The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 5, 2006, Pages 1587-1592

  Simonini, M V ^a   Camargo, L M ^b   Dong, E ^a   Maloku, E ^a   Veldic, M ^a   Costa, E ^a,c   Guidotti, A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Merck Sharp & Dohme Limited   (United Kingdom)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Bipolar disorder; Chromatin remodeling; Histone code; Reelin; Schizophrenia

Indexed keywords

ACETYLHISTONE 3; ATYPICAL ANTIPSYCHOTIC AGENT; BENZAMIDE DERIVATIVE; GLUTAMATE DECARBOXYLASE 67; HISTONE; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NEUROLEPTIC AGENT; REELIN; SULPIRIDE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIPOLAR DISORDER; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; FRONTAL CORTEX; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MENTAL DISEASE; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SCHIZOPHRENIA;

ANIMALS; BENZAMIDES; BIPOLAR DISORDER; BLOTTING, WESTERN; BRAIN; CELL ADHESION MOLECULES, NEURONAL; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXTRACELLULAR MATRIX PROTEINS; FRONTAL LOBE; HIPPOCAMPUS; HISTONE DEACETYLASES; HISTONES; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MALE; MICE; MODELS, STATISTICAL; NERVE TISSUE PROTEINS; NEURONS; PROMOTER REGIONS (GENETICS); PYRIDINES; SCHIZOPHRENIA; SERINE ENDOPEPTIDASES; TIME FACTORS;

ANIMALIA;

EID: 31944444233     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510341103     Document Type: Article

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