메뉴 건너뛰기




Volumn 11, Issue 12, 2012, Pages 2402-2407

Suppression of replicative senescence by rapamycin in rodent embryonic cells

Author keywords

Aging; Hypertrophy; mTOR; Rapamycin; Senescence

Indexed keywords

RAPAMYCIN;

EID: 84862869280     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.20882     Document Type: Article
Times cited : (71)

References (74)
  • 1
    • 0034304960 scopus 로고    scopus 로고
    • Hayflick, his limit and cellular ageing
    • PMID:11413492
    • Shay JW, Wright WE. Hayflick, his limit and cellular ageing. Nat Rev Mol Cell Biol 2000; 1:72-6; PMID:11413492; http://dx.doi.org/10.1038/35036093.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 72-76
    • Shay, J.W.1    Wright, W.E.2
  • 2
    • 0034774859 scopus 로고    scopus 로고
    • Cellular senescence, cancer and aging: The telomere connection
    • PMID:11672984
    • Campisi J, Kim SH, Lim CS, Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 2001; 36:1619-37; PMID:11672984; http://dx.doi.org/10.1016/S0531-5565(01)00160-7.
    • (2001) Exp Gerontol , vol.36 , pp. 1619-1637
    • Campisi, J.1    Kim, S.H.2    Lim, C.S.3    Rubio, M.4
  • 3
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • PMID:9454332
    • Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-52; PMID:9454332; http://dx.doi.org/10.1126/science.279. 5349.349.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3    Holt, S.E.4    Chiu, C.P.5    Morin, G.B.6
  • 4
    • 0344558209 scopus 로고    scopus 로고
    • A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization
    • PMID:10030665
    • Russo I, Silver AR, Cuthbert AP, Griffin DK, Trott DA, Newbold RF. A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. Oncogene 1998; 17:3417-26; PMID:10030665; http://dx.doi.org/10.1038/sj.onc.1202261.
    • (1998) Oncogene , vol.17 , pp. 3417-3426
    • Russo, I.1    Silver, A.R.2    Cuthbert, A.P.3    Griffin, D.K.4    Trott, D.A.5    Newbold, R.F.6
  • 5
    • 1842789989 scopus 로고    scopus 로고
    • Mechanisms of cellular senescence in human and mouse cells
    • PMID:15138376
    • Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004; 5:1-10; PMID:15138376; http://dx.doi. org/10.1023/B:BGEN.0000017682.96395.10.
    • (2004) Biogerontology , vol.5 , pp. 1-10
    • Itahana, K.1    Campisi, J.2    Dimri, G.P.3
  • 6
    • 0035545802 scopus 로고    scopus 로고
    • Putting the stress on senescence
    • PMID:11698192
    • Serrano M, Blasco MA. Putting the stress on senescence. Curr Opin Cell Biol 2001; 13:748-53; PMID:11698192; http://dx.doi.org/10.1016/S0955-0674(00) 00278-7.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 748-753
    • Serrano, M.1    Blasco, M.A.2
  • 8
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • PMID:9765203
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998; 12:3008-19; PMID:9765203; http://dx.doi.org/10.1101/gad.12.19.3008.
    • (1998) Genes Dev , vol.12 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    Van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 9
    • 0030950537 scopus 로고    scopus 로고
    • Cooperating oncogenes converge to regulate cyclin/cdk complexes
    • PMID:9119230
    • Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H. Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev 1997; 11:663-77; PMID:9119230; http://dx.doi.org/10.1101/gad.11.5.663.
    • (1997) Genes Dev , vol.11 , pp. 663-677
    • Lloyd, A.C.1    Obermüller, F.2    Staddon, S.3    Barth, C.F.4    McMahon, M.5    Land, H.6
  • 12
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • PMID:9765202
    • Zhu JY, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998; 12:2997-3007; PMID:9765202; http://dx.doi.org/10.1101/gad.12.19.2997.
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.Y.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 13
    • 0032522816 scopus 로고    scopus 로고
    • High-intensity Raf signals convert mitotic cell cycling into cellular growth
    • PMID:9563474
    • Kerkhoff E, Rapp UR. High-intensity Raf signals convert mitotic cell cycling into cellular growth. Cancer Res 1998; 58:1636-40; PMID:9563474.
