-
1
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
R. Katso Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer Annu. Rev. Cell Dev. Biol. 17 2001 615 675
-
(2001)
Annu. Rev. Cell Dev. Biol.
, vol.17
, pp. 615-675
-
-
Katso, R.1
-
2
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655 1657
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
3
-
-
0344305782
-
Insulin signaling in health and disease
-
M.F. White Insulin signaling in health and disease Science 302 2003 1710 1711
-
(2003)
Science
, vol.302
, pp. 1710-1711
-
-
White, M.F.1
-
4
-
-
1642617693
-
PI3K/Akt signalling pathway and cancer
-
J.A. Fresno Vara PI3K/Akt signalling pathway and cancer Cancer Treat. Rev. 30 2004 193 204
-
(2004)
Cancer Treat. Rev.
, vol.30
, pp. 193-204
-
-
Fresno Vara, J.A.1
-
5
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
W.S. Chen Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene Genes Dev. 15 2001 2203 2208
-
(2001)
Genes Dev.
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
-
6
-
-
0033258521
-
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
-
J. Verdu Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB Nat. Cell Biol. 1 1999 500 506
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 500-506
-
-
Verdu, J.1
-
7
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
B.D. Manning Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway Mol. Cell 10 2002 151 162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
-
8
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
K. Inoki TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell Biol. 4 2002 648 657
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
-
9
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
C.J. Potter Akt regulates growth by directly phosphorylating Tsc2 Nat. Cell Biol. 4 2002 658 665
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
-
10
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
M. van Slegtenhorst Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products Hum. Mol. Genet. 7 1998 1053 1057
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1053-1057
-
-
Van Slegtenhorst, M.1
-
11
-
-
0042701991
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
A.R. Tee Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Curr. Biol. 13 2003 1259 1268
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
-
12
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
A. Garami Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 Mol. Cell 11 2003 1457 1466
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
-
13
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
K. Inoki Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Genes Dev. 17 2003 1829 1834
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
-
14
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Y. Zhang Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins Nat. Cell Biol. 5 2003 578 581
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
-
15
-
-
4043171462
-
Upstream and downstream of mTOR
-
N. Hay, and N. Sonenberg Upstream and downstream of mTOR Genes Dev. 18 2004 1926 1945
-
(2004)
Genes Dev.
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
16
-
-
0036712741
-
TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
-
E.J. McManus, and D.R. Alessi TSC1-TSC2: a complex tale of PKB-mediated S6K regulation Nat. Cell Biol. 4 2002 E214 E216
-
(2002)
Nat. Cell Biol.
, vol.4
-
-
McManus, E.J.1
Alessi, D.R.2
-
17
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
P.P. Roux Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase Proc. Natl. Acad. Sci. U. S. A. 101 2004 13489 13494
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
-
18
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
K. Inoki TSC2 mediates cellular energy response to control cell growth and survival Cell 115 2003 577 590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
-
19
-
-
0036847930
-
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
-
H. Hanafusa Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway Nat. Cell Biol. 4 2002 850 858
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 850-858
-
-
Hanafusa, H.1
-
20
-
-
2942568167
-
Modulation of signalling by Sprouty: A developing story
-
H.J. Kim, and D. Bar-Sagi Modulation of signalling by Sprouty: a developing story Nat. Rev. Mol. Cell Biol. 5 2004 441 450
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 441-450
-
-
Kim, H.J.1
Bar-Sagi, D.2
-
21
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
E. Araki Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene Nature 372 1994 186 190
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
-
22
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
D.J. Withers Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 1998 900 904
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
-
23
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
T. Haruta A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1 Mol. Endocrinol. 14 2000 783 794
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 783-794
-
-
Haruta, T.1
-
24
-
-
0036149984
-
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
-
R. Zhande Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1 Mol. Cell. Biol. 22 2002 1016 1026
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1016-1026
-
-
Zhande, R.1
-
25
-
-
0036298262
-
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
-
C.E. Berg Rapamycin partially prevents insulin resistance induced by chronic insulin treatment Biochem. Biophys. Res. Commun. 293 2002 1021 1027
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 1021-1027
-
-
Berg, C.E.1
-
26
-
-
0038521284
-
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells
-
L. Pirola Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells J. Biol. Chem. 278 2003 15641 15651
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15641-15651
-
-
Pirola, L.1
-
27
-
-
0037424466
-
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation
-
M.W. Greene Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation J. Biol. Chem. 278 2003 8199 8211
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8199-8211
-
-
Greene, M.W.1
-
28
-
-
0036213626
-
Role of mTOR in the degradation of IRS-1: Regulation of PP2A activity
-
D. Hartley, and G.M. Cooper Role of mTOR in the degradation of IRS-1: regulation of PP2A activity J. Cell. Biochem. 85 2002 304 314
-
(2002)
