Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 4, 2003, Pages 2041-2046

  Hockly, Emma ^a   Richon, Victoria M ^b   Woodman, Benjamin ^a   Smith, Donna L ^a   Zhou, Xianbo ^b   Rosa, Eddie ^b   Sathasivam, Kirupa ^a   Ghazi Noori, Shabnam ^a   Mahal, Amarbirpal ^a   Lowden, Philip A S ^c   Steffan, Joan S ^d   Marsh, J Lawrence ^d   Thompson, Leslie M ^d   Lewis, Cathryn M ^a   Marks, Paul A ^e   Bates, Gillian P ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Aton Pharma Inc   (United States)

^c UNIVERSITY OF EXETER   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; HISTONE; HISTONE DEACETYLASE INHIBITOR; PLACEBO; POLYGLUTAMINE; RNA; VORINOSTAT;

ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; BLOOD BRAIN BARRIER; COMPLEX FORMATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFECT; DRUG FORMULATION; ENZYME INHIBITION; FEMALE; HUNTINGTON CHOREA; MOTOR DYSFUNCTION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL;

ACETYLATION; ANIMALS; BASE SEQUENCE; BLOOD-BRAIN BARRIER; BRAIN; DISEASE MODELS, ANIMAL; DNA PRIMERS; ENZYME INHIBITORS; FEMALE; HISTONE DEACETYLASES; HISTONES; HUNTINGTON DISEASE; HYDROXAMIC ACIDS; MICE; MICE, TRANSGENIC; MOVEMENT DISORDERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSGENES;

ANIMALIA;

EID: 0037452775     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0437870100     Document Type: Article

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