    • (1998) Cancer Res , vol.58 , pp. 1636-1640
    • Kerkhoff, E.1    Rapp, U.R.2
  • 14
    • 33644758575 scopus 로고    scopus 로고
    • The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence
    • PMID:16507997
    • Kortum RL, Johnson HJ, Costanzo DL, Volle DJ, Razidlo GL, Fusello AM, et al. The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol 2006; 26:2202-14; PMID:16507997; http://dx.doi.org/10.1128/MCB.26.6.2202-14.2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 2202-2214
    • Kortum, R.L.1    Johnson, H.J.2    Costanzo, D.L.3    Volle, D.J.4    Razidlo, G.L.5    Fusello, A.M.6
  • 15
    • 0347988005 scopus 로고    scopus 로고
    • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
    • PMID:14561707
    • Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 2003; 112:1223-33; PMID:14561707.
    • (2003) J Clin Invest , vol.112 , pp. 1223-1233
    • Zhang, H.1    Cicchetti, G.2    Onda, H.3    Koon, H.B.4    Asrican, K.5    Bajraszewski, N.6
  • 16
    • 33847394119 scopus 로고    scopus 로고
    • PDGFRs are critical for PI3K/ Akt activation and negatively regulated by mTOR
    • PMID:17290308
    • Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, et al. PDGFRs are critical for PI3K/ Akt activation and negatively regulated by mTOR. J Clin Invest 2007; 117:730-8; PMID:17290308; http://dx.doi.org/10.1172/JCI28984.
    • (2007) J Clin Invest , vol.117 , pp. 730-738
    • Zhang, H.1    Bajraszewski, N.2    Wu, E.3    Wang, H.4    Moseman, A.P.5    Dabora, S.L.6
  • 17
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • PMID:15314020
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-45; PMID:15314020; http://dx.doi.org/10.1101/gad.1212704.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 18
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • PMID:15624019
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24; PMID:15624019; http://dx.doi.org/10. 1038/ng1494.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 19
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • PMID:16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84; PMID:16469695; http://dx.doi.org/10.1016/j. cell.2006.01.016.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 20
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • PMID:17452018
    • Dann SG, Selvaraj A, Thomas G. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007; 13:252-9; PMID:17452018; http://dx.doi.org/10.1016/j.molmed.2007.04.002.
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 21
    • 82555166000 scopus 로고    scopus 로고
    • MTOR signaling in disease
    • PMID:21963299
    • Dazert E, Hall MN. mTOR signaling in disease. Curr Opin Cell Biol 2011; 23:744-55; PMID:21963299; http://dx.doi.org/10.1016/j.ceb.2011.09.003.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 744-755
    • Dazert, E.1    Hall, M.N.2
  • 22
    • 79959191028 scopus 로고    scopus 로고
    • MTOR signaling in protein homeostasis: Less is more?
    • PMID:21555915
    • Conn CS, Qian SB. mTOR signaling in protein homeostasis: less is more? Cell Cycle 2011; 10:1940-7; PMID:21555915; http://dx.doi.org/10.4161/cc.10.12. 15858.
    • (2011) Cell Cycle , vol.10 , pp. 1940-1947
    • Conn, C.S.1    Qian, S.B.2
  • 23
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • PMID:19339977
    • Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009; 10:307-18; PMID:19339977; http://dx.doi.org/10.1038/nrm2672.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 24
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • PMID:18948731
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61; PMID:18948731; http://dx.doi.org/10.4161/cc.7.21.6919.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 26
    • 67649369064 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
    • PMID:19478560
    • Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-900; PMID:19478560; http://dx.doi.org/10. 4161/cc.8.12.8809.
    • (2009) Cell Cycle , vol.8 , pp. 1896-1900
    • Demidenko, Z.N.1    Shtutman, M.2    Blagosklonny, M.V.3
  • 27
    • 67649369072 scopus 로고    scopus 로고
    • At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
    • PMID:19471118
    • Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 2009; 8:1901-4; PMID:19471118; http://dx.doi.org/10.4161/cc.8.12.8810.
