-
2
-
-
0000055057
-
Pleiotropy, natural selection and the evolution of senescence
-
Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 11:398-411.
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
3
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120:437-47.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
4
-
-
0028118111
-
Tumor spectrum analysis in p53-mutant mice
-
DOI 10.1016/S0960-9822(00)00002-6
-
Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994; 4:1-7. (Pubitemid 2027671)
-
(1994)
Current Biology
, vol.4
, Issue.1
, pp. 1-7
-
-
Jacks, T.1
Remington, L.2
Williams, B.O.3
Schmitt, E.M.4
Halachmi, S.5
Bronson, R.T.6
Weinberg, R.A.7
-
5
-
-
33748928423
-
The role of p53 in atherosclerosis
-
Mercer J, Bennett M. The role of p53 in atherosclerosis. Cell Cycle 2006; 5:1907-9.
-
(2006)
Cell Cycle
, vol.5
, pp. 1907-1909
-
-
Mercer, J.1
Bennett, M.2
-
6
-
-
0032978142
-
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
-
DOI 10.1038/6585
-
Guevara NV, Kim HS, Antonova EI, Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 1999; 5:335-9. (Pubitemid 29124372)
-
(1999)
Nature Medicine
, vol.5
, Issue.3
, pp. 335-339
-
-
Guevara, N.V.1
Kim, H.-S.2
Antonova, E.I.3
Chan, L.4
-
7
-
-
20444437233
-
P53 is a suppressor of inflammatory response in mice
-
DOI 10.1096/fj.04-3213fje
-
Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG, et al. p53 is a suppressor of inflammatory response in mice. FASEB J 2005; 19:1030-2. (Pubitemid 40827741)
-
(2005)
FASEB Journal
, vol.19
, Issue.8
, pp. 1030-1032
-
-
Komarova, E.A.1
Krivokrysenko, V.2
Wang, K.3
Neznanov, N.4
Chernov, M.V.5
Komarov, P.G.6
Brennan, M.-L.7
Golovkina, T.V.8
Rokhlin, O.W.9
Kuprash, D.V.10
Nedospasov, S.A.11
Hazen, S.L.12
Feinstein, E.13
Gudkov, A.V.14
-
8
-
-
33747172229
-
Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
-
DOI 10.2174/138161206777947470
-
Salvioli S, Capri M, Valensin S, Tieri P, Monti D, Ottaviani E, et al. Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology. Curr Pharm Des 2006; 12:161-3171. (Pubitemid 44227576)
-
(2006)
Current Pharmaceutical Design
, vol.12
, Issue.24
, pp. 3161-3171
-
-
Salvioli, S.1
Capri, M.2
Valensin, S.3
Tieri, P.4
Monti, D.5
Ottaviani, E.6
Franceschi, C.7
-
9
-
-
33846111415
-
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
-
DOI 10.1016/j.mad.2006.11.016, PII S0047637406002491, Functional Genomics of Aging III
-
Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128:92-105. (Pubitemid 46073065)
-
(2007)
Mechanisms of Ageing and Development
, vol.128
, Issue.1
, pp. 92-105
-
-
Franceschi, C.1
Capri, M.2
Monti, D.3
Giunta, S.4
Olivieri, F.5
Sevini, F.6
Panourgia, M.P.7
Invidia, L.8
Celani, L.9
Scurti, M.10
Cevenini, E.11
Castellani, G.C.12
Salvioli, S.13
-
10
-
-
77953071800
-
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
-
Altmeyer M, Hottiger MO. Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging. Aging 2009; 1:458-69.
-
(2009)
Aging
, vol.1
, pp. 458-469
-
-
Altmeyer, M.1
Hottiger, M.O.2
-
12
-
-
77955747085
-
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
-
Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging 2010; 2:344-52.
-
(2010)
Aging
, vol.2
, pp. 344-352
-
-
Korotchkina, L.G.1
Leontieva, O.V.2
Bukreeva, E.I.3
Demidenko, Z.N.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
13
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6:2853-68.
-
(2008)
PLoS Biol
, vol.6
, pp. 2853-2868
-
-
Coppé, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Muñoz, D.P.5
Goldstein, J.6
-
14
-
-
0037011958
-
P53 mutant mice that display early ageing-associated phenotypes
-
DOI 10.1038/415045a
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415:45-53. (Pubitemid 34062443)
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Sang, H.P.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
15
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
DOI 10.1101/gad.1162404
-
Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004; 18:306-19. (Pubitemid 38199255)
-
(2004)
Genes and Development
, vol.18
, Issue.3
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
Sutherland, A.7
Thorner, M.8
Scrable, H.9
-
16
-
-
33645711615
-
Tumor Suppression by p53 Without Accelerated Aging: Just Enough of a Good Thing?
