Remarkable longevity and stress resistance of nematode PI3K-null mutants

Aging Cell

Volumn 7, Issue 1, 2008, Pages 13-22

  Ayyadevara, Srinivas ^a   Alla, Ramani ^a   Thaden, John J ^a   Shmookler Reis, Robert J ^a,b,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; Caenorhabditis elegans; Dauer; Genetics; Lifespan; Stress resistance

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE;

AGING; ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ELECTROPHILIC STRESS; FEEDING; HEAT TOLERANCE; LIFESPAN; LONGEVITY; MUTANT; NEMATODE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STRESS; SURVIVAL TIME; TEMPERATURE; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CODON, NONSENSE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAT; LIPID PEROXIDATION; LONGEVITY; OOGENESIS; OXIDATIVE STRESS; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; MUS;

EID: 38349093613     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2007.00348.x     Document Type: Article

References (50)

1. Apfeld J, Kenyon C (1998) Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95, 199-210.
2. Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C (2002) Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295, 502-505.
3. Arantes-Oliveira N, Berman JR, Kenyon C (2003) Healthy animals with extreme longevity. Science 302, 611.
4. Ayyadevara S, Ayyadevera R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ (2003) Genetic loci modulating fitness and life span in Caenorhabditis elegans: Categorical trait interval mapping in CL2a × Bergerac-BO recombinant-inbred worms. Genetics 163, 557-570.
5. Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P (2005a) Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging Cell 4, 299-307.
6. Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L, Zimniak P (2007) Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. Mech. Ageing Dev. 128, 196-205.
7. Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Beneš H, Shmookler Reis RJ, Liebau E, Zimniak P (2005b) Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal. Aging Cell 4, 257-271.
8. Bartke AJ, Wright JC, Mattison JA, Ingram DK, Miller RA, Roth GS (2001) Extending the lifespan of long-lived mice. Nature 414, 412.
9. Bluher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574.
10. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106.
11. Ebert RH, Cherkasova VA, Dennis RA, Wu JH, Ruggles S, Perrin TE, Shmookler Reis RJ (1993) Longevity-determining genes in Caenorhabditis elegans: Chromosomal mapping of multiple noninteractive loci. Genetics 135, 1003-1010.
12. Edgley ML, Riddle DL (2001) LG II balancer chromosomes in Caenorhabditis elegans: MT1 (II;III) and the mIn1 set of dominantly and recessively marked inversions. Mol. Genet. Genomics 266, 385-395.
13. Finney M, Ruvkun G (1990) The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell 63, 895-905.
14. Friedman DB, Johnson TE (1988a) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118, 75-86.
15. Friedman DB, Johnson TE (1988b) Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. J. Gerontol. 43, B102-B109.
16. Gami MS, Iser WB, Hanselman KB, Wolkow CA (2006) Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/ insulin-like signaling. BMC Dev. Biol. 6, 45.
17. Gems D, McElwee JJ (2005) Broad spectrum detoxification: The major longevity assurance process regulated by insulin/IGF-1 signaling? Mech. Ageing Dev. 126, 381-387.
18. Gems D, Riddle DL (2000) Defining wild-type life span in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 55, B215-B219.
19. Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL (1998) Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150, 129-155.
20. Gottlieb S, Ruvkun G (1994) daf-2, daf-16 and daf-23: Genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics 137, 107-120.
21. Guarente L, Kenyon C (2000) Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262.
22. Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T (2006) PI(3,4,5)P 3 and PI(4,5)P 2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458-1461.
23. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
24. Houthoofd K, Braeckman BP, Johnson TE, Vanfleteren JR (2003) Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp. Gerontol. 38, 947-954.
25. Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362-366.
26. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464.
27. Klass MR (1983) A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech. Ageing Dev. 22, 279-286.
28. Kondo M, Yanase S, Ishii T, Hartman PS, Matsumoto K, Ishii N (2005) The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech. Ageing Dev. 126, 642-647.
29. Kurosu H, Yamamoto M, Clark JD (2005) Suppression of aging in mice by the hormone Klotho. Science 309, 1829-1833.
30. Larsen PL, Albert PS, Riddle DL (1995) Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 1567-1583.
31. Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322.
32. Lin K, Hsin H, Libina N, Kenyon C (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28, 139-145.
33. Lin YJ, Seroude L, Benzer S (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282, 943-946.
34. Lithgow GJ, White TM, Melov S, Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92, 7540-7544.
35. Matsumoto M, Han S, Kitamura T, Accili D (2006) Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J. Clin. Invest 116, 2464-2472.
36. Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539.
37. Murakami S (2006) Stress resistance in long-lived mouse models. Exp. Gerontol. 41, 1014-1019.
38. Partridge L, Gems D (2002) Mechanisms of ageing: Public or private? Nat. Rev. Genet. 3, 165-175.
39. Remenyi A, Good MC, Lim WA (2006) Docking interactions in protein kinase and phosphatase networks. Curr. Opin. Struct. Biol. 16, 676-685.
40. Riddle DL, Swanson MM, Albert PS (1981) Interacting genes in nematode dauer larva formation. Nature 290, 668-671.
41. Rogina B, Reenan RA, Nilsen SP, Helfand SL (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290, 2137-2140.
42. Rottiers V, Antebi A (2006) Control of Caenorhabditis elegans life history by nuclear receptor signal transduction. Exp. Gerontol. 41, 904-909.
43. Singh SS, Chauhan A, Brockerhoff H, Chauhan VP (1993) Activation of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. Biochem. Biophys. Res. Commun. 195, 104-112.
44. Shmookler Reis RJ, Kang P, Ayyadevara S (2007) Quantitative trait loci define genes and pathways underlying genetic variation in longevity. Exp. Gerontol. 41, 1046-1054.
45. Sulston J, Hodgkin J (1988) Methods. In The Nematode Caenorhabditis elegans (Wood WB, ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
46. Tanaka D, Furusawa K, Kameyama K, Okamoto H, Doi M (2007) Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans. Neuropharmacology 53, 157-168.
47. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110.
48. Tirosh O, Schwartz B, Zusman I, Kossoy G, Yahav S, Miskin R (2004) Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity. Ann. N. Y. Acad. Sci. 1019, 439-442.
49. Tissenbaum HA, Ruvkun G (1998) An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717.
50. Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, Kim DH (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2, e183.