    • (2009) Cell Cycle , vol.8 , pp. 1901-1904
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 28
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
    • PMID:20157583
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 2009; 1:1008-16; PMID:20157583.
    • (2009) Aging , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 30
    • 77958449473 scopus 로고    scopus 로고
    • P21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate
    • PMID:20935470
    • Romanov VS, Abramova MV, Svetlikova SB, Bykova TV, Zubova SG, Aksenov ND, et al. p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate. Cell Cycle 2010; 9:3945-55; PMID:20935470; http://dx.doi.org/10.4161/cc.9.19.13160.
    • (2010) Cell Cycle , vol.9 , pp. 3945-3955
    • Romanov, V.S.1    Abramova, M.V.2    Svetlikova, S.B.3    Bykova, T.V.4    Zubova, S.G.5    Aksenov, N.D.6
  • 33
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • PMID:21212465
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging 2010; 2:924-35; PMID:21212465.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 34
    • 78349286289 scopus 로고    scopus 로고
    • Weak p53 permits senescence during cell cycle arrest
    • PMID:21051933
    • Leontieva OV, Gudkov AV, Blagosklonny MV. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-7; PMID:21051933; http:// dx.doi.org/10.4161/cc.9.21.13584.
    • (2010) Cell Cycle , vol.9 , pp. 4323-4327
    • Leontieva, O.V.1    Gudkov, A.V.2    Blagosklonny, M.V.3
  • 35
    • 80054005335 scopus 로고    scopus 로고
    • Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin
    • PMID:22022534
    • Leontieva OV, Demidenko ZN, Gudkov AV, Blagosklonny MV. Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin. PLoS ONE 2011; 6:26126; PMID:22022534; http://dx.doi.org/10.1371/ journal. pone.0026126.
    • (2011) PLoS ONE , vol.6 , pp. 26126
    • Leontieva, O.V.1    Demidenko, Z.N.2    Gudkov, A.V.3    Blagosklonny, M.V.4
  • 36
    • 50549090486 scopus 로고    scopus 로고
    • Aging, stem cells and mammalian target of rapamycin: A prospect of pharmacologic rejuvenation of aging stem cells
    • PMID:18729812
    • Blagosklonny MV. Aging, stem cells and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res 2008; 11:801-8; PMID:18729812; http://dx.doi.org/10.1089/rej.2008.0722.
    • (2008) Rejuvenation Res , vol.11 , pp. 801-808
    • Blagosklonny, M.V.1
  • 37
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • PMID:19934433
    • Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009; 2:75; PMID:19934433; http://dx.doi.org/10.1126/scisignal.2000559.
    • (2009) Sci Signal , vol.2 , pp. 75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 38
    • 65949104286 scopus 로고    scopus 로고
    • MTORC1 signaling governs hematopoietic stem cell quiescence
    • PMID:19270523
    • Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 2009; 8:1003-6; PMID:19270523; http://dx.doi.org/10.4161/ cc.8.7.8045.
    • (2009) Cell Cycle , vol.8 , pp. 1003-1006
    • Gan, B.1    DePinho, R.A.2
  • 39
    • 69249206717 scopus 로고    scopus 로고
    • MTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
    • PMID:19733540
    • Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009; 5:279-89; PMID:19733540; http://dx.doi.org/10.1016/j.stem.2009.06.017.
    • (2009) Cell Stem Cell , vol.5 , pp. 279-289
    • Castilho, R.M.1    Squarize, C.H.2    Chodosh, L.A.3    Williams, B.O.4    Gutkind, J.S.5
  • 40
    • 84855518671 scopus 로고    scopus 로고
    • A new path to longevity
    • PMID:22279832
    • Stipp D. A new path to longevity. Sci Am 2012; 306:32-9; PMID:22279832; http://dx.doi.org/10.1038/scientificamerican0112-32.
    • (2012) Sci Am , vol.306 , pp. 32-39
    • Stipp, D.1
  • 41
    • 0642367846 scopus 로고    scopus 로고
    • Genetics: Influence of TOR kinase on lifespan in C. elegans
    • PMID:14668850
    • Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Müller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID:14668850;http://dx.doi.org/10.1038/426620a.