-
Mendrysa SM, Perry ME. Tumor Suppression by p53 Without Accelerated Aging: Just Enough of a Good Thing? Cell Cycle 2006; 5:714-7.
-
(2006)
Cell Cycle
, vol.5
, pp. 714-717
-
-
Mendrysa, S.M.1
Perry, M.E.2
-
17
-
-
0037112844
-
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
García-Cao I, García-Cao M, Martín-Caballero J, Criado LM, Klatt P, Flores JM, et al. "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J 2002; 21:6225-35.
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
García-Cao, I.1
García-Cao, M.2
Martín-Caballero, J.3
Criado, L.M.4
Klatt, P.5
Flores, J.M.6
-
18
-
-
29944447632
-
Tumor suppression and normal aging in mice with constitutively high p53 activity
-
DOI 10.1101/gad.1378506
-
Mendrysa SM, O'Leary KA, McElwee MK, Michalowski J, Eisenman RN, Powell DA, et al. Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev 2006; 20:16-21. (Pubitemid 43042663)
-
(2006)
Genes and Development
, vol.20
, Issue.1
, pp. 16-21
-
-
Mendrysa, S.M.1
O'Leary, K.A.2
McElwee, M.K.3
Michalowski, J.4
Eisenman, R.N.5
Powell, D.A.6
Perry, M.E.7
-
19
-
-
34447517413
-
Delayed ageing through damage protection by the Arf/p53 pathway
-
DOI 10.1038/nature05949, PII NATURE05949
-
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, et al. Delayed ageing through damage protection by the Arf/p53 pathway. Nature 2007; 448:375-9. (Pubitemid 47080339)
-
(2007)
Nature
, vol.448
, Issue.7151
, pp. 375-379
-
-
Matheu, A.1
Maraver, A.2
Klatt, P.3
Flores, I.4
Garcia-Cao, I.5
Borras, C.6
Flores, J.M.7
Vina, J.8
Blasco, M.A.9
Serrano, M.10
-
20
-
-
35548929551
-
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
-
DOI 10.1073/pnas.0708043104
-
Feng Z, Hu W, Teresky AK, Hernando E, Cordon-Cardo C, Levine AJ. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci USA 2007; 104:16633-8. (Pubitemid 350211068)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.42
, pp. 16633-16638
-
-
Feng, Z.1
Hu, W.2
Teresky, A.K.3
Hernando, E.4
Cordon-Cardo, C.5
Levine, A.J.6
-
21
-
-
77953641048
-
Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3
-
Huang B, Vassilev LT. Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3. Aging 2009; 1:845-54.
-
(2009)
Aging
, vol.1
, pp. 845-854
-
-
Huang, B.1
Vassilev, L.T.2
-
22
-
-
0037238101
-
Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
-
DOI 10.1016/S0531-5565(02)00152-3, PII S0531556502001523
-
Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 2003; 38:5-11. (Pubitemid 36110494)
-
(2003)
Experimental Gerontology
, vol.38
, Issue.1-2
, pp. 5-11
-
-
Campisi, J.1
-
24
-
-
77955725147
-
Impact papers on aging in 2009
-
Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, et al. Impact papers on aging in 2009. Aging 2010; 2:111-21.
-
(2010)
Aging
, vol.2
, pp. 111-121
-
-
Blagosklonny, M.V.1
Campisi, J.2
Sinclair, D.A.3
Bartke, A.4
Blasco, M.A.5
Bonner, W.M.6
-
25
-
-
77953417589
-
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy
-
Waskar M, Landis GN, Shen J, Curtis C, Tozer K, Abdueva D, et al. Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging 2009; 1:903-36.
-
(2009)
Aging
, vol.1
, pp. 903-936
-
-
Waskar, M.1
Landis, G.N.2
Shen, J.3
Curtis, C.4
Tozer, K.5
Abdueva, D.6
-
26
-
-
67649332816
-
Longevity regulation in flies: A role for p53
-
Donehower LA. Longevity regulation in flies: a role for p53. Aging 2009; 1:6-8.
