    • Aberrant crypt foci and K-ras mutations: Earliest recognized players or innocent bystanders in colon carcinogenesis?
    • Pretlow, T.P. Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis? Gastroenterology 108, 600-603 (1995).
    • (1995) Gastroenterology , vol.108 , pp. 600-603
    • Pretlow, T.P.1
  • 53
    • 12144287841 scopus 로고    scopus 로고
    • In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours
    • Sieben, N.L. et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J. Pathol. 202, 336-340 (2004).
    • (2004) J. Pathol. , vol.202 , pp. 336-340
    • Sieben, N.L.1
  • 54
    • 0002866241 scopus 로고    scopus 로고
    • Colorectal tumors
    • (eds. Vogelstein, B. & Kinzler, K.W.) (McGraw-Hill, New York)
    • Kinzler, K.W. & Vogelstein, B. Colorectal Tumors. in The Genetic Basis of Human Cancer (eds. Vogelstein, B. & Kinzler, K.W.) 565-587 (McGraw-Hill, New York, 1998).
    • (1998) The Genetic Basis of Human Cancer , pp. 565-587
    • Kinzler, K.W.1    Vogelstein, B.2
  • 56
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J.L. ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 57
    • 17944369909 scopus 로고    scopus 로고
    • Wildtype Kras2 can inhibit lung carcinogenesis in mice
    • Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Genet. 29, 25-33 (2001).
    • (2001) Nat. Genet. , vol.29 , pp. 25-33
    • Zhang, Z.1
  • 58
    • 0036682167 scopus 로고    scopus 로고
    • The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene
    • Diaz, R. et al. The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene. Cancer Res. 62, 4514-4518 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4514-4518
    • Diaz, R.1
  • 59
    • 1442333425 scopus 로고    scopus 로고
    • Development. Making sense of the sensory lineage
    • Bronner-Fraser, M. Development. Making sense of the sensory lineage. Science 303, 966-968 (2004).
    • (2004) Science , vol.303 , pp. 966-968
    • Bronner-Fraser, M.1
  • 60
    • 0031743804 scopus 로고    scopus 로고
    • Eukaryotic mismatch repair: An update
    • Jiricny, J. Eukaryotic mismatch repair: an update. Mutat. Res. 409, 107-121 (1998).
    • (1998) Mutat. Res. , vol.409 , pp. 107-121
    • Jiricny, J.1
  • 61
  • 63
    • 0036221744 scopus 로고    scopus 로고
    • Gastrointestinal cancer of the microsatellite mutator phenotype pathway
    • Yamamoto, H., Imai, K. & Perucho, M. Gastrointestinal cancer of the microsatellite mutator phenotype pathway. J. Gastroenterol. 37, 153-163 (2002).
    • (2002) J. Gastroenterol. , vol.37 , pp. 153-163
    • Yamamoto, H.1    Imai, K.2    Perucho, M.3
  • 65
    • 84984932472 scopus 로고    scopus 로고
    • Exploring the new world of the genome with DNA microarrays
    • Brown, P.O. & Botstein, D. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21, 33-37 (1999).
    • (1999) Nat. Genet. , vol.21 , pp. 33-37
    • Brown, P.O.1    Botstein, D.2
  • 66
    • 0035367507 scopus 로고    scopus 로고
    • Gene discovery using the serial analysis of gene expression technique: Implications for cancer research
    • Polyak, K. & Riggins, G.J. Gene discovery using the serial analysis of gene expression technique: implications for cancer research. J. Clin. Oncol. 19, 2948-2958 (2001).
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2948-2958
    • Polyak, K.1    Riggins, G.J.2
  • 67
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 68
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143-153 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 70
    • 0037396404 scopus 로고    scopus 로고
    • A new paradigm for drug discovery: Integrating clinical genetic, genomic and molecular phenotype data to identify drug targets
    • Schadt, E.E., Monks, S.A. & Friend, S.H. A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. Biochem. Soc. Trans. 31, 437-443 (2003).
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 437-443
    • Schadt, E.E.1    Monks, S.A.2    Friend, S.H.3
  • 71
    • 12144288006 scopus 로고    scopus 로고
    • A resource for large-scale RNA-interference-based screens in mammals
    • Paddison, P.J. et al. A resource for large-scale RNA-interference-based screens in mammals. Nature 428, 427-431 (2004).
