-
1
-
-
0037221445
-
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases
-
Denu J.M. Linking chromatin function with metabolic networks: sir2 family of NAD(+)-dependent deacetylases. Trends Biochem. Sci. 28:2003;41-48
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 41-48
-
-
Denu, J.M.1
-
2
-
-
0036279988
-
SIR2 family of NAD(+)-dependent protein deacetylases
-
Smith J.S., Avalos J., Celic I., Muhammad S., Wolberger C., Boeke J.D. SIR2 family of NAD(+)-dependent protein deacetylases. Methods Enzymol. 353:2002;282-300
-
(2002)
Methods Enzymol.
, vol.353
, pp. 282-300
-
-
Smith, J.S.1
Avalos, J.2
Celic, I.3
Muhammad, S.4
Wolberger, C.5
Boeke, J.D.6
-
3
-
-
0030978951
-
Localization of Sir2p: The nucleolus as a compartment for silent information regulators
-
Gotta M., Strahl-Bolsinger S., Renauld H., Laroche T., Kennedy B.K., Grunstein M., Gasser S.M. Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J. 16:1997;3243-3255
-
(1997)
EMBO J.
, vol.16
, pp. 3243-3255
-
-
Gotta, M.1
Strahl-Bolsinger, S.2
Renauld, H.3
Laroche, T.4
Kennedy, B.K.5
Grunstein, M.6
Gasser, S.M.7
-
4
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273:2000;793-798
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
5
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S-I., Armstrong C.M., Kaeberlein M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:2000;795-800
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
6
-
-
0035862199
-
The human histone deacetylase family
-
Gray S.G., Ekstrom T.J. The human histone deacetylase family. Exp. Cell Res. 262:2001;75-83
-
(2001)
Exp. Cell Res.
, vol.262
, pp. 75-83
-
-
Gray, S.G.1
Ekstrom, T.J.2
-
7
-
-
0034687694
-
Silent information regulator-2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
-
Tanner K.G., Landry J., Sternglanz R., Denu J.M. Silent information regulator-2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc. Natl. Acad. Sci. USA. 97:2000;14178-14182
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14178-14182
-
-
Tanner, K.G.1
Landry, J.2
Sternglanz, R.3
Denu, J.M.4
-
8
-
-
0036753953
-
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
-
Avalos J.L., Celic I., Muhammad S., Cosgrove M.S., Boeke J.D., Wolberger C. Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol. Cell. 10:2002;523-535
-
(2002)
Mol. Cell
, vol.10
, pp. 523-535
-
-
Avalos, J.L.1
Celic, I.2
Muhammad, S.3
Cosgrove, M.S.4
Boeke, J.D.5
Wolberger, C.6
-
9
-
-
0035913903
-
HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H., Dessain S.K., Eagon E.N., Imai S.-I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:2001;149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Eagon, E.N.3
Imai, S.-I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
10
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., Chua K.F. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA. 100:2003;10794-10799
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
11
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W., Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 90:1997;595-606
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
12
-
-
0035913911
-
Negative control of p53 by Sir2-alpha promotes cell survival under stress
-
Luo J., Nikolaev A.Y., Imai S.-I., Chen D.L., Su F., Shiloh A., Guarente L., Gu W. Negative control of p53 by Sir2-alpha promotes cell survival under stress. Cell. 107:2001;137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.-I.3
Chen, D.L.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
13
-
-
0036709074
-
Human Sir2 and the "silencing" of p53 activity
-
Smith J.S. Human Sir2 and the "silencing" of p53 activity. Trends Cell Biol. 12:2002;404-406
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 404-406
-
-
Smith, J.S.1
-
14
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E., Pearson M., Faretta M., Bauer U.M., Frye R.A., Minucci S., Pelicci P.G., Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21:2002;2383-2396
-
(2002)
EMBO J.
