HDAC inihibitors correct frataxin deficiency in a Friedreich ataxia mouse model

PLoS ONE

Volumn 3, Issue 4, 2008, Pages

  Rai, Myriam ^a   Soragni, Elisabetta ^b   Jenssen, Kai ^b,d   Burnett, Ryan ^b   Herman, David ^b   Coppola, Giovanni ^c   Geschwind, Daniel H ^c   Gottesfeld, Joel M ^b   Pandolfo, Massimo ^a  

^a ERASME HOSPITAL   (Belgium)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; MESSENGER RNA; N (2 AMINOPHENYL) N7 PARA TOLYLHEPTANEDIAMIDE; ENZYME INHIBITOR; HISTONE; HISTONE DEACETYLASE; IRON BINDING PROTEIN;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG EFFICACY; EPIGENETICS; FRIEDREICH ATAXIA; GENE EXPRESSION; GENE SILENCING; HETEROCHROMATIN; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; TOXICITY TESTING; WESTERN BLOTTING; ANIMAL; CEREBELLUM; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETICS; HEART MUSCLE; INTRON; METABOLISM;

ANIMALIA; MUS;

ACETYLATION; ANIMALS; CEREBELLUM; CHROMATIN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPIGENESIS, GENETIC; FRIEDREICH ATAXIA; GENE EXPRESSION PROFILING; HISTONE DEACETYLASES; HISTONES; INTRONS; IRON-BINDING PROTEINS; MICE; MYOCARDIUM; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER;

EID: 44349114629     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001958     Document Type: Article

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