    • (2004) Nature , vol.428 , pp. 427-431
    • Paddison, P.J.1
  • 72
    • 12144289681 scopus 로고    scopus 로고
    • A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    • Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
    • (2004) Nature , vol.428 , pp. 431-437
    • Berns, K.1
  • 73
    • 1542329047 scopus 로고    scopus 로고
    • Serum proteomics in cancer diagnosis and management
    • Rosenblatt, K.P. et al. Serum proteomics in cancer diagnosis and management. Annu. Rev. Med. 55, 97-112 (2004).
    • (2004) Annu. Rev. Med. , vol.55 , pp. 97-112
    • Rosenblatt, K.P.1
  • 74
    • 0347357903 scopus 로고    scopus 로고
    • Looking beyond morphology: Cancer gene expression profiling using DNA microarrays
    • Luo, J., Isaacs, W.B., Trent, J.M. & Duggan, D.J. Looking beyond morphology: cancer gene expression profiling using DNA microarrays. Cancer Invest. 21, 937-949 (2003).
    • (2003) Cancer Invest. , vol.21 , pp. 937-949
    • Luo, J.1    Isaacs, W.B.2    Trent, J.M.3    Duggan, D.J.4
  • 75
    • 2942578063 scopus 로고    scopus 로고
    • A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
    • Ma, X.J. et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5, 607-616 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 607-616
    • Ma, X.J.1
  • 76
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 177-183
    • Futreal, P.A.1
  • 77
    • 2942588529 scopus 로고    scopus 로고
    • Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression
    • Masayesva, B.G. et al. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc. Natl. Acad. Sci. USA 101, 8715-8720 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8715-8720
    • Masayesva, B.G.1
  • 78
    • 0037148276 scopus 로고    scopus 로고
    • Senescence: Does it all happen at the ends?
    • Stewart, S.A. & Weinberg, R.A. Senescence: does it all happen at the ends? Oncogene 21, 627-630 (2002).
    • (2002) Oncogene , vol.21 , pp. 627-630
    • Stewart, S.A.1    Weinberg, R.A.2
  • 79
    • 0042386051 scopus 로고    scopus 로고
    • Telomere dysfunction and the initiation of genome instability
    • Feldser, D.M., Hackett, J.A. & Greider, C.W. Telomere dysfunction and the initiation of genome instability. Nat. Rev. Cancer 3, 623-627 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 623-627
    • Feldser, D.M.1    Hackett, J.A.2    Greider, C.W.3
  • 81
    • 0842346436 scopus 로고    scopus 로고
    • Beginning to understand the end of the chromosome
    • Cech, T.R. Beginning to understand the end of the chromosome. Cell 116, 273-279 (2004).
    • (2004) Cell , vol.116 , pp. 273-279
    • Cech, T.R.1
  • 82
    • 2342624566 scopus 로고    scopus 로고
    • Microarray reality checks in the context of a complex disease
    • Miklos, G.L. & Maleszka, R. Microarray reality checks in the context of a complex disease. Nat. Biotechnol. 22, 615-621 (2004).
    • (2004) Nat. Biotechnol. , vol.22 , pp. 615-621
    • Miklos, G.L.1    Maleszka, R.2
  • 83
    • 0346374774 scopus 로고    scopus 로고
    • Human acute myeloid leukemia stem cells
    • Hope, K.J., Jin, L. & Dick, J.E. Human acute myeloid leukemia stem cells. Arch. Med. Res. 34, 507-514 (2003).
    • (2003) Arch. Med. Res. , vol.34 , pp. 507-514
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 84
    • 0035071889 scopus 로고    scopus 로고
    • Human skin reconstruct models: A new application for studies of melanocyte and melanoma biology
    • Berking, C. & Herlyn, M. Human skin reconstruct models: a new application for studies of melanocyte and melanoma biology. Histol. Histopathol. 16, 669-674 (2001).