-
(2009)
Aging
, vol.1
, pp. 6-8
-
-
Donehower, L.A.1
-
27
-
-
66849111716
-
Stimulation of autophagy by the p53 target gene Sestrin2
-
Maiuri MC, Malik SA, Morselli E, Kepp O, Criollo A, Mouchel PL, et al. Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 2009; 8:1571-6.
-
(2009)
Cell Cycle
, vol.8
, pp. 1571-1576
-
-
Maiuri, M.C.1
Malik, S.A.2
Morselli, E.3
Kepp, O.4
Criollo, A.5
Mouchel, P.L.6
-
28
-
-
42449113363
-
P53: A new player in reproduction
-
Hu W, Feng Z, Atwal GS, Levine AJ. p53: a new player in reproduction. Cell Cycle 2008; 7:848-52. (Pubitemid 351573775)
-
(2008)
Cell Cycle
, vol.7
, Issue.7
, pp. 848-852
-
-
Hu, W.1
Feng, Z.2
Atwal, G.S.3
Levine, A.J.4
-
29
-
-
67649844319
-
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans
-
Kang HJ, Feng Z, Sun Y, Atwal G, Murphy ME, Rebbeck TR, et al. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci USA 2009; 106:9761-6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9761-9766
-
-
Kang, H.J.1
Feng, Z.2
Sun, Y.3
Atwal, G.4
Murphy, M.E.5
Rebbeck, T.R.6
-
30
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18:1926-45.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
31
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-84.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
32
-
-
33645738458
-
Complexity of the TOR signaling network
-
Inoki K, Guan KL. Complexity of the TOR signaling network. Trends Cell Biol 2006; 16:206-12.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 206-212
-
-
Inoki, K.1
Guan, K.L.2
-
33
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-74.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
34
-
-
36749047009
-
Amino acids and mTOR signalling in anabolic function
-
Proud CG. Amino acids and mTOR signalling in anabolic function. Biochem Soc Trans 2007; 35:1187-90.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1187-1190
-
-
Proud, C.G.1
-
35
-
-
34249679614
-
MTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
-
DOI 10.1016/j.molmed.2007.04.002, PII S1471491407000664
-
Dann SG, Selvaraj A, Thomas G. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007; 13:252-9. (Pubitemid 46836871)
-
(2007)
Trends in Molecular Medicine
, vol.13
, Issue.6
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
36
-
-
61449235398
-
Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance and cancer therapy
-
Choo AY, Blenis J. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 2009; 8:567-72.
-
(2009)
Cell Cycle
, vol.8
, pp. 567-572
-
-
Choo, A.Y.1
Blenis, J.2
-
37
-
-
77953577017
-
mTOR's role in ageing: Protein synthesis or autophagy?
-
Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: protein synthesis or autophagy? Aging 2009; 586-97.
-
(2009)
Aging
, pp. 586-597
-
-
Hands, S.L.1
Proud, C.G.2
Wyttenbach, A.3
-
38
-
-
65949090057
-
RAG GTPases in nutrient-mediated TOR signaling pathway
-
Kim E, Guan KL. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle 2009; 8:1014-8.
-
(2009)
Cell Cycle
, vol.8
, pp. 1014-1018
-
-
Kim, E.1
Guan, K.L.2
-
39
-
-
66749130276
-
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
-
Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 2009; 8:1738-46.
-
(2009)
Cell Cycle
, vol.8
, pp. 1738-1746
-
-
Glazer, H.P.1
Osipov, R.M.2
Clements, R.T.3
Sellke, F.W.4
Bianchi, C.5
-
40
-
-
77955747346
-
With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
-
Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11:453-65.
-
(2010)
Cell Metab
, vol.11
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
-
41
-
-
67649347537
-
Growth and Aging: A common molecular mechanism
-
Blagosklonny MV, Hall MN. Growth and Aging: a common molecular mechanism. Aging 2009; 1:357-62.
-
(2009)
Aging
, vol.1
, pp. 357-362
-
-
Blagosklonny, M.V.1
Hall, M.N.2
-
42
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61.
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
43
-
-
56149126490
-
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells
-
Zhuang D, Mannava S, Grachtchouk V, Tang WH, Patil S, Wawrzyniak JA, et al. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells. Oncogene 2008; 27:6623-34.