    • (2003) Nature , vol.426 , pp. 620
    • Vellai, T.1    Takacs-Vellai, K.2    Zhang, Y.3    Kovacs, A.L.4    Orosz, L.5    Müller, F.6
  • 42
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological lifespan in yeast by decreased TOR pathway signaling
    • PMID:16418483
    • Powers RW, 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological lifespan in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20:174-84; PMID:16418483; http://dx.doi.org/10.1101/gad. 1381406.
    • (2006) Genes Dev , vol.20 , pp. 174-184
    • Powers III, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 43
    • 27744511769 scopus 로고    scopus 로고
    • Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    • PMID:16293764
    • Kaeberlein M, Powers RW, 3rd, Steffen KK, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6; PMID:16293764; http://dx.doi.org/10.1126/ science.1115535.
    • (2005) Science , vol.310 , pp. 1193-1196
    • Kaeberlein, M.1    Powers III, R.W.2    Steffen, K.K.3    Westman, E.A.4    Hu, D.5    Dang, N.6
  • 44
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • PMID:15253933
    • Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897-906; PMID:15253933;http://dx.doi.org/10.1242/ dev.01255.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 45
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • PMID:15186745
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90; PMID:15186745; http://dx.doi.org/10.1016/j.cub.2004.03. 059.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 46
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • PMID:19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID:19587680.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 47
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • PMID:19797661
    • Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4; PMID:19797661; http://dx.doi.org/10.1126/science.1177221.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1    Tullet, J.M.2    Wieser, D.3    Irvine, E.4    Lingard, S.J.5    Choudhury, A.I.6
  • 48
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster
    • PMID:20017609
    • Moskalev AA, Shaposhnikov MV. Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res 2010; 13:246-7; PMID:20017609; http://dx.doi.org/10.1089/rej. 2009.0903.
    • (2010) Rejuvenation Res , vol.13 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 49
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    • PMID:20074526
    • Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010; 11:35-46; PMID:20074526; http://dx.doi.org/10. 1016/j.cmet.2009.11.010.
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3    Slack, C.4    Jacobson, J.5    Foley, A.6
  • 50
    • 79951794971 scopus 로고    scopus 로고
    • Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    • PMID:20974732
    • Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011; 66:191-201; PMID:20974732; http://dx.doi.org/10.1093/gerona/glq178.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 191-201
    • Miller, R.A.1    Harrison, D.E.2    Astle, C.M.3    Baur, J.A.4    Boyd, A.R.5    De Cabo, R.6
  • 51
    • 83755165458 scopus 로고    scopus 로고
    • Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    • PMID:22107964
    • Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 2011; 10:4230-6; PMID:22107964; http://dx.doi.org/10.4161/cc.10.24.18486.
    • (2011) Cell Cycle , vol.10 , pp. 4230-4236
    • Anisimov, V.N.1    Zabezhinski, M.A.2    Popovich, I.G.3    Piskunova, T.S.4    Semenchenko, A.V.5    Tyndyk, M.L.6
  • 52
    • 33947574775 scopus 로고    scopus 로고
    • Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
    • PMID:17403371
    • Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab 2007; 5:265-77; PMID:17403371; http://dx.doi.org/10.1016/j. cmet.2007.02.009.
    • (2007) Cell Metab , vol.5 , pp. 265-277
    • Bonawitz, N.D.1    Chatenay-Lapointe, M.2    Pan, Y.3    Shadel, G.S.4
  • 53
    • 69449106873 scopus 로고    scopus 로고
    • Autophagy is required for extension of yeast chronological life span by rapamycin
    • PMID:19458476
    • Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA, Jr, Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 2009; 5:847-9; PMID:19458476.
    • (2009) Autophagy , vol.5 , pp. 847-849
    • Alvers, A.L.1    Wood, M.S.2    Hu, D.3    Kaywell, A.C.4    Dunn Jr., W.A.5    Aris, J.P.6
  • 54
    • 68049109688 scopus 로고    scopus 로고
    • Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density
    • PMID:20157595
    • Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 2009; 1:131-45; PMID:20157595.