J. Cell. Biochem.
, vol.85
, pp. 304-314
-
-
Hartley, D.1
Cooper, G.M.2
-
29
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
F. Tremblay, and A. Marette Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells J. Biol. Chem. 276 2001 38052 38060
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
31
-
-
0030669392
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
-
K. Paz A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation J. Biol. Chem. 272 1997 29911 29918
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29911-29918
-
-
Paz, K.1
-
32
-
-
0037018924
-
Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
-
M.W. Greene, and R.S. Garofalo Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation Biochemistry 41 2002 7082 7091
-
(2002)
Biochemistry
, vol.41
, pp. 7082-7091
-
-
Greene, M.W.1
Garofalo, R.S.2
-
33
-
-
0035500813
-
Insulin resistance: A phosphorylation-based uncoupling of insulin signaling
-
Y. Zick Insulin resistance: a phosphorylation-based uncoupling of insulin signaling Trends Cell Biol. 11 2001 437 441
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 437-441
-
-
Zick, Y.1
-
34
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
V. Aguirre Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action J. Biol. Chem. 277 2002 1531 1537
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
-
35
-
-
0037474274
-
C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Y.H. Lee c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade J. Biol. Chem. 278 2003 2896 2902
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
-
36
-
-
0035793592
-
Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
-
L.V. Ravichandran Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin J. Biol. Chem. 276 2001 3543 3549
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3543-3549
-
-
Ravichandran, L.V.1
-
37
-
-
2942623679
-
Protein kinase C-ζ-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1
-
K. Moeschel Protein kinase C-ζ-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1 J. Biol. Chem. 279 2004 25157 25163
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 25157-25163
-
-
Moeschel, K.1
-
38
-
-
0038712570
-
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
-
P. Gual Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes J. Biol. Chem. 278 2003 26550 26557
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 26550-26557
-
-
Gual, P.1
-
39
-
-
0344686538
-
MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632
-
P. Gual MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632 Diabetologia 46 2003 1532 1542
-
(2003)
Diabetologia
, vol.46
, pp. 1532-1542
-
-
Gual, P.1
-
40
-
-
1542616960
-
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
-
C.J. Carlson Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation Biochem. Biophys. Res. Commun. 316 2004 533 539
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 533-539
-
-
Carlson, C.J.1
-
41
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
O.N. Ozes A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1 Proc. Natl. Acad. Sci. U. S. A. 98 2001 4640 4645
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
-
42
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
D.H. Kim mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery Cell 110 2002 163 175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
-
43
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
K. Hara Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action Cell 110 2002 177 189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
-
44
-
-
0037623417
-
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
D.H. Kim GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR Mol. Cell 11 2003 895 904
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
-
45
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
D. Sarbassov dos Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Curr. Biol. 14 2004 1296 1302
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov Dos, D.1
-
46
-
-
0032486268
-
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
-
K. Hara Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism J. Biol. Chem. 273 1998 14484 14494
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
-
47
-
-
0001437616
-
Bidirectional modulation of insulin action by amino acids
-
M.E. Patti Bidirectional modulation of insulin action by amino acids J. Clin. Invest. 101 1998 1519 1529
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1519-1529
-
-
Patti, M.E.1
-
48
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
A. Jaeschke Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent J. Cell Biol. 159 2002 217 224
-
(2002)
J. Cell Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
-
49
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
D.J. Kwiatkowski A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells Hum. Mol. Genet. 11 2002 525 534
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
-
50
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
L.S. Harrington The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins J. Cell Biol. 166 2004 213 223
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
-
51
-
-
4544343980
-
Inappropriate activation of the TSC1-TSC2/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
O.J. Shah Inappropriate activation of the TSC1-TSC2/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies Curr. Biol. 14 2004 1650 1656
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
-
52
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
H. Zhang Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR J. Clin. Invest. 112 2003 1223 1233
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
-
53
-
-
0037108151
-
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
-
T. Radimerski Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling Genes Dev. 16 2002 2627 2632
-
(2002)
Genes Dev.
, vol.16
, pp. 2627-2632
-
-
Radimerski, T.1
-
54
-
-
0037108682
-
Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
-
H.L. Kenerson Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors Cancer Res. 62 2002 5645 5650
-
(2002)
Cancer Res.
, vol.62
, pp. 5645-5650
-
-
Kenerson, H.L.1
-
55
-
-
4143050204
-
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302
-
E.D. Werner Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302 J. Biol. Chem. 279 2004 35298 35305
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35298-35305
-
-
Werner, E.D.1
-
56
-
-
0942276379
-
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling
-
J. Giraud Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling J. Biol. Chem. 279 2004 3447 3454
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3447-3454
-
-
Giraud, J.1
-
57
-
-
1542284652
-
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cδ
-
M.W. Greene Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cδ Biochem. J. 378 2004 105 116
-
(2004)
Biochem. J.
