Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

Nature Reviews Drug Discovery

Volumn 7, Issue 10, 2008, Pages 854-868

  Kazantsev, Aleksey G ^a   Thompson, Leslie M ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 4 PHENYLBUTYRIC ACID; AGK 2; AMIDOHYDROLASE INHIBITOR; APICIDIN; BELINOSTAT; BUTYRIC ACID; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 5 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; ITF 2357; LBG 589; MC 1568; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; PANOBINOSTAT; RESVERATROL; SIRTINOL; SIRTUIN ACTIVATOR; SIRTUIN INHIBITOR; SRTT 720; TRICHOSTATIN A; TUBUCIN; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

ACETYLATION; AGING; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CALORIC RESTRICTION; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR ACCIDENT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; FRAGILE X SYNDROME; FRIEDREICH ATAXIA; HUMAN; INFLAMMATION; MENTAL DISEASE; MOTOR NEURON DISEASE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RETT SYNDROME; REVIEW; RUBINSTEIN SYNDROME; STRUCTURE ACTIVITY RELATION;

ANIMALS; CENTRAL NERVOUS SYSTEM DISEASES; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS;

EID: 53249130741     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd2681     Document Type: Review

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