HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

EMBO Journal

Volumn 22, Issue 5, 2003, Pages 1168-1179

  Zhang, Yu ^a   Li, Na ^a   Caron, Cécile ^b   Matthias, Gabriele ^a   Hess, Daniel ^a   Khochbin, Saadi ^a   Matthias, Patrick ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b INSERM   (France)

Author keywords

Chromatin; Cytoskeleton; Deacetylase; HDAC (histone deacetylase); Tubulin

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; TUBULIN;

ACETYLATION; ARTICLE; CONTROLLED STUDY; DEACETYLATION; EMBRYO CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STEM CELL; TWO HYBRID SYSTEM;

EUKARYOTA; MAMMALIA;

EID: 0037416151     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg115     Document Type: Article

References (37)

1. Adachi, N., Kimura, A. and Horikoshi, M. (2002) A conserved motif common to the histone acetyltransferase Esal and the histone deacetylase Rpd3. J. Biol. Chem., 277, 35688-35695.
2. Brown, C.E., Lechner, T., Howe, L. and Workman, J.L. (2000) The many HATs of transcription coactivators. Trends Biochem. Sci., 25, 15-19.
3. Cheung, W.L., Briggs, S.D. and Allis, C.D. (2000) Acetylation and chromosomal functions. Curr. Opin. Cell Biol., 12, 326-333.
4. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
5. Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., Breslow, R. and Pavletich, N.P. (1999) Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401, 188-193.
6. Fischer, D.D. et al. (2002) Isolation and characterization of a novel class II histone deacetylase, HDAC10. J. Biol. Chem., 277, 6656-6666.
7. Gaertig, J., Cruz, M.A., Bowen, J., Gu, L., Pennock, D.G. and Gorovsky, M.A. (1995) Acetylation of lysine 40 in α-tubulin is not essential in Tetrahymena thermophila. J. Cell Biol., 129, 1301-1310.
8. Gray, S.G. and Ekstrom, T.J. (2001) The human histone deacetylase family. Exp. Cell Res., 262, 75-83.
9. Grozinger, C.M. and Schreiber, S.L. (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl Acad. Sci. USA, 97, 7835-7840.
10. Grozinger, C.M., Hassig, C.A. and Schreiber, S.L. (1999) Three proteins define a class of human histone deacetylases related to yeast Hdalp. Proc. Natl Acad. Sci. USA, 96, 4868-4873.
11. Guardiola, A.R. and Yao, T.P. (2002) Molecular cloning and characterization of a novel histone deacetylase HDAC10. J. Biol. Chem., 277, 3350-3356.
12. 1 and S phase protein phosphatase that associates with Cdk2. Cell, 75, 791-803.
13. Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.F. and Yao, T.P. (2002) HDAC6 is a microtubule-associated deacetylase. Nature, 417, 455-458.
14. Jenuwein, T. and Allis, C.D. (2001) Translating the histone code. Science, 293, 1074-1080.
15. Kao, H.Y., Lee, C.H., Komarov, A., Han, C.C. and Evans, R.M. (2002) Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J. Biol. Chem., 277, 187-193.
16. Khochbin, S., Verdel, A., Lemercier, C. and Seigneurin-Berny, D. (2001) Functional significance of histone deacetylase diversity. Curr. Opin. Genet. Dev., 11, 162-166.
17. Kozminski, K.G., Diener, D.R. and Rosenbaum, J.L. (1993) High level expression of nonacetylatable α-tubulin in Chlamydomonas reinhardtii. Cell Motil. Cytoskeleton, 25, 158-170.
18. Krieg, J., Hartmann, S., Vicentini, A., Glasner, W., Hess, D. and Hofsteenge, J. (1998) Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp. Mol. Biol. Cell, 9, 301-309.
19. Kuzmichev, A. and Reinberg, D. (2001) Role of histone deacetylase complexes in the regulation of chromatin metabolism. Curr. Top. Microbiol. Immunol., 254, 35-58.
20. Lagger, G. et al. (2002) Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J., 21, 2672-2681.
21. LeDizet, M. and Piperno, G. (1991) Detection of acetylated α-tubulin by specific antibodies. Methods Enzymol., 196, 264-274.
22. Marks, P., Rifkind, R.A., Richon, V.M., Breslow, R., Miller, T. and Kelly, W.K. (2001) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer, 1, 194-202.
23. Marmorstein, R. and Roth, S.Y. (2001) Histone acetyltransferases: function, structure and catalysis. Curr. Opin. Genet. Dev., 11, 155-161.
24. McKinsey, T.A., Zhang, C.L., Lu, J. and Olson, E.N. (2000a) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature, 408, 106-111.
25. McKinsey, T.A., Zhang, C.L. and Olson, E.N. (2000b) Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc. Natl Acad. Sci. USA, 97, 14400-14405.
26. Means, G.D., Toy, D.Y., Baum, P.R. and Derry, J.M. (2000) A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics, 65, 213-223.
27. Melnick, A. and Licht, J.D. (2002) Histone deacetylases as therapeutic targets in hematologic malignancies. Curr. Opin. Hematol., 9, 322-332.
28. Narlikar, G.J., Fan, H.Y. and Kingston, R.E. (2002) Cooperation between complexes that regulate chromatin structure and transcription. Cell, 108, 475-487.
29. Peterson, C.L. (2002) HDAC's at work. Everyone doing their part. Mol. Cell, 9, 921-922.
30. Piperno, G., LeDizet, M. and Chang, X.J. (1987) Microtubules containing acetylated α-tubulin in mammalian cells in culture. J. Cell Biol., 104, 289-302.
31. Polevoda, B. and Sherman, F. (2002) The diversity of acetylated proteins. Genome Biol., 3, reviews0006.
32. Richon, V.M., Sandhoff, T.W., Rifkind, R.A. and Marks, P.A. (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl Acad. Sci. USA, 97, 10014-10019.
33. Seigneurin-Berny, D., Verdel, A., Curtet, S., Lemercier, C., Garin, J., Rousseaux, S. and Khochbin, S. (2001) Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol., 21, 8035-8044.
34. Tian, L., Nelson, D.L. and Stewart, D.M. (2000) Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. J. Biol. Chem., 275, 7854-7861.
35. Tong, J.J., Liu, J., Bertos, N.R. and Yang, X.J. (2002) Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res., 30, 1114-1123.
36. Verdel, A. and Khochbin, S. (1999) Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J. Biol. Chem., 274, 2440-2445.
37. Verdel, A., Curtet, S., Brocard, M.P., Rousseaux, S., Lemercier, C., Yoshida, M. and Khochbin, S. (2000) Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm. Curr. Biol., 10, 747-749.