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
Bauer, U.M.4
Frye, R.A.5
Minucci, S.6
Pelicci, P.G.7
Kouzarides, T.8
-
15
-
-
0035914304
-
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
-
Grozinger C.M., Chao E.D., Blackwell H.E., Moazed D., Schreiber S.L. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 276:2001;38837-38843
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38837-38843
-
-
Grozinger, C.M.1
Chao, E.D.2
Blackwell, H.E.3
Moazed, D.4
Schreiber, S.L.5
-
16
-
-
0037108799
-
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
-
Onyango P., Celic I., McCaffery J.M., Boeke J.D., Feinberg A.P. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc. Natl. Acad. Sci. USA. 99:2002;13653-13658
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13653-13658
-
-
Onyango, P.1
Celic, I.2
McCaffery, J.M.3
Boeke, J.D.4
Feinberg, A.P.5
-
17
-
-
0035910031
-
Identification of a small molecule inhibitor of Sir2p
-
Bedalov A., Gatbonton T., Irvine W.P., Gottschling D.E., Simon J.A. Identification of a small molecule inhibitor of Sir2p. Proc. Natl. Acad. Sci. USA. 98:2001;15113-15118
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 15113-15118
-
-
Bedalov, A.1
Gatbonton, T.2
Irvine, W.P.3
Gottschling, D.E.4
Simon, J.A.5
-
18
-
-
0037166269
-
′-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta-NAD(+)-dependent histone/protein deacetylases
-
′ -O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta-NAD(+)-dependent histone/protein deacetylases J. Biol. Chem. 277:2002;18535-18544
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18535-18544
-
-
Jackson, M.D.1
Denu, J.M.2
-
19
-
-
0037160097
-
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
-
Bitterman K.J., Anderson R.M., Cohen H.Y., Latorre-Esteves M., Sinclair D.A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. J. Biol. Chem. 277:2002;45099-45107
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45099-45107
-
-
Bitterman, K.J.1
Anderson, R.M.2
Cohen, H.Y.3
Latorre-Esteves, M.4
Sinclair, D.A.5
-
20
-
-
0033551152
-
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
-
Saito A., Yamashita T., Mariko Y., Nosaka Y., Tsuchiya K., Ando T., Suzuki T., Tsuruo T., Nakanishi O. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc. Natl. Acad. Sci. USA. 96:1999;4592-4597
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4592-4597
-
-
Saito, A.1
Yamashita, T.2
Mariko, Y.3
Nosaka, Y.4
Tsuchiya, K.5
Ando, T.6
Suzuki, T.7
Tsuruo, T.8
Nakanishi, O.9
-
21
-
-
0000094639
-
Characterization of matrix metalloproteinase inhibitors: Enzymatic assays
-
S.J. Enna, M. Williams, J.W. Ferkany, T. Kenakin, R.D. Porsolt, & J.P. Sullivan. New York: John Wiley
-
Marcotte P.A., Davidsen S.K. Characterization of matrix metalloproteinase inhibitors: Enzymatic assays. Enna S.J., Williams M., Ferkany J.W., Kenakin T., Porsolt R.D., Sullivan J.P. Current Protocols in Pharmacology. 2001;3.7.1-3.7.14 John Wiley, New York
-
(2001)
Current Protocols in Pharmacology
, pp. 371-3714
-
-
Marcotte, P.A.1
Davidsen, S.K.2
-
22
-
-
0022067728
-
Human p53 cellular tumor antigen: CDNA sequence and expression in COS cells
-
Zakut-Houri R., Bienz-Tadmor B., Givol D., Oren M. Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1985;1251-1255
-
(1985)
EMBO J.
, vol.4
, pp. 1251-1255
-
-
Zakut-Houri, R.1
Bienz-Tadmor, B.2
Givol, D.3
Oren, M.4
-
23
-
-
12444313031
-
Indole amide hydroxamic acids as potent inhibitors of histone deacetylases
-
Dai Y., Guo Y., Guo J., Pease L.J., Li J., Marcotte P.A., Glaser K.B., Tapang P., Albert D.H., Richardson P.L., Davidsen S.K., Michaelides M.R. Indole amide hydroxamic acids as potent inhibitors of histone deacetylases. Bioorg. Med. Chem. Lett. 13:2003;1897-1901