, vol.378
, pp. 105-116
-
-
Greene, M.W.1
-
58
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
S.H. Um Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature 431 2004 200 205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
-
59
-
-
0022977709
-
Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats
-
L.H. Storlien Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats Am. J. Physiol. 251 1986 E576 E583
-
(1986)
Am. J. Physiol.
, vol.251
-
-
Storlien, L.H.1
-
60
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
-
M. Pende Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice Nature 408 2000 994 997
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
-
61
-
-
0023739445
-
Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo
-
A.B. Jenkins Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo J. Clin. Invest. 82 1988 293 299
-
(1988)
J. Clin. Invest.
, vol.82
, pp. 293-299
-
-
Jenkins, A.B.1
-
62
-
-
0030987889
-
High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect
-
J.R. Zierath High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect Diabetes 46 1997 215 223
-
(1997)
Diabetes
, vol.46
, pp. 215-223
-
-
Zierath, J.R.1
-
63
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
C. Yu Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J. Biol. Chem. 277 2002 50230 50236
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
-
64
-
-
0028908804
-
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP
-
M. Monfar Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP Mol. Cell. Biol. 15 1995 326 337
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 326-337
-
-
Monfar, M.1
-
65
-
-
0035862960
-
Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes
-
A. Khan Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes J. Neurosci. 21 2001 382 391
-
(2001)
J. Neurosci.
, vol.21
, pp. 382-391
-
-
Khan, A.1
-
66
-
-
0035900712
-
Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: Comparison with the effects of insulin
-
N. Takei Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin J. Biol. Chem. 276 2001 42818 42825
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42818-42825
-
-
Takei, N.1
-
67
-
-
0033966768
-
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
-
Y. Kido Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 J. Clin. Invest. 105 2000 199 205
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 199-205
-
-
Kido, Y.1
-
68
-
-
2642683510
-
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
-
N.J. Kerouz Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse J. Clin. Invest. 100 1997 3164 3172
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3164-3172
-
-
Kerouz, N.J.1
-
69
-
-
4143050204
-
Insulin resistance due to phosphorylation of IRS-1 at serine 302
-
E.D. Werner Insulin resistance due to phosphorylation of IRS-1 at serine 302 J. Biol. Chem. 279 2004 35298 35308
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35298-35308
-
-
Werner, E.D.1
-
70
-
-
2442574729
-
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
-
B. Raught Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases EMBO J. 23 2004 1761 1769
-
(2004)
EMBO J.
, vol.23
, pp. 1761-1769
-
-
Raught, B.1
-
71
-
-
0026688510
-
Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver
-
H. Flotow, and G. Thomas Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver J. Biol. Chem. 267 1992 3074 3078
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 3074-3078
-
-
Flotow, H.1
Thomas, G.2
-
72
-
-
0034535175
-
Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex
-
K.F. Wilson Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex J. Biol. Chem. 275 2000 37307 37310
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37307-37310
-
-
Wilson, K.F.1
-
73
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor κb kinase complex
-
Z. Gao Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex J. Biol. Chem. 277 2002 48115 48121
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
-
74
-
-
0038043252
-
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2
-
N. Horike Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2 J. Biol. Chem. 278 2003 18440 18447
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18440-18447
-
-
Horike, N.1
-
75
-
-
0035861644
-
5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside
-
S.N. Jakobsen 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside J. Biol. Chem. 276 2001 46912 46916
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46912-46916
-
-
Jakobsen, S.N.1
-
76
-
-
0030931560
-
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action
-
H. Eldar-Finkelman, and E.G. Krebs Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action Proc. Natl. Acad. Sci. U. S. A. 94 1997 9660 9664
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 9660-9664
-
-
Eldar-Finkelman, H.1
Krebs, E.G.2
-
77
-
-
8544233570
-
PKCθ inhibits insulin signaling by phosphorylating IRS1 at Ser1101
-
Y. Li PKCθ inhibits insulin signaling by phosphorylating IRS1 at Ser1101 J. Biol. Chem. 279 2004 45304 45307
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45304-45307
-
-
Li, Y.1
-
78
-
-
0030669094
-
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612
-
K. De Fea, and R.A. Roth Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612 Biochemistry 36 1997 12939 12947
-
(1997)
Biochemistry
, vol.36
, pp. 12939-12947
-
-
De Fea, K.1
Roth, R.A.2
-
79
-
-
0031465447
-
Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase
-
K. De Fea, and R.A. Roth Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase J. Biol. Chem. 272 1997 31400 31406
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31400-31406
-
-
De Fea, K.1
Roth, R.A.2
-
80
-
-
0035957949
-
Insulin stimulates PKCζ-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins
-
Y.F. Liu Insulin stimulates PKCζ-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins J. Biol. Chem. 276 2001 14459 14465
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14459-14465
-
-
Liu, Y.F.1
|