-
(2008)
Oncogene
, vol.27
, pp. 6623-6634
-
-
Zhuang, D.1
Mannava, S.2
Grachtchouk, V.3
Tang, W.H.4
Patil, S.5
Wawrzyniak, J.A.6
-
44
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle 2009; 8:1888-95.
-
(2009)
Cell Cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
45
-
-
67649369064
-
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence
-
Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-900.
-
(2009)
Cell Cycle
, vol.8
, pp. 1896-1900
-
-
Demidenko, Z.N.1
Shtutman, M.2
Blagosklonny, M.V.3
-
46
-
-
67649369072
-
At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
-
Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle 2009; 8:1901-4.
-
(2009)
Cell Cycle
, vol.8
, pp. 1901-1904
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
47
-
-
77953111224
-
Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
-
Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging 2009; 1:1008-16.
-
(2009)
Aging
, vol.1
, pp. 1008-1016
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
48
-
-
74849091341
-
Pseudo-DNA damage response in senescent cells
-
Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009; 8:4112-8.
-
(2009)
Cell Cycle
, vol.8
, pp. 4112-4118
-
-
Pospelova, T.V.1
Demidenko, Z.N.2
Bukreeva, E.I.3
Pospelov, V.A.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
49
-
-
27744511769
-
Cell biology: Regulation of yeast replicative life span by TOR and Sch9 response to nutrients
-
DOI 10.1126/science.1115535
-
Kaeberlein M, Powers R, Wr KKS, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-6. (Pubitemid 41681747)
-
(2005)
Science
, vol.310
, Issue.5751
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
50
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
DOI 10.1101/gad.1381406
-
Powers RWr, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 2006; 20:174-84. (Pubitemid 43112936)
-
(2006)
Genes and Development
, vol.20
, Issue.2
, pp. 174-184
-
-
Powers III, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
52
-
-
68049109688
-
Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density
-
Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 2009; 1:131-5.
-
(2009)
Aging
, vol.1
, pp. 131-135
-
-
Pan, Y.1
Shadel, G.S.2
-
53
-
-
77950214581
-
Lessons on longevity from budding yeast
-
Kaeberlein M. Lessons on longevity from budding yeast. Nature 2010; 464:513-9.
-
(2010)
Nature
, vol.464
, pp. 513-519
-
-
Kaeberlein, M.1
-
54
-
-
13944276264
-
Life extension in the dwarf mouse
-
Bartke A, Brown-Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol 2004; 63:189-225.
-
(2004)
Curr Top Dev Biol
, vol.63
, pp. 189-225
-
-
Bartke, A.1
Brown-Borg, H.2
-
55
-
-
33644507693
-
Long-lived Klotho mice: New insights into the roles of IGF-1 and insulin in aging
-
DOI 10.1016/j.tem.2006.01.002, PII S1043276006000087
-
Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab 2006; 17:33-5. (Pubitemid 43306725)
-
(2006)
Trends in Endocrinology and Metabolism
, vol.17
, Issue.2
, pp. 33-35
-
-
Bartke, A.1
-
56
-
-
70350540920
-
Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice
-
Inuzuka Y, Okuda J, Kawashima T, Kato T, Niizuma S, Tamaki Y, et al. Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice. Circulation 2009; 120:1695-703.
-
(2009)
Circulation
, vol.120
, pp. 1695-1703
-
-
Inuzuka, Y.1
Okuda, J.2
Kawashima, T.3
Kato, T.4
Niizuma, S.5
Tamaki, Y.6
-
57
-
-
4544220704
-
Absence of S6K1 protects against age- And diet-induced obesity while enhancing insulin sensitivity
-
DOI 10.1038/nature02866
-
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-5. (Pubitemid 39243474)
-
(2004)
Nature
, vol.431
, Issue.7005
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
58
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
-
59
-
-
0027771804
-
C. elegans mutant that lives twice as long as wild type
-
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 1993; 461-4.
-
(1993)
Nature
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.A.5
-
60
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
Dorman JB, Albinder B, Shroyer T, Kenyon C. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 1995; 141:1399-406.
-
(1995)
Genetics
, vol.141
, pp. 1399-1406
-
-
Dorman, J.B.1
Albinder, B.2
Shroyer, T.3
Kenyon, C.4
-
61
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
DOI 10.1126/science.277.5328.942
-
Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997; 277:942-6. (Pubitemid 27366677)
-
(1997)
Science
, vol.277
, Issue.5328
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
62
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996; 382:536-9.