    • (2009) Aging , vol.1 , pp. 131-145
    • Pan, Y.1    Shadel, G.S.2
  • 55
    • 79958068191 scopus 로고    scopus 로고
    • Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling
    • PMID:21641548
    • Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab 2011; 13:668-78; PMID:21641548; http://dx.doi.org/10.1016/j.cmet. 2011.03.018.
    • (2011) Cell Metab , vol.13 , pp. 668-678
    • Pan, Y.1    Schroeder, E.A.2    Ocampo, A.3    Barrientos, A.4    Shadel, G.S.5
  • 56
    • 83755186554 scopus 로고    scopus 로고
    • Yeast-like chronological senescence in mammalian cells: Phenomenon, mechanism and pharmacological suppression
    • PMID:22156391
    • Leontieva OV, Blagosklonny MV. Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging 2011; 3:1078-91; PMID:22156391.
    • (2011) Aging , vol.3 , pp. 1078-1091
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 57
    • 84859485410 scopus 로고    scopus 로고
    • Conserved role of medium acidification in chronological senescence of yeast and mammalian cells
    • PMID:22184281
    • Fabrizio P, Wei M. Conserved role of medium acidification in chronological senescence of yeast and mammalian cells. Aging 2011; 3:1127-9; PMID:22184281.
    • (2011) Aging , vol.3 , pp. 1127-1129
    • Fabrizio, P.1    Wei, M.2
  • 58
    • 84856121278 scopus 로고    scopus 로고
    • A new chronological survival assay in mammalian cell culture
    • PMID:22214665
    • Kaeberlein M, Kennedy BK. A new chronological survival assay in mammalian cell culture. Cell Cycle 2012; 11:201-2; PMID:22214665; http://dx.doi.org/10. 4161/cc.11.2.18959.
    • (2012) Cell Cycle , vol.11 , pp. 201-202
    • Kaeberlein, M.1    Kennedy, B.K.2
  • 59
    • 29244489494 scopus 로고    scopus 로고
    • Increased life span due to calorie restriction in respiratory-deficient yeast
    • PMID:16311627
    • Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, et al. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2005; 1:69; PMID:16311627; http://dx.doi. org/10.1371/journal.pgen. 0010069.
    • (2005) PLoS Genet , vol.1 , pp. 69
    • Kaeberlein, M.1    Hu, D.2    Kerr, E.O.3    Tsuchiya, M.4    Westman, E.A.5    Dang, N.6
  • 60
    • 34249813098 scopus 로고    scopus 로고
    • Sch9 is a major target of TORC1 in Saccharomyces cerevisiae
    • PMID:17560372
    • Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, et al. Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 2007; 26:663-74; PMID:17560372; http://dx.doi.org/10.1016/j.molcel.2007.04.020.
    • (2007) Mol Cell , vol.26 , pp. 663-674
    • Urban, J.1    Soulard, A.2    Huber, A.3    Lippman, S.4    Mukhopadhyay, D.5    Deloche, O.6
  • 61
    • 41949089130 scopus 로고    scopus 로고
    • Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    • PMID:18423200
    • Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, et al. Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell 2008; 133:292-302; PMID:18423200; http://dx.doi.org/10.1016/j.cell.2008.02. 037.
    • (2008) Cell , vol.133 , pp. 292-302
    • Steffen, K.K.1    MacKay, V.L.2    Kerr, E.O.3    Tsuchiya, M.4    Hu, D.5    Fox, L.A.6
  • 62
    • 55849153499 scopus 로고    scopus 로고
    • Replicative aging in yeast: The means to the end
    • PMID:18616424
    • Steinkraus KA, Kaeberlein M, Kennedy BK. Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol 2008; 24:29-54; PMID:18616424; http://dx.doi. org/10.1146/annurev.cellbio.23.090506.123509.
    • (2008) Annu Rev Cell Dev Biol , vol.24 , pp. 29-54
    • Steinkraus, K.A.1    Kaeberlein, M.2    Kennedy, B.K.3
  • 63
    • 80051662823 scopus 로고    scopus 로고
    • The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae
    • PMID:21415463
    • Ha CW, Huh WK. The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae. Aging 2011; 3:319-24; PMID:21415463.