    • (2001) Histol. Histopathol. , vol.16 , pp. 669-674
    • Berking, C.1    Herlyn, M.2
  • 85
    • 1842687362 scopus 로고    scopus 로고
    • Reconstruction of functionally normal and malignant human breast tissues in mice
    • Kuperwasser, C. et al. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl Acad. Sci. USA 101, 4966-4971 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4966-4971
    • Kuperwasser, C.1
  • 86
    • 4043100086 scopus 로고    scopus 로고
    • Principles of dose, schedule, and combination Therapy
    • (eds. Kufe, D.W. et al.) (B.C. Decker, Inc., Hamilton, Ontario)
    • Frei, E.I. & Eder, J.P. Principles of dose, schedule, and combination Therapy. in Cancer Medicine (eds. Kufe, D.W. et al.) 669-677 (B.C. Decker, Inc., Hamilton, Ontario, 2003).
    • (2003) Cancer Medicine , pp. 669-677
    • Frei, E.I.1    Eder, J.P.2
  • 87
    • 0033651234 scopus 로고    scopus 로고
    • The molecular and cellular biology of HER2/neu gene amplification/ overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer
    • Pegram, M.D., Konecny, G. & Slamon, D.J. The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat. Res. 103, 57-75 (2000).
    • (2000) Cancer Treat. Res. , vol.103 , pp. 57-75
    • Pegram, M.D.1    Konecny, G.2    Slamon, D.J.3
  • 88
    • 0035237649 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia
    • (American Society of Hematology Education Program) (American Society of Hematology)
    • Druker, B.J. et al. Chronic myelogenous leukemia. in Hematology 2001 (American Society of Hematology Education Program) 87-112 (American Society of Hematology, 2001).
    • (2001) Hematology 2001 , pp. 87-112
    • Druker, B.J.1
  • 89
    • 1542315370 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib
    • Mechtersheimer, G. et al. Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch. 444, 108-118 (2004).
    • (2004) Virchows Arch. , vol.444 , pp. 108-118
    • Mechtersheimer, G.1
  • 90
    • 1242293090 scopus 로고    scopus 로고
    • Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: Focus on NSCLC
    • Langer, C.J. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. Int. J. Radiat. Oncol. Biol. Phys. 58, 991-1002 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.58 , pp. 991-1002
    • Langer, C.J.1
  • 91
    • 1942473596 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors: KIT mutations and beyond
    • Duensing, A., Heinrich, M.C., Fletcher, C.D. & Fletcher, J.A. Biology of gastrointestinal stromal tumors: KIT mutations and beyond. Cancer Invest. 22, 106-116 (2004).
    • (2004) Cancer Invest. , vol.22 , pp. 106-116
    • Duensing, A.1    Heinrich, M.C.2    Fletcher, C.D.3    Fletcher, J.A.4
  • 92
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez, J.G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 93
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 94
    • 0032962588 scopus 로고    scopus 로고
    • Apoptosis and therapy
    • Schmitt, C.A. & Lowe, S.W. Apoptosis and therapy. J. Pathol. 187, 127-137 (1999).
    • (1999) J. Pathol. , vol.187 , pp. 127-137
    • Schmitt, C.A.1    Lowe, S.W.2
  • 95
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial, N.N. & Korsmeyer, S.J. Cell death: critical control points. Cell 116, 205-219 (2004).
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 96
    • 0034931001 scopus 로고    scopus 로고
    • Apoptosis: Mediator or mode of cell killing by anticancer agents?
    • Brown, J.M. & Wouters, B.G. Apoptosis: mediator or mode of cell killing by anticancer agents? Drug Resist. Updat. 4, 135-136 (2001).
    • (2001) Drug Resist. Updat. , vol.4 , pp. 135-136
    • Brown, J.M.1    Wouters, B.G.2
  • 97
    • 0031417677 scopus 로고    scopus 로고
    • Disorders in cell circuitry associated with multistage carcinogenesis: Exploitable targets for cancer prevention and therapy
    • Weinstein, I.B. et al. Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin. Cancer Res. 3, 2696-2702 (1997).
    • (1997) Clin. Cancer Res. , vol.3 , pp. 2696-2702
    • Weinstein, I.B.1
  • 98
    • 0037238780 scopus 로고    scopus 로고
    • Overview of the clinical efficacy of investigational anticancer drugs
    • Nygren, P. & Larsson, R. Overview of the clinical efficacy of investigational anticancer drugs. J. Intern. Med. 253, 46-75 (2003).