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
63
-
-
0642367846
-
Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620. (Pubitemid 38009359)
-
(2003)
Nature
, vol.426
, Issue.6967
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
64
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 2004; 131:3897-906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
65
-
-
10644282295
-
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
-
DOI 10.1101/gad.1255404
-
Apfeld J, O'Connor G, McDonagh T, DiStefano PS, Curtis R. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev 2004; 18:3004-9. (Pubitemid 39658169)
-
(2004)
Genes and Development
, vol.18
, Issue.24
, pp. 3004-3009
-
-
Apfeld, J.1
O'Connor, G.2
McDonagh, T.3
DiStefano, P.S.4
Curtis, R.5
-
66
-
-
77950200010
-
The genetics of ageing
-
Kenyon CJ. The genetics of ageing. Nature 2010; 464:504-12.
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
67
-
-
77955747346
-
With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
-
Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11:453-65.
-
(2010)
Cell Metab
, vol.11
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
-
68
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol 2002; 12:1448-61.
-
(2002)
Curr Biol
, vol.12
, pp. 1448-1461
-
-
Long, X.1
Spycher, C.2
Han, Z.S.3
Rose, A.M.4
Muller, F.5
Avruch, J.6
-
70
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
DOI 10.1016/j.cub.2004.03.059, PII S0960982204002386
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90. (Pubitemid 38800910)
-
(2004)
Current Biology
, vol.14
, Issue.10
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
71
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
DOI 10.1126/science.1057987
-
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 2001; 292:107-10. (Pubitemid 32289137)
-
(2001)
Science
, vol.292
, Issue.5514
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.-P.4
Yin, C.-M.5
Garofalo, R.S.6
-
72
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
DOI 10.1126/science.1081447
-
Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science 2003; 299:1346-51. (Pubitemid 36254639)
-
(2003)
Science
, vol.299
, Issue.5611
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
73
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, et al. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004; 24:9508-16.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
-
74
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, Edenhofer F, et al. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 2004; 24:6710-8.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
-
75
-
-
33748950810
-
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
-
DOI 10.1016/j.devcel.2006.08.013, PII S1534580706003935
-
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 2006; 11:583-9. (Pubitemid 44430900)
-
(2006)
Developmental Cell
, vol.11
, Issue.4
, pp. 583-589
-
-
Shiota, C.1
Woo, J.-T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
76
-
-
11144356304
-
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, et al. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 2004; 24:3112-24.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
-
77
-
-
0033576579
-
Regulation of lifespan by sensory perception in Caenorhabditis elegans
-
Apfeld J, Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 1999; 402:804-9.
-
(1999)
Nature
, vol.402
, pp. 804-809
-
-
Apfeld, J.1
Kenyon, C.2
-
78
-
-
0347854376
-
Regulation of C. elegans longevity by specific gustatory and olfactory neurons
-
Alcedo J, Kenyon C. Regulation of C. elegans longevity by specific gustatory and olfactory neurons. Neuron 2004; 41:45-55.
-
(2004)
Neuron
, vol.41
, pp. 45-55
-
-
Alcedo, J.1
Kenyon, C.2
-
79
-
-
33847259770
-
Regulation of Drosophila life span by olfaction and food-derived odors
-
DOI 10.1126/science.1136610
-
Libert S, Zwiener J, Chu X, Vanvoorhies W, Roman G, Pletcher SD. Regulation of Drosophila life span by olfaction and food-derived odors. Science 2007; 315:1133-7. (Pubitemid 46328025)
-
(2007)
Science
, vol.315
, Issue.5815
, pp. 1133-1137
-
-
Libert, S.1
Zwiener, J.2
Chu, X.3
VanVoorhies, W.4
Roman, G.5
Pletcher, S.D.6
-
80
-
-
70449706046
-
Brood pheromone suppresses physiology of extreme longevity in honeybees (Apis mellifera)
-
Smedal B, Brynem M, Kreibich CD, Amdam GV. Brood pheromone suppresses physiology of extreme longevity in honeybees (Apis mellifera). J Exp Biol Dec 2009; 212:3795-801.
-
(2009)
J Exp Biol Dec
, vol.212
, pp. 3795-3801
-
-
Smedal, B.1
Brynem, M.2
Kreibich, C.D.3
Amdam, G.V.4
-
81
-
-
77953642042
-
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
-
Vinogradova IA, Anisimov VN, Bukalev AV, Semenchenko AV, Zabezhinski MA. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. Aging 2009; 1:855-65.