    • (2011) Aging , vol.3 , pp. 319-324
    • Ha, C.W.1    Huh, W.K.2
  • 64
    • 2942529456 scopus 로고    scopus 로고
    • Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
    • PMID:15169907
    • Satyanarayana A, Greenberg RA, Schaetzlein S, Buer J, Masutomi K, Hahn WC, et al. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Mol Cell Biol 2004; 24:5459-74; PMID:15169907; http://dx.doi.org/10.1128/MCB.24.12.5459-5474.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 5459-5474
    • Satyanarayana, A.1    Greenberg, R.A.2    Schaetzlein, S.3    Buer, J.4    Masutomi, K.5    Hahn, W.C.6
  • 65
    • 0042195820 scopus 로고    scopus 로고
    • Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    • PMID:12855956
    • Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003; 5:741-7; PMID:12855956; http://dx.doi.org/10. 1038/ncb1024.
    • (2003) Nat Cell Biol , vol.5 , pp. 741-747
    • Parrinello, S.1    Samper, E.2    Krtolica, A.3    Goldstein, J.4    Melov, S.5    Campisi, J.6
  • 66
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • PMID:15988001
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 2005; 25:5834-45; PMID:15988001; http://dx.doi.org/10.1128/MCB.25.14.5834-5845.2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 67
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxiainducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • PMID:12777372
    • Arsham AM, Howell JJ, Simon MC. A novel hypoxiainducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 2003; 278:29655-60; PMID:12777372; http://dx.doi.org/10.1074/jbc.M212770200.
    • (2003) J Biol Chem , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 68
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • PMID:15545625
    • Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004; 18:2893-904; PMID:15545625; http://dx.doi.org/10.1101/gad.1256804.
    • (2004) Genes Dev , vol.18 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3    Manning, B.D.4    Reiling, J.H.5    Hafen, E.6
  • 69
    • 33646550165 scopus 로고    scopus 로고
    • Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
    • PMID:16648488
    • Connolly E, Braunstein S, Formenti S, Schneider RJ. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol 2006; 26:3955-65; PMID:16648488; http://dx.doi.org/10.1128/MCB.26.10.3955-3965.2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 3955-3965
    • Connolly, E.1    Braunstein, S.2    Formenti, S.3    Schneider, R.J.4
  • 70
    • 32444433450 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress regulates mRNA translation and cell growth
    • PMID:16483933
    • Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 2006; 21:521-31; PMID:16483933; http://dx.doi.org/10.1016/j.molcel.2006.01.010.
    • (2006) Mol Cell , vol.21 , pp. 521-531
    • Liu, L.1    Cash, T.P.2    Jones, R.G.3    Keith, B.4    Thompson, C.B.5    Simon, M.C.6
  • 71
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • PMID:18198340
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 2008; 22:239-51; PMID:18198340; http://dx.doi.org/10.1101/ gad.1617608.
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • DeYoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 72
    • 78649231611 scopus 로고    scopus 로고
    • MTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
    • PMID:21095582
    • Cam H, Easton JB, High A, Houghton PJ. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell 2010; 40:509-20; PMID:21095582; http://dx.doi.org/10.1016/j.molcel.2010.10. 030.
    • (2010) Mol Cell , vol.40 , pp. 509-520
    • Cam, H.1    Easton, J.B.2    High, A.3    Houghton, P.J.4
  • 73
    • 79955389182 scopus 로고    scopus 로고
    • Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia
    • PMID:21383064
    • Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia. Mol Cell Biol 2011; 31:1870-84; PMID:21383064; http://dx.doi.org/10.1128/MCB.01393-10.
    • (2011) Mol Cell Biol , vol.31 , pp. 1870-1884
    • Wolff, N.C.1    Vega-Rubin-de-Celis, S.2    Xie, X.J.3    Castrillon, D.H.4    Kabbani, W.5    Brugarolas, J.6
  • 74
    • 84862881961 scopus 로고    scopus 로고
    • Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
    • PMID:22157090
    • Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle 2012; 11:11-2; PMID:22157090.
    • (2012) Cell Cycle , vol.11 , pp. 11-12
    • Kolesnichenko, M.1    Hong, L.2    Liao, R.3    Vogt, P.K.4    Sun, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.