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1897-1901
-
-
Dai, Y.1
Guo, Y.2
Guo, J.3
Pease, L.J.4
Li, J.5
Marcotte, P.A.6
Glaser, K.B.7
Tapang, P.8
Albert, D.H.9
Richardson, P.L.10
Davidsen, S.K.11
Michaelides, M.R.12
-
24
-
-
10744230376
-
Alpha-keto amides as inhibitors of histone deacetylase
-
Wada C.K., Frey R.R., Ji Z., Curtin M.L., Garland R.B., Holms J.H., Li J., Pease L.J., Guo J., Glaser K.B., Marcotte P.A., Richardson P.L., Murphy S.S., Bouska J.J., Tapang P., Magoc T.J., Albert D.H., Davidsen S.K., Michaelides M.R. Alpha-keto amides as inhibitors of histone deacetylase. Bioorg. Med. Chem. Lett. 13:2003;3331-3335
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 3331-3335
-
-
Wada, C.K.1
Frey, R.R.2
Ji, Z.3
Curtin, M.L.4
Garland, R.B.5
Holms, J.H.6
Li, J.7
Pease, L.J.8
Guo, J.9
Glaser, K.B.10
Marcotte, P.A.11
Richardson, P.L.12
Murphy, S.S.13
Bouska, J.J.14
Tapang, P.15
Magoc, T.J.16
Albert, D.H.17
Davidsen, S.K.18
Michaelides, M.R.19
-
25
-
-
12444251034
-
A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units
-
Dai Y., Guo Y., Curtin M.L., Li J., Pease L.J., Guo J., Marcotte P.A., Glaser K.B., Davidsen S.K., Michaelides M.R. A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg. Med. Chem. Lett. 13:2003;3817-3820
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 3817-3820
-
-
Dai, Y.1
Guo, Y.2
Curtin, M.L.3
Li, J.4
Pease, L.J.5
Guo, J.6
Marcotte, P.A.7
Glaser, K.B.8
Davidsen, S.K.9
Michaelides, M.R.10
-
26
-
-
10744233418
-
Heterocyclic ketones as inhibitors of histone deacetylase
-
Vasudevan A., Ji Z., Frey R.R., Wada C.K., Steinman D., Heyman H.R., Guo Y., Curtin M.L., Guo J., Li J., Pease L., Glaser K.B., Marcotte P.A., Bouska J.J., Davidsen S.K., Michaelides M.R. Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg. Med. Chem. Lett. 13:2003;3909-3913
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 3909-3913
-
-
Vasudevan, A.1
Ji, Z.2
Frey, R.R.3
Wada, C.K.4
Steinman, D.5
Heyman, H.R.6
Guo, Y.7
Curtin, M.L.8
Guo, J.9
Li, J.10
Pease, L.11
Glaser, K.B.12
Marcotte, P.A.13
Bouska, J.J.14
Davidsen, S.K.15
Michaelides, M.R.16
-
27
-
-
0020433627
-
Human spleen histone H4: Isolation and amino acid sequence
-
Hayashi T., Ohe Y., Hayashi H., Iwai K. Human spleen histone H4: isolation and amino acid sequence. J. Biochem. (Tokyo). 92:1982;1995-2000
-
(1982)
J. Biochem. (Tokyo)
, vol.92
, pp. 1995-2000
-
-
Hayashi, T.1
Ohe, Y.2
Hayashi, H.3
Iwai, K.4
-
28
-
-
0142143529
-
A novel homogeneous fluorescent method to monitor histone deacetylase activity
-
September 6-9, Vancouver, British Columbia
-
G.A. Hofmann, E. Hu, J.D. Winkler, X.L. Zhang, J.D. Martin, W-S. Liu, S.A. Carr, T. Meek, R. Macarron, A novel homogeneous fluorescent method to monitor histone deacetylase activity, in: Sixth Annual Conference of the Society for Biomolecular Screening, September 6-9, 2000, Vancouver, British Columbia, p. 209
-
(2000)
Sixth Annual Conference of the Society for Biomolecular Screening
, pp. 209
-
-
Hofmann, G.A.1
Hu, E.2
Winkler, J.D.3
Zhang, X.L.4
Martin, J.D.5
Liu, W.-S.6
Carr, S.A.7
Meek, T.8
Macarron, R.9
-
29
-
-
0142179154
-
Identification of novel isoform-selective inhibitors within class I histone deacetylases
-
Hu E., Dul E., Sung C.M., Chen Z., Kirkpatrick R., Zhang G.F., Johanson K., Liu R., Lago A., Hofmann G., Macarron R., de los Frailes M., Perez P., Krawiec J., Winkler J., Jaye M. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J. Pharmacol. Exp. Ther. 307:2003;720-728
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.307
, pp. 720-728
-
-
Hu, E.1
Dul, E.2
Sung, C.M.3
Chen, Z.4
Kirkpatrick, R.5
Zhang, G.F.6
Johanson, K.7
Liu, R.8
Lago, A.9
Hofmann, G.10
MacArron, R.11
De Los Frailes, M.12
Perez, P.13
Krawiec, J.14
Winkler, J.15
Jaye, M.16
|