-
(2009)
Aging
, vol.1
, pp. 855-865
-
-
Vinogradova, I.A.1
Anisimov, V.N.2
Bukalev, A.V.3
Semenchenko, A.V.4
Zabezhinski, M.A.5
-
82
-
-
0001047561
-
The effect of retardation of growth upon the breeding period and duration of life of rats
-
Osborne TB, Mendel LB, Ferry EL. The effect of retardation of growth upon the breeding period and duration of life of rats. Science 1917; 45:294-5.
-
(1917)
Science
, vol.45
, pp. 294-295
-
-
Osborne, T.B.1
Mendel, L.B.2
Ferry, E.L.3
-
83
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005; 6:298-305.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
84
-
-
0037470488
-
Evolutionary medicine: From dwarf model systems to healthy centenarians?
-
Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 2003; 299:1342-6.
-
(2003)
Science
, vol.299
, pp. 1342-1346
-
-
Longo, V.D.1
Finch, C.E.2
-
86
-
-
34447316421
-
Caloric restriction in humans
-
Holloszy JO, Fontana L. Caloric restriction in humans. Exp Gerontol 2007; 42:709-12.
-
(2007)
Exp Gerontol
, vol.42
, pp. 709-712
-
-
Holloszy, J.O.1
Fontana, L.2
-
87
-
-
72949117234
-
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
-
Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 2009; 462:1061-4.
-
(2009)
Nature
, vol.462
, pp. 1061-1064
-
-
Grandison, R.C.1
Piper, M.D.2
Partridge, L.3
-
88
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009; 325:201-4.
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
Anderson, R.M.2
Johnson, S.C.3
Kastman, E.K.4
Kosmatka, K.J.5
Beasley, T.M.6
-
89
-
-
77953149043
-
Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)
-
Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle 2010; 9:683-8.
-
(2010)
Cell Cycle
, vol.9
, pp. 683-688
-
-
Blagosklonny, M.V.1
-
90
-
-
68049109688
-
Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density
-
Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires downregulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 2009; 1:131-45.
-
(2009)
Aging
, vol.1
, pp. 131-145
-
-
Pan, Y.1
Shadel, G.S.2
-
91
-
-
33750029285
-
Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
-
Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-102.
-
(2006)
Cell Cycle
, vol.5
, pp. 2087-2102
-
-
Blagosklonny, M.V.1
-
92
-
-
33847226657
-
An anti-aging drug today: From senescence-promoting genes to anti-aging pill
-
Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today 2007; 12:218-24.
-
(2007)
Drug Disc Today
, vol.12
, pp. 218-224
-
-
Blagosklonny, M.V.1
-
93
-
-
77953645579
-
Rapamycin and quasi-programmed aging: Four years later
-
Blagosklonny MV. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010; 9:1859-62.
-
(2010)
Cell Cycle
, vol.9
, pp. 1859-1862
-
-
Blagosklonny, M.V.1
-
94
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogenous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460:392-6.
-
(2009)
Nature
, vol.460
, pp. 392-396
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
95
-
-
77952083662
-
Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
-
Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice. Am J Pathol 2010; 176:2092-7.
-
(2010)
Am J Pathol
, vol.176
, pp. 2092-2097
-
-
Anisimov, V.N.1
Zabezhinski, M.A.2
Popovich, I.G.3
Piskunova, T.S.4
Semenchenko, A.V.5
Tyndyk, M.L.6
-
96
-
-
72649091698
-
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
-
Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 2010; 11:35-46.
-
(2010)
Cell Metab
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
Toivonen, J.M.2
Kerr, F.3
Slack, C.4
Jacobson, J.5
Foley, A.6
-
97
-
-
77953635172
-
Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster
-
Moskalev AA, Shaposhnikov MV. Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster. Rejuvenation Res 2009.
-
(2009)
Rejuvenation Res
-
-
Moskalev, A.A.1
Shaposhnikov, M.V.2
-
98
-
-
74849106934
-
Inhibition of S6K by resveratrol: In search of the purpose
-
Blagosklonny MV. Inhibition of S6K by resveratrol: In search of the purpose. Aging 2009; 1:511-4.