    • (2003) J. Intern. Med. , vol.253 , pp. 46-75
    • Nygren, P.1    Larsson, R.2
  • 99
    • 1642301466 scopus 로고    scopus 로고
    • Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples
    • Shih, L.Y. et al. Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples. Clin. Cancer Res. 10, 1326-1332 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1326-1332
    • Shih, L.Y.1
  • 100
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colon cancer
    • Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colon cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 101
    • 0037236238 scopus 로고    scopus 로고
    • Shedding light onto live molecular targets
    • Weissleder, R. & Ntziachristos, V. Shedding light onto live molecular targets. Nat. Med. 9, 123-128 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 123-128
    • Weissleder, R.1    Ntziachristos, V.2
  • 102
    • 0036515416 scopus 로고    scopus 로고
    • Emerging molecular markers of cancer
    • Sidransky, D. Emerging molecular markers of cancer. Nat. Rev. Cancer 2, 210-219 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 210-219
    • Sidransky, D.1
  • 103
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind, A., Fischer, O.M. & Ullrich, A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat. Rev. Cancer 4, 361-370 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 104
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 105
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle: A critical decision in cancer
    • Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nat. Rev. Cancer 1, 222-231 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 106
  • 107
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L.C. The phosphoinositide 3-kinase pathway. Science 296, 1655-1657 (2002).
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 108
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y. & Massague, J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 109
    • 0842265834 scopus 로고    scopus 로고
    • Hedgehog-Gli signaling in brain tumors: Stem cells and paradevelopmental programs in cancer
    • Ruiz i Altaba, A., Stecca, B. & Sanchez, P. Hedgehog-Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer. Cancer Lett. 204, 145-157 (2004).
    • (2004) Cancer Lett. , vol.204 , pp. 145-157
    • Ruiz I Altaba, A.1    Stecca, B.2    Sanchez, P.3
  • 110
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • Adams, J.M. Ways of dying: multiple pathways to apoptosis. Genes Dev. 17, 2481-2495 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 111
    • 0036491845 scopus 로고    scopus 로고
    • The restriction point of the cell cycle
    • Blagosklonny, M.V. & Pardee, A.B. The restriction point of the cell cycle. Cell Cycle 1, 103-110 (2002).
    • (2002) Cell Cycle , vol.1 , pp. 103-110
    • Blagosklonny, M.V.1    Pardee, A.B.2
  • 112
    • 0036515618 scopus 로고    scopus 로고
    • Cell metabolism in the regulation of programmed cell death
    • Plas, D.R. & Thompson, C.B. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol. Metab. 13, 75-78 (2002).
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 75-78
    • Plas, D.R.1    Thompson, C.B.2
  • 113
    • 0036463405 scopus 로고    scopus 로고
    • A matter of life and death
    • Green, D.R. & Evan, G.I. A matter of life and death. Cancer Cell 1, 19-30 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 19-30
    • Green, D.R.1    Evan, G.I.2
  • 114
    • 0037364314 scopus 로고    scopus 로고
    • A role for mitochondrial enzymes in inherited neoplasia and beyond
    • Eng, C., Kiuru, M., Fernandez, M.J. & Aaltonen, L.A. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat. Rev. Cancer 3, 193-202 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 193-202
    • Eng, C.1    Kiuru, M.2    Fernandez, M.J.3    Aaltonen, L.A.4
  • 115
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum, L. & Beachy, P.A. The Hedgehog response network: sensors, switches, and routers. Science 304, 1755-1759 (2004).
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 116
    • 0036469065 scopus 로고    scopus 로고
    • Signal transduction and the control of gene expression
    • Brivanlou, A.H. & Darnell, J.E. Jr. Signal transduction and the control of gene expression. Science 295, 813-818 (2002).
    • (2002) Science , vol.295 , pp. 813-818
    • Brivanlou, A.H.1    Darnell Jr., J.E.2
  • 118
    • 2942548983 scopus 로고    scopus 로고
    • The Runx genes: Lineage-specific oncogenes and tumor suppressors
    • Cameron, E.R. & Neil, J.C. The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene 23, 4308-4314 (2004).
    • (2004) Oncogene , vol.23 , pp. 4308-4314
    • Cameron, E.R.1    Neil, J.C.2


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