HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

Brain Research

Volumn 1226, Issue , 2008, Pages 181-191

  Zhang, Bin ^a,b   West, Eric J ^b   Van, Ken C ^b   Gurkoff, Gene G ^b   Zhou, Jia ^d   Zhang, Xiu Mei ^a   Kozikowski, Alan P ^c   Lyeth, Bruce G ^b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d PSYCHOGENICS INC   (United States)

Author keywords

Fluid percussion; Histone deacetylase; Inflammation; Microglia; Traumatic brain injury

Indexed keywords

4 DIMETHYLAMINO N [5 (2 MERCAPTOACETYLAMINO)PENTYL]BENZAMIDE; BENZAMIDE DERIVATIVE; HISTONE H3; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; ENCEPHALITIS; FLUORESCENCE; HIPPOCAMPUS; IMMUNOLOCALIZATION; INFLAMMATORY DISEASE; MALE; MICROGLIA; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY;

ACETYLATION; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD11B; BENZAMIDES; BODY TEMPERATURE; BRAIN INJURIES; CELL COUNT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONE DEACETYLASES; HISTONES; INFLAMMATION; MALE; MICROGLIA; ORGANIC CHEMICALS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 48849095167     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.05.085     Document Type: Article

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