-
(2009)
Aging
, vol.1
, pp. 511-514
-
-
Blagosklonny, M.V.1
-
99
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310:1642-6.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
-
100
-
-
50849113473
-
Metformin slows down aging and extends life span of female SHR mice
-
Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 2008; 7:2769-73.
-
(2008)
Cell Cycle
, vol.7
, pp. 2769-2773
-
-
Anisimov, V.N.1
Berstein, L.M.2
Egormin, P.A.3
Piskunova, T.S.4
Popovich, I.G.5
Zabezhinski, M.A.6
-
101
-
-
77649311383
-
Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1 and SKN-1
-
Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1 and SKN-1. PLoS One 5:8758.
-
PLoS One
, vol.5
, pp. 8758
-
-
Onken, B.1
Driscoll, M.2
-
102
-
-
33845509065
-
Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?
-
Cheang KI, Sharma ST, Nestler JE. Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? Gynecol Endocrinol 2006; 22:595-604.
-
(2006)
Gynecol Endocrinol
, vol.22
, pp. 595-604
-
-
Cheang, K.I.1
Sharma, S.T.2
Nestler, J.E.3
-
103
-
-
34548784576
-
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome
-
DOI 10.1210/jc.2007-1009
-
Palomba S, Orio FJ, Falbo A, Russo T, Tolino A, Zullo F. Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2007; 92:3498-503. (Pubitemid 47435326)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.9
, pp. 3498-3503
-
-
Palomba, S.1
Orio Jr., F.2
Falbo, A.3
Russo, T.4
Tolino, A.5
Zullo, F.6
-
104
-
-
13944253348
-
Calorie restriction - The SIR2 connection
-
Guarente L, Picard F. Calorie restriction - the SIR2 connection. Cell 2005; 120:473-82.
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
105
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000; 408:255-62.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
106
-
-
34547101264
-
FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
-
Southgate RJ, Neill B, Prelovsek O, El-Osta A, Kamei Y, Miura S, et al. FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. J Biol Chem 2007; 282:21176-86.
-
(2007)
J Biol Chem
, vol.282
, pp. 21176-21186
-
-
Southgate, R.J.1
Neill, B.2
Prelovsek, O.3
El-Osta, A.4
Kamei, Y.5
Miura, S.6
-
107
-
-
77951911593
-
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
-
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, et al. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell 2010; 18:592-604.
-
(2010)
Dev Cell
, vol.18
, pp. 592-604
-
-
Chen, C.C.1
Jeon, S.M.2
Bhaskar, P.T.3
Nogueira, V.4
Sundararajan, D.5
Tonic, I.6
-
108
-
-
40849142411
-
FOXO-regulated transcription restricts overgrowth of Tsc mutant organs
-
DOI 10.1083/jcb.200710100
-
Harvey KF, Mattila J, Sofer A, Bennett FC, Ramsey MR, Ellisen LW, et al. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. J Cell Biol 2008; 180:691-6. (Pubitemid 351397767)
-
(2008)
Journal of Cell Biology
, vol.180
, Issue.4
, pp. 691-696
-
-
Harvey, K.F.1
Mattila, J.2
Sofer, A.3
Bennett, F.C.4
Ramsey, M.R.5
Ellisen, L.W.6
Puig, O.7
Hariharan, I.K.8
-
109
-
-
40849131141
-
Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components
-
DOI 10.1210/en.2007-1470
-
Wu AL, Kim JH, Zhang C, Unterman TG, Chen J. Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology 2008; 149:1407-14. (Pubitemid 351397941)
-
(2008)
Endocrinology
, vol.149
, Issue.3
, pp. 1407-1414
-
-
Wu, A.-L.1
Kim, J.-H.2
Zhang, C.3
Unterman, T.G.4
Chen, J.5
-
110
-
-
77952373274
-
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
-
Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J Biol Chem 2010; 285:15960-5.
-
(2010)
J Biol Chem
, vol.285
, pp. 15960-15965
-
-
Khatri, S.1
Yepiskoposyan, H.2
Gallo, C.A.3
Tandon, P.4
Plas, D.R.5
-
111
-
-
0028807085
-
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
-
Dorman JB, Albinder B, Shroyer T, Kenyon C. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 1995; 141:1399-406.
-
(1995)
Genetics
, vol.141
, pp. 1399-1406
-
-
Dorman, J.B.1
Albinder, B.2
Shroyer, T.3
Kenyon, C.4
-
112
-
-
0033595003
-
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
-
Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H. The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci USA 1999; 96:7427-32.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7427-7432
-
-
Mihaylova, V.T.1
Borland, C.Z.2
Manjarrez, L.3
Stern, M.J.4
Sun, H.5
-
113
-
-
25844512127
-
Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18
-
Masse I, Molin L, Billaud M, Solari F. Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18. Dev Biol 2005; 286:91-101.
-
(2005)
Dev Biol
, vol.286
, pp. 91-101
-
-
Masse, I.1
Molin, L.2
Billaud, M.3
Solari, F.4
-
114
-
-
12444296522
-
The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans
-
Solari F, Bourbon-Piffaut A, Masse I, Payrastre B, Chan AM, Billaud M. The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans. Oncogene 2005; 24:20-7.
-
(2005)
Oncogene
, vol.24
, pp. 20-27
-
-
Solari, F.1
Bourbon-Piffaut, A.2
Masse, I.3
Payrastre, B.4
Chan, A.M.5
Billaud, M.6
-
115
-
-
35648995939
-
MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
-
Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae. PLoS Biol 2007; 5:261.
-
(2007)
PLoS Biol
, vol.5
, pp. 261
-
-
Medvedik, O.1
Lamming, D.W.2
Kim, K.D.3
Sinclair, D.A.4
-
116
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
DOI 10.1073/pnas.0502857102
-
Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 2005; 102:8204-9. (Pubitemid 40800067)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.23
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
Jin, S.4
-
117
-
-
48449101433
-
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
-
Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008; 134:451-60.
-
(2008)
Cell
, vol.134
, pp. 451-460
-
-
Budanov, A.V.1
Karin, M.2
-
118
-
-
74849113290
-
The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions
-
Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, et al. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle 2009; 8:4168-75.
-
(2009)
Cell Cycle
, vol.8
, pp. 4168-4175
-
-
Matthew, E.M.1
Hart, L.S.2
Astrinidis, A.3
Navaraj, A.4
Dolloff, N.G.5
Dicker, D.T.6
-
119
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, et al. Regulation of PTEN transcription by p53. Mol Cell 2001; 8:317-25.
-
(2001)
Mol Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
-
120
-
-
77955734995
-
Sestrins at the crossroad between stress and aging
-
Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging 2010; 2:369-74.
-
(2010)
Aging
, vol.2
, pp. 369-374
-
-
Lee, J.H.1
Bodmer, R.2
Bier, E.3
Karin, M.4
-
121
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
DOI 10.1016/j.drudis.2006.12.008, PII S1359644606004910
-
Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today 2007; 12:112-24. (Pubitemid 46176669)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.3-4
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.S.4
-
122
-
-
77955739991
-
Why men age faster but reproduce longer than women: MTOR and evolutionary perspectives
-
Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging 2010; 2:265-73.
-
(2010)
Aging
, vol.2
, pp. 265-273
-
-
Blagosklonny, M.V.1
-
123
-
-
70350266820
-
The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
-
Roa J, Garcia-Galiano D, Varela L, Sanchez-Garrido MA, Pineda R, Castellano JM, et al. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 2009; 150:5016-26.
-
(2009)
Endocrinology
, vol.150
, pp. 5016-5026
-
-
Roa, J.1
Garcia-Galiano, D.2
Varela, L.3
Sanchez-Garrido, M.A.4
Pineda, R.5
Castellano, J.M.6
-
124
-
-
77953917251
-
Metabolic control of puberty onset: New players, new mechanisms
-
Roa J, Garcia-Galiano D, Castellano JM, Gaytan F, Pinilla L, Tena-Sempere M. Metabolic control of puberty onset: New players, new mechanisms. Mol Cell Endocrinol 2010; 324:87-94.
-
(2010)
Mol Cell Endocrinol
, vol.324
, pp. 87-94
-
-
Roa, J.1
Garcia-Galiano, D.2
Castellano, J.M.3
Gaytan, F.4
Pinilla, L.5
Tena-Sempere, M.6
-
125
-
-
85011938256
-
Energy balance and puberty onset: Emerging role of central mTOR signaling
-
Roa J, Tena-Sempere M. Energy balance and puberty onset: emerging role of central mTOR signaling. Trends Endocrinol Metab Jun 14.
-
Trends Endocrinol Metab
, vol.14
-
-
Roa, J.1
Tena-Sempere, M.2
-
126